ES8105151A1 - Un metodo para la preparacion de un anticuerpo monoclonico. - Google Patents

Un metodo para la preparacion de un anticuerpo monoclonico.

Info

Publication number
ES8105151A1
ES8105151A1 ES490943A ES490943A ES8105151A1 ES 8105151 A1 ES8105151 A1 ES 8105151A1 ES 490943 A ES490943 A ES 490943A ES 490943 A ES490943 A ES 490943A ES 8105151 A1 ES8105151 A1 ES 8105151A1
Authority
ES
Spain
Prior art keywords
diagnostic
monoclonal antibody
cells
cell line
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490943A
Other languages
English (en)
Other versions
ES490943A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21871570&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8105151(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of ES490943A0 publication Critical patent/ES490943A0/es
Publication of ES8105151A1 publication Critical patent/ES8105151A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/966—Chemistry: molecular biology and microbiology involving an enzyme system with high turnover rate or complement magnified assay, e.g. multi-enzyme systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Hybrid Cells (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE UN ANTICUERPO MONOCLONICO. CONSTA DE LAS SIGUIENTES ETAPAS: 1. INMUNIZAR RATONES CON CELULAS T HUMANAS PURIFICADAS POSITIVAS A ROSETRE E. 2. SEPARAR LOS BAZOS DE DICHOS RATONES Y CONFECCIONAR UNA SUSPENSION DE CELULAS DE BAZO. 3. FUSIONAR DICHAS CELULAS DE BAZO CON CELULAS DE MIELOMA DE RATON EN PRESENCIA DE UN PROMOTOR DE LA FUSION. 4. DILUIR Y CULTIVAR LAS CELULAS FUSIONADAS EN POCILLOS SEPARADOS EN UN MEDIO QUE NO SOPORTARA LAS CELULAS DE MIELOMA NO FUSIONADAS. 5. EVALUAR EL SOBRENADANTE EN CADA POCILLO QUE CONTIENE UN HIBRIDOMA EN RELACION CON LA PRESENCIA DE UN ANTICUERPO PARA CELULAS T PURIFICADAS. 6. SELECCIONAR Y CLONAR UN HIBRIDOMA PRODUCTOR DE UN ANTICUERPO QUE REACCIONA CON TODAS LAS CELULAS T AUXILIARES PERIFERICAS HUMANAS NORMALES, PERO NO CON LAS CELULAS B PERIFERICAS HUMANAS NORMALES, LAS CELULAS NULAS O LOS MACROFAGOS. C
ES490943A 1979-04-26 1980-04-25 Un metodo para la preparacion de un anticuerpo monoclonico. Expired ES8105151A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/033,639 US4381295A (en) 1979-04-26 1979-04-26 Monoclonal antibody to human helper T cells and methods of preparing same

Publications (2)

Publication Number Publication Date
ES490943A0 ES490943A0 (es) 1981-05-16
ES8105151A1 true ES8105151A1 (es) 1981-05-16

Family

ID=21871570

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490943A Expired ES8105151A1 (es) 1979-04-26 1980-04-25 Un metodo para la preparacion de un anticuerpo monoclonico.

Country Status (22)

Country Link
US (1) US4381295A (es)
EP (1) EP0018794B1 (es)
JP (2) JPS55145616A (es)
AT (1) ATE14454T1 (es)
AU (1) AU544792B2 (es)
CA (1) CA1170592A (es)
DE (2) DE18794T1 (es)
DK (1) DK154087C (es)
ES (1) ES8105151A1 (es)
FI (1) FI75363C (es)
GR (1) GR67298B (es)
HK (1) HK23786A (es)
IE (1) IE50459B1 (es)
IL (1) IL59919A (es)
MY (1) MY8600513A (es)
NO (1) NO159883C (es)
NZ (1) NZ193470A (es)
PH (1) PH16656A (es)
PT (1) PT71148B (es)
SG (1) SG6586G (es)
YU (1) YU44957B (es)
ZA (1) ZA802524B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4381292A (en) * 1980-11-14 1983-04-26 The Board Of Trustees Of The Leland Stanford Jr. University Anti-human T-lymphocyte monoclonal antibody
US4824432A (en) * 1981-03-24 1989-04-25 S.V.S. Laboratories, Inc. Method for treating AIDS and other immune deficiencies and immune disorders
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
USRE32011E (en) * 1981-12-14 1985-10-22 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4511662A (en) * 1982-06-18 1985-04-16 Bio-Rad Laboratories, Inc. Simultaneous assay for T and B lymphocyte populations and subpopulations
US4443427A (en) * 1982-06-21 1984-04-17 Sidney Farber Cancer Institute, Inc. Monoclonal antibody
US4582790A (en) * 1983-02-15 1986-04-15 Wisconsin Alumni Research Foundation Monoclonal antibody to angiotension-converting enzyme and methods of preparing and using same
US4550086A (en) * 1983-02-16 1985-10-29 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that recognize human T cells
US4677056A (en) * 1983-08-18 1987-06-30 Sloan-Kettering Institute For Cancer Research Monoclonal antibody subsetting human helper and killer T-cells and method
IL69686A (en) * 1983-09-11 1988-03-31 Yeda Res & Dev Compositions containing cell membrane proteins and process for their preparation
USRE35277E (en) * 1983-09-11 1996-06-18 Yeda Research And Development Co. Ltd. Cell membrane proteins, compositions containing them and procedure for their preparation
US4645738A (en) * 1983-09-30 1987-02-24 Memorial Sloan-Kettering Institute Cancer Center Method for differential diagnosis of T cell leukemias using monoclonal antibodies
JPS60231699A (ja) * 1983-11-09 1985-11-18 Aichiken 正常及び悪性ヒト造血器細胞に対するモノクローナル抗体
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
EP0146050B1 (en) 1983-12-16 1990-07-04 Denis M. Callewaert Site selective plasminogen activator and method of making and using same
US5130144B1 (en) * 1984-02-06 1995-08-15 Univ Johns Hopkins Human stem cells and monoclonal antibodies
US4965204A (en) * 1984-02-06 1990-10-23 The Johns Hopkins University Human stem cells and monoclonal antibodies
US4604235A (en) * 1984-05-23 1986-08-05 J. T. Baker Chemical Company Purification of monoclonal antibodies
EP0335426B1 (fr) * 1984-09-14 1991-07-03 Institut Pasteur Composition et procédé pour protéger les lymphocytes T contre l'agent étiologique des lymphadénopathies et du syndrome d'immunisation acquise
FR2570278B1 (fr) * 1984-09-14 1987-02-13 Pasteur Institut Compositions et procede pour proteger les lymphocytes t contre l'agent etiologique des lymphadenopathies et du syndrome d'immunodepression acquise
US4695459A (en) * 1984-12-26 1987-09-22 The Board Of Trustees Of Leland Stanford Junior University Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells
US4661446A (en) * 1985-02-19 1987-04-28 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies and method of immunizing therewith
US5776093A (en) * 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
DE3541033A1 (de) * 1985-11-19 1987-05-21 Boehringer Mannheim Gmbh Verfahren zur quantifizierung von zellpopulationen bzw. subpopulationen sowie hierfuer geeignetes reagenz
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies
CA1296622C (en) * 1986-08-12 1992-03-03 Jeffrey E. Anderson Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system
US5601819A (en) * 1988-08-11 1997-02-11 The General Hospital Corporation Bispecific antibodies for selective immune regulation and for selective immune cell binding
US5068178A (en) * 1988-12-06 1991-11-26 Genetic Systems Corporation Method of enhancing direct immunofluorescence staining of cells
US7037496B2 (en) * 1989-12-27 2006-05-02 Centocor, Inc. Chimeric immunoglobulin for CD4 receptors
JPH0424999U (es) * 1990-06-26 1992-02-28
GB9021677D0 (en) * 1990-10-05 1990-11-21 Xaar Ltd Method of testing multi-channel array pulsed droplet deposition apparatus
JPH05505112A (ja) * 1990-11-27 1993-08-05 バイオジェン，インコーポレイテッド Ａｉｄｓ、ａｒｃおよびｈｉｖ感染の予防および治療に有用な抗ｃｄ４抗体ホモログ
US5747265A (en) * 1992-10-30 1998-05-05 T Cell Diagnostics, Inc. Method for measuring the amount of a cell-associated molecule
ES2108460T3 (es) * 1993-06-03 1997-12-16 Therapeutic Antibodies Inc Fragmentos de anticuerpos en terapeutica.
US5961976A (en) * 1996-06-03 1999-10-05 United Biomedical, Inc. Antibodies against a host cell antigen complex for pre- and post-exposure protection from infection by HIV
ES2322877T3 (es) 1996-08-30 2009-06-30 Human Genome Sciences, Inc. Interleucina 19.
US6498006B2 (en) 1997-11-24 2002-12-24 Johnson T. Wong Methods for treatment of HIV and other infections using A T cell or viral activator and anti-retroviral combination therapy
US6790796B2 (en) 2001-10-05 2004-09-14 Albany International Corp. Nonwovens forming or conveying fabrics with enhanced surface roughness and texture
US20080279848A1 (en) * 2006-03-16 2008-11-13 Genentech, Inc. Methods of treating lupus using CD4 antibodies
EP2001510A4 (en) * 2006-03-16 2010-06-09 Genentech Inc METHODS OF TREATING LUPUS USING CD4 ANTIBODIES
US20100021460A1 (en) * 2008-07-15 2010-01-28 Genentech, Inc. Methods of Treating Autoimmune Diseases Using CD4 Antibodies
CA2961464A1 (en) 2014-09-16 2016-03-24 Ubi Ip Holdings Treatment and functional cure of hiv infection by monoclonal antibodies to cd4 mediating competitive hiv entry inhibition
US11292839B2 (en) 2016-08-13 2022-04-05 Ubi Us Holdings, Llc Treatment and sustained virologic remission of HIV infection by antibodies to CD4 in HAART stabilized patients

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies

Also Published As

Publication number Publication date
DK180580A (da) 1980-10-27
ES490943A0 (es) 1981-05-16
US4381295A (en) 1983-04-26
ZA802524B (en) 1981-12-30
ATE14454T1 (de) 1985-08-15
JPH0198477A (ja) 1989-04-17
IE50459B1 (en) 1986-04-30
IE800839L (en) 1980-10-26
GR67298B (es) 1981-06-29
NO801216L (no) 1980-10-27
CA1170592A (en) 1984-07-10
JPS55145616A (en) 1980-11-13
DE3070896D1 (en) 1985-08-29
FI75363B (fi) 1988-02-29
IL59919A (en) 1983-12-30
EP0018794A3 (en) 1981-01-07
FI801343A (fi) 1980-10-27
NO159883C (no) 1989-02-15
FI75363C (fi) 1988-06-09
DK154087B (da) 1988-10-10
PH16656A (en) 1983-12-09
PT71148B (en) 1981-08-11
PT71148A (en) 1980-05-01
YU114880A (en) 1985-04-30
YU44957B (en) 1991-06-30
HK23786A (en) 1986-04-11
IL59919A0 (en) 1980-06-30
JPS6362519B2 (es) 1988-12-02
AU544792B2 (en) 1985-06-13
EP0018794A2 (en) 1980-11-12
DK154087C (da) 1989-02-27
MY8600513A (en) 1986-12-31
NO159883B (no) 1988-11-07
DE18794T1 (de) 1984-07-19
EP0018794B1 (en) 1985-07-24
AU5775880A (en) 1980-10-30
JPH0159867B2 (es) 1989-12-20
SG6586G (en) 1986-08-01
NZ193470A (en) 1984-07-06

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