ES412380A1 - Salicylanilide derivatives - Google Patents

Salicylanilide derivatives

Info

Publication number
ES412380A1
ES412380A1 ES412380A ES412380A ES412380A1 ES 412380 A1 ES412380 A1 ES 412380A1 ES 412380 A ES412380 A ES 412380A ES 412380 A ES412380 A ES 412380A ES 412380 A1 ES412380 A1 ES 412380A1
Authority
ES
Spain
Prior art keywords
halogen
hydrogen
formula
phenyl
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES412380A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES412380A1 publication Critical patent/ES412380A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A procedure for the preparation of salicylanilides of the formula: **(See formula)** where R is hydrogen or halogen; R1 is halogen or nitro; R2 is halogen, phenyl, or lower alkyl; R3 is hydrogen or halogen; R4 is hydrogen or halogen; R5 is hydrogen, halogen, or lower alkyl; Y is CO, CH2 and CH (CH3) and Ar is phenyl or mono-, di- or tri-substituted phenyl in which each substituent of said substituted phenyls is halogen, lower alkyl, trifluoromethyl or nitro, with the proviso that: (i) when R1 is nitro, then R is hydrogen and R2 is halogen; (ii) when Ar is phenyl, then Y is CH (CH3) and (iii) when R is halogen, R1 and R2 are halogen, whose procedure is characterized by condensing a compound of formula: **(See formula)** with a compound of formula: **(See formula)** in an organic solvent inert to the reaction, said compound (III) being in basic form or in the form of an appropriate acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES412380A 1972-03-07 1973-03-06 Salicylanilide derivatives Expired ES412380A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23237472A 1972-03-07 1972-03-07
US32817073A 1973-01-31 1973-01-31

Publications (1)

Publication Number Publication Date
ES412380A1 true ES412380A1 (en) 1976-05-01

Family

ID=26925928

Family Applications (1)

Application Number Title Priority Date Filing Date
ES412380A Expired ES412380A1 (en) 1972-03-07 1973-03-06 Salicylanilide derivatives

Country Status (10)

Country Link
JP (1) JPS4899153A (en)
ES (1) ES412380A1 (en)
GB (1) GB1421589A (en)
HU (1) HU166581B (en)
IL (1) IL41714A0 (en)
IT (1) IT984259B (en)
LU (1) LU67158A1 (en)
NL (1) NL7303067A (en)
OA (1) OA04342A (en)
PH (1) PH9618A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57159261A (en) * 1981-03-26 1982-10-01 Yoshiaki Kawada Connnecting method for stainless steel pipes
EP0104677B1 (en) * 1982-09-17 1986-11-12 Janssen Pharmaceutica N.V. Chemical sterilisation of insects with salicyl anilides
MX2017003251A (en) 2014-09-12 2017-12-20 Antibiotx Aps Antibacterial use of halogenated salicylanilides.
GB201509326D0 (en) 2015-05-29 2015-07-15 Antibio Tx Aps Novel use
GB201604484D0 (en) 2016-03-16 2016-04-27 Antibiotx Aps And Københavns Uni University Of Copenhagen Topical antibacterial compositions
US11419834B2 (en) 2019-02-25 2022-08-23 Rhode Island Hospital Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide

Also Published As

Publication number Publication date
GB1421589A (en) 1976-01-21
OA04342A (en) 1980-01-31
JPS4899153A (en) 1973-12-15
IL41714A0 (en) 1973-05-31
NL7303067A (en) 1973-09-11
PH9618A (en) 1976-01-20
LU67158A1 (en) 1973-05-22
HU166581B (en) 1975-04-28
IT984259B (en) 1974-11-20

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