KR830007614A - 푸란유도체의 제조방법 - Google Patents

푸란유도체의 제조방법 Download PDF

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Publication number
KR830007614A
KR830007614A KR1019810005251A KR810005251A KR830007614A KR 830007614 A KR830007614 A KR 830007614A KR 1019810005251 A KR1019810005251 A KR 1019810005251A KR 810005251 A KR810005251 A KR 810005251A KR 830007614 A KR830007614 A KR 830007614A
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KR
South Korea
Prior art keywords
producing
general formula
furan derivative
derivative according
reducing agent
Prior art date
Application number
KR1019810005251A
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English (en)
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KR850001935B1 (ko
Inventor
에드먼드 배이스 대비드
와트슨 크리더로 존
부르스 주드 던칸
Original Assignee
그랙소 그룹 리밋티드
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Publication of KR830007614A publication Critical patent/KR830007614A/ko
Application granted granted Critical
Publication of KR850001935B1 publication Critical patent/KR850001935B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

푸란유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(I)의 라디티딘을 제조하는 방법에 있어서, 일반식(II)의 알데히드를 적절한 용매내에서 디메틸아민과 환원제(니트로에텐기는 환원시키지 않으면서 환원성 알킬화반응을 일으켜서 디메틸아미 노메틸기를 삽입시킬 수 있는 환원제)로 처리하여 일반식(I)의 라니티닌을 제조하는 푸란유도체의 제조방법.
  2. 제1항에 있어서, 용매가 수성알카놀, 수성디옥산 또는 수성 테트라히드로푸란인 푸란 유도체의 제조방법.
  3. 제1항이나 2항에 있어서, 환원제가 디보란, 수소 화알루미늄 또는 수소화붕소 알칼리토금속인 푸란유도체의 제조방법.
  4. 제3항에 있어서, 환원제가 수소화붕소나트륨이나 수소화붕소 시아노나트륨인 푸란유동체의 제조방법.
  5. 제4항에 있어서, 반응이 산성 존재하에서 일어나거나 또는 산으로 처리되므로써 환원제의 반응이 일어나는 푸란유도체의 제조방법.
  6. 제1-5항에 있어서, 반응이 10-100℃의 온도에서 일어나는 푸란유도체의 제조방법.
  7. 제1-6항중 어느 한가지 항에 있어서, 일반식(Ⅱ)알 의데히드가 일반식(Ⅲ)으로 부터 그대로 이루어
    (이식이서 R1과 R2는 둘다 알킬기이거나 또는 이세탈고리를 형성하는 R1OCHOR2기이다.)
  8. 제7항에 있어서, 과량의 디메틸아민 염산염의 존재하에서 R1OCHOR2기가 1,3-디옥솔란-2일 기인 일반식(Ⅲ)의 아세탈일 유기산이나 무기산을 이용하여 가수분해 되어서 일반식(Ⅱ)의 알데히드를 형성하는 푸란유도체의 제조방법.
  9. 제1-8항중 어느 한가지 항에 있어서, 일반식(I)의 화합물이 산성부가염으로 변화되는 푸란유도체의 제조방법.
  10. 제9항에 있어서, 산성부가염이 염산염인 푸란유도체의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810005251A 1980-12-30 1981-12-30 푸란유도체의 제조방법 KR850001935B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8041493 1980-12-30
GB80.41493 1980-12-30
GB80-41493 1980-12-30

Publications (2)

Publication Number Publication Date
KR830007614A true KR830007614A (ko) 1983-11-04
KR850001935B1 KR850001935B1 (ko) 1985-12-31

Family

ID=10518248

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810005251A KR850001935B1 (ko) 1980-12-30 1981-12-30 푸란유도체의 제조방법

Country Status (11)

Country Link
US (1) US4399294A (ko)
EP (1) EP0055625B1 (ko)
JP (1) JPS57134475A (ko)
KR (1) KR850001935B1 (ko)
AR (2) AR230275A1 (ko)
AT (1) ATE13057T1 (ko)
DE (1) DE3170346D1 (ko)
DK (1) DK153841C (ko)
ES (1) ES508474A0 (ko)
FI (1) FI82241C (ko)
PT (1) PT74235B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5988458A (ja) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd アミン誘導体およびその塩
SU1384197A3 (ru) * 1983-07-15 1988-03-23 Рихтер Гедеон Ведьесети Дьяр Рт (Инопредприятие) Способ получени 1- @ 2-(5-(ди-метиламинометил)-2-(фурилметилтио)-этил) @ амино-1-(метиламино)-2-нитроэтилена или его гидрохлорида и способ получени дигидрохлорида 2-(2-аминоэтил)-тиометил-5-(диметиламинометил)-фурана или его моногидрохлорида
DK153758C (da) * 1985-09-27 1995-10-02 Gea Farmaceutisk Fabrik As Fremgangsmåde til fremstilling af ranitidin eller syreadditionssalte deraf samt derivat af 5-((2-aminoethyl)thiomethyl)-2-furanmethanol til brug som udgangsmateriale for fremgangsmåden
AR245716A1 (es) * 1986-03-28 1994-02-28 Janus Farma Srl Procedimiento para la sintesis de niperotidina que tiene actividad terapeutica anti-ulcera.
YU52598A (sh) * 1998-11-19 2001-05-28 D.D. Zdravlje- sektor za istraživanje i razvoj POSTUPAK ZA sintezu N-[2[[[5=[(DIALKILAMINO)METIL]-2= FURANIL]METIL]TIO]ETIL]-N'-ALKIL-2-NITRO 1,1 ALKENDIAMINA I NJIHOVIH HIDROHLORIDA
CN108864001A (zh) * 2018-06-30 2018-11-23 郑州明泽医药科技有限公司 一种合成雷尼替丁的新方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
CH654830A5 (en) * 1980-01-08 1986-03-14 Glaxo Group Ltd Aziridine derivative

Also Published As

Publication number Publication date
JPS57134475A (en) 1982-08-19
ES8301955A1 (es) 1983-01-01
PT74235B (en) 1984-01-04
AR230442A1 (es) 1984-04-30
EP0055625A1 (en) 1982-07-07
FI82241C (fi) 1991-02-11
JPH038349B2 (ko) 1991-02-05
ES508474A0 (es) 1983-01-01
US4399294A (en) 1983-08-16
DK153841C (da) 1989-02-20
DK582081A (da) 1982-07-01
DK153841B (da) 1988-09-12
EP0055625B1 (en) 1985-05-02
DE3170346D1 (en) 1985-06-05
AR230275A1 (es) 1984-03-01
PT74235A (en) 1982-01-02
FI82241B (fi) 1990-10-31
FI814215L (fi) 1982-07-01
ATE13057T1 (de) 1985-05-15
KR850001935B1 (ko) 1985-12-31

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