JPS5553286A - Preparation of azetidine derivative - Google Patents

Preparation of azetidine derivative

Info

Publication number
JPS5553286A
JPS5553286A JP12645178A JP12645178A JPS5553286A JP S5553286 A JPS5553286 A JP S5553286A JP 12645178 A JP12645178 A JP 12645178A JP 12645178 A JP12645178 A JP 12645178A JP S5553286 A JPS5553286 A JP S5553286A
Authority
JP
Japan
Prior art keywords
compound
chloramine
acid
penicillin derivative
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12645178A
Other languages
Japanese (ja)
Inventor
Yasuo Hoshiide
Kenichi Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Original Assignee
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIKKEN KAGAKU KK, Nikken Chemicals Co Ltd filed Critical NIKKEN KAGAKU KK
Priority to JP12645178A priority Critical patent/JPS5553286A/en
Publication of JPS5553286A publication Critical patent/JPS5553286A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound useful as an synthetic intermediate of antibiotic substance, easily, by reacting a penicillin derivative with a compound such as chloramine-T which is safe, easily handleable, and low-cost compound, and an acid, in the presence of a lower alcohol, at a specific pH range.
CONSTITUTION: A compound III is prepared by reacting a penicillin derivative I [R1 is (substituted) alkyl, aryl, or arylalkyl] with a compound II (R is lower alkyl; n is 0W3; M is alkali metal; X is halogen), e.g. chloramine-T, chloramine-B or chloramine-X, and an acid, e.g. acetic acid, in the presence of a lower alcohol of formula R2-OH (R2 is lower alkyl),e.g. methanol, at pH3W8, in an inert organic solvent such as acetone. To prevent the decomposition of the penicillin derivative and to proceed the reaction, it is necessary to keep the pH of the reaction system between 3 and 8 by adding the compound II and the acid gradually and alterately to the reaction system.
COPYRIGHT: (C)1980,JPO&Japio
JP12645178A 1978-10-14 1978-10-14 Preparation of azetidine derivative Pending JPS5553286A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12645178A JPS5553286A (en) 1978-10-14 1978-10-14 Preparation of azetidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12645178A JPS5553286A (en) 1978-10-14 1978-10-14 Preparation of azetidine derivative

Publications (1)

Publication Number Publication Date
JPS5553286A true JPS5553286A (en) 1980-04-18

Family

ID=14935533

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12645178A Pending JPS5553286A (en) 1978-10-14 1978-10-14 Preparation of azetidine derivative

Country Status (1)

Country Link
JP (1) JPS5553286A (en)

Similar Documents

Publication Publication Date Title
DE2962643D1 (en) 3,5-dihydroxypentanoic ester derivatives having antihyperlipaemic activity, their manufacture and pharmaceutical compositions containing them
SE7712060L (en) PROCEDURE FOR THE PREPARATION OF FUROCUMARINES
JPS54119494A (en) Preparation of cephalosporin compound
JPS5517386A (en) Novel oxadiazolopyrimidine derivative
JPS5452043A (en) Preparation of peroxide
JPS5553286A (en) Preparation of azetidine derivative
GB2017087A (en) Process for the preparation of xanthone derivatives
ES8307236A1 (en) Process for the preparation of a furan derivative.
JPS54112873A (en) Preparation of 2,2,6,6-tetramethyl-4-oxopiperidine
ES8206535A1 (en) Improvement in the method for producing 7-aminocephem compounds.
JPS54138586A (en) Preparation of isocyanuric acid ester
CS9100950A2 (en) Method of n-succinimidylcarbonates production
JPS56108743A (en) 3-nitro-2-hydroxy-4-phenylbutyric acid derivative, its ester and preparation thereof
JPS559041A (en) Synthesis of thioketal
JPS5653682A (en) Production of novel rifamycin derivative
JPS5726686A (en) Preparation of indole derivative
IE792291L (en) Process for the manufacture of 5-mercapto-1,2,3-triazoles.
JPS5659727A (en) Preparation of substituted phenol
JPS55151547A (en) Production of guanidinocapronic ester
JPS55147275A (en) Ppacetamidophenollalphaamethyll4*2**thienyll carbonyl*phenylacetate and its use and manufacture
JPS5547687A (en) Preparaton of oxazoline derivative
KR0138528B1 (en) Preparation of 2,3-trans-1,4-bridged cyclohexane sulfonamide derivatives
JPS55120591A (en) Phosphinoethylmalonic acid derivative, and preparation thereof
JPS5679668A (en) 1,4-dihydro-4-oxonicotinic acid derivatice and its preparation
JPS57109794A (en) Preparation of cephalosporin analog