ES8206430A1 - Procedimiento para preparar 5z,8z,11z,14z,17z-eicosapentae- noatos de alquilfenilo. - Google Patents

Procedimiento para preparar 5z,8z,11z,14z,17z-eicosapentae- noatos de alquilfenilo.

Info

Publication number
ES8206430A1
ES8206430A1 ES507123A ES507123A ES8206430A1 ES 8206430 A1 ES8206430 A1 ES 8206430A1 ES 507123 A ES507123 A ES 507123A ES 507123 A ES507123 A ES 507123A ES 8206430 A1 ES8206430 A1 ES 8206430A1
Authority
ES
Spain
Prior art keywords
eicosapentaenoates
alkylphenyl
preparation
disclosed
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507123A
Other languages
English (en)
Other versions
ES507123A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES507123A0 publication Critical patent/ES507123A0/es
Publication of ES8206430A1 publication Critical patent/ES8206430A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 5Z,8Z,11Z,14Z-EICOSAPENTAENOATOS DE ALQUIL-FENILO, DE FORMULA (I), EN LA QUE R1 ES HIDROGENO, 2-ALQUILO C1-2 O 3-METILO, R2 ES HIDROGENO O ALQUILO C1-2 Y X ES FENILO SUSTITUIDO POR 1 A 3 ALQUILOS C1-4. CONSISTE EN LA REACCION DEL COMPUESTO 2-MONOALQUILADO DE FORMULA (II), EN LA QUE R1 Y X TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON N-LITIO-N-(1-METILETIL)CICLOHEXANAMINA EN TETRAHIDROFURANO BAJO NITROGENO A - 78 C, SEGUIDA DE LA REACCION IN SITU CON UN HALOGENO DE ALQUILO DE FORMULA R2HAL, EN LA QUE R2 ES EL MISMO QUE EN LA FORMULA (I) Y HAL ES HALOGENO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD COMO INHIBIDORES DE LA AGREGACION DE PLAQUETAS Y COMO AGENTES ANTISECRETORIOS.
ES507123A 1979-10-26 1981-11-13 Procedimiento para preparar 5z,8z,11z,14z,17z-eicosapentae- noatos de alquilfenilo. Expired ES8206430A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/088,502 US4264517A (en) 1978-12-11 1979-10-26 Alkylphenyl 5Z,8Z,11Z,14Z,17Z-eicosapentaenoates

Publications (2)

Publication Number Publication Date
ES507123A0 ES507123A0 (es) 1982-08-16
ES8206430A1 true ES8206430A1 (es) 1982-08-16

Family

ID=22211743

Family Applications (3)

Application Number Title Priority Date Filing Date
ES496248A Granted ES496248A0 (es) 1979-10-26 1980-10-24 Procedimiento para preparar 5z, 8z, 11z, 14z, 17z-eicosapen-taenoatos de alquifenilo
ES507122A Granted ES507122A0 (es) 1979-10-26 1981-11-13 Procedimiento para preparar 5z,8z,11z,14z,17z,eicosapentae- noatos de alquilfenilo.
ES507123A Expired ES8206430A1 (es) 1979-10-26 1981-11-13 Procedimiento para preparar 5z,8z,11z,14z,17z-eicosapentae- noatos de alquilfenilo.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES496248A Granted ES496248A0 (es) 1979-10-26 1980-10-24 Procedimiento para preparar 5z, 8z, 11z, 14z, 17z-eicosapen-taenoatos de alquifenilo
ES507122A Granted ES507122A0 (es) 1979-10-26 1981-11-13 Procedimiento para preparar 5z,8z,11z,14z,17z,eicosapentae- noatos de alquilfenilo.

Country Status (11)

Country Link
US (1) US4264517A (es)
JP (1) JPS5686134A (es)
BE (1) BE885890A (es)
CA (1) CA1140576A (es)
DE (1) DE3039960A1 (es)
DK (1) DK452380A (es)
ES (3) ES496248A0 (es)
FR (1) FR2468577A1 (es)
GB (1) GB2061277B (es)
IT (1) IT1133047B (es)
NL (1) NL8005876A (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576758A (en) * 1984-06-01 1986-03-18 The Upjohn Company Anti-inflammatory lipoxin B analogs
WO2006117664A1 (en) * 2005-05-04 2006-11-09 Pronova Biopharma Norge As New dha derivatives and their use as medicaments
GB0605900D0 (en) * 2006-03-23 2006-05-03 Lipigen As Modulators of nuclear receptors
JP2010508262A (ja) * 2006-11-01 2010-03-18 プロノヴァ バイオファーマ ノルゲ アーエス 組成物
MX2009004337A (es) * 2006-11-01 2009-05-22 Pronova Biopharma Norge As Compuestos lipidos omega-3.
BRPI0717972A2 (pt) * 2006-11-01 2013-11-12 Pronova Biopharma Norge As Lipídeos de ômega-3 alfa-substituídos que são ativadores ou moduladores do receptor ativado por proliferadores de peroxissoma (ppar)
MX2009004336A (es) * 2006-11-01 2009-05-22 Pronova Biopharma Norge As Lipidos omega-3 alfa-sustituidos que son activadores o moduladores del receptor activado por proliferadores de peroxisoma (ppar).
KR20100100818A (ko) * 2007-10-31 2010-09-15 프로노바 바이오파마 노르지 에이에스 새로운 ｄｈａ 유도체 및 약물로서 그들의 사용
WO2009070748A1 (en) * 2007-11-27 2009-06-04 Umber Systems System for collecting and analyzing data on application-level activity on a mobile data network
LT2315740T (lt) 2008-07-08 2018-02-26 Catabasis Pharmaceuticals, Inc. Acetilinti riebalų rūgščių salicilatai ir jų panaudojimas
US9085527B2 (en) * 2008-07-08 2015-07-21 Catabasis Pharmaceuticals, Inc. Fatty acid acylated salicylates and their uses
CN102724877B (zh) 2009-09-01 2015-05-13 凯特贝希制药公司 脂肪酸烟酸缀合物及其用途
USRE46608E1 (en) 2009-09-01 2017-11-14 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
TW201138832A (en) * 2010-01-20 2011-11-16 Pronova Biopharma Norge As Salicylate fatty acid derivatives
CN114853627B (zh) * 2022-04-26 2023-06-20 自然资源部第三海洋研究所 一种取代苯甲酸二十二碳六烯酰胺乙基酯衍生物及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181670A (en) * 1978-12-11 1980-01-01 G. D. Searle & Co. Phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners

Also Published As

Publication number Publication date
DK452380A (da) 1981-04-27
BE885890A (fr) 1981-04-27
JPS5686134A (en) 1981-07-13
US4264517A (en) 1981-04-28
ES8202781A1 (es) 1982-02-16
FR2468577A1 (fr) 1981-05-08
IT1133047B (it) 1986-07-09
ES8206429A1 (es) 1982-08-16
ES507122A0 (es) 1982-08-16
GB2061277B (en) 1983-11-16
CA1140576A (en) 1983-02-01
NL8005876A (nl) 1981-04-28
IT8050013A0 (it) 1980-10-27
ES507123A0 (es) 1982-08-16
ES496248A0 (es) 1982-02-16
GB2061277A (en) 1981-05-13
DE3039960A1 (de) 1981-05-07

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