ES412203A1 - Procedimiento para la preparacion de nuevos compuestos qui-micos de accion cardiovascular. - Google Patents

Procedimiento para la preparacion de nuevos compuestos qui-micos de accion cardiovascular.

Info

Publication number
ES412203A1
ES412203A1 ES412203A ES412203A ES412203A1 ES 412203 A1 ES412203 A1 ES 412203A1 ES 412203 A ES412203 A ES 412203A ES 412203 A ES412203 A ES 412203A ES 412203 A1 ES412203 A1 ES 412203A1
Authority
ES
Spain
Prior art keywords
formula
reacted
phase
new
insufficiencies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES412203A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EUROP DE RECH MAUVERNAY SOCIET
Original Assignee
EUROP DE RECH MAUVERNAY SOCIET
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EUROP DE RECH MAUVERNAY SOCIET filed Critical EUROP DE RECH MAUVERNAY SOCIET
Publication of ES412203A1 publication Critical patent/ES412203A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ES412203A 1972-03-06 1973-03-01 Procedimiento para la preparacion de nuevos compuestos qui-micos de accion cardiovascular. Expired ES412203A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7207647A FR2174655B1 (https=) 1972-03-06 1972-03-06

Publications (1)

Publication Number Publication Date
ES412203A1 true ES412203A1 (es) 1975-12-01

Family

ID=9094658

Family Applications (1)

Application Number Title Priority Date Filing Date
ES412203A Expired ES412203A1 (es) 1972-03-06 1973-03-01 Procedimiento para la preparacion de nuevos compuestos qui-micos de accion cardiovascular.

Country Status (12)

Country Link
US (2) US3962238A (https=)
JP (1) JPS4899127A (https=)
BE (1) BE795735A (https=)
CA (2) CA1015360A (https=)
CH (1) CH556815A (https=)
DE (1) DE2310918C3 (https=)
ES (1) ES412203A1 (https=)
FR (1) FR2174655B1 (https=)
GB (1) GB1377327A (https=)
IL (1) IL41619A (https=)
NL (1) NL153190C (https=)
ZA (1) ZA731411B (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2378024A1 (fr) * 1977-01-25 1978-08-18 Cerm Cent Europ Rech Mauvernay Nouvelle propylamine substituee, obtention et application
FR2472567A1 (fr) 1979-12-28 1981-07-03 Cerm Cent Europ Rech Mauvernay Ethers de 1- (2-propynyloxy)-2-amino-3-propanol, leur preparation et leur application en therapeutique
AU559555B2 (en) * 1981-12-28 1987-03-12 Carter-Wallace, Inc. Chemical process
US4405581A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for the selective removal of hydrogen sulfide from gaseous mixtures with severely sterically hindered secondary amino compounds
US4405582A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for selective removal of H2 S from mixtures containing H22 using diaminoether solutions
US4405580A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for selective removal of H2 S from mixtures containing H22 with tertiary amino azabicyclic alcohols
US4483833A (en) * 1982-01-18 1984-11-20 Exxon Research & Engineering Co. Process for selective removal of H2 S from mixtures containing H22 with heterocyclic tertiary aminoalkanols
US4405811A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Severely sterically hindered tertiary amino compounds
US4471138A (en) * 1982-01-18 1984-09-11 Exxon Research And Engineering Co. Severely sterically hindered secondary aminoether alcohols
US4405583A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for selective removal of H2 S from mixtures containing H22 using di-severely sterically hindered secondary aminoethers
US4405585A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for the selective removal of hydrogen sulfide from gaseous mixtures with severely sterically hindered secondary aminoether alcohols
US4417075A (en) * 1982-01-18 1983-11-22 Exxon Research And Engineering Co. Di-(Secondary and tertiaryalkylaminoalkoxy)alkanes
US4508692A (en) * 1982-01-18 1985-04-02 Exxon Research & Engineering Co. Process for the selective removal of hydrogen sulfide from gaseous mixtures with strongly basic tertiary amino compounds
US4762934A (en) * 1982-01-18 1988-08-09 Exxon Research And Engineering Company Diaminoether compositions
DK156396C (da) * 1983-09-27 1990-01-08 Cerm Cent Europ Rech Mauvernay 2-(n-pyrrolidino)-3-isobutoxy-n-substituerede phenyl-n-benzyl-propylamin-forbindelser og farmaceutiske midler indeholdende disse
AU568704B2 (en) * 1983-11-11 1988-01-07 Akzo N.V. Ether of n-propanolamine derivative
GB8330197D0 (en) * 1983-11-11 1983-12-21 Akzo Nv Ether of n-propanolamine derivative
US4758563A (en) * 1986-02-12 1988-07-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyamines, cardiovascular compositions and use
US4727072A (en) * 1986-02-12 1988-02-23 Mcneilab, Inc. 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents
DE3726632A1 (de) * 1987-08-11 1989-05-18 Boehringer Mannheim Gmbh 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE3726633A1 (de) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US4888335A (en) 1988-07-25 1989-12-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents
US5185362A (en) * 1988-09-14 1993-02-09 Mcneilab, Inc. Diphenylamine cardiovascular agents, compositions and use
CA2495962A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
KR20110117731A (ko) * 2003-05-30 2011-10-27 랜박시 래보러터리스 리미티드 치환된 피롤 유도체와 ｈｍｇ―ｃｏ 억제제로서의 이의 용도
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
MX2007000979A (es) * 2004-07-26 2007-07-11 Cotherix Inc Tratamiento de la hipertension pulmonar por iloprost inhalado con una formulacion microparticulada.
WO2006056845A1 (en) * 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP1951253A2 (en) 2005-10-26 2008-08-06 Cotherix, Inc. Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
CA2627599A1 (en) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2008020314A2 (en) * 2006-03-14 2008-02-21 Ranbaxy Laboratories Limited Statin stabilizing dosage formulations
US20080153896A1 (en) * 2006-07-14 2008-06-26 Gyan Chand Yadav Polymorphic Forms of an HMG-CoA Reductase Inhibitor and Uses Thereof
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8748648B2 (en) 2007-09-06 2014-06-10 Nektar Therapeutics Oligomer-calcium channel blocker conjugates
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2016098128A1 (en) 2014-12-16 2016-06-23 Council Of Scientific & Industrial Research Process for the preparation of bepridil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH268689A (de) * 1947-07-01 1950-05-31 Spojene Farmaceuticke Z Narodn Verfahren zur Darstellung eines biologisch wirksamen Phenyläthylendiaminderivates.
US2600301A (en) * 1948-06-04 1952-06-10 Smith Kline French Lab N-substituted-beta halo-ethyl amines
BE546290A (https=) * 1955-04-09
GB1219609A (en) * 1968-07-19 1971-01-20 Koninklijke Pharma Fab Nv Diphenylmethoxyethylamino derivatives

Also Published As

Publication number Publication date
FR2174655B1 (https=) 1975-08-01
NL7303117A (https=) 1973-09-10
CA1015360A (fr) 1977-08-09
GB1377327A (en) 1974-12-11
ZA731411B (en) 1974-04-24
DE2310918B2 (de) 1979-10-25
CH556815A (fr) 1974-12-13
DE2310918A1 (de) 1973-09-20
USRE30577E (en) 1981-04-14
IL41619A0 (en) 1973-04-30
NL153190C (nl) 1980-12-15
US3962238A (en) 1976-06-08
JPS4899127A (https=) 1973-12-15
IL41619A (en) 1976-05-31
NL153190B (nl) 1977-05-16
FR2174655A1 (https=) 1973-10-19
CA1048027A (fr) 1979-02-06
BE795735A (fr) 1973-06-18
DE2310918C3 (de) 1980-07-03

Similar Documents

Publication Publication Date Title
ES412203A1 (es) Procedimiento para la preparacion de nuevos compuestos qui-micos de accion cardiovascular.
DK213087A (da) 1,4-disubstituerede piperazinderivater og farmaceutisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelse
IL47529A (en) Substituted (1-(-4,4-bisphenylbutyl)-4-piperidyl-)1,3-dihydro-2h-benzimidazol-2-one derivatives and certain intermediates for obtaining such compounds,their preparation and pharmaceutical compositions containing them
ES413639A1 (es) Un procedimiento para la preparacion de un compuesto deri- vado de dopamina.
DK204686A (da) Quinolylglycinamidderivater og fremgangsmaade til fremstilling deraf
ES391633A1 (es) Un procedimiento para la preparacion de una 2,2-diaril-4- piperidinobutiramida.
FR2437405A1 (fr) Nouveaux alcoylbenzenes substitues basiques utiles comme medicaments
ES8702399A1 (es) Un procedimiento para preparar derivdos de 1,5-benzoxatiepina
SE8903312D0 (sv) New 2-carbonyl substituted n,n'-di-(trimethoxybenzol)piperazines, process for preparing the same and therapeutical compounds containing them
Parham et al. The Reaction of Myleran with L-Cysteine Ethyl Ester1, 2
FUJII et al. Purines. XVI. One-Step Alkylation of Adenine 1-Oxide Leading to 1-Alkoxy-9-alkyladenine Hydriodide
ES8602786A1 (es) Derivados de pirimidoisoquinolina
US3502724A (en) P-chloro-n-(chloropropyl)-alpha-methyl-phenethylamines and the salts thereof
RU2002113655A (ru) Ароматические дикетопроизводные, способы получения и применение данных соединений в качестве фармацевтических средств
ES426949A1 (es) Procedimiento para la preparacion de nuevas 1,4-benzodia- zepinas.
FR2449688A1 (fr) Nouveaux derives de la pyrido(3,4-e)-as-triazine, procede de preparation de ces derives et medicaments les contenant
ES420221A1 (es) Un procedimiento para la preparacion de compuestos deriva- dos de estibazol.
GB970965A (en) Ajmaline derivatives
ES419284A1 (es) Procedimiento para la obtencion de derivados de benzoileti-lendiaminas sustituidas.
PT71895A (en) Process for the preparation of nb-quaternary 10-bromosanduicine and 10-bromoisosanduicine derivatives
KR840003812A (ko) 치료 작용을 갖는 d-2-(6-메톡시-2-나프틸)-프로 피온산 유도체의 제조방법 및 이들을 함유하는 약리학적 조성물
ES379120A1 (es) Procedimiento para la preparacion de nuevos derivados de imidazolidinona.
GB886965A (en) Substituted isonicotinic acid amides and process for their manufacture
ES391964A1 (es) Un procedimiento para la preparacion de guayacolsulfonato de ampicilina.
ES454153A2 (es) Procedimiento para la obtencion de derivados de triazol.