CU20892L - NEW DERIVATIVES OF IMIDAZOBENZODIACEPINAS - Google Patents
NEW DERIVATIVES OF IMIDAZOBENZODIACEPINASInfo
- Publication number
- CU20892L CU20892L CU34346A CU34346A CU20892L CU 20892 L CU20892 L CU 20892L CU 34346 A CU34346 A CU 34346A CU 34346 A CU34346 A CU 34346A CU 20892 L CU20892 L CU 20892L
- Authority
- CU
- Cuba
- Prior art keywords
- lower alkyl
- hydrogen
- group
- imidazobenzodiacepinas
- new derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un compuesto de la formula: En la que A es -C=N, R1 se elige del grupo constituido por hidrógeno y alquilo inferior; R3 y R5 se eligen del grupo constituido por hidrógeno, alquilo inferior, alcanoiloxilo inferior e hidroxilo con la limitación de que cuando R3 y R5 son alcanoiloxilo o hidroxilo el radical restante es hidrógeno o alquilo inferior; R4 se elige del grupo constituido por halógeno, ciano, nitro, trifluorometilo, hidrógeno, alquilo inferior, amino, amino sustituido, alcanoilo inferior e hidroxi-alquilo inferior; R6 se elige del grupo constituido por fenilo, fenilo mono sustituido, fenilo di-sustituido y el procedimiento de producción de estos compuestos.A compound of the formula: Where A is -C = N, R1 is selected from the group consisting of hydrogen and lower alkyl; R3 and R5 are chosen from the group consisting of hydrogen, lower alkyl, lower alkanoyloxy and hydroxyl with the limitation that when R3 and R5 are alkanoyloxy or hydroxyl the remaining radical is hydrogen or lower alkyl; R4 is selected from the group consisting of halogen, cyano, nitro, trifluoromethyl, hydrogen, lower alkyl, amino, substituted amino, lower alkanoyl, and hydroxy-lower alkyl; R6 is chosen from the group consisting of phenyl, mono-substituted phenyl, di-substituted phenyl and the method of production of these compounds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50492474A | 1974-09-11 | 1974-09-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU34346A CU34346A (en) | 1982-08-24 |
| CU20892L true CU20892L (en) | 1982-08-24 |
Family
ID=24008278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU34346A CU20892L (en) | 1974-09-11 | 1975-09-11 | NEW DERIVATIVES OF IMIDAZOBENZODIACEPINAS |
Country Status (32)
| Country | Link |
|---|---|
| JP (1) | JPS51125099A (en) |
| AT (1) | AT360023B (en) |
| AU (1) | AU505998B2 (en) |
| BE (1) | BE833248A (en) |
| BR (1) | BR7505864A (en) |
| CA (1) | CA1067491A (en) |
| CH (2) | CH619953A5 (en) |
| CU (1) | CU20892L (en) |
| DD (1) | DD121640A5 (en) |
| DE (1) | DE2540522A1 (en) |
| DK (1) | DK157615C (en) |
| ES (1) | ES440850A1 (en) |
| FI (3) | FI801764A7 (en) |
| FR (2) | FR2285890A1 (en) |
| GB (1) | GB1527131A (en) |
| HK (1) | HK63381A (en) |
| HU (1) | HU174752B (en) |
| IE (1) | IE41844B1 (en) |
| IL (1) | IL48069A (en) |
| KE (1) | KE3173A (en) |
| LU (1) | LU73356A1 (en) |
| MX (1) | MX160600A (en) |
| MY (1) | MY8200214A (en) |
| NL (1) | NL171060C (en) |
| NO (4) | NO147109C (en) |
| NZ (1) | NZ178635A (en) |
| PH (2) | PH16152A (en) |
| PL (1) | PL106563B1 (en) |
| SE (4) | SE425785B (en) |
| SU (1) | SU814278A3 (en) |
| YU (1) | YU40267B (en) |
| ZA (1) | ZA755418B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125726A (en) * | 1977-03-11 | 1978-11-14 | Hoffmann-La Roche Inc. | Imidazo[1,5-a][1,4]benzodiazepines |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| US4226768A (en) * | 1979-05-29 | 1980-10-07 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US4226771A (en) * | 1979-07-25 | 1980-10-07 | Hoffmann-La Roche Inc. | 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives |
| US4256637A (en) * | 1979-12-20 | 1981-03-17 | Hoffmann-La Roche Inc. | Intermediates for the production of imidazobenzodiazepines |
| FR2479818A1 (en) * | 1980-04-03 | 1981-10-09 | Roussel Uclaf | 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione |
| US4335042A (en) * | 1980-04-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Process to produce imidazobenzodiazepine intermediates |
| DE3329515C2 (en) * | 1983-08-16 | 1985-11-14 | Krohne Meßtechnik GmbH & Co KG, 4100 Duisburg | Electrical switching arrangement for a magnetic-inductive transducer |
| ZA845757B (en) * | 1983-08-25 | 1985-04-24 | Hoffmann La Roche | Benzodiazepine derivatives |
| PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
| FI880814A7 (en) * | 1987-03-10 | 1988-09-11 | Hoffmann La Roche | IMIDAZODIAZEPIN DERIVATIVES. |
| DE69332929T2 (en) * | 1992-12-04 | 2004-02-26 | Janssen Pharmaceutica N.V. | ANTIALLERGIC IMIDAZO [1,2-a] THIENO [2,3-d] AZEPINE DERIVATIVES |
| WO1994026723A2 (en) * | 1993-05-14 | 1994-11-24 | Genentech, Inc. | ras FARNESYL TRANSFERASE INHIBITORS |
| CA2143246C (en) * | 1994-03-16 | 2000-08-22 | Thierry Godel | Imidazodiazepines |
| IN184976B (en) * | 1996-06-13 | 2000-10-14 | Ranbaxy Lab Ltd | |
| IT1399764B1 (en) | 2010-05-04 | 2013-05-03 | F S I Fabbrica Italiana Sint | PROCEDURE FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-A] [1,4] BENZODIAZEPINE, IN PARTICULAR OF MIDAZOLAM. |
| CN103086986B (en) * | 2011-11-01 | 2015-11-04 | 上海医药工业研究院 | Preparation method and application of 1,4-benzodiazepine-N-nitrosamine intermediates |
| CN103804384B (en) * | 2014-01-27 | 2016-01-20 | 李宏 | The preparation method of benzodiazepine compounds |
| DK3439665T3 (en) | 2016-03-18 | 2022-09-26 | Uwm Res Foundation Inc | TREATMENT OF COGNITIVE AND MOOD SYMPTOMS IN NEURODEGENERATE AND NEUROPSYCHIATRIC DISORDERS WITH ALPHA5-CONTAINING GABAA RECEPTOR AGONISTS |
| JP7013446B2 (en) | 2016-08-16 | 2022-02-15 | ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド | GABA (A) receptor modulators and methods for suppressing airway hypersensitivity and inflammation in asthma |
| CN111410658B (en) * | 2020-03-30 | 2021-03-26 | 江苏恩华药业股份有限公司 | Impurity A and impurity B of midazolam or pharmaceutical composition thereof and application thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA716775B (en) * | 1970-10-30 | 1972-06-28 | Takeda Chemical Industries Ltd | Benzodiazepine derivatives |
| DE2056265A1 (en) * | 1970-11-16 | 1972-05-31 | Sumitomo Chemical Co. Ltd., Osaka (Japan) | Benzodiazepine derivs - from glycylamidobenzophenone derivs in dmso |
| JPS4932874B1 (en) * | 1970-12-11 | 1974-09-03 | ||
| BE787251A (en) * | 1971-08-04 | 1973-02-05 | Upjohn Co | NEW BENZODIAZEPINES AND THEIR PREPARATION |
| BE790839A (en) * | 1971-11-02 | 1973-04-30 | Upjohn Co | NEW BENZODIAZEPINES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM |
| BE792972A (en) * | 1971-12-20 | 1973-06-19 | Hoffmann La Roche | BENZODIAZEPINE DERIVATIVES |
| FR2183716A1 (en) * | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| CA1005443A (en) * | 1972-06-22 | 1977-02-15 | Michio Nakanishi | Thienodiazepine compounds |
-
1975
- 1975-08-25 ZA ZA755418A patent/ZA755418B/en unknown
- 1975-09-03 CH CH1141075A patent/CH619953A5/en not_active IP Right Cessation
- 1975-09-08 NO NO753069A patent/NO147109C/en unknown
- 1975-09-08 FI FI801764A patent/FI801764A7/en not_active Application Discontinuation
- 1975-09-08 FI FI801763A patent/FI801763A7/en not_active Application Discontinuation
- 1975-09-08 SE SE7509991A patent/SE425785B/en active Protection Beyond IP Right Term
- 1975-09-08 FI FI752517A patent/FI63234C/en not_active IP Right Cessation
- 1975-09-09 NZ NZ178635A patent/NZ178635A/en unknown
- 1975-09-09 IL IL48069A patent/IL48069A/en unknown
- 1975-09-09 FR FR7527599A patent/FR2285890A1/en active Granted
- 1975-09-09 MX MX201652A patent/MX160600A/en unknown
- 1975-09-09 NL NLAANVRAGE7510620,A patent/NL171060C/en not_active IP Right Cessation
- 1975-09-09 LU LU73356A patent/LU73356A1/xx unknown
- 1975-09-10 JP JP50109060A patent/JPS51125099A/en active Granted
- 1975-09-10 DD DD188275A patent/DD121640A5/xx unknown
- 1975-09-10 PL PL1975204027A patent/PL106563B1/en unknown
- 1975-09-10 AU AU84704/75A patent/AU505998B2/en not_active Expired
- 1975-09-10 HU HU75HO1835A patent/HU174752B/en unknown
- 1975-09-10 SU SU752170852A patent/SU814278A3/en active
- 1975-09-10 AT AT697775A patent/AT360023B/en not_active IP Right Cessation
- 1975-09-10 GB GB37252/75A patent/GB1527131A/en not_active Expired
- 1975-09-10 PH PH17566A patent/PH16152A/en unknown
- 1975-09-10 DK DK404175A patent/DK157615C/en not_active IP Right Cessation
- 1975-09-10 YU YU2285/75A patent/YU40267B/en unknown
- 1975-09-10 ES ES440850A patent/ES440850A1/en not_active Expired
- 1975-09-10 BE BE159891A patent/BE833248A/en not_active IP Right Cessation
- 1975-09-10 CA CA235,138A patent/CA1067491A/en not_active Expired
- 1975-09-11 BR BR7505864*A patent/BR7505864A/en unknown
- 1975-09-11 IE IE1973/75A patent/IE41844B1/en unknown
- 1975-09-11 CU CU34346A patent/CU20892L/en unknown
- 1975-09-11 DE DE19752540522 patent/DE2540522A1/en active Granted
-
1976
- 1976-06-10 FR FR7617552A patent/FR2303016A1/en active Granted
-
1979
- 1979-03-23 SE SE7902666A patent/SE440504B/en not_active IP Right Cessation
- 1979-03-23 SE SE7902668A patent/SE449098B/en not_active IP Right Cessation
- 1979-03-23 SE SE7902667A patent/SE433080B/en not_active IP Right Cessation
- 1979-05-24 PH PH22557A patent/PH15091A/en unknown
-
1980
- 1980-09-12 NO NO802719A patent/NO147914C/en unknown
- 1980-09-12 NO NO802718A patent/NO146573C/en unknown
- 1980-09-12 NO NO802720A patent/NO148188C/en unknown
-
1981
- 1981-02-27 CH CH133781A patent/CH628053A5/en not_active IP Right Cessation
- 1981-11-24 KE KE3173A patent/KE3173A/en unknown
- 1981-12-17 HK HK633/81A patent/HK63381A/en unknown
-
1982
- 1982-12-30 MY MY214/82A patent/MY8200214A/en unknown
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