ES402638A1 - Halogen-substituted phenyl-alkylamines and their derivatives - Google Patents

Halogen-substituted phenyl-alkylamines and their derivatives

Info

Publication number
ES402638A1
ES402638A1 ES402638A ES402638A ES402638A1 ES 402638 A1 ES402638 A1 ES 402638A1 ES 402638 A ES402638 A ES 402638A ES 402638 A ES402638 A ES 402638A ES 402638 A1 ES402638 A1 ES 402638A1
Authority
ES
Spain
Prior art keywords
group
radicals
transformed
indicated above
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES402638A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES402638A1 publication Critical patent/ES402638A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/32—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by introduction of halogenated alkyl groups into ring compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
    • C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C07C45/565—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom by reaction with hexamethylene-tetramine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Procedure for the preparation of phenylaminoalkanes of the general formula I **(See formula)** where Cl signifies a 4 or 6 position chlorine atom, R1, R2 and R3 signify hydrogen a methyl group, R4 signifies hydrogen, a lower alcohol radical, a benzyl or theophylline (7) -ethyl group, or one of the radicals -CnH2n-R5 (where n is 1 or 2 and R5 is a carboxyl group, an alkoxycarbonyl group, an aminocarbonyl group or a nitrile group), CmH2m-1 (C6-H5) -R6 (where n is 2, 3 or 4, and R6 means halogen, a hydroxyl group, an amino group or an acylamino group), -CnH2n-CO-R (where n is 1 or 2; R is a lower alcohol group or a phenyl group) or - CO-R7 (where R7 means a lower alkoxy, lower alcoholylthio group or a benzyloxy group or an alcohol radical, which may be substituted by a halogen atom, a hydroxyl group or an amino group), as well as its optically active forms and/or salts with physiologically compatible acid anion, characterized in that it is transformed by hydrolysis or hydrogenolysis in the corresponding Amin is a compound of the general formula VIII **(See formula)** where Cl, R1, R2 and R3 correspond to the meanings indicated above and A means the phthalimido or succinimido group, the isocyanic acid radical or the group (see formula) (where R'corresponds to the meanings indicated above and Sch represents easily separable radicals by hydrolysis -such as the acyl group, especially- or by hydrogenolysis, -such as the benzyl group-; and why, in case necessary, in the obtained primary amines (formula I, R4 = H) the other radicals indicated above for R4 apart from hydrogen are introduced, by alcoholization or by acylation, and/or these R4 radicals are transformed one into another, if they contain groups functional, the racemates possibly present in the optically active forms are split, and/or the bases prepared according to the invention are transformed into physiologically harmless acid addition salts. (Machine-translation by Google Translate, not legally binding)
ES402638A 1970-05-02 1972-05-12 Halogen-substituted phenyl-alkylamines and their derivatives Expired ES402638A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2021620A DE2021620C3 (en) 1970-05-02 1970-05-02 New phenylaminoalkanes and processes for their preparation

Publications (1)

Publication Number Publication Date
ES402638A1 true ES402638A1 (en) 1975-11-01

Family

ID=5770113

Family Applications (4)

Application Number Title Priority Date Filing Date
ES390778A Expired ES390778A1 (en) 1970-05-02 1971-04-30 Halogen-substituted phenyl-alkylamines and their derivatives
ES402638A Expired ES402638A1 (en) 1970-05-02 1972-05-12 Halogen-substituted phenyl-alkylamines and their derivatives
ES402636A Expired ES402636A1 (en) 1970-05-02 1972-05-12 Halogen-substituted phenyl-alkylamines and their derivatives
ES402637A Expired ES402637A1 (en) 1970-05-02 1972-05-12 Halogen-substituted phenyl-alkylamines and their derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES390778A Expired ES390778A1 (en) 1970-05-02 1971-04-30 Halogen-substituted phenyl-alkylamines and their derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES402636A Expired ES402636A1 (en) 1970-05-02 1972-05-12 Halogen-substituted phenyl-alkylamines and their derivatives
ES402637A Expired ES402637A1 (en) 1970-05-02 1972-05-12 Halogen-substituted phenyl-alkylamines and their derivatives

Country Status (22)

Country Link
JP (4) JPS5750773B1 (en)
AT (6) AT317176B (en)
BE (1) BE766654A (en)
BG (5) BG21017A3 (en)
CH (4) CH579022A5 (en)
CS (3) CS194665B2 (en)
DE (1) DE2021620C3 (en)
ES (4) ES390778A1 (en)
FI (1) FI53571C (en)
FR (1) FR2092123B1 (en)
GB (1) GB1354451A (en)
HU (1) HU162545B (en)
IE (1) IE35608B1 (en)
IL (1) IL36743A (en)
NL (1) NL169462C (en)
NO (1) NO133708C (en)
PL (3) PL85189B1 (en)
RO (5) RO57814A (en)
SE (1) SE374355B (en)
SU (2) SU440824A3 (en)
YU (6) YU35571B (en)
ZA (1) ZA712788B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2239012A1 (en) * 1972-08-08 1974-02-21 Knoll Ag BASIC SUBSTITUTED THEOPHYLLINE COMPOUNDS
JPS6016016U (en) * 1983-07-12 1985-02-02 本田技研工業株式会社 Positioning clip
EP0146067A3 (en) * 1983-12-06 1987-03-04 Merrell Dow Pharmaceuticals Inc. Novel substrates for d-amino acid oxidase
JPS6314015U (en) * 1986-07-11 1988-01-29
JPS63136497A (en) * 1986-11-28 1988-06-08 Hitachi Medical Corp X-ray device
JPH0378128U (en) * 1989-11-30 1991-08-07

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2029385A1 (en) * 1969-01-27 1970-10-23 Science Union & Cie

Also Published As

Publication number Publication date
NL7105946A (en) 1971-11-04
BG21016A3 (en) 1976-01-20
YU35571B (en) 1981-04-30
JPS5655351A (en) 1981-05-15
SE374355B (en) 1975-03-03
NL169462B (en) 1982-02-16
PL90714B1 (en) 1977-01-31
BG19589A3 (en) 1975-06-25
SU440825A3 (en) 1974-08-25
CH570968A5 (en) 1975-12-31
YU36285B (en) 1982-06-18
JPS5655352A (en) 1981-05-15
AT317174B (en) 1974-08-12
SU440824A3 (en) 1974-08-25
RO57821A (en) 1975-06-15
AT317172B (en) 1974-08-12
JPS5750773B1 (en) 1982-10-28
YU108071A (en) 1980-10-31
ES402637A1 (en) 1975-12-16
IL36743A (en) 1974-12-31
ZA712788B (en) 1973-01-31
SU398031A3 (en) 1973-09-17
AT317175B (en) 1974-08-12
CH561169A5 (en) 1975-04-30
RO62418A (en) 1978-03-15
CS194665B2 (en) 1979-12-31
DE2021620A1 (en) 1971-11-18
YU36482B (en) 1984-02-29
BG18601A3 (en) 1975-02-25
JPS589090B2 (en) 1983-02-18
IE35608B1 (en) 1976-03-31
JPS5725535B2 (en) 1982-05-29
NO133708C (en) 1976-06-16
YU159080A (en) 1983-04-27
ES402636A1 (en) 1976-01-01
FR2092123A1 (en) 1972-01-21
ES390778A1 (en) 1973-06-01
SU439963A3 (en) 1974-08-15
AT317171B (en) 1974-08-12
BE766654A (en) 1971-11-03
AT317176B (en) 1974-08-12
IE35608L (en) 1971-11-02
YU249878A (en) 1981-08-31
YU36286B (en) 1982-06-18
NL169462C (en) 1982-07-16
FI53571B (en) 1978-02-28
PL85189B1 (en) 1976-04-30
RO62296A (en) 1978-01-15
IL36743A0 (en) 1971-06-23
JPS5751822B2 (en) 1982-11-04
BG21017A3 (en) 1976-01-20
YU249978A (en) 1981-08-31
CS170545B2 (en) 1976-08-27
YU250078A (en) 1982-02-25
DE2021620B2 (en) 1979-06-13
HU162545B (en) 1973-03-28
NO133708B (en) 1976-03-08
JPS5655350A (en) 1981-05-15
AT317173B (en) 1974-08-12
RO57681A (en) 1975-02-15
PL91964B1 (en) 1977-03-31
YU43381A (en) 1982-06-30
BG19131A3 (en) 1975-04-30
FI53571C (en) 1978-06-12
CH579022A5 (en) 1976-08-31
FR2092123B1 (en) 1974-08-30
CH579023A5 (en) 1976-08-31
CS175428B2 (en) 1977-05-31
GB1354451A (en) 1974-06-05
YU37114B (en) 1984-08-31
RO57814A (en) 1975-06-15
DE2021620C3 (en) 1980-02-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19850206