ES440850A1 - Benzo or heterocyclic fused imidazodiazepines and pharmaceutical compositions containing them - Google Patents
Benzo or heterocyclic fused imidazodiazepines and pharmaceutical compositions containing themInfo
- Publication number
- ES440850A1 ES440850A1 ES440850A ES440850A ES440850A1 ES 440850 A1 ES440850 A1 ES 440850A1 ES 440850 A ES440850 A ES 440850A ES 440850 A ES440850 A ES 440850A ES 440850 A1 ES440850 A1 ES 440850A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- imidazodiazepines
- benzo
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
Imidazo[1,5-a][1,4]diazepine compounds of the formula < IMAGE > in which the symbols < IMAGE >, A, R1, R2 and R3 have the meaning given in Claim 1, analogues thereof as are defined in Claims 2 to 4, and pharmaceutical utilisable acid addition salts of these compounds have useful muscle-relaxant, sedative and anti-convulsive properties. They are particularly suitable for the preparation of injection solutions on account of the good water solubility of their acid addition salts. The compounds are prepared by dehydrogenation of the corresponding 3a,4-dihydro derivatives and optional N-oxidation, reduction or reaction with ethylene oxide or propylene oxide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50492474A | 1974-09-11 | 1974-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES440850A1 true ES440850A1 (en) | 1977-07-01 |
Family
ID=24008278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES440850A Expired ES440850A1 (en) | 1974-09-11 | 1975-09-10 | Benzo or heterocyclic fused imidazodiazepines and pharmaceutical compositions containing them |
Country Status (32)
| Country | Link |
|---|---|
| JP (1) | JPS51125099A (en) |
| AT (1) | AT360023B (en) |
| AU (1) | AU505998B2 (en) |
| BE (1) | BE833248A (en) |
| BR (1) | BR7505864A (en) |
| CA (1) | CA1067491A (en) |
| CH (2) | CH619953A5 (en) |
| CU (1) | CU34346A (en) |
| DD (1) | DD121640A5 (en) |
| DE (1) | DE2540522A1 (en) |
| DK (1) | DK157615C (en) |
| ES (1) | ES440850A1 (en) |
| FI (1) | FI63234C (en) |
| FR (2) | FR2285890A1 (en) |
| GB (1) | GB1527131A (en) |
| HK (1) | HK63381A (en) |
| HU (1) | HU174752B (en) |
| IE (1) | IE41844B1 (en) |
| IL (1) | IL48069A (en) |
| KE (1) | KE3173A (en) |
| LU (1) | LU73356A1 (en) |
| MX (1) | MX160600A (en) |
| MY (1) | MY8200214A (en) |
| NL (1) | NL171060C (en) |
| NO (4) | NO147109C (en) |
| NZ (1) | NZ178635A (en) |
| PH (2) | PH16152A (en) |
| PL (1) | PL106563B1 (en) |
| SE (4) | SE425785B (en) |
| SU (1) | SU814278A3 (en) |
| YU (1) | YU40267B (en) |
| ZA (1) | ZA755418B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125726A (en) * | 1977-03-11 | 1978-11-14 | Hoffmann-La Roche Inc. | Imidazo[1,5-a][1,4]benzodiazepines |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| US4226768A (en) * | 1979-05-29 | 1980-10-07 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US4226771A (en) * | 1979-07-25 | 1980-10-07 | Hoffmann-La Roche Inc. | 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives |
| US4256637A (en) * | 1979-12-20 | 1981-03-17 | Hoffmann-La Roche Inc. | Intermediates for the production of imidazobenzodiazepines |
| FR2479818A1 (en) * | 1980-04-03 | 1981-10-09 | Roussel Uclaf | 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione |
| US4335042A (en) * | 1980-04-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Process to produce imidazobenzodiazepine intermediates |
| DE3329515C2 (en) * | 1983-08-16 | 1985-11-14 | Krohne Meßtechnik GmbH & Co KG, 4100 Duisburg | Electrical switching arrangement for a magnetic-inductive transducer |
| ZA845757B (en) * | 1983-08-25 | 1985-04-24 | Hoffmann La Roche | Benzodiazepine derivatives |
| PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
| FI880814A (en) * | 1987-03-10 | 1988-09-11 | Hoffmann La Roche | IMIDAZODIAZEPIN-derivate. |
| WO1994026723A2 (en) * | 1993-05-14 | 1994-11-24 | Genentech, Inc. | ras FARNESYL TRANSFERASE INHIBITORS |
| IN184976B (en) * | 1996-06-13 | 2000-10-14 | Ranbaxy Lab Ltd | |
| IT1399764B1 (en) | 2010-05-04 | 2013-05-03 | F S I Fabbrica Italiana Sint | PROCEDURE FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-A] [1,4] BENZODIAZEPINE, IN PARTICULAR OF MIDAZOLAM. |
| CN103086986B (en) * | 2011-11-01 | 2015-11-04 | 上海医药工业研究院 | The preparation method of Isosorbide-5-Nitrae-Benzodiazepine-N-nitrosamines intermediate and application thereof |
| CN103804384B (en) * | 2014-01-27 | 2016-01-20 | 李宏 | The preparation method of benzodiazepine compounds |
| PT3439665T (en) * | 2016-03-18 | 2022-09-27 | Uwm Res Foundation Inc | Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with alpha5-containing gabaa receptor agonists |
| BR112019003065A2 (en) | 2016-08-16 | 2019-05-21 | The Trustees Of Columbia University In The City Of New York | gaba (a) receptor modulators and methods for controlling airway hyperresponsiveness and inflammation in asthma |
| CN111410658B (en) * | 2020-03-30 | 2021-03-26 | 江苏恩华药业股份有限公司 | Impurity A and impurity B of midazolam or pharmaceutical composition thereof and application thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA716775B (en) * | 1970-10-30 | 1972-06-28 | Takeda Chemical Industries Ltd | Benzodiazepine derivatives |
| DE2056265A1 (en) * | 1970-11-16 | 1972-05-31 | Sumitomo Chemical Co. Ltd., Osaka (Japan) | Benzodiazepine derivs - from glycylamidobenzophenone derivs in dmso |
| JPS4932874B1 (en) * | 1970-12-11 | 1974-09-03 | ||
| BE787251A (en) * | 1971-08-04 | 1973-02-05 | Upjohn Co | NEW BENZODIAZEPINES AND THEIR PREPARATION |
| BE790839A (en) * | 1971-11-02 | 1973-04-30 | Upjohn Co | NEW BENZODIAZEPINES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM |
| BE792972A (en) * | 1971-12-20 | 1973-06-19 | Hoffmann La Roche | BENZODIAZEPINE DERIVATIVES |
| FR2183716A1 (en) * | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| CA1005443A (en) * | 1972-06-22 | 1977-02-15 | Michio Nakanishi | Thienodiazepine compounds |
-
1975
- 1975-08-25 ZA ZA755418A patent/ZA755418B/en unknown
- 1975-09-03 CH CH1141075A patent/CH619953A5/en not_active IP Right Cessation
- 1975-09-08 NO NO753069A patent/NO147109C/en unknown
- 1975-09-08 FI FI752517A patent/FI63234C/en not_active IP Right Cessation
- 1975-09-08 SE SE7509991A patent/SE425785B/en active Protection Beyond IP Right Term
- 1975-09-09 IL IL48069A patent/IL48069A/en unknown
- 1975-09-09 NZ NZ178635A patent/NZ178635A/en unknown
- 1975-09-09 MX MX201652A patent/MX160600A/en unknown
- 1975-09-09 NL NLAANVRAGE7510620,A patent/NL171060C/en not_active IP Right Cessation
- 1975-09-09 FR FR7527599A patent/FR2285890A1/en active Granted
- 1975-09-09 LU LU73356A patent/LU73356A1/xx unknown
- 1975-09-10 PH PH17566A patent/PH16152A/en unknown
- 1975-09-10 ES ES440850A patent/ES440850A1/en not_active Expired
- 1975-09-10 DD DD188275A patent/DD121640A5/xx unknown
- 1975-09-10 JP JP50109060A patent/JPS51125099A/en active Granted
- 1975-09-10 HU HU75HO1835A patent/HU174752B/en unknown
- 1975-09-10 BE BE159891A patent/BE833248A/en not_active IP Right Cessation
- 1975-09-10 CA CA235,138A patent/CA1067491A/en not_active Expired
- 1975-09-10 AU AU84704/75A patent/AU505998B2/en not_active Expired
- 1975-09-10 YU YU2285/75A patent/YU40267B/en unknown
- 1975-09-10 DK DK404175A patent/DK157615C/en not_active IP Right Cessation
- 1975-09-10 GB GB37252/75A patent/GB1527131A/en not_active Expired
- 1975-09-10 PL PL1975204027A patent/PL106563B1/en unknown
- 1975-09-10 SU SU752170852A patent/SU814278A3/en active
- 1975-09-10 AT AT697775A patent/AT360023B/en not_active IP Right Cessation
- 1975-09-11 BR BR7505864*A patent/BR7505864A/en unknown
- 1975-09-11 DE DE19752540522 patent/DE2540522A1/en active Granted
- 1975-09-11 IE IE1973/75A patent/IE41844B1/en unknown
- 1975-09-11 CU CU34346A patent/CU34346A/en unknown
-
1976
- 1976-06-10 FR FR7617552A patent/FR2303016A1/en active Granted
-
1979
- 1979-03-23 SE SE7902667A patent/SE433080B/en not_active IP Right Cessation
- 1979-03-23 SE SE7902666A patent/SE440504B/en not_active IP Right Cessation
- 1979-03-23 SE SE7902668A patent/SE449098B/en not_active IP Right Cessation
- 1979-05-24 PH PH22557A patent/PH15091A/en unknown
-
1980
- 1980-09-12 NO NO802718A patent/NO146573C/en unknown
- 1980-09-12 NO NO802719A patent/NO147914C/en unknown
- 1980-09-12 NO NO802720A patent/NO148188C/en unknown
-
1981
- 1981-02-27 CH CH133781A patent/CH628053A5/en not_active IP Right Cessation
- 1981-11-24 KE KE3173A patent/KE3173A/en unknown
- 1981-12-17 HK HK633/81A patent/HK63381A/en unknown
-
1982
- 1982-12-30 MY MY214/82A patent/MY8200214A/en unknown
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