ES473837A1 - Un procedimiento para aislar acido pseudomonico - Google Patents
Un procedimiento para aislar acido pseudomonicoInfo
- Publication number
- ES473837A1 ES473837A1 ES473837A ES473837A ES473837A1 ES 473837 A1 ES473837 A1 ES 473837A1 ES 473837 A ES473837 A ES 473837A ES 473837 A ES473837 A ES 473837A ES 473837 A1 ES473837 A1 ES 473837A1
- Authority
- ES
- Spain
- Prior art keywords
- organic solvent
- solution
- isolation
- organic acids
- pseudomonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002955 isolation Methods 0.000 title 1
- 150000007524 organic acids Chemical class 0.000 title 1
- 235000005985 organic acids Nutrition 0.000 title 1
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 3
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 2
- MINDHVHHQZYEEK-HBBNESRFSA-N mupirocin Chemical compound C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-HBBNESRFSA-N 0.000 abstract 2
- 229960003128 mupirocin Drugs 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 229930194369 pseudomonic acid Natural products 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940043265 methyl isobutyl ketone Drugs 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/38—Pseudomonas
- C12R2001/39—Pseudomonas fluorescens
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4067877 | 1977-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES473837A1 true ES473837A1 (es) | 1979-10-16 |
Family
ID=10416087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES473837A Expired ES473837A1 (es) | 1977-09-30 | 1978-09-29 | Un procedimiento para aislar acido pseudomonico |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4222942A (Direct) |
| JP (1) | JPS5459281A (Direct) |
| BE (1) | BE870855A (Direct) |
| CA (1) | CA1103264A (Direct) |
| CH (1) | CH642366A5 (Direct) |
| DE (1) | DE2842358A1 (Direct) |
| DK (1) | DK152126C (Direct) |
| ES (1) | ES473837A1 (Direct) |
| FR (1) | FR2404638A1 (Direct) |
| IE (1) | IE47386B1 (Direct) |
| IT (1) | IT1157197B (Direct) |
| NL (1) | NL7809859A (Direct) |
| NZ (1) | NZ188559A (Direct) |
| ZA (1) | ZA785515B (Direct) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60243011A (ja) * | 1984-05-17 | 1985-12-03 | Seiwa Kasei:Kk | パ−マネントウエ−ブ用第１剤 |
| JPS60243010A (ja) * | 1984-05-17 | 1985-12-03 | Seiwa Kasei:Kk | 毛髪保護剤 |
| US5594026A (en) * | 1990-12-11 | 1997-01-14 | Smithkline Beecham Group P.L.C. | Polymorphs of crystalline mupirocin |
| GB9026873D0 (en) * | 1990-12-11 | 1991-01-30 | Beecham Group Plc | Novel compounds |
| KR20010113674A (ko) | 1999-02-03 | 2001-12-28 | 자노스 바르가, 테레지아 밀레 | 미생물적 방법에 의하여 슈도몬산 ａ 항생제를 제조하는방법 |
| PL349153A1 (en) * | 1999-02-03 | 2002-07-01 | Biogal Gyogyszergyar | Process for the isolation of pseudomonic acid a from pseudomonic acid complex-containing culture broth |
| EP1409703A4 (en) * | 2001-06-21 | 2004-08-18 | Biogal Gyogyszergyar | METABOLICALLY CONTROLLED FERMENTATION PROCESS FOR THE PRODUCTION OF PSEUDOMONIC ACID |
| EP1455769A4 (en) * | 2001-12-28 | 2004-09-22 | Biogal Gyogyszergyar | METHOD FOR PRODUCING CRYSTALLINE AND AMORPHIC MUPIROCIN CALCIUM |
| IL150907A (en) * | 2002-07-25 | 2007-07-04 | Stephan Cherkez | Process for the preparation of stable amorphous calcium pseudomonate |
| DK1641438T3 (da) * | 2004-06-01 | 2010-06-07 | Teva Gyogyszergyar Zartkoeruen | Fremgangsmåde til fremstilling af den amorfe form af et lægemiddel |
| EP1655242B1 (en) * | 2004-10-29 | 2007-07-25 | PED Invest A/S | Side-flexing conveyor belt |
| ES2455518T3 (es) * | 2005-02-21 | 2014-04-15 | Syngen Biotech Co., Ltd. | Purificación de mupirocina |
| GB2441328A (en) | 2006-08-30 | 2008-03-05 | Alpharma Aps | A method for obtaining mupirocin calcium |
| CN104370896A (zh) * | 2013-11-29 | 2015-02-25 | 江苏汉邦科技有限公司 | 一种纯化假单孢菌素的方法 |
| TW202214611A (zh) * | 2020-08-25 | 2022-04-16 | 大陸商杭州中美華東製藥有限公司 | 莫匹羅星的提取方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1395907A (en) * | 1971-06-12 | 1975-05-29 | Beecham Group Ltd | Antibiotics |
| JPS5270083A (en) * | 1975-12-04 | 1977-06-10 | Yoshitomi Pharmaceut Ind Ltd | Manufacture of an antibiotics, trans-pseudomonic acid |
| GB1565083A (en) * | 1976-02-20 | 1980-04-16 | Beecham Group Ltd | Pseudomonic acid amides |
-
1978
- 1978-09-27 CA CA312,240A patent/CA1103264A/en not_active Expired
- 1978-09-28 BE BE190787A patent/BE870855A/xx not_active IP Right Cessation
- 1978-09-28 IT IT51285/78A patent/IT1157197B/it active
- 1978-09-28 FR FR7827765A patent/FR2404638A1/fr active Granted
- 1978-09-28 ZA ZA00785515A patent/ZA785515B/xx unknown
- 1978-09-28 DE DE19782842358 patent/DE2842358A1/de active Granted
- 1978-09-29 US US05/946,873 patent/US4222942A/en not_active Expired - Lifetime
- 1978-09-29 CH CH1016178A patent/CH642366A5/de not_active IP Right Cessation
- 1978-09-29 IE IE1955/78A patent/IE47386B1/en not_active IP Right Cessation
- 1978-09-29 ES ES473837A patent/ES473837A1/es not_active Expired
- 1978-09-29 NL NL7809859A patent/NL7809859A/xx active Search and Examination
- 1978-09-29 DK DK433878A patent/DK152126C/da not_active IP Right Cessation
- 1978-09-30 JP JP12111878A patent/JPS5459281A/ja active Granted
- 1978-10-02 NZ NZ188559A patent/NZ188559A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ188559A (en) | 1981-01-23 |
| IE47386B1 (en) | 1984-03-07 |
| NL7809859A (nl) | 1979-04-03 |
| JPS5459281A (en) | 1979-05-12 |
| US4222942A (en) | 1980-09-16 |
| DK433878A (da) | 1979-03-31 |
| DE2842358A1 (de) | 1979-04-05 |
| DK152126C (da) | 1988-06-20 |
| CH642366A5 (de) | 1984-04-13 |
| AU531316B2 (en) | 1983-08-18 |
| FR2404638B1 (Direct) | 1982-04-16 |
| IE781955L (en) | 1979-03-30 |
| DE2842358C2 (Direct) | 1989-05-24 |
| IT7851285A0 (it) | 1978-09-28 |
| BE870855A (fr) | 1979-03-28 |
| JPH032867B2 (Direct) | 1991-01-17 |
| AU4030478A (en) | 1980-04-03 |
| FR2404638A1 (fr) | 1979-04-27 |
| ZA785515B (en) | 1979-09-26 |
| DK152126B (da) | 1988-02-01 |
| IT1157197B (it) | 1987-02-11 |
| CA1103264A (en) | 1981-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES473837A1 (es) | Un procedimiento para aislar acido pseudomonico | |
| FI813182L (fi) | Foerfarande foer framstaellning av n-substituerade 1-desoxinojirimycinderivat | |
| GB713947A (en) | Photomechanical resist compositions | |
| ES8301876A1 (es) | Un procedimiento para preparar esteres piretroides de 1,1'-bifenil-3-ilmetilo. | |
| GB2005680A (en) | Purification of pseudomonic acid | |
| GB1490123A (en) | 3-alkanoyloxyquinuclidines | |
| UA6027A1 (uk) | Спосіб одержання похідних ерголіна або його солей | |
| UA6043A1 (uk) | Спосіб одержання похідних хлорамбуціла /його варіанти/ | |
| GB948769A (en) | New alkaloids of the funtumia species and processes for obtaining same | |
| GB1457200A (en) | Process for the preparation of 6-substituted penicillins parcel holder | |
| ES485157A1 (es) | Procedimiento para la obtencion de esteres de acido benzimi-dazolilcarbamico,de efecto antihelmintico | |
| IE780477L (en) | Preparation of clavulanic acid derivatives | |
| ATE29028T1 (de) | Verfahren zur herstellung von giberellinen. | |
| ES290275A2 (es) | Procedimiento para preparar nuevos compuestos de la 6-metil y la 1,6-dimetil-er-golina ii | |
| GB1174385A (en) | 0-Pyridyl-1,2,3,4-Tetrahydroisoquinoline Derivatives | |
| GB1018780A (en) | Steroid (2,3í¬c) furazan compounds and the process for the production thereof | |
| GB1282896A (en) | New 4-oxo-1,4-dihydro-3-quinolyl-carboxylic acid derivatives and process for their preparation | |
| GB766325A (en) | Penicillin salts of esters of 4-aminosalicylic acids | |
| JPS55130987A (en) | Production of phosphate diester | |
| GB833149A (en) | Rauwolfia alkaloids and their extraction | |
| GB977088A (en) | Process for the preparation of phenylalkanolamine derivatives | |
| GB777686A (en) | Polyhydrophenanthrene compounds and their preparation | |
| ES450472A1 (es) | Un procedimiento para la preparacion de nuevos derivados de 3-benzoil-pirazol. | |
| GB787456A (en) | Aetiocholane derivatives | |
| GB837949A (en) | Reserpic acid diesters and salts thereof and process for their manufacture |