ES425535A1 - Procedimiento para la obtencion de un material sintetico quirurgico. - Google Patents

Procedimiento para la obtencion de un material sintetico quirurgico.

Info

Publication number
ES425535A1
ES425535A1 ES425535A ES425535A ES425535A1 ES 425535 A1 ES425535 A1 ES 425535A1 ES 425535 A ES425535 A ES 425535A ES 425535 A ES425535 A ES 425535A ES 425535 A1 ES425535 A1 ES 425535A1
Authority
ES
Spain
Prior art keywords
resin material
treating osteomyelitis
osteomyelitis
surgical
synthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES425535A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES425535A1 publication Critical patent/ES425535A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0058—Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Neurosurgery (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Procedimiento para la obtención de un material sintético quirúrgico que contiene un material sintético a base de polimetacrilatos y/o poliacrilatos y como mínimo un antibiótico, caracterizado porque en una primera etapa se polimeriza radicalmente el copolímero con el monómero en presencia de 0,2 a 15% de un antibiótico tal como gentamicina y en una segunda etapa, antes de endurecer el copolímero, ester producto obtenido se conforma a partículas lo mas uniformes posible con un diámetro de 1 a 20, preferentemente unos 5 a 15mm de diámetro y en caso dado, dichas partículas se unen entre sí, como mínimo parcialmente, empleándose para ello hilos o alambres
ES425535A 1973-04-21 1974-04-20 Procedimiento para la obtencion de un material sintetico quirurgico. Expired ES425535A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2320373A DE2320373B2 (de) 1973-04-21 1973-04-21 Antibioticahaltiges Mittel und seine Verwendung als chirurgisches Kunststoffmaterial

Publications (1)

Publication Number Publication Date
ES425535A1 true ES425535A1 (es) 1976-12-16

Family

ID=5878879

Family Applications (1)

Application Number Title Priority Date Filing Date
ES425535A Expired ES425535A1 (es) 1973-04-21 1974-04-20 Procedimiento para la obtencion de un material sintetico quirurgico.

Country Status (14)

Country Link
US (1) US3882858A (es)
JP (2) JPS5912293B2 (es)
BE (1) BE813943A (es)
CA (1) CA1020831A (es)
DD (1) DD112352A5 (es)
DE (1) DE2320373B2 (es)
DK (1) DK134095C (es)
ES (1) ES425535A1 (es)
FR (1) FR2226160B1 (es)
GB (1) GB1432299A (es)
HK (1) HK77376A (es)
IL (1) IL44522A (es)
MY (1) MY7700066A (es)
ZA (1) ZA741943B (es)

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* Cited by examiner, † Cited by third party
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DE2650306A1 (de) * 1976-11-02 1978-05-03 Merck Patent Gmbh Antibakteriell wirkender wundverband und verfahren zu seiner herstellung
DE2727535C2 (de) * 1977-06-18 1986-09-18 Merck Patent Gmbh, 6100 Darmstadt Antibioticahaltiges Mittel
DE2713162A1 (de) * 1977-03-25 1978-10-05 Merck Patent Gmbh Muffe fuer zur knochenstabilisierung dienende chirurgische naegel und deren verwendung
DE2908794C2 (de) * 1978-03-09 1984-09-13 Japan Atomic Energy Research Institute, Tokio/Tokyo Verfahren zur Herstellung eines eine physiologisch aktive Substanz enthaltenden Polymerpräparates
US4900303A (en) * 1978-03-10 1990-02-13 Lemelson Jerome H Dispensing catheter and method
DE2905878A1 (de) * 1979-02-16 1980-08-28 Merck Patent Gmbh Implantationsmaterialien und verfahren zu ihrer herstellung
US4536158A (en) * 1980-12-08 1985-08-20 Medical Biological Sciences, Inc. Oral prosthesis and method for producing same
US4547327A (en) * 1980-12-08 1985-10-15 Medical Biological Sciences, Inc. Method for producing a porous prosthesis
GB2093348B (en) * 1981-02-23 1984-09-12 Leo Pharm Prod Ltd Pharmaceutical composition for implantation
WO1982003174A1 (en) * 1981-03-19 1982-09-30 Haerle Anton Corpuscles containing drugs and use thereof in medecine and surgery
DE3110805A1 (de) * 1981-03-19 1982-10-28 Anton Dr. 4400 Münster Härle "pharmakahaltiges koerperchen und seine verwendung als medizinisches und chirurgisches hilfsmittel"
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DE3217109A1 (de) * 1982-05-07 1983-11-10 Anton Dr. 4400 Münster Härle Chirurgisches hilfsmittel
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EP0223245A3 (en) * 1985-11-21 1989-05-10 Mitsui Petrochemical Industries, Ltd. Curable compositions for dental drugs having sustained release property
DE3542972A1 (de) * 1985-12-05 1987-06-11 Merck Patent Gmbh Pharmakadepot
DE3613213A1 (de) * 1986-04-18 1987-10-22 Merck Patent Gmbh Tricalciumphosphat fuer implantationsmaterialien
DE3627487A1 (de) * 1986-08-13 1988-02-25 Bernd Dr Steckmeier Gefaessprothese
US4843112A (en) * 1987-03-12 1989-06-27 The Beth Israel Hospital Association Bioerodable implant composition
US5085861A (en) * 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
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DE3841401A1 (de) * 1988-12-08 1990-06-13 Martin Lemperle Alloplastisches implantat
US5268178A (en) * 1989-09-25 1993-12-07 The Board Of Regents, The University Of Texas System Biodegradable antibiotic implants and methods of their use in treating and preventing infections
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US5342557A (en) * 1990-11-27 1994-08-30 United States Surgical Corporation Process for preparing polymer particles
US5123927A (en) * 1990-12-05 1992-06-23 University Of British Columbia Method and apparatus for antibiotic knee prothesis
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DE10114247A1 (de) * 2001-03-22 2002-10-10 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Polymer-Kombination
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Also Published As

Publication number Publication date
HK77376A (en) 1976-12-17
DD112352A5 (es) 1975-04-12
DK134095C (da) 1977-02-14
ZA741943B (en) 1975-03-26
IL44522A (en) 1976-10-31
DE2320373A1 (de) 1974-11-07
JPS5014183A (es) 1975-02-14
JPS5912293B2 (ja) 1984-03-22
DK134095B (da) 1976-09-13
DE2320373B2 (de) 1978-04-06
DE2320373C3 (es) 1979-12-20
AU6760674A (en) 1975-10-09
CA1020831A (en) 1977-11-15
MY7700066A (en) 1977-12-31
FR2226160B1 (es) 1976-12-10
JPS57131434A (en) 1982-08-14
US3882858A (en) 1975-05-13
IL44522A0 (en) 1974-06-30
BE813943A (fr) 1974-10-21
GB1432299A (en) 1976-04-14
FR2226160A1 (es) 1974-11-15

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