GB2005680A - Purification of pseudomonic acid - Google Patents

Purification of pseudomonic acid

Info

Publication number
GB2005680A
GB2005680A GB7838927A GB7838927A GB2005680A GB 2005680 A GB2005680 A GB 2005680A GB 7838927 A GB7838927 A GB 7838927A GB 7838927 A GB7838927 A GB 7838927A GB 2005680 A GB2005680 A GB 2005680A
Authority
GB
United Kingdom
Prior art keywords
pseudomonic acid
purification
organic solvent
solution
acidic components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7838927A
Other versions
GB2005680B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB7838927A priority Critical patent/GB2005680B/en
Publication of GB2005680A publication Critical patent/GB2005680A/en
Application granted granted Critical
Publication of GB2005680B publication Critical patent/GB2005680B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/38—Pseudomonas
    • C12R2001/39—Pseudomonas fluorescens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A process for the purification of pseudomonic acid, particularly suitable for isolating the compound when prepared by bacterial culture, comprises making a solution in an organic solvent of the acidic components of the crude preparation substantially free of the neutral components. The polarity of the organic solvent is adjusted so that the pseudomonic acid crystallises. This may be achieved either by adding a non-polar diluent such as n-heptane to the solution for example in methyl iso-butyl ketone; or by employing a di-C1-6 alkyl ether in which the acidic components dissolve and then crystallise out.
GB7838927A 1977-09-30 1978-10-02 Isolation of organic acids Expired GB2005680B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7838927A GB2005680B (en) 1977-09-30 1978-10-02 Isolation of organic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4067877 1977-09-30
GB7838927A GB2005680B (en) 1977-09-30 1978-10-02 Isolation of organic acids

Publications (2)

Publication Number Publication Date
GB2005680A true GB2005680A (en) 1979-04-25
GB2005680B GB2005680B (en) 1982-04-07

Family

ID=26264474

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7838927A Expired GB2005680B (en) 1977-09-30 1978-10-02 Isolation of organic acids

Country Status (1)

Country Link
GB (1) GB2005680B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068680A1 (en) * 1981-06-20 1983-01-05 Beecham Group Plc Antibiotics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068680A1 (en) * 1981-06-20 1983-01-05 Beecham Group Plc Antibiotics

Also Published As

Publication number Publication date
GB2005680B (en) 1982-04-07

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 19981001