IE35608L - Phenylalkylamines - Google Patents

Phenylalkylamines

Info

Publication number
IE35608L
IE35608L IE710545A IE54571A IE35608L IE 35608 L IE35608 L IE 35608L IE 710545 A IE710545 A IE 710545A IE 54571 A IE54571 A IE 54571A IE 35608 L IE35608 L IE 35608L
Authority
IE
Ireland
Prior art keywords
group
carbon atoms
hydroxyl
atom
alkyl group
Prior art date
Application number
IE710545A
Other versions
IE35608B1 (en
Inventor
K Schromm
Eo Renth
A Mentrup
R Reichl
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of IE35608L publication Critical patent/IE35608L/en
Publication of IE35608B1 publication Critical patent/IE35608B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/32—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by introduction of halogenated alkyl groups into ring compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
    • C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C07C45/565—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom by reaction with hexamethylene-tetramine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Abstract

1354451 Anorexigenic compositions BOEHRINGER INGELHEIM GmbH 30 April 1971 [2 May 1970] 12443/71 Heading A5B [Also in Division C2] Pharmaceutical compositions having good anorexigenic activity with only a slight central stimulating activity and low toxicity comprise halogen-substituted phenylalkylamine and their derivatives of the formula (I): wherein Cl represents a chlorine atom in the 4- or 6-position; R 1 , R 2 and R 3 , which may be the same or different, each represents a hydrogen atom or a methyl group; and R 4 represents a hydrogen atom, an alkyl group with 1 to 4 carbon atoms, or a benzyl or theophylline - (7) - ethyl group, the group -CH 2 -CH 2 -R 5 (wherein R 5 represents a carboxyl, alkoxycarbonyl, aminocarbonyl or cyano group), the group -CH 2 -CN, the group -(CH 2 ) m -R 6 or -C m H 2m-1 (C 6 H 5 )-R 6 (wherein m is 2, 3 or 4 and R 6 represents a halogen atom or a hydroxyl, amino or acylamino group), the group -C n H 2n -CO-R (wherein n is 1 or 2 and R represents an alkyl group with I to 4 carbon atoms or a phenyl group), or the group -CO-R 7 (wherein R 7 represents an alkoxy group with 1 to 4 carbon atoms, or an alkylthio or benzyloxy group or an alkyl group which may if desired be substituted by a halogen atom or a hydroxyl or amino group) and acid addition salts thereof in association with a pharmaceutical carrier or excipient, and if desired with other physiologically active ingredients, such as laxatives, in a form suitable for oral or rectal administration. [GB1354451A]
IE545/71A 1970-05-02 1971-04-30 Halogen-substituted phenylalkylamines and their derivatives IE35608B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2021620A DE2021620C3 (en) 1970-05-02 1970-05-02 New phenylaminoalkanes and processes for their preparation

Publications (2)

Publication Number Publication Date
IE35608L true IE35608L (en) 1971-11-02
IE35608B1 IE35608B1 (en) 1976-03-31

Family

ID=5770113

Family Applications (1)

Application Number Title Priority Date Filing Date
IE545/71A IE35608B1 (en) 1970-05-02 1971-04-30 Halogen-substituted phenylalkylamines and their derivatives

Country Status (22)

Country Link
JP (4) JPS5750773B1 (en)
AT (6) AT317171B (en)
BE (1) BE766654A (en)
BG (5) BG18601A3 (en)
CH (4) CH561169A5 (en)
CS (3) CS175428B2 (en)
DE (1) DE2021620C3 (en)
ES (4) ES390778A1 (en)
FI (1) FI53571C (en)
FR (1) FR2092123B1 (en)
GB (1) GB1354451A (en)
HU (1) HU162545B (en)
IE (1) IE35608B1 (en)
IL (1) IL36743A (en)
NL (1) NL169462C (en)
NO (1) NO133708C (en)
PL (3) PL90714B1 (en)
RO (5) RO62418A (en)
SE (1) SE374355B (en)
SU (2) SU440824A3 (en)
YU (6) YU35571B (en)
ZA (1) ZA712788B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2239012A1 (en) * 1972-08-08 1974-02-21 Knoll Ag BASIC SUBSTITUTED THEOPHYLLINE COMPOUNDS
JPS6016016U (en) * 1983-07-12 1985-02-02 本田技研工業株式会社 Positioning clip
NZ210420A (en) * 1983-12-06 1988-04-29 Merrell Dow Pharma D-amino acid oxidase substrates and pharmaceutical compositions
JPS6314015U (en) * 1986-07-11 1988-01-29
JPS63136497A (en) * 1986-11-28 1988-06-08 Hitachi Medical Corp X-ray device
JPH0378128U (en) * 1989-11-30 1991-08-07

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2029385A1 (en) * 1969-01-27 1970-10-23 Science Union & Cie

Also Published As

Publication number Publication date
ES402636A1 (en) 1976-01-01
RO62418A (en) 1978-03-15
YU35571B (en) 1981-04-30
JPS5750773B1 (en) 1982-10-28
BE766654A (en) 1971-11-03
CH579023A5 (en) 1976-08-31
BG21016A3 (en) 1976-01-20
BG19131A3 (en) 1975-04-30
SU440825A3 (en) 1974-08-25
YU36286B (en) 1982-06-18
AT317176B (en) 1974-08-12
SU439963A3 (en) 1974-08-15
YU36285B (en) 1982-06-18
CH579022A5 (en) 1976-08-31
JPS5655350A (en) 1981-05-15
YU108071A (en) 1980-10-31
JPS5725535B2 (en) 1982-05-29
AT317174B (en) 1974-08-12
ES402637A1 (en) 1975-12-16
SE374355B (en) 1975-03-03
YU250078A (en) 1982-02-25
IE35608B1 (en) 1976-03-31
PL91964B1 (en) 1977-03-31
JPS589090B2 (en) 1983-02-18
FR2092123B1 (en) 1974-08-30
CS194665B2 (en) 1979-12-31
AT317172B (en) 1974-08-12
BG21017A3 (en) 1976-01-20
NL169462B (en) 1982-02-16
NO133708C (en) 1976-06-16
JPS5751822B2 (en) 1982-11-04
YU36482B (en) 1984-02-29
YU249978A (en) 1981-08-31
YU159080A (en) 1983-04-27
IL36743A (en) 1974-12-31
PL90714B1 (en) 1977-01-31
NL7105946A (en) 1971-11-04
FR2092123A1 (en) 1972-01-21
BG19589A3 (en) 1975-06-25
JPS5655352A (en) 1981-05-15
RO57821A (en) 1975-06-15
RO57681A (en) 1975-02-15
FI53571B (en) 1978-02-28
PL85189B1 (en) 1976-04-30
RO62296A (en) 1978-01-15
ES402638A1 (en) 1975-11-01
YU43381A (en) 1982-06-30
DE2021620A1 (en) 1971-11-18
AT317175B (en) 1974-08-12
CH561169A5 (en) 1975-04-30
YU37114B (en) 1984-08-31
SU440824A3 (en) 1974-08-25
AT317171B (en) 1974-08-12
NO133708B (en) 1976-03-08
ZA712788B (en) 1973-01-31
JPS5655351A (en) 1981-05-15
YU249878A (en) 1981-08-31
HU162545B (en) 1973-03-28
IL36743A0 (en) 1971-06-23
SU398031A3 (en) 1973-09-17
RO57814A (en) 1975-06-15
FI53571C (en) 1978-06-12
CS170545B2 (en) 1976-08-27
ES390778A1 (en) 1973-06-01
AT317173B (en) 1974-08-12
NL169462C (en) 1982-07-16
CS175428B2 (en) 1977-05-31
GB1354451A (en) 1974-06-05
CH570968A5 (en) 1975-12-31
BG18601A3 (en) 1975-02-25
DE2021620C3 (en) 1980-02-07
DE2021620B2 (en) 1979-06-13

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