ES334942A1 - Un procedimiento de preparacion de derivados nitrogenados. - Google Patents
Un procedimiento de preparacion de derivados nitrogenados.Info
- Publication number
- ES334942A1 ES334942A1 ES334942A ES334942A ES334942A1 ES 334942 A1 ES334942 A1 ES 334942A1 ES 334942 A ES334942 A ES 334942A ES 334942 A ES334942 A ES 334942A ES 334942 A1 ES334942 A1 ES 334942A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- propenyl
- halogen
- compounds
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 methylallyl Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000006017 1-propenyl group Chemical group 0.000 abstract 1
- 125000006020 2-methyl-1-propenyl group Chemical group 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 150000008064 anhydrides Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000003887 narcotic antagonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000006215 rectal suppository Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52170866A | 1966-01-19 | 1966-01-19 | |
| US677727A US3393197A (en) | 1966-01-19 | 1967-10-24 | Nu-substituted-14-hydroxydihydronormorphines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES334942A1 true ES334942A1 (es) | 1968-03-01 |
Family
ID=27060549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES334942A Expired ES334942A1 (es) | 1966-01-19 | 1966-12-26 | Un procedimiento de preparacion de derivados nitrogenados. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3393197A (en:Method) |
| AT (1) | AT292206B (en:Method) |
| CH (1) | CH493522A (en:Method) |
| DE (2) | DE1795707C3 (en:Method) |
| DK (1) | DK115631B (en:Method) |
| ES (1) | ES334942A1 (en:Method) |
| FR (1) | FR6112M (en:Method) |
| GB (1) | GB1119270A (en:Method) |
| IL (1) | IL26896A (en:Method) |
| LU (1) | LU52650A1 (en:Method) |
| NL (2) | NL165744C (en:Method) |
| NO (1) | NO120368B (en:Method) |
| SE (1) | SE329402B (en:Method) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3476757A (en) * | 1966-04-18 | 1969-11-04 | Syntex Corp | Tetrahydropyranyl and tetrahydrofuranyl ethers of benzomorphans and morphanans |
| US4161597A (en) * | 1976-12-20 | 1979-07-17 | Research Corporation | N-alkyl-14-hydroxymorphinans and derivatives |
| GB1593191A (en) * | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| GB1587831A (en) * | 1977-03-23 | 1981-04-08 | Reckitt & Colmann Prod Ltd | Morphine derivatives |
| US4218454A (en) * | 1977-07-08 | 1980-08-19 | Sri International | N-αMethylcyclopropylmethyl derivatives of normorphine and noroodeine, and analgesic compositions and methods employing the normorphine derivatives |
| US4269843A (en) * | 1978-05-24 | 1981-05-26 | Sri International | N-Sec-alkyl analogs of norcodeine and normorphine and analgesic compositions and methods employing the normorphine derivatives |
| US4272541A (en) * | 1978-06-02 | 1981-06-09 | Miles Laboratories, Inc. | 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them |
| US4236008A (en) * | 1978-09-19 | 1980-11-25 | E. I. Du Pont De Nemours And Company | Fluorination of precursors for fluorine analogs of hydrocodone and oxycodone |
| US4241065A (en) * | 1979-07-02 | 1980-12-23 | E. I. Du Pont De Nemours And Company | Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both |
| US4237140A (en) * | 1979-05-18 | 1980-12-02 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and acetaminophen |
| US4282215A (en) * | 1980-06-17 | 1981-08-04 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof |
| US4366159A (en) * | 1981-09-08 | 1982-12-28 | Michael Richard Magruder | Nalbuphine-narcotic analgesic composition and method of producing analgesia |
| US4404210A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and ibuprofen |
| US4404209A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and sulindac |
| US4404208A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| US4404211A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and flurbiprofen |
| US4407804A (en) * | 1982-06-30 | 1983-10-04 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and indomethacin |
| US4407805A (en) * | 1982-06-30 | 1983-10-04 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and zomepirac |
| AU565634B2 (en) * | 1982-06-30 | 1987-09-24 | E.I. Du Pont De Nemours And Company | Synergistic compositions of nalbuphine and non-narcotic analgesic compounds |
| US4402962A (en) * | 1982-06-30 | 1983-09-06 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole |
| US4477457A (en) * | 1982-10-28 | 1984-10-16 | E. I. Du Pont De Nemours And Company | Method for inducing anorexia using nalmetrene |
| US4478840A (en) * | 1983-10-11 | 1984-10-23 | E. I. Du Pont De Nemours And Company | Appetite suppressing compositions and methods |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| CA1280695C (en) * | 1985-04-29 | 1991-02-26 | Benigno M. Sulit, Jr. | Nalbuphine-local anesthetic analgesic composition and method of producing analgesia |
| DE4132159A1 (de) * | 1991-09-27 | 1993-04-01 | Boehringer Ingelheim Kg | 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| AU699114B2 (en) * | 1994-05-31 | 1998-11-19 | Mallinckrodt Chemical, Inc. | The preparation of nalbuphine having low levels of beta-epimer |
| US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
| US6361794B1 (en) | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US20030138508A1 (en) * | 2001-12-18 | 2003-07-24 | Novack Gary D. | Method for administering an analgesic |
| JP2005503425A (ja) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | 所定の吸入ルートによる薬剤エステルの送出 |
| US20030129234A1 (en) * | 2001-07-06 | 2003-07-10 | Penwest Pharmaceuticals Company | Methods of making sustained release formulations of oxymorphone |
| US8329216B2 (en) * | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
| AU2002318211B2 (en) | 2001-07-06 | 2007-07-12 | Endo Pharmaceuticals, Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
| JP2005523876A (ja) * | 2001-09-26 | 2005-08-11 | ペンウェスト ファーマシューティカルズ カンパニー | 乱用の可能性が低減したオピオイド製剤 |
| US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| JP2007516149A (ja) | 2003-05-21 | 2007-06-21 | アレックザ ファーマシューティカルズ， インコーポレイテッド | 基板温度の均一性を制御する方法、および、内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット |
| EP1628664A4 (en) | 2003-06-04 | 2008-11-05 | Alkermes Inc | POLYMORPHIC FORMS OF NALTREXONE |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| WO2006022714A1 (en) | 2004-08-12 | 2006-03-02 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| US20070093517A1 (en) * | 2005-10-24 | 2007-04-26 | Gary Newton | Local anesthetic compositions |
| US20070212414A1 (en) * | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations |
| NZ572252A (en) * | 2006-04-21 | 2011-09-30 | Nektar Therapeutics | Stereoselective reduction of a morphinone |
| WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| AU2008231127B2 (en) * | 2007-03-23 | 2013-05-02 | SpecGx LLC | Improved preparation of oxymorphone from oripavine |
| CA2684458A1 (en) * | 2007-04-16 | 2008-10-30 | Mallinckrodt Inc. | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
| US20090124650A1 (en) * | 2007-06-21 | 2009-05-14 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol |
| US8067596B2 (en) | 2007-12-17 | 2011-11-29 | Mallinckrodt Llc | Processes for the production of (+)- “Nal” morphinan compounds |
| WO2017046814A1 (en) * | 2015-09-14 | 2017-03-23 | Rusan Pharma Limited | A safe and environment friendly process for producing nalbuphine or its pharmaceutically acceptable salts thereof |
| EP3746138A4 (en) | 2018-02-02 | 2021-11-03 | Alexza Pharmaceuticals, Inc. | ELECTRIC CONDENSING AEROSOL DEVICE |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3320262A (en) * | 1964-09-22 | 1967-05-16 | Lewenstein | 14 hydroxy morphine and codeine carboxymethyloximes |
-
1966
- 1966-11-20 IL IL26896A patent/IL26896A/en unknown
- 1966-12-16 GB GB56530/66A patent/GB1119270A/en not_active Expired
- 1966-12-16 CH CH1803266A patent/CH493522A/de not_active IP Right Cessation
- 1966-12-19 DE DE1795707A patent/DE1795707C3/de not_active Expired
- 1966-12-19 DE DE1670616A patent/DE1670616C3/de not_active Expired
- 1966-12-20 LU LU52650D patent/LU52650A1/xx unknown
- 1966-12-22 SE SE17639/66A patent/SE329402B/xx unknown
- 1966-12-22 NL NL6618022.A patent/NL165744C/xx not_active IP Right Cessation
- 1966-12-23 AT AT1135867A patent/AT292206B/de not_active IP Right Cessation
- 1966-12-23 DK DK667766AA patent/DK115631B/da not_active IP Right Cessation
- 1966-12-23 NO NO166137A patent/NO120368B/no unknown
- 1966-12-26 ES ES334942A patent/ES334942A1/es not_active Expired
-
1967
- 1967-01-13 FR FR91097A patent/FR6112M/fr not_active Expired
- 1967-10-24 US US677727A patent/US3393197A/en not_active Expired - Lifetime
-
1978
- 1978-05-24 NL NL7805652A patent/NL7805652A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR6112M (en:Method) | 1968-06-17 |
| AT292206B (de) | 1971-08-25 |
| SE329402B (en:Method) | 1970-10-12 |
| DE1670616A1 (de) | 1970-09-10 |
| NL165744B (nl) | 1980-12-15 |
| DE1795707C3 (de) | 1979-12-20 |
| NL7805652A (nl) | 1978-09-29 |
| DE1795707B2 (de) | 1979-04-19 |
| IL26896A (en) | 1970-11-30 |
| DK115631B (da) | 1969-10-27 |
| LU52650A1 (en:Method) | 1967-02-20 |
| DE1670616B2 (de) | 1977-11-10 |
| DE1795707A1 (de) | 1973-10-11 |
| US3393197A (en) | 1968-07-16 |
| NL165744C (nl) | 1981-05-15 |
| CH493522A (de) | 1970-07-15 |
| NL6618022A (en:Method) | 1967-07-20 |
| GB1119270A (en) | 1968-07-10 |
| NO120368B (en:Method) | 1970-10-12 |
| DE1670616C3 (de) | 1978-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19871026 |