ES422006A1 - Procedure for the preparation of N- (heteroaril-methyl) -benzomorphanes and mordinan. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of N- (heteroaril-methyl) -benzomorphanes and mordinan. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES422006A1 ES422006A1 ES422006A ES422006A ES422006A1 ES 422006 A1 ES422006 A1 ES 422006A1 ES 422006 A ES422006 A ES 422006A ES 422006 A ES422006 A ES 422006A ES 422006 A1 ES422006 A1 ES 422006A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- methyl
- compound
- hydrogen atom
- signifies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Procedure for the preparation of N- (heteroaryl-methyl) -benzomorphanes and morphinan of the general formula **(See formula)** where R signifies a hydrogen atom or a methyl or acetyl group, R1 and R2, which may be the same or different, signify a hydrogen atom or an alcohol group with 1 to 4 carbon atoms or a 1,4-butylene chain, R3 signifies a hydrogen atom or a methyl or ethyl group, and X signifies an oxygen or sulfur atom, as well as its acid addition salts, characterized in that a quaternary ammonium salt of the formula is reduced. **(See formula)** where R1 to R4 as well as X are as defined above, Y means an oxygen or sulfur atom, R5 means a lower alcohol radical with 1 to 4 carbon atoms, means an anion of an organic or inorganic acid, for form a compound of formula III; and eventually -to prepare a compound of the formula **(See formula)** - a compound of the formula III is dealkoxylated or deacylated, wherein R4 designates an alcoholic, aralkoxy or acyl group; and optionally - in order to prepare a compound of formula I, where R represents a methyl or acetyl group - a compound of formula III is methylated or acetylated, where R4 designates a hydrogen atom; and eventually the compounds of the general formula I are transformed into their physiologically harmless acid addition salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722243703 DE2243703A1 (en) | 1972-09-06 | 1972-09-06 | N-(heteroaryl-methyl)-benzomorphan and -morphinans prodn. - from corr-esp. heteroaryl-thioamides or quat. ammonium derivs. by smooth reducn. with alternative reducing agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES422006A1 true ES422006A1 (en) | 1976-06-16 |
Family
ID=5855589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES418488A Expired ES418488A1 (en) | 1972-09-06 | 1973-09-05 | Procedure for the preparation of N- (heteroaril-methyl) - benzomorphanes and morphinants. (Machine-translation by Google Translate, not legally binding) |
| ES422006A Expired ES422006A1 (en) | 1972-09-06 | 1974-01-04 | Procedure for the preparation of N- (heteroaril-methyl) -benzomorphanes and mordinan. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES418488A Expired ES418488A1 (en) | 1972-09-06 | 1973-09-05 | Procedure for the preparation of N- (heteroaril-methyl) - benzomorphanes and morphinants. (Machine-translation by Google Translate, not legally binding) |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS578109B2 (en) |
| AT (1) | AT327408B (en) |
| BG (1) | BG22392A3 (en) |
| CH (2) | CH590270A5 (en) |
| CS (2) | CS168043B2 (en) |
| DD (1) | DD107035A5 (en) |
| DE (1) | DE2243703A1 (en) |
| DK (1) | DK140171C (en) |
| ES (2) | ES418488A1 (en) |
| FI (1) | FI63027C (en) |
| HU (1) | HU176927B (en) |
| NL (1) | NL7312177A (en) |
| PL (1) | PL86931B1 (en) |
| RO (1) | RO62924A (en) |
| SE (1) | SE417821B (en) |
| SU (1) | SU543347A3 (en) |
| YU (2) | YU36022B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR069545A1 (en) * | 2007-11-16 | 2010-02-03 | Boehringer Ingelheim Pharma | DERIVATIVES OF ARIL AND HETEROARILCARBONILO OF RELATED BENZOMORPHANS AND RELATED STRUCTURES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, OBTAINING THEMSELVES, THEIR USE IN THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF THE HIDDEN AND DISEASE |
-
1972
- 1972-09-06 DE DE19722243703 patent/DE2243703A1/en active Pending
-
1973
- 1973-08-14 AT AT710973A patent/AT327408B/en not_active IP Right Cessation
- 1973-09-03 CH CH1260873A patent/CH590270A5/xx not_active IP Right Cessation
- 1973-09-03 CH CH24277A patent/CH599953A5/xx not_active IP Right Cessation
- 1973-09-04 FI FI274873A patent/FI63027C/en active
- 1973-09-04 CS CS615673A patent/CS168043B2/cs unknown
- 1973-09-04 DD DD17326773A patent/DD107035A5/xx unknown
- 1973-09-04 NL NL7312177A patent/NL7312177A/xx not_active Application Discontinuation
- 1973-09-04 HU HU73BO1460A patent/HU176927B/en unknown
- 1973-09-04 BG BG2559773A patent/BG22392A3/xx unknown
- 1973-09-04 CS CS812174A patent/CS185228B2/en unknown
- 1973-09-05 SE SE7312111A patent/SE417821B/en unknown
- 1973-09-05 DK DK489973A patent/DK140171C/en not_active IP Right Cessation
- 1973-09-05 YU YU236573A patent/YU36022B/en unknown
- 1973-09-05 ES ES418488A patent/ES418488A1/en not_active Expired
- 1973-09-05 PL PL16504273A patent/PL86931B1/pl unknown
- 1973-09-05 JP JP10010173A patent/JPS578109B2/ja not_active Expired
- 1973-09-05 RO RO7599273A patent/RO62924A/en unknown
-
1974
- 1974-01-04 ES ES422006A patent/ES422006A1/en not_active Expired
- 1974-10-10 SU SU2065404A patent/SU543347A3/en active
-
1979
- 1979-11-27 YU YU291379A patent/YU36023B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU543347A3 (en) | 1977-01-15 |
| CS168043B2 (en) | 1976-05-28 |
| YU36022B (en) | 1981-11-13 |
| BG22392A3 (en) | 1977-02-20 |
| CH599953A5 (en) | 1978-06-15 |
| YU291379A (en) | 1981-04-30 |
| SE417821B (en) | 1981-04-13 |
| CS185228B2 (en) | 1978-09-15 |
| DE2243703A1 (en) | 1974-03-14 |
| AT327408B (en) | 1976-01-26 |
| DK140171C (en) | 1979-11-26 |
| HU176927B (en) | 1981-06-28 |
| YU236573A (en) | 1981-04-30 |
| YU36023B (en) | 1981-11-13 |
| DD107035A5 (en) | 1974-07-12 |
| FI63027B (en) | 1982-12-31 |
| NL7312177A (en) | 1974-03-08 |
| PL86931B1 (en) | 1976-06-30 |
| ES418488A1 (en) | 1976-04-01 |
| JPS578109B2 (en) | 1982-02-15 |
| DK140171B (en) | 1979-07-02 |
| RO62924A (en) | 1978-05-15 |
| JPS49100085A (en) | 1974-09-20 |
| ATA710973A (en) | 1975-04-15 |
| CH590270A5 (en) | 1977-07-29 |
| FI63027C (en) | 1983-04-11 |
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