ES8301210A1 - Un procedimiento para la preparacion de un derivado del indol. - Google Patents
Un procedimiento para la preparacion de un derivado del indol.Info
- Publication number
- ES8301210A1 ES8301210A1 ES504693A ES504693A ES8301210A1 ES 8301210 A1 ES8301210 A1 ES 8301210A1 ES 504693 A ES504693 A ES 504693A ES 504693 A ES504693 A ES 504693A ES 8301210 A1 ES8301210 A1 ES 8301210A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- compounds
- hydrogen atom
- indole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000019695 Migraine disease Diseases 0.000 title abstract 2
- 206010027599 migraine Diseases 0.000 title abstract 2
- ZLGOIJVZHJWSPL-UHFFFAOYSA-N 2-(1h-indol-5-yl)acetamide Chemical class NC(=O)CC1=CC=C2NC=CC2=C1 ZLGOIJVZHJWSPL-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002560 nitrile group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001391 thioamide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8026286 | 1980-08-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES504693A0 ES504693A0 (es) | 1982-12-01 |
| ES8301210A1 true ES8301210A1 (es) | 1982-12-01 |
Family
ID=10515410
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES504693A Expired ES8301210A1 (es) | 1980-08-12 | 1981-08-11 | Un procedimiento para la preparacion de un derivado del indol. |
| ES513933A Expired ES8402268A1 (es) | 1980-08-12 | 1982-07-13 | Un procedimiento para la preparacion de un derivado del indol. |
| ES520784A Granted ES520784A0 (es) | 1980-08-12 | 1983-03-18 | Un procedimiento para la preparacion de un derivado del indol. |
| ES520785A Expired ES8500903A1 (es) | 1980-08-12 | 1983-03-18 | Un procedimiento para la preparacion de un derivado del indol. |
| ES520783A Granted ES520783A0 (es) | 1980-08-12 | 1983-03-18 | Un procedimiento para la preparacion de un derivado del indol. |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES513933A Expired ES8402268A1 (es) | 1980-08-12 | 1982-07-13 | Un procedimiento para la preparacion de un derivado del indol. |
| ES520784A Granted ES520784A0 (es) | 1980-08-12 | 1983-03-18 | Un procedimiento para la preparacion de un derivado del indol. |
| ES520785A Expired ES8500903A1 (es) | 1980-08-12 | 1983-03-18 | Un procedimiento para la preparacion de un derivado del indol. |
| ES520783A Granted ES520783A0 (es) | 1980-08-12 | 1983-03-18 | Un procedimiento para la preparacion de un derivado del indol. |
Country Status (16)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1170387B (it) * | 1982-06-07 | 1987-06-03 | Glaxo Group Ltd | Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono |
| GB8332435D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
| GB8419575D0 (en) * | 1984-08-01 | 1984-09-05 | Glaxo Group Ltd | Chemical compounds |
| US4833153A (en) * | 1985-11-08 | 1989-05-23 | Glaxo Group Limited | Indole derivatives |
| GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
| US5270333A (en) * | 1986-01-28 | 1993-12-14 | Glaxo Group Limited | Indole derivatives |
| GB8607824D0 (en) * | 1986-03-27 | 1986-04-30 | Glaxo Group Ltd | Chemical compounds |
| EP0486666B1 (en) * | 1990-06-07 | 1997-08-13 | Zeneca Limited | Therapeutic heterocyclic compounds |
| SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| US5254383A (en) * | 1992-09-14 | 1993-10-19 | Allied-Signal Inc. | Composites having improved penetration resistance and articles fabricated from same |
| FR2701026B1 (fr) * | 1993-02-02 | 1995-03-31 | Adir | Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US5468768A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
| ES2084560B1 (es) * | 1994-03-09 | 1997-01-16 | Almirall Lab | Procedimiento de preparacion de derivados el indol. |
| US5891885A (en) * | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
| US20030096379A1 (en) * | 2001-03-28 | 2003-05-22 | Kilgore James L. | Method for producing tryptamine derivatives |
| US6685951B2 (en) | 2001-07-05 | 2004-02-03 | R. T. Alamo Ventures I, Inc. | Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine |
| US20030017175A1 (en) * | 2001-07-05 | 2003-01-23 | R.T. Alamo Ventures I, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
| US20030198669A1 (en) * | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
| CN1729174B (zh) * | 2002-12-20 | 2015-10-21 | 西巴特殊化学品控股有限公司 | 胺的合成以及用于合成胺的中间体 |
| WO2008097664A1 (en) * | 2007-02-11 | 2008-08-14 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
| CL2008000838A1 (es) | 2007-03-23 | 2008-10-10 | Neuraxon Inc | Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios |
| CA2681979A1 (en) | 2007-03-29 | 2008-10-09 | Asubio Pharma Co., Ltd. | Indole derivatives having cpla2 inhibiting activity and applications and production methods of the same |
| WO2010151804A1 (en) * | 2009-06-26 | 2010-12-29 | Map Pharmaceuticals, Inc. | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
| EP3628325A1 (en) | 2011-07-22 | 2020-04-01 | The University of Chicago | Treatments for migraine and related disorders |
| US9394314B2 (en) | 2012-12-21 | 2016-07-19 | Map Pharmaceuticals, Inc. | 8′-hydroxy-dihydroergotamine compounds and compositions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3182071A (en) * | 1961-06-27 | 1965-05-04 | Warner Lambert Pharmaceutical | Acylated indole derivatives |
| US3472870A (en) * | 1966-08-29 | 1969-10-14 | Mead Johnson & Co | Sulfonamidotryptamines |
| ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
-
1981
- 1981-08-11 BE BE0/205642A patent/BE889929A/fr not_active IP Right Cessation
- 1981-08-11 ZA ZA815540A patent/ZA815540B/xx unknown
- 1981-08-11 IT IT49084/81A patent/IT1171449B/it active
- 1981-08-11 AU AU73994/81A patent/AU548467B2/en not_active Ceased
- 1981-08-11 SE SE8104781A patent/SE454880B/sv not_active IP Right Cessation
- 1981-08-11 NZ NZ197996A patent/NZ197996A/en unknown
- 1981-08-11 DE DE19813131728 patent/DE3131728A1/de active Granted
- 1981-08-11 ES ES504693A patent/ES8301210A1/es not_active Expired
- 1981-08-11 FR FR8115513A patent/FR2488607A1/fr active Granted
- 1981-08-11 CH CH5159/81A patent/CH651551A5/fr not_active IP Right Cessation
- 1981-08-11 IE IE1830/81A patent/IE51491B1/en unknown
- 1981-08-11 DK DK357081A patent/DK157920C/da not_active IP Right Cessation
- 1981-08-11 NL NL8103769A patent/NL8103769A/nl not_active Application Discontinuation
- 1981-08-12 JP JP56125411A patent/JPS5764669A/ja active Granted
- 1981-08-12 CA CA000383670A patent/CA1169428A/en not_active Expired
-
1982
- 1982-07-13 ES ES513933A patent/ES8402268A1/es not_active Expired
-
1983
- 1983-01-26 US US06/461,233 patent/US4650810A/en not_active Expired - Fee Related
- 1983-03-18 ES ES520784A patent/ES520784A0/es active Granted
- 1983-03-18 ES ES520785A patent/ES8500903A1/es not_active Expired
- 1983-03-18 ES ES520783A patent/ES520783A0/es active Granted
Also Published As
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