NL171060C - METHOD FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH MUSCLE-RELAXING, SEDATIVE AND ANTI-COMPOSITION EFFECTS, AND METHOD FOR PREPARING IMIDAZODIAZEPINE DERIVATIVES - Google Patents
METHOD FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH MUSCLE-RELAXING, SEDATIVE AND ANTI-COMPOSITION EFFECTS, AND METHOD FOR PREPARING IMIDAZODIAZEPINE DERIVATIVESInfo
- Publication number
- NL171060C NL171060C NLAANVRAGE7510620,A NL7510620A NL171060C NL 171060 C NL171060 C NL 171060C NL 7510620 A NL7510620 A NL 7510620A NL 171060 C NL171060 C NL 171060C
- Authority
- NL
- Netherlands
- Prior art keywords
- sedative
- relaxing
- muscle
- preparing
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title 2
- 230000000694 effects Effects 0.000 title 1
- BMGXAZCDDYTVFV-UHFFFAOYSA-N imidazo[4,5-c]diazepine Chemical class C1=CN=NC2=NC=NC2=C1 BMGXAZCDDYTVFV-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 239000000932 sedative agent Substances 0.000 title 1
- 230000001624 sedative effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50492474A | 1974-09-11 | 1974-09-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL7510620A NL7510620A (en) | 1976-03-15 |
| NL171060C true NL171060C (en) | 1983-02-01 |
Family
ID=24008278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NLAANVRAGE7510620,A NL171060C (en) | 1974-09-11 | 1975-09-09 | METHOD FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH MUSCLE-RELAXING, SEDATIVE AND ANTI-COMPOSITION EFFECTS, AND METHOD FOR PREPARING IMIDAZODIAZEPINE DERIVATIVES |
Country Status (32)
| Country | Link |
|---|---|
| JP (1) | JPS51125099A (en) |
| AT (1) | AT360023B (en) |
| AU (1) | AU505998B2 (en) |
| BE (1) | BE833248A (en) |
| BR (1) | BR7505864A (en) |
| CA (1) | CA1067491A (en) |
| CH (2) | CH619953A5 (en) |
| CU (1) | CU20892L (en) |
| DD (1) | DD121640A5 (en) |
| DE (1) | DE2540522A1 (en) |
| DK (1) | DK157615C (en) |
| ES (1) | ES440850A1 (en) |
| FI (1) | FI63234C (en) |
| FR (2) | FR2285890A1 (en) |
| GB (1) | GB1527131A (en) |
| HK (1) | HK63381A (en) |
| HU (1) | HU174752B (en) |
| IE (1) | IE41844B1 (en) |
| IL (1) | IL48069A (en) |
| KE (1) | KE3173A (en) |
| LU (1) | LU73356A1 (en) |
| MX (1) | MX160600A (en) |
| MY (1) | MY8200214A (en) |
| NL (1) | NL171060C (en) |
| NO (4) | NO147109C (en) |
| NZ (1) | NZ178635A (en) |
| PH (2) | PH16152A (en) |
| PL (1) | PL106563B1 (en) |
| SE (4) | SE425785B (en) |
| SU (1) | SU814278A3 (en) |
| YU (1) | YU40267B (en) |
| ZA (1) | ZA755418B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125726A (en) * | 1977-03-11 | 1978-11-14 | Hoffmann-La Roche Inc. | Imidazo[1,5-a][1,4]benzodiazepines |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| US4226768A (en) * | 1979-05-29 | 1980-10-07 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US4226771A (en) * | 1979-07-25 | 1980-10-07 | Hoffmann-La Roche Inc. | 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives |
| US4256637A (en) * | 1979-12-20 | 1981-03-17 | Hoffmann-La Roche Inc. | Intermediates for the production of imidazobenzodiazepines |
| FR2479818A1 (en) * | 1980-04-03 | 1981-10-09 | Roussel Uclaf | 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione |
| US4335042A (en) * | 1980-04-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Process to produce imidazobenzodiazepine intermediates |
| DE3329515C2 (en) * | 1983-08-16 | 1985-11-14 | Krohne Meßtechnik GmbH & Co KG, 4100 Duisburg | Electrical switching arrangement for a magnetic-inductive transducer |
| ZA845757B (en) * | 1983-08-25 | 1985-04-24 | Hoffmann La Roche | Benzodiazepine derivatives |
| PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
| FI880814A (en) * | 1987-03-10 | 1988-09-11 | Hoffmann La Roche | IMIDAZODIAZEPIN-derivate. |
| WO1994026723A2 (en) * | 1993-05-14 | 1994-11-24 | Genentech, Inc. | ras FARNESYL TRANSFERASE INHIBITORS |
| IN184976B (en) * | 1996-06-13 | 2000-10-14 | Ranbaxy Lab Ltd | |
| IT1399764B1 (en) * | 2010-05-04 | 2013-05-03 | F S I Fabbrica Italiana Sint | PROCEDURE FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-A] [1,4] BENZODIAZEPINE, IN PARTICULAR OF MIDAZOLAM. |
| CN103086986B (en) * | 2011-11-01 | 2015-11-04 | 上海医药工业研究院 | The preparation method of Isosorbide-5-Nitrae-Benzodiazepine-N-nitrosamines intermediate and application thereof |
| CN103804384B (en) * | 2014-01-27 | 2016-01-20 | 李宏 | The preparation method of benzodiazepine compounds |
| DK3439665T3 (en) | 2016-03-18 | 2022-09-26 | Uwm Res Foundation Inc | TREATMENT OF COGNITIVE AND MOOD SYMPTOMS IN NEURODEGENERATE AND NEUROPSYCHIATRIC DISORDERS WITH ALPHA5-CONTAINING GABAA RECEPTOR AGONISTS |
| BR112019003065A2 (en) | 2016-08-16 | 2019-05-21 | The Trustees Of Columbia University In The City Of New York | gaba (a) receptor modulators and methods for controlling airway hyperresponsiveness and inflammation in asthma |
| CN111410658B (en) * | 2020-03-30 | 2021-03-26 | 江苏恩华药业股份有限公司 | Impurity A and impurity B of midazolam or pharmaceutical composition thereof and application thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA716775B (en) * | 1970-10-30 | 1972-06-28 | Takeda Chemical Industries Ltd | Benzodiazepine derivatives |
| DE2056265A1 (en) * | 1970-11-16 | 1972-05-31 | Sumitomo Chemical Co. Ltd., Osaka (Japan) | Benzodiazepine derivs - from glycylamidobenzophenone derivs in dmso |
| JPS4932874B1 (en) * | 1970-12-11 | 1974-09-03 | ||
| BE787251A (en) * | 1971-08-04 | 1973-02-05 | Upjohn Co | NEW BENZODIAZEPINES AND THEIR PREPARATION |
| BE790839A (en) * | 1971-11-02 | 1973-04-30 | Upjohn Co | NEW BENZODIAZEPINES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM |
| BE792972A (en) * | 1971-12-20 | 1973-06-19 | Hoffmann La Roche | BENZODIAZEPINE DERIVATIVES |
| FR2183716A1 (en) * | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| CA1005443A (en) * | 1972-06-22 | 1977-02-15 | Michio Nakanishi | Thienodiazepine compounds |
-
1975
- 1975-08-25 ZA ZA755418A patent/ZA755418B/en unknown
- 1975-09-03 CH CH1141075A patent/CH619953A5/en not_active IP Right Cessation
- 1975-09-08 SE SE7509991A patent/SE425785B/en active Protection Beyond IP Right Term
- 1975-09-08 FI FI752517A patent/FI63234C/en not_active IP Right Cessation
- 1975-09-08 NO NO753069A patent/NO147109C/en unknown
- 1975-09-09 NZ NZ178635A patent/NZ178635A/en unknown
- 1975-09-09 FR FR7527599A patent/FR2285890A1/en active Granted
- 1975-09-09 MX MX201652A patent/MX160600A/en unknown
- 1975-09-09 NL NLAANVRAGE7510620,A patent/NL171060C/en not_active IP Right Cessation
- 1975-09-09 LU LU73356A patent/LU73356A1/xx unknown
- 1975-09-09 IL IL48069A patent/IL48069A/en unknown
- 1975-09-10 HU HU75HO1835A patent/HU174752B/en unknown
- 1975-09-10 CA CA235,138A patent/CA1067491A/en not_active Expired
- 1975-09-10 DD DD188275A patent/DD121640A5/xx unknown
- 1975-09-10 PH PH17566A patent/PH16152A/en unknown
- 1975-09-10 PL PL1975204027A patent/PL106563B1/en unknown
- 1975-09-10 GB GB37252/75A patent/GB1527131A/en not_active Expired
- 1975-09-10 ES ES440850A patent/ES440850A1/en not_active Expired
- 1975-09-10 BE BE159891A patent/BE833248A/en not_active IP Right Cessation
- 1975-09-10 DK DK404175A patent/DK157615C/en not_active IP Right Cessation
- 1975-09-10 YU YU2285/75A patent/YU40267B/en unknown
- 1975-09-10 JP JP50109060A patent/JPS51125099A/en active Granted
- 1975-09-10 AT AT697775A patent/AT360023B/en not_active IP Right Cessation
- 1975-09-10 SU SU752170852A patent/SU814278A3/en active
- 1975-09-10 AU AU84704/75A patent/AU505998B2/en not_active Expired
- 1975-09-11 IE IE1973/75A patent/IE41844B1/en unknown
- 1975-09-11 DE DE19752540522 patent/DE2540522A1/en active Granted
- 1975-09-11 BR BR7505864*A patent/BR7505864A/en unknown
- 1975-09-11 CU CU34346A patent/CU20892L/en unknown
-
1976
- 1976-06-10 FR FR7617552A patent/FR2303016A1/en active Granted
-
1979
- 1979-03-23 SE SE7902667A patent/SE433080B/en not_active IP Right Cessation
- 1979-03-23 SE SE7902668A patent/SE449098B/en not_active IP Right Cessation
- 1979-03-23 SE SE7902666A patent/SE440504B/en not_active IP Right Cessation
- 1979-05-24 PH PH22557A patent/PH15091A/en unknown
-
1980
- 1980-09-12 NO NO802718A patent/NO146573C/en unknown
- 1980-09-12 NO NO802720A patent/NO148188C/en unknown
- 1980-09-12 NO NO802719A patent/NO147914C/en unknown
-
1981
- 1981-02-27 CH CH133781A patent/CH628053A5/en not_active IP Right Cessation
- 1981-11-24 KE KE3173A patent/KE3173A/en unknown
- 1981-12-17 HK HK633/81A patent/HK63381A/en unknown
-
1982
- 1982-12-30 MY MY214/82A patent/MY8200214A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SNR | Assignments of patents or rights arising from examined patent applications |
Owner name: F. HOFFMANN-LA ROCHE AG |
|
| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Free format text: 950909 |