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Sanofi Aventis France
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Roussel Uclaf SA
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Publication of ES219958A1publicationCriticalpatent/ES219958A1/en
C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
C07H15/20—Carbocyclic rings
C07H15/24—Condensed ring systems having three or more rings
C07H15/248—Colchicine radicals, e.g. colchicosides
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Chemical & Material Sciences
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Organic Chemistry
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Life Sciences & Earth Sciences
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Engineering & Computer Science
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Biochemistry
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General Health & Medical Sciences
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Molecular Biology
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Organic Low-Molecular-Weight Compounds And Preparation Thereof
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Low-Molecular Organic Synthesis Reactions Using Catalysts
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Abstract
A process for preparing thiocolchicein alkyl alcohol characterized in that the methyl mercaptan is reacted at room temperature or at a higher temperature (preferably between 20 and 50º c) on a tropolinic compound of the general formula ** (see formula) ** ( where r have the same meaning as in claim i and where the amino group can be acetylated or alkylated) in the presence of a third solvent without solvent and in the presence of a catalyst during the time necessary to replace the methoxy function of the tropolonic cycle by an sch <sub > 3 the mercaptan and eventually the solvent are separated and the thioderivative is purified by fractional crystallization or chromatography. (Machine-translation by Google Translate, not legally binding)
ES0219958A1954-02-101955-02-05A procedure for preparation of alcohiltiocolchiceinas (Machine-translation by Google Translate, not legally binding)
ExpiredES219958A1
(en)
A procedure for the preparation of 1,2-diaril-3,5-dioxo-pirazolidines, replaced in position 4 (Machine-translation by Google Translate, not legally binding)
A procedure for the preparation of acil-anylides with basic substitutors and their derivatives (Machine-translation by Google Translate, not legally binding)