ES406725A1 - A procedure for preparing a substitute 2,4-diamino-5-bencilpirimidine. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for preparing a substitute 2,4-diamino-5-bencilpirimidine. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES406725A1
ES406725A1 ES406725A ES406725A ES406725A1 ES 406725 A1 ES406725 A1 ES 406725A1 ES 406725 A ES406725 A ES 406725A ES 406725 A ES406725 A ES 406725A ES 406725 A1 ES406725 A1 ES 406725A1
Authority
ES
Spain
Prior art keywords
diamino
translation
preparing
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES406725A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES406725A1 publication Critical patent/ES406725A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A process for preparing a substituted 2,4-diamino-5-benzylpyrimidine, comprising reacting with guanidine a nitrile β -amine-α-benzylacrylic of formula (XI) **(See formula)** wherein R1 is one or more alkoxy groups, preferably containing from 1 to 4 carbon atoms (eg, methoxy, ethoxy, n-propoxy, t-butoxy), R2 is an optional substituent, such as a halogen atom, especially chlorine, bromine or iodine, an alcohol group, preferably containing from 1 to 4 carbon atoms (eg methyl, ethyl, propyl or butyl), an amide group or an amine group, and Z is an amino, alkoxy or thioalcohilo. (Machine-translation by Google Translate, not legally binding)
ES406725A 1969-05-16 1972-09-15 A procedure for preparing a substitute 2,4-diamino-5-bencilpirimidine. (Machine-translation by Google Translate, not legally binding) Expired ES406725A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2517169 1969-05-16

Publications (1)

Publication Number Publication Date
ES406725A1 true ES406725A1 (en) 1975-10-01

Family

ID=10223379

Family Applications (3)

Application Number Title Priority Date Filing Date
ES379700A Expired ES379700A1 (en) 1969-05-16 1970-05-14 A procedure for preparing beta-amino-alpha-bencilacrilic nitril derivatives. (Machine-translation by Google Translate, not legally binding)
ES406726A Expired ES406726A1 (en) 1969-05-16 1972-09-15 A procedure for preparing substituted benzoic acid dimetilsulfoxidos and dimetilsulfonas. (Machine-translation by Google Translate, not legally binding)
ES406725A Expired ES406725A1 (en) 1969-05-16 1972-09-15 A procedure for preparing a substitute 2,4-diamino-5-bencilpirimidine. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES379700A Expired ES379700A1 (en) 1969-05-16 1970-05-14 A procedure for preparing beta-amino-alpha-bencilacrilic nitril derivatives. (Machine-translation by Google Translate, not legally binding)
ES406726A Expired ES406726A1 (en) 1969-05-16 1972-09-15 A procedure for preparing substituted benzoic acid dimetilsulfoxidos and dimetilsulfonas. (Machine-translation by Google Translate, not legally binding)

Country Status (14)

Country Link
JP (1) JPS505184B1 (en)
AT (1) AT308082B (en)
BR (1) BR6915082D0 (en)
CA (1) CA994812A (en)
CH (1) CH544071A (en)
DE (1) DE2023977C2 (en)
ES (3) ES379700A1 (en)
FI (1) FI56375C (en)
FR (1) FR2070070A1 (en)
IL (1) IL34433A (en)
IT (1) IT1021507B (en)
NL (2) NL173395C (en)
PL (1) PL92440B1 (en)
SE (2) SE400777B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1469521A (en) * 1973-01-05 1977-04-06 Wellcome Found Antimicrobial preparations
US4687861A (en) * 1984-11-28 1987-08-18 Ciba-Geigy Corporation Microbicidal compositions
WO2005095359A1 (en) * 2004-03-05 2005-10-13 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049544A (en) * 1962-08-14 Method for the preparation of
DE1103931B (en) 1957-02-21 1961-04-06 Wellcome Found Process for the preparation of 2,4-diamino-5-benzylpyrimidine derivatives
DE1303727B (en) 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-arylidene-substituted propioni-iriles
NL122146C (en) * 1960-09-02
DE1620729A1 (en) 1965-07-08 1970-08-20 Wellcome Found Process for the preparation of substituted benzylpyrimidines
GB1261455A (en) 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles

Also Published As

Publication number Publication date
ES406726A1 (en) 1975-10-01
NL7007108A (en) 1970-11-18
SE398878B (en) 1978-01-23
FI56375B (en) 1979-09-28
BR6915082D0 (en) 1973-03-08
FR2070070B1 (en) 1974-10-11
NL173395B (en) 1983-08-16
IT1021507B (en) 1978-02-20
IL34433A (en) 1971-10-20
DE2023977A1 (en) 1971-02-18
FI56375C (en) 1980-01-10
PL92440B1 (en) 1977-04-30
AT308082B (en) 1973-06-25
CA994812A (en) 1976-08-10
DE2023977C2 (en) 1984-03-15
IL34433A0 (en) 1970-07-19
NL173395C (en) 1984-01-16
SE400777B (en) 1978-04-10
CH544071A (en) 1973-11-15
ES379700A1 (en) 1973-01-16
NL8004796A (en) 1980-11-28
JPS505184B1 (en) 1975-02-28
FR2070070A1 (en) 1971-09-10

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