ES8303095A1 - Un metodo de preparacion de un inticuerpo monocloral. - Google Patents

Un metodo de preparacion de un inticuerpo monocloral.

Info

Publication number
ES8303095A1
ES8303095A1 ES497422A ES497422A ES8303095A1 ES 8303095 A1 ES8303095 A1 ES 8303095A1 ES 497422 A ES497422 A ES 497422A ES 497422 A ES497422 A ES 497422A ES 8303095 A1 ES8303095 A1 ES 8303095A1
Authority
ES
Spain
Prior art keywords
antibody
cells
diagnostic
cell line
therapeutic uses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497422A
Other languages
English (en)
Other versions
ES497422A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22277475&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8303095(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of ES497422A0 publication Critical patent/ES497422A0/es
Publication of ES8303095A1 publication Critical patent/ES8303095A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hybrid Cells (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN ANTICUERPO MONOCLONAL QUE REACCIONA CON TODAS LAS CELULAS T SUPRESORAS HUMANAS NORMALES, PERO CON MENOS DEL 2% DE LAS CELULAS DE LA MEDULA OSEA Y NO REACCIONA CON LAS CELULAS B PERIFERICAS NI CON LAS CELULAS NULAS. CONSISTE EN INMUNIZAR RATONES CON TIMOCITOS HUMANOS NORMALES; EXTIRPAR SUS BAZOS Y PREPARAR UNA SUSPENSION DE LAS CELULAS; FUSIONAR LAS CELULAS DE BAZO CON CELULAS DE MIELOMA, EN PRESENCIA DE UN PROMOTOR DE FUSION; DILUIR Y CULTIVAR LAS CELULAS; EVALUAR EL LIQUIDO SOBRENADANTE QUE CONTIENE EL HIBRIDOMA; SELECCIONAR Y CLONAR UN HIBRIDOMA PRODUCTOR DEL ANTICUERPO; RECUPERAR EL ANTICUERPO DEL LIQUIDO QUE SOBRENADA POR ENCIMA DE LOS CLONES Y RECOGER LOS ASCITES MALIGNOS O EL SUERO, QUE CONTIENE EL ANTICUERPO DESEADO. ESTOS COMPUESTOS TIENEN APLICACIONES PARA LA DIAGNOSIS Y EL TRATAMIENTO DE ENFERMEDADES MALIGNAS.
ES497422A 1979-12-04 1980-12-03 Un metodo de preparacion de un inticuerpo monocloral. Expired ES8303095A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/099,969 US4361550A (en) 1979-12-04 1979-12-04 Complement-fixing monoclonal antibody to human suppressor T cells and methods of preparing same

Publications (2)

Publication Number Publication Date
ES497422A0 ES497422A0 (es) 1982-12-16
ES8303095A1 true ES8303095A1 (es) 1983-02-16

Family

ID=22277475

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497422A Expired ES8303095A1 (es) 1979-12-04 1980-12-03 Un metodo de preparacion de un inticuerpo monocloral.

Country Status (21)

Country Link
US (1) US4361550A (es)
EP (1) EP0030450B1 (es)
JP (3) JPS5695121A (es)
AT (1) ATE13692T1 (es)
AU (1) AU545182B2 (es)
CA (1) CA1183469A (es)
DE (2) DE30450T1 (es)
DK (1) DK154091C (es)
ES (1) ES8303095A1 (es)
FI (1) FI75366C (es)
GR (1) GR72922B (es)
HK (1) HK24086A (es)
IE (1) IE50673B1 (es)
IL (1) IL61623A (es)
MY (1) MY8600517A (es)
NO (1) NO159885C (es)
NZ (1) NZ195646A (es)
PH (1) PH16819A (es)
PT (1) PT72143B (es)
YU (1) YU45068B (es)
ZA (1) ZA807563B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4709015A (en) * 1979-12-04 1987-11-24 Ortho Pharmaceutical Corporation Monoclonal antibody to human suppressor T cells
DE3105150A1 (de) * 1981-02-12 1982-08-19 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg Herstellung von anti-t-lymphozyten-globulin.
US4434156A (en) 1981-10-26 1984-02-28 The Salk Institute For Biological Studies Monoclonal antibodies specific for the human transferrin receptor glycoprotein
USRE32011E (en) * 1981-12-14 1985-10-22 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4511662A (en) * 1982-06-18 1985-04-16 Bio-Rad Laboratories, Inc. Simultaneous assay for T and B lymphocyte populations and subpopulations
US4443427A (en) * 1982-06-21 1984-04-17 Sidney Farber Cancer Institute, Inc. Monoclonal antibody
US5766920A (en) * 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
US4550086A (en) * 1983-02-16 1985-10-29 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that recognize human T cells
US4579827A (en) * 1983-03-11 1986-04-01 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies
US4797475A (en) * 1983-05-20 1989-01-10 The Regents Of The University Of California Method and composition for isolating white cell elements
AU576499B2 (en) * 1983-08-18 1988-09-01 Quidel Suppressive factor of allergy
US4677056A (en) * 1983-08-18 1987-06-30 Sloan-Kettering Institute For Cancer Research Monoclonal antibody subsetting human helper and killer T-cells and method
US4645738A (en) * 1983-09-30 1987-02-24 Memorial Sloan-Kettering Institute Cancer Center Method for differential diagnosis of T cell leukemias using monoclonal antibodies
US4469630A (en) * 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
FR2560212B1 (fr) * 1984-02-24 1989-12-29 Unicet Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
US4604235A (en) * 1984-05-23 1986-08-05 J. T. Baker Chemical Company Purification of monoclonal antibodies
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
US5308835A (en) * 1984-07-09 1994-05-03 Praxis Biologics, Inc. Production of the E. coli LT-B enterotoxin subunit
CA1340372C (en) * 1984-07-09 1999-02-02 John D. Clements Production of e. coli lt-b enterotoxin subunit
US4661446A (en) * 1985-02-19 1987-04-28 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies and method of immunizing therewith
US5431897A (en) * 1985-04-19 1995-07-11 Sloan-Kettering Institute For Cancer Research Method of imaging colorectal carcinoma lesion and composition for use therein
US4886743A (en) * 1985-04-24 1989-12-12 California Institute Of Technology Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof
AU6032786A (en) * 1985-07-25 1987-01-29 University Of Minnesota Detection, imaging and therapy of renal cell carcinoma with monoclonal antibodies in vivo
US4970299A (en) * 1986-07-03 1990-11-13 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies selective for prostate cancer
DK172110B1 (da) * 1988-04-15 1997-10-27 Gen Hospital Corp Fremgangsmåde til isolation af mutanter af DNA-sekvenser og anvendelsen heraf til identifikation af celleoverfladeproteiner
US5601819A (en) * 1988-08-11 1997-02-11 The General Hospital Corporation Bispecific antibodies for selective immune regulation and for selective immune cell binding
US5068178A (en) * 1988-12-06 1991-11-26 Genetic Systems Corporation Method of enhancing direct immunofluorescence staining of cells
US5081011A (en) * 1990-01-26 1992-01-14 Board Of Trustees Operating Michigan State University Method and test kit for detecting inherited substance abuse dependency
US6498006B2 (en) 1997-11-24 2002-12-24 Johnson T. Wong Methods for treatment of HIV and other infections using A T cell or viral activator and anti-retroviral combination therapy
EP2476754A1 (en) * 2011-01-14 2012-07-18 Bundesrepublik Deutschland, Letztvertreten Durch Den Präsidenten Des Paul-Ehrlich-Instituts Methods for the identification and repair of amino acid residues destabilizing single-chain variable fragments (scFv)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4172124A (en) * 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses

Also Published As

Publication number Publication date
PH16819A (en) 1984-03-06
ES497422A0 (es) 1982-12-16
GR72922B (es) 1984-01-11
HK24086A (en) 1986-04-11
DE3070744D1 (en) 1985-07-11
IL61623A (en) 1984-07-31
JPS649998B2 (es) 1989-02-21
YU306580A (en) 1984-04-30
DK154091C (da) 1989-03-06
AU6501180A (en) 1981-06-11
JPH0160231B2 (es) 1989-12-21
PT72143B (en) 1982-07-05
YU45068B (en) 1991-08-31
NO159885B (no) 1988-11-07
JPS5695121A (en) 1981-08-01
IL61623A0 (en) 1981-01-30
EP0030450A3 (en) 1981-11-04
IE802509L (en) 1981-06-04
JPS64466A (en) 1989-01-05
DE30450T1 (de) 1984-07-19
NZ195646A (en) 1984-07-06
NO159885C (no) 1989-02-15
EP0030450B1 (en) 1985-06-05
ZA807563B (en) 1982-07-28
DK154091B (da) 1988-10-10
IE50673B1 (en) 1986-06-11
PT72143A (en) 1981-01-01
NO803658L (no) 1981-06-05
DK517480A (da) 1981-06-05
AU545182B2 (en) 1985-07-04
FI75366B (fi) 1988-02-29
US4361550A (en) 1982-11-30
FI75366C (fi) 1988-06-09
EP0030450A2 (en) 1981-06-17
CA1183469A (en) 1985-03-05
FI803758L (fi) 1981-06-05
MY8600517A (en) 1986-12-31
ATE13692T1 (de) 1985-06-15
JPS6413992A (en) 1989-01-18

Similar Documents

Publication Publication Date Title
ES8303095A1 (es) Un metodo de preparacion de un inticuerpo monocloral.
ES8105151A1 (es) Un metodo para la preparacion de un anticuerpo monoclonico.
ES8303097A1 (es) Un metodo de preparacion de un anticuerpo monoclonal.
ES8105152A1 (es) Un metodo para la preparacion de un anticuerpo monoclonico, de fijacion de complemento
DE3070848D1 (en) Monoclonal antibody to human t cells, method for preparing it, hybrid cell line producing it, therapeutic composition comprising it and diagnostic method using it
ES8200559A1 (es) Un anticuerpo monoclonal
ES8301636A1 (es) Un metodo de preparacion de un anticuerpo monoclonal.
ES8303096A1 (es) Un anticuerpo monoclonico