GB852974A - Ethers and means for producing the same - Google Patents

Ethers and means for producing the same

Info

Publication number
GB852974A
GB852974A GB13164/59A GB1316459A GB852974A GB 852974 A GB852974 A GB 852974A GB 13164/59 A GB13164/59 A GB 13164/59A GB 1316459 A GB1316459 A GB 1316459A GB 852974 A GB852974 A GB 852974A
Authority
GB
United Kingdom
Prior art keywords
formula
acid
products
carbon atoms
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB13164/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of GB852974A publication Critical patent/GB852974A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

The invention comprises compounds of the general formula : <FORM:0852974/IV(b)/1> in which n is 2, 3 or 4, R is an aliphatic hydrocarbon group containing 2 or 3 carbon atoms and R1 and R2 are alkoxy groups each having up to 3 carbon atoms and either R1 or R2, but not both, may be hydrogen ; and acid addition salts thereof ; and the preparation thereof by N-acylating a 1-o-(substituted thio)-phenylpiperazine with an appropriately substituted phenyl-alkanoic acid or reactive derivative thereof and reducing the product with a complex metal hydride, or by reacting a compound of the formula : <FORM:0852974/IV(b)/2> with a compound of the formula : <FORM:0852974/IV(b)/3> where X is halide, hydrogen sulphate or sulphonate ; and, if desired, converting the products into their acid-addition salts. The products have central nervous system depressant and hypotensive properties.
GB13164/59A 1958-04-17 1959-04-17 Ethers and means for producing the same Expired GB852974A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US852974XA 1958-04-17 1958-04-17

Publications (1)

Publication Number Publication Date
GB852974A true GB852974A (en) 1960-11-02

Family

ID=22190676

Family Applications (1)

Application Number Title Priority Date Filing Date
GB13164/59A Expired GB852974A (en) 1958-04-17 1959-04-17 Ethers and means for producing the same

Country Status (1)

Country Link
GB (1) GB852974A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3173917A (en) * 1960-11-25 1965-03-16 American Cyanamid Co Method of preparing substituted phenylpiperazines
US8598348B2 (en) 2009-02-17 2013-12-03 H. Lundbeck A/S Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3173917A (en) * 1960-11-25 1965-03-16 American Cyanamid Co Method of preparing substituted phenylpiperazines
US8598348B2 (en) 2009-02-17 2013-12-03 H. Lundbeck A/S Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

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