ES395969A1 - Neuroleptic 1-aralkyl-4-phenyl-piperazines prodn - by reacting ethylenediamines with oxalic acid derivs,and reducing resulting dioxo - Google Patents

Neuroleptic 1-aralkyl-4-phenyl-piperazines prodn - by reacting ethylenediamines with oxalic acid derivs,and reducing resulting dioxo

Info

Publication number
ES395969A1
ES395969A1 ES395969A ES395969A ES395969A1 ES 395969 A1 ES395969 A1 ES 395969A1 ES 395969 A ES395969 A ES 395969A ES 395969 A ES395969 A ES 395969A ES 395969 A1 ES395969 A1 ES 395969A1
Authority
ES
Spain
Prior art keywords
piperazines
dioxo
aralkyl
phenyl
neuroleptic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES395969A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES395969A1 publication Critical patent/ES395969A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

Title 1-aralkyl-4-phenyl-piperazines of formula (I): (where Ar is an aromatic residue with 2 fused rings of which the one not linked to the rest of the molecule may be an iso- or heterocyclic satd. or aromatic ring, and R1 and R2 are H, halogen, amino, acylamino, CN, CF3 or 1-4C alkyl, alkoxy, alkylcarbonyl or alkylthio) are prepd. by reacting an ethylene-diamine deriv. of formula (II): with a cpd. X-CO-CO-X (where X is halogen or lower alkoxy) and reducing the resulting dioxo-piperazine cpd. (III): with metal hydrides (e.g. LiAlH4, sodium bis-(2-methoxyethoxy)-aluminium hydride or diborane). (I) thus obtained may be converted into a physiologically tolerable acid addn. salt. The process uses very readily available starting materials and proceeds smoothy and with good yields sterically hindered products are easily produced.
ES395969A 1970-10-15 1971-10-14 Neuroleptic 1-aralkyl-4-phenyl-piperazines prodn - by reacting ethylenediamines with oxalic acid derivs,and reducing resulting dioxo Expired ES395969A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19702050684 DE2050684A1 (en) 1970-10-15 1970-10-15 Neuroleptic 1-aralkyl-4-phenyl-piperazines prodn - by reacting ethylenediamines with oxalic acid derivs,and reducing resulting dioxo

Publications (1)

Publication Number Publication Date
ES395969A1 true ES395969A1 (en) 1973-12-16

Family

ID=5785239

Family Applications (1)

Application Number Title Priority Date Filing Date
ES395969A Expired ES395969A1 (en) 1970-10-15 1971-10-14 Neuroleptic 1-aralkyl-4-phenyl-piperazines prodn - by reacting ethylenediamines with oxalic acid derivs,and reducing resulting dioxo

Country Status (12)

Country Link
AT (1) AT313902B (en)
BG (1) BG18869A3 (en)
CA (1) CA967159A (en)
CH (1) CH562236A5 (en)
DE (1) DE2050684A1 (en)
DK (1) DK142580C (en)
ES (1) ES395969A1 (en)
FI (1) FI54922C (en)
HU (1) HU162740B (en)
PL (1) PL77016B1 (en)
SE (1) SE395144B (en)
YU (1) YU34695B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2604838A1 (en) * 1976-02-07 1977-08-11 Knoll Ag ALKYLENE DIOXYPIPERAZINE DERIVATIVES

Also Published As

Publication number Publication date
YU34695B (en) 1979-12-31
CH562236A5 (en) 1975-05-30
DK142580B (en) 1980-11-24
FI54922B (en) 1978-12-29
DE2050684A1 (en) 1972-04-20
SE395144B (en) 1977-08-01
PL77016B1 (en) 1975-02-28
BG18869A3 (en) 1975-03-20
FI54922C (en) 1979-04-10
YU263371A (en) 1979-07-10
HU162740B (en) 1973-04-28
DK142580C (en) 1981-07-13
AT313902B (en) 1974-03-11
CA967159A (en) 1975-05-06

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