ES418488A1 - Procedure for the preparation of N- (heteroaril-methyl) - benzomorphanes and morphinants. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of N- (heteroaril-methyl) - benzomorphanes and morphinants. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES418488A1 ES418488A1 ES418488A ES418488A ES418488A1 ES 418488 A1 ES418488 A1 ES 418488A1 ES 418488 A ES418488 A ES 418488A ES 418488 A ES418488 A ES 418488A ES 418488 A1 ES418488 A1 ES 418488A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- methyl
- compound
- hydrogen atom
- signifies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Procedure for the preparation of N- (heteroaryl-methyl) -benzoniorphanes and morphinanes of the general formula **(See formula)** where R signifies a hydrogen atom or a methyl or acetyl group, R1 and R2, which may be the same or different, signify a hydrogen atom or an alcohol group with 1 to 4 carbon atoms or a 1,4-butylene chain, R3 signifies a hydrogen atom or a methyl or ethyl group, and X signifies an oxygen or sulfur atom, as well as its acid addition salts, characterized in that a compound of the formula is reduced **(See formula)** wherein R1, R2, R3 and X have the aforementioned meanings and R4 signifies a hydrogen atom, an alcohol, aralcohyl or acyl group, to form a compound of the formula **(See formula)** and eventually to prepare a compound of the formula **(See formula)** a compound of formula III is dealkoxylated or deacylated, wherein R4 designates an alcohol, aralkoxy or acyl group; and optionally in order to prepare a compound of formula I, where R represents a methyl or acetyl group, a compound of formula III is methylated or acetylated, where R4 designates a hydrogen atom 5 and eventually the compounds are transformed of the general formula I in its physiologically safe acid addition salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722243703 DE2243703A1 (en) | 1972-09-06 | 1972-09-06 | N-(heteroaryl-methyl)-benzomorphan and -morphinans prodn. - from corr-esp. heteroaryl-thioamides or quat. ammonium derivs. by smooth reducn. with alternative reducing agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES418488A1 true ES418488A1 (en) | 1976-04-01 |
Family
ID=5855589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES418488A Expired ES418488A1 (en) | 1972-09-06 | 1973-09-05 | Procedure for the preparation of N- (heteroaril-methyl) - benzomorphanes and morphinants. (Machine-translation by Google Translate, not legally binding) |
| ES422006A Expired ES422006A1 (en) | 1972-09-06 | 1974-01-04 | Procedure for the preparation of N- (heteroaril-methyl) -benzomorphanes and mordinan. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES422006A Expired ES422006A1 (en) | 1972-09-06 | 1974-01-04 | Procedure for the preparation of N- (heteroaril-methyl) -benzomorphanes and mordinan. (Machine-translation by Google Translate, not legally binding) |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS578109B2 (en) |
| AT (1) | AT327408B (en) |
| BG (1) | BG22392A3 (en) |
| CH (2) | CH590270A5 (en) |
| CS (2) | CS168043B2 (en) |
| DD (1) | DD107035A5 (en) |
| DE (1) | DE2243703A1 (en) |
| DK (1) | DK140171C (en) |
| ES (2) | ES418488A1 (en) |
| FI (1) | FI63027C (en) |
| HU (1) | HU176927B (en) |
| NL (1) | NL7312177A (en) |
| PL (1) | PL86931B1 (en) |
| RO (1) | RO62924A (en) |
| SE (1) | SE417821B (en) |
| SU (1) | SU543347A3 (en) |
| YU (2) | YU36022B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5769970B2 (en) * | 2007-11-16 | 2015-08-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Aryl- and heteroarylcarbonyl derivatives of benzomorphan and related skeletons, medicaments containing such compounds and their use |
-
1972
- 1972-09-06 DE DE19722243703 patent/DE2243703A1/en active Pending
-
1973
- 1973-08-14 AT AT710973A patent/AT327408B/en not_active IP Right Cessation
- 1973-09-03 CH CH1260873A patent/CH590270A5/xx not_active IP Right Cessation
- 1973-09-03 CH CH24277A patent/CH599953A5/xx not_active IP Right Cessation
- 1973-09-04 CS CS615673A patent/CS168043B2/cs unknown
- 1973-09-04 HU HU73BO1460A patent/HU176927B/en unknown
- 1973-09-04 CS CS812174A patent/CS185228B2/en unknown
- 1973-09-04 DD DD17326773A patent/DD107035A5/xx unknown
- 1973-09-04 NL NL7312177A patent/NL7312177A/xx not_active Application Discontinuation
- 1973-09-04 BG BG025597A patent/BG22392A3/en unknown
- 1973-09-04 FI FI274873A patent/FI63027C/en active
- 1973-09-05 PL PL16504273A patent/PL86931B1/pl unknown
- 1973-09-05 JP JP10010173A patent/JPS578109B2/ja not_active Expired
- 1973-09-05 YU YU236573A patent/YU36022B/en unknown
- 1973-09-05 SE SE7312111A patent/SE417821B/en unknown
- 1973-09-05 RO RO7599273A patent/RO62924A/en unknown
- 1973-09-05 DK DK489973A patent/DK140171C/en not_active IP Right Cessation
- 1973-09-05 ES ES418488A patent/ES418488A1/en not_active Expired
-
1974
- 1974-01-04 ES ES422006A patent/ES422006A1/en not_active Expired
- 1974-10-10 SU SU2065404A patent/SU543347A3/en active
-
1979
- 1979-11-27 YU YU291379A patent/YU36023B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU176927B (en) | 1981-06-28 |
| AT327408B (en) | 1976-01-26 |
| JPS578109B2 (en) | 1982-02-15 |
| FI63027C (en) | 1983-04-11 |
| DK140171C (en) | 1979-11-26 |
| ES422006A1 (en) | 1976-06-16 |
| YU291379A (en) | 1981-04-30 |
| CH599953A5 (en) | 1978-06-15 |
| NL7312177A (en) | 1974-03-08 |
| JPS49100085A (en) | 1974-09-20 |
| BG22392A3 (en) | 1977-02-20 |
| CS168043B2 (en) | 1976-05-28 |
| YU36022B (en) | 1981-11-13 |
| YU236573A (en) | 1981-04-30 |
| SU543347A3 (en) | 1977-01-15 |
| CS185228B2 (en) | 1978-09-15 |
| DD107035A5 (en) | 1974-07-12 |
| RO62924A (en) | 1978-05-15 |
| SE417821B (en) | 1981-04-13 |
| DE2243703A1 (en) | 1974-03-14 |
| FI63027B (en) | 1982-12-31 |
| YU36023B (en) | 1981-11-13 |
| CH590270A5 (en) | 1977-07-29 |
| PL86931B1 (en) | 1976-06-30 |
| DK140171B (en) | 1979-07-02 |
| ATA710973A (en) | 1975-04-15 |
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