GB1305502A - - Google Patents

Info

Publication number
GB1305502A
GB1305502A GB1252771A GB1252771A GB1305502A GB 1305502 A GB1305502 A GB 1305502A GB 1252771 A GB1252771 A GB 1252771A GB 1252771 A GB1252771 A GB 1252771A GB 1305502 A GB1305502 A GB 1305502A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydrogen
formula
aldehyde
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1252771A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1305502A publication Critical patent/GB1305502A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems

Abstract

1305502 N-secondary alkyl alkane diamines and derivatives thereof PFIZER Inc 30 April 1971 [16 Dec 1970] 12527/71 Heading C2C [Also in Division A5] Novel compounds of the Formula II or III and acid addition salts thereof wherein Y is (CH 2 ) n , where n is 2 to 5; R 1 is C 4-13 alkyl; R 4 is hydrogen, C 1-20 alkyl, C 3-7 cycloalkyl or phenyl optionally substituted by halogen, C 1-4 alkyl or alkoxy, cyano or trifluoromethyl; R 5 is R 4 or thienyl, furyl or pyridyl; or R 4 and R 5 together with the carbon atom to which they are attached are C 3-7 cycloalkyl may be prepared (a) in the case of II by reacting a compound of the Formula I wherein one of R 2 and R 3 is CH 2 CH 2 OH and the other is hydrogen with an aldehyde or ketone R 4 R 5 C = O; (b) in the case III reacting a compound of the Formula I wherein R 2 is hydrogen and R 3 is C 1-20 alkyl with an aldehyde or ketone R 4 R 5 C = O.
GB1252771A 1970-12-16 1971-04-30 Expired GB1305502A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9886070A 1970-12-16 1970-12-16

Publications (1)

Publication Number Publication Date
GB1305502A true GB1305502A (en) 1973-02-07

Family

ID=22271290

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1252771A Expired GB1305502A (en) 1970-12-16 1971-04-30

Country Status (2)

Country Link
US (1) US3729564A (en)
GB (1) GB1305502A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033748A (en) 1976-07-02 1977-07-05 Merck & Co., Inc. Dibicyclo[3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines having a piperidine moiety
US4100193A (en) * 1976-06-10 1978-07-11 Merck & Co., Inc. Novel dibicyclo [2.2.2] octyl and dibicyclo [2.2.2] octenyl polyamines and methods for their preparation
GB2153831A (en) * 1984-01-14 1985-08-29 Claude Hepburn The use of cationic surfactants as crosslinking agents
WO1994025426A1 (en) * 1993-04-28 1994-11-10 Alcon Laboratories, Inc. Diamines as antimicrobial agents and use thereof in ophthalmic composition

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049417A (en) * 1975-04-28 1977-09-20 Merck & Co., Inc. Alicyclic alkylene polyamine microorganism and algae growth inhibitors
DK1692092T3 (en) * 2003-12-09 2009-06-22 Alcon Inc Use of bis-amines to enhance the antimicrobial activity of aqueous compositions
DK3988537T1 (en) 2011-12-07 2022-05-23 Alnylam Pharmaceuticals Inc BIODEGRADABLE LIPIDES FOR DELIVERY OF ACTIVE AGENTS
LT3766916T (en) 2014-06-25 2023-01-10 Acuitas Therapeutics Inc. Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
EP3313829B1 (en) 2015-06-29 2024-04-10 Acuitas Therapeutics Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
LT3368507T (en) 2015-10-28 2023-03-10 Acuitas Therapeutics Inc. Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
WO2018191657A1 (en) 2017-04-13 2018-10-18 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
CN116693411A (en) 2017-04-28 2023-09-05 爱康泰生治疗公司 Novel carbonyl lipid and lipid nanoparticle formulations for delivery of nucleic acids
WO2019036008A1 (en) 2017-08-16 2019-02-21 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
WO2019036028A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
US11524932B2 (en) 2017-08-17 2022-12-13 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
EP3728181A4 (en) * 2017-12-20 2021-07-14 Rhodia Operations New cationic quaternary ammonium compounds and compositions comprising same and processes for their manufacture
SG11202106987WA (en) 2019-01-11 2021-07-29 Acuitas Therapeutics Inc Lipids for lipid nanoparticle delivery of active agents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4100193A (en) * 1976-06-10 1978-07-11 Merck & Co., Inc. Novel dibicyclo [2.2.2] octyl and dibicyclo [2.2.2] octenyl polyamines and methods for their preparation
US4033748A (en) 1976-07-02 1977-07-05 Merck & Co., Inc. Dibicyclo[3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines having a piperidine moiety
GB2153831A (en) * 1984-01-14 1985-08-29 Claude Hepburn The use of cationic surfactants as crosslinking agents
WO1994025426A1 (en) * 1993-04-28 1994-11-10 Alcon Laboratories, Inc. Diamines as antimicrobial agents and use thereof in ophthalmic composition
US5900213A (en) * 1993-04-28 1999-05-04 Alcon Laboratories, Inc. Use of diamines to disinfect and clean contact lenses and preserve ophthalmic compositions

Also Published As

Publication number Publication date
US3729564A (en) 1973-04-24

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee