ES483839A1 - Un procedimiento para preparar compuestos de acido 3-cefem- -4-carboxilico disustituido en las posiciones 3 y 7 - Google Patents

Un procedimiento para preparar compuestos de acido 3-cefem- -4-carboxilico disustituido en las posiciones 3 y 7

Info

Publication number
ES483839A1
ES483839A1 ES483839A ES483839A ES483839A1 ES 483839 A1 ES483839 A1 ES 483839A1 ES 483839 A ES483839 A ES 483839A ES 483839 A ES483839 A ES 483839A ES 483839 A1 ES483839 A1 ES 483839A1
Authority
ES
Spain
Prior art keywords
compound
salt
formula
33cephem
microbism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483839A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES483839A1 publication Critical patent/ES483839A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un procedimiento para preparar compuestos de ácido 3-cefem-4- carboxílico disustituídos en las posiciones 3 y 7, de la fórmula-01: **(Fórmula-01)** en donde R1 es amino o amino protegido; R2 es un grupo de un hidrocarburo alifático que posee un substituyente o substituyentes adecuados; R3 es carboxi o carboxi protegidos; y R4 es hidrógeno, aciloxi o un grupo heterocíclico-tio que puede tener alcohilo inferior, con la condición de que R2 no sea carboxi-alcohilo (inferior), carboxi-alcohilo (inferior) protegido o bencilo cuando R4 es acetoxi y que R2 no sea bencilo cuando R4 es tetrazoliltio que tiene un metilo, o una de sus sales farmacéuticamente aceptable, procedimiento que comprende hacer reaccionar un compuesto de la fórmula-02: **(Fórmula-02)** en donde R3 y R4 son, cada uno, como se ha definido anteriormente, o su derivado reactivo en el grupo amino, o una de sus sales, con un compuesto de la fórmula-03: **(Fórmula-03)** en donde R1 y R2 son, cada uno, como se ha definido antes, o suderivado reactivo en el grupo carboxi, o una de sus sales, y, en caso necesario, someter el compuesto resultante, en donde R1 es un amino protegido, a una reacción de eliminación del grupo protector del grupo amino, y además, en caso necesario, someter el compuesto resultante, en donde R2 es un carboxi-alcohilo (inferior) protegido a una reacción de eliminación del grupo protector del grupo carboxilo para dar un compuesto, en donde R2 es carboxi-alcohilo (inferior).
ES483839A 1978-09-04 1979-09-03 Un procedimiento para preparar compuestos de acido 3-cefem- -4-carboxilico disustituido en las posiciones 3 y 7 Expired ES483839A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7835435 1978-09-04

Publications (1)

Publication Number Publication Date
ES483839A1 true ES483839A1 (es) 1980-09-01

Family

ID=10499419

Family Applications (2)

Application Number Title Priority Date Filing Date
ES483839A Expired ES483839A1 (es) 1978-09-04 1979-09-03 Un procedimiento para preparar compuestos de acido 3-cefem- -4-carboxilico disustituido en las posiciones 3 y 7
ES490888A Granted ES490888A0 (es) 1978-09-04 1980-04-25 Un procedimiento para preparar compuestos de acido 3-ce- fem-4-carboxilico disustituidos en las posiciones 3 y 7

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES490888A Granted ES490888A0 (es) 1978-09-04 1980-04-25 Un procedimiento para preparar compuestos de acido 3-ce- fem-4-carboxilico disustituidos en las posiciones 3 y 7

Country Status (8)

Country Link
JP (1) JPS5535096A (es)
BE (1) BE878514A (es)
CH (1) CH643849A5 (es)
DE (1) DE2935232A1 (es)
ES (2) ES483839A1 (es)
FR (1) FR2434810A1 (es)
NL (1) NL7906624A (es)
SE (1) SE7907320L (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2945248A1 (de) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel
JPS5585594A (en) * 1978-11-13 1980-06-27 Fujisawa Pharmaceut Co Ltd Cephem compound and their preparation
US4331666A (en) * 1979-05-11 1982-05-25 Farmitalia Carlo Erba S.P.A. 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid
JPS56131591A (en) * 1980-02-20 1981-10-15 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent
JPS57131794A (en) * 1980-12-31 1982-08-14 Fujisawa Pharmaceut Co Ltd Novel cephem compound or salt thereof, preparation of the same and preventing agent and remedy for microbism containing the same as active constituent
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
JPS5874680A (ja) * 1981-10-01 1983-05-06 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
US4499088A (en) * 1983-01-04 1985-02-12 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
FR2381053A1 (fr) * 1977-02-18 1978-09-15 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-thiadiazolyl thiomethyl 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
AU520269B2 (en) * 1977-03-14 1982-01-21 Fujisawa Pharmaceutical Co., Ltd. Cephem and cepham compounds
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
DE2804040C3 (de) * 1978-01-31 1981-03-19 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Cephemverbindungen
SE7901262L (sv) * 1978-02-15 1979-08-16 Fujisawa Pharmaceutical Co 3,7-disubstituerade 3-cefem-4-karboxylsyraforeningar och forfarande for deras framstellning
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
GB2024808B (en) * 1978-05-26 1982-11-17 Glaxo Group Ltd Cephalosporin antibiotics
NZ190557A (en) * 1978-05-26 1982-05-25 Glaxo Group Ltd Cephalosporin antibiotics and pharmaceutical compositions containing them
AR231986A1 (es) * 1978-05-26 1985-04-30 Glaxo Group Ltd Procedimiento para preparar antibioticos de cefalosporina
GB1604722A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-(2-amino-4-thiozolyl)-2-oxymino-acetamido)-cephem derivatives
IT1116187B (it) * 1978-05-26 1986-02-10 Glaxo Group Ltd Antibiotici cefalosporinici composizioni che li contengono e relativo procedimento di produzione
EP0059486B1 (en) * 1978-07-17 1985-10-02 Fujisawa Pharmaceutical Co., Ltd. New starting compounds for preparing cephem compounds and processes for their preparation
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
JPS5858353A (ja) * 1981-09-30 1983-04-06 ピ−シ−株式会社 強化コンクリ−ト構造体

Also Published As

Publication number Publication date
BE878514A (fr) 1980-02-29
SE7907320L (sv) 1980-03-05
NL7906624A (nl) 1980-03-06
JPS5535096A (en) 1980-03-11
ES8102142A1 (es) 1980-12-16
CH643849A5 (en) 1984-06-29
JPH0240678B2 (es) 1990-09-12
FR2434810B1 (es) 1983-06-03
FR2434810A1 (fr) 1980-03-28
ES490888A0 (es) 1980-12-16
DE2935232A1 (de) 1980-03-13

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