JPS5553286A - Preparation of azetidine derivative - Google Patents
Preparation of azetidine derivativeInfo
- Publication number
- JPS5553286A JPS5553286A JP12645178A JP12645178A JPS5553286A JP S5553286 A JPS5553286 A JP S5553286A JP 12645178 A JP12645178 A JP 12645178A JP 12645178 A JP12645178 A JP 12645178A JP S5553286 A JPS5553286 A JP S5553286A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- chloramine
- acid
- penicillin derivative
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound useful as an synthetic intermediate of antibiotic substance, easily, by reacting a penicillin derivative with a compound such as chloramine-T which is safe, easily handleable, and low-cost compound, and an acid, in the presence of a lower alcohol, at a specific pH range.
CONSTITUTION: A compound III is prepared by reacting a penicillin derivative I [R1 is (substituted) alkyl, aryl, or arylalkyl] with a compound II (R is lower alkyl; n is 0W3; M is alkali metal; X is halogen), e.g. chloramine-T, chloramine-B or chloramine-X, and an acid, e.g. acetic acid, in the presence of a lower alcohol of formula R2-OH (R2 is lower alkyl),e.g. methanol, at pH3W8, in an inert organic solvent such as acetone. To prevent the decomposition of the penicillin derivative and to proceed the reaction, it is necessary to keep the pH of the reaction system between 3 and 8 by adding the compound II and the acid gradually and alterately to the reaction system.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12645178A JPS5553286A (en) | 1978-10-14 | 1978-10-14 | Preparation of azetidine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12645178A JPS5553286A (en) | 1978-10-14 | 1978-10-14 | Preparation of azetidine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5553286A true JPS5553286A (en) | 1980-04-18 |
Family
ID=14935533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12645178A Pending JPS5553286A (en) | 1978-10-14 | 1978-10-14 | Preparation of azetidine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5553286A (en) |
-
1978
- 1978-10-14 JP JP12645178A patent/JPS5553286A/en active Pending
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