ES8205207A1 - Un procedimiento para la preparacion de una sal de amina - Google Patents

Un procedimiento para la preparacion de una sal de amina

Info

Publication number
ES8205207A1
ES8205207A1 ES496210A ES496210A ES8205207A1 ES 8205207 A1 ES8205207 A1 ES 8205207A1 ES 496210 A ES496210 A ES 496210A ES 496210 A ES496210 A ES 496210A ES 8205207 A1 ES8205207 A1 ES 8205207A1
Authority
ES
Spain
Prior art keywords
dihalo
carboxylic acids
salts
radical
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496210A
Other languages
English (en)
Other versions
ES496210A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES496210A0 publication Critical patent/ES496210A0/es
Publication of ES8205207A1 publication Critical patent/ES8205207A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UNA SAL DE AMINA DE FORMULA (I), DONDE R Y R1 SON HALOGENO; R2, HIDROGENO, METIL O ETIL; R3, HIDROGENO, METIL, ETIL U OTROS; R4, UN RADICAL DE HIDROCARBILO IMPEDIDO, PUDIENDO FORMAR R3 Y R4 ENTRE SI UNA ADAMANTILESPIROPIRROLIDINA. UN ACIDO LIBRE O UNA SAL DEL ACIDO CAARBOXILICO DE 6,7-DIHALO-3,4-DIHIDRO-3-OXO-2-QUINOXALINA, DE FORMULA (II), ONTENIDO POR REACCION DE UNA O-FENILENDIAMINA SUSTITUIDA Y UN 2-CETOMALONATO DE DIALQUILO, SE HACE REACCIONAR CON UNA BASE LIBRE O SAL DE AMINA IMPEIDA, DE FORMULA (III). SE AGITA LA MEZCLA Y SE MANTIENE A TEMPERATURA DE 100 GRADOS CENTIGRADOS. SE ENFRIA. SE FILTRA Y SE SECA LA TORTA DEL FILTRO A TEMPERATURA DE 90 GRADOS CENTIGRADOS Y A PRESION EDUCIDA.
ES496210A 1979-10-25 1980-10-23 Un procedimiento para la preparacion de una sal de amina Expired ES8205207A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/088,275 US4252954A (en) 1979-10-25 1979-10-25 Salts of dihalo-3,4-dihydro-3-oxo-2-quinoxaline carboxylic acids and hindered amines

Publications (2)

Publication Number Publication Date
ES496210A0 ES496210A0 (es) 1981-10-01
ES8205207A1 true ES8205207A1 (es) 1981-10-01

Family

ID=22210429

Family Applications (1)

Application Number Title Priority Date Filing Date
ES496210A Expired ES8205207A1 (es) 1979-10-25 1980-10-23 Un procedimiento para la preparacion de una sal de amina

Country Status (20)

Country Link
US (1) US4252954A (es)
EP (1) EP0029658A1 (es)
JP (1) JPS5681569A (es)
AU (1) AU6351280A (es)
BE (1) BE885793A (es)
CA (1) CA1149381A (es)
CS (1) CS212304B2 (es)
DD (1) DD153689A5 (es)
DK (1) DK449780A (es)
ES (1) ES8205207A1 (es)
FI (1) FI803294L (es)
FR (1) FR2467848A1 (es)
GB (1) GB2061936A (es)
GR (1) GR69994B (es)
IL (1) IL61313A0 (es)
IT (1) IT1134009B (es)
PL (1) PL227421A1 (es)
PT (1) PT71939B (es)
YU (1) YU268880A (es)
ZA (1) ZA806437B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD281614A5 (de) * 1988-09-02 1990-08-15 Univ Berlin Humboldt Verfahren zur herstellung von virostatisch wirksamendiazinsubstituierten 1-adamantanen
AU9049391A (en) * 1990-12-20 1992-07-22 Warner-Lambert Company 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
US6348461B1 (en) * 1997-09-01 2002-02-19 Kyorin Pharmaceutical Co., Ltd. 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, addition salts thereof, and processes for the preparation of both
CA2520763A1 (en) * 2003-04-03 2004-10-21 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
JP2007532484A (ja) 2004-03-16 2007-11-15 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 可溶性エポキシド加水分解酵素の阻害剤およびエポキシエイコサノイドを用いて腎症を緩和する方法
WO2006045119A2 (en) * 2004-10-20 2006-04-27 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
AR059826A1 (es) * 2006-03-13 2008-04-30 Univ California Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble
US9296693B2 (en) 2010-01-29 2016-03-29 The Regents Of The University Of California Acyl piperidine inhibitors of soluble epoxide hydrolase
WO2012045280A1 (en) * 2010-10-08 2012-04-12 Novartis Ag Salts and polymorphs of sulfamide ns3 inhibitors
JP6406159B2 (ja) 2015-08-04 2018-10-17 株式会社デンソー 車載表示制御装置、車載表示制御方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355355A (en) * 1965-02-05 1967-11-28 Smith Kline French Lab Antiviral cycloalkylamine compositions and method
DE1770697C3 (de) * 1967-07-06 1981-04-23 Dupher International Research B.V., Weesp 2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel
GB1438349A (en) * 1973-09-13 1976-06-03 Post Office Conductor assemblies for cables
US4181724A (en) * 1978-09-11 1980-01-01 The Upjohn Company Quinoxalinone compounds useful for expanding the lumina or air passages in mammals
PH15791A (en) * 1978-10-20 1983-03-25 Lilly Co Eli Pharmaceutical composition containing 3,4-dihydro-3-oxoquinoxalines

Also Published As

Publication number Publication date
PT71939B (en) 1981-08-31
ES496210A0 (es) 1981-10-01
PL227421A1 (es) 1981-06-19
JPS5681569A (en) 1981-07-03
IL61313A0 (en) 1980-12-31
PT71939A (en) 1980-11-01
IT8025538A0 (it) 1980-10-23
US4252954A (en) 1981-02-24
DK449780A (da) 1981-04-26
AU6351280A (en) 1981-04-30
GR69994B (es) 1982-07-23
ZA806437B (en) 1982-05-26
DD153689A5 (de) 1982-01-27
YU268880A (en) 1983-02-28
GB2061936A (en) 1981-05-20
EP0029658A1 (en) 1981-06-03
FR2467848A1 (fr) 1981-04-30
BE885793A (fr) 1981-04-21
FI803294L (fi) 1981-04-26
CA1149381A (en) 1983-07-05
CS212304B2 (en) 1982-03-26
IT1134009B (it) 1986-07-24

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