ES8202781A1 - Procedimiento para preparar 5z, 8z, 11z, 14z, 17z-eicosapen-taenoatos de alquifenilo - Google Patents

Procedimiento para preparar 5z, 8z, 11z, 14z, 17z-eicosapen-taenoatos de alquifenilo

Info

Publication number
ES8202781A1
ES8202781A1 ES496248A ES496248A ES8202781A1 ES 8202781 A1 ES8202781 A1 ES 8202781A1 ES 496248 A ES496248 A ES 496248A ES 496248 A ES496248 A ES 496248A ES 8202781 A1 ES8202781 A1 ES 8202781A1
Authority
ES
Spain
Prior art keywords
eicosapentaenoates
alkylphenyl
preparation
disclosed
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496248A
Other languages
English (en)
Other versions
ES496248A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES496248A0 publication Critical patent/ES496248A0/es
Publication of ES8202781A1 publication Critical patent/ES8202781A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 5Z, 8Z, 11Z, 14Z, 17Z-EICOSAPENTONOATOS DE ALQUILFENILO DE FORMULA (I), EN LA QUE R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES; Y X ES FENILO SUSTITUIDO POR 1 A 3 ALQUILOS C1-4. CONSISTE EN LA REACCION DE UN ACIDO DE FORMULA (II) CON N,N- METANOTETRAILBISCICLOHEXANAMINA, PARA OBTENER LA CORRESPONDIENTE O-ACILISOUREA, SEGUIDA DE LA REACCION CON UN FENOL DE FORMULA XOJ, EN LAS QUE R1, R2 Y X TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN DICLOROMETANO, INICIANDOSE A LA TEMPERATURA DE 0 C Y DEJANDOLA HASTA LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES INHIBIDORES DE LA AGREGARION DE PLAQUETAS Y ANTISECRETORIOS.
ES496248A 1979-10-26 1980-10-24 Procedimiento para preparar 5z, 8z, 11z, 14z, 17z-eicosapen-taenoatos de alquifenilo Expired ES8202781A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/088,502 US4264517A (en) 1978-12-11 1979-10-26 Alkylphenyl 5Z,8Z,11Z,14Z,17Z-eicosapentaenoates

Publications (2)

Publication Number Publication Date
ES496248A0 ES496248A0 (es) 1982-02-16
ES8202781A1 true ES8202781A1 (es) 1982-02-16

Family

ID=22211743

Family Applications (3)

Application Number Title Priority Date Filing Date
ES496248A Expired ES8202781A1 (es) 1979-10-26 1980-10-24 Procedimiento para preparar 5z, 8z, 11z, 14z, 17z-eicosapen-taenoatos de alquifenilo
ES507122A Expired ES8206429A1 (es) 1979-10-26 1981-11-13 Procedimiento para preparar 5z,8z,11z,14z,17z,eicosapentae- noatos de alquilfenilo.
ES507123A Expired ES8206430A1 (es) 1979-10-26 1981-11-13 Procedimiento para preparar 5z,8z,11z,14z,17z-eicosapentae- noatos de alquilfenilo.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES507122A Expired ES8206429A1 (es) 1979-10-26 1981-11-13 Procedimiento para preparar 5z,8z,11z,14z,17z,eicosapentae- noatos de alquilfenilo.
ES507123A Expired ES8206430A1 (es) 1979-10-26 1981-11-13 Procedimiento para preparar 5z,8z,11z,14z,17z-eicosapentae- noatos de alquilfenilo.

Country Status (11)

Country Link
US (1) US4264517A (es)
JP (1) JPS5686134A (es)
BE (1) BE885890A (es)
CA (1) CA1140576A (es)
DE (1) DE3039960A1 (es)
DK (1) DK452380A (es)
ES (3) ES8202781A1 (es)
FR (1) FR2468577A1 (es)
GB (1) GB2061277B (es)
IT (1) IT1133047B (es)
NL (1) NL8005876A (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576758A (en) * 1984-06-01 1986-03-18 The Upjohn Company Anti-inflammatory lipoxin B analogs
AU2006242914B2 (en) 2005-05-04 2012-02-02 Pronova Biopharma Norge As New DHA derivatives and their use as medicaments
GB0605900D0 (en) * 2006-03-23 2006-05-03 Lipigen As Modulators of nuclear receptors
WO2008142482A2 (en) * 2006-11-01 2008-11-27 Pronova Biopharma Norge As Omega-3 lipid compounds
BRPI0717972A2 (pt) * 2006-11-01 2013-11-12 Pronova Biopharma Norge As Lipídeos de ômega-3 alfa-substituídos que são ativadores ou moduladores do receptor ativado por proliferadores de peroxissoma (ppar)
CA2667150A1 (en) * 2006-11-01 2008-11-06 Pronova Biopharma Norge As Omega-3 lipid compounds
CA2667211A1 (en) * 2006-11-01 2008-05-08 Pronova Biopharma Norge As Alpha-substituted omega-3 lipids that are activators or modulators of the peroxisome proliferators-activated receptor (ppar)
EP2217558A1 (en) * 2007-10-31 2010-08-18 Pronova Biopharma Norge AS New dha derivatives and their use as medicaments
WO2009070748A1 (en) * 2007-11-27 2009-06-04 Umber Systems System for collecting and analyzing data on application-level activity on a mobile data network
US9085527B2 (en) 2008-07-08 2015-07-21 Catabasis Pharmaceuticals, Inc. Fatty acid acylated salicylates and their uses
ES2656903T3 (es) * 2008-07-08 2018-02-28 Catabasis Pharmaceuticals, Inc. Salicilatos acetilados de ácidos grasos y sus usos
SG10201500431SA (en) 2009-09-01 2015-03-30 Catabasis Pharmaceuticals Inc Fatty acid niacin conjugates and their uses
USRE46608E1 (en) 2009-09-01 2017-11-14 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
EP2526084A1 (en) * 2010-01-20 2012-11-28 Pronova BioPharma Norge AS Salicylate fatty acid derivatives
CN114853627B (zh) * 2022-04-26 2023-06-20 自然资源部第三海洋研究所 一种取代苯甲酸二十二碳六烯酰胺乙基酯衍生物及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181670A (en) * 1978-12-11 1980-01-01 G. D. Searle & Co. Phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners

Also Published As

Publication number Publication date
GB2061277A (en) 1981-05-13
DE3039960A1 (de) 1981-05-07
US4264517A (en) 1981-04-28
FR2468577A1 (fr) 1981-05-08
GB2061277B (en) 1983-11-16
BE885890A (fr) 1981-04-27
ES496248A0 (es) 1982-02-16
IT1133047B (it) 1986-07-09
ES507123A0 (es) 1982-08-16
NL8005876A (nl) 1981-04-28
ES8206430A1 (es) 1982-08-16
ES507122A0 (es) 1982-08-16
CA1140576A (en) 1983-02-01
DK452380A (da) 1981-04-27
IT8050013A0 (it) 1980-10-27
ES8206429A1 (es) 1982-08-16
JPS5686134A (en) 1981-07-13

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