ES3002432T3 - Rho kinase inhibitor ba-1049 (r) and active metabolites thereof - Google Patents

Rho kinase inhibitor ba-1049 (r) and active metabolites thereof Download PDF

Info

Publication number
ES3002432T3
ES3002432T3 ES17882341T ES17882341T ES3002432T3 ES 3002432 T3 ES3002432 T3 ES 3002432T3 ES 17882341 T ES17882341 T ES 17882341T ES 17882341 T ES17882341 T ES 17882341T ES 3002432 T3 ES3002432 T3 ES 3002432T3
Authority
ES
Spain
Prior art keywords
rock2
hydroxy
cells
brain
mice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17882341T
Other languages
English (en)
Spanish (es)
Inventor
Kenneth Rosen
Matthew Abbinanti
Joerg Ruschel
Lisa Mckerracher
Lisa Moritz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioaxone Biosciences Inc
Original Assignee
Bioaxone Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioaxone Biosciences Inc filed Critical Bioaxone Biosciences Inc
Application granted granted Critical
Publication of ES3002432T3 publication Critical patent/ES3002432T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES17882341T 2016-12-21 2017-05-09 Rho kinase inhibitor ba-1049 (r) and active metabolites thereof Active ES3002432T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662437181P 2016-12-21 2016-12-21
PCT/US2017/031836 WO2018118109A1 (en) 2016-12-21 2017-05-09 Rho kinase inhibitor ba-1049 (r) and active metabolites thereof

Publications (1)

Publication Number Publication Date
ES3002432T3 true ES3002432T3 (en) 2025-03-06

Family

ID=62627011

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17882341T Active ES3002432T3 (en) 2016-12-21 2017-05-09 Rho kinase inhibitor ba-1049 (r) and active metabolites thereof

Country Status (8)

Country Link
EP (2) EP4509138A3 (enExample)
JP (2) JP7117306B2 (enExample)
DK (1) DK3558314T3 (enExample)
ES (1) ES3002432T3 (enExample)
FI (1) FI3558314T3 (enExample)
PL (1) PL3558314T3 (enExample)
PT (1) PT3558314T (enExample)
WO (1) WO2018118109A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10106525B2 (en) 2015-01-26 2018-10-23 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10857157B2 (en) 2015-01-26 2020-12-08 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US11198680B2 (en) 2016-12-21 2021-12-14 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
ES3002432T3 (en) * 2016-12-21 2025-03-06 Bioaxone Biosciences Inc Rho kinase inhibitor ba-1049 (r) and active metabolites thereof
WO2019014322A1 (en) 2017-07-11 2019-01-17 BioAxone BioSciences, Inc. KINASE INHIBITORS FOR THE TREATMENT OF DISEASES
SI3877364T1 (sl) * 2018-11-06 2025-02-28 Cervello Therapeutics, Llc Inhibitorji rock kinaze
WO2021085645A1 (ja) 2019-11-01 2021-05-06 キリンホールディングス株式会社 多成分試料における物質の構造決定方法
JP7213839B2 (ja) * 2019-11-21 2023-01-27 キリンホールディングス株式会社 結晶スポンジ法による構造解析のための結晶構造解析用試料の調製方法
EP4063839A4 (en) * 2019-11-21 2023-11-22 Kirin Holdings Kabushiki Kaisha METHOD FOR PREPARING A CRYSTAL STRUCTURAL ANALYSIS SAMPLE FOR STRUCTURAL ANALYSIS BY CRYSTAL SPONGE METHOD
CN115975940B (zh) * 2021-10-15 2025-09-02 合肥中科普瑞昇生物医药科技有限公司 胃癌原代细胞的培养基和培养方法
JPWO2023085369A1 (enExample) 2021-11-11 2023-05-19

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050014783A1 (en) * 2003-05-29 2005-01-20 Schering Aktiengesellschaft Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy
JP2007523202A (ja) 2004-02-24 2007-08-16 ビオアクソン・テラプティーク・インコーポレーテッド 4置換ピペリジン誘導体
JP4652112B2 (ja) 2005-04-26 2011-03-16 富士フイルム株式会社 投射型表示装置
JP5313125B2 (ja) 2007-02-28 2013-10-09 旭化成ファーマ株式会社 スルホンアミド誘導体
JP2011530518A (ja) 2008-08-05 2011-12-22 アボット・ラボラトリーズ タンパク質キナーゼの阻害剤として有用な化合物
US8957093B2 (en) 2011-06-06 2015-02-17 The Scripps Research Institute N-biphenylmethylindole modulators of PPARG
JP6397831B2 (ja) * 2013-03-06 2018-09-26 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation Jak阻害剤の製造方法及びその中間体
ES2774923T3 (es) * 2014-04-28 2020-07-23 China Resources Pharmaceutical Holdings Company Ltd Derivados de isoquinolinsulfonilo como inhibidores de RHO quinasa
US9902702B2 (en) * 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
US9687483B2 (en) 2015-01-26 2017-06-27 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors
ES3002432T3 (en) * 2016-12-21 2025-03-06 Bioaxone Biosciences Inc Rho kinase inhibitor ba-1049 (r) and active metabolites thereof

Also Published As

Publication number Publication date
EP3558314A1 (en) 2019-10-30
PT3558314T (pt) 2024-12-19
PL3558314T3 (pl) 2025-02-24
JP2022141695A (ja) 2022-09-29
JP7461414B2 (ja) 2024-04-03
WO2018118109A1 (en) 2018-06-28
DK3558314T3 (da) 2024-11-04
EP3558314B1 (en) 2024-10-23
JP2020502248A (ja) 2020-01-23
FI3558314T3 (fi) 2024-11-29
JP7117306B2 (ja) 2022-08-12
EP4509138A3 (en) 2025-04-23
EP3558314A4 (en) 2020-08-26
EP4509138A2 (en) 2025-02-19

Similar Documents

Publication Publication Date Title
ES3002432T3 (en) Rho kinase inhibitor ba-1049 (r) and active metabolites thereof
US10526313B2 (en) Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
KR102836833B1 (ko) 신규 메틸퀴나졸리논 유도체
US12384759B2 (en) Rho kinase inhibitor ba-1049 (r) and active metabolites thereof
JP6887996B2 (ja) Tead転写因子自己パルミトイル化阻害剤
CA3214155A1 (en) Methods for inhibiting ras
ES2780382T3 (es) Derivados de pirazolopirimidina
KR20170082628A (ko) (s)-n-(5-((r)-2-(2,5-디플루오로페닐)-피롤리딘-1-일)-피라졸로[1,5-a]피리미딘-3-일)-3-히드록시피롤리딘-1-카르복스아미드 히드로겐 술페이트의 결정질 형태
CA3222549A1 (en) Combination therapy for cancer treatment
ES2795666T3 (es) Una triazolopiridazina deuterada como un modulador de quinasa
CN110903283B (zh) 一种取代的喹唑啉类化合物、包含该化合物的药物组合物和该化合物的用途
CA2974781C (en) BA-1049 (R) RHO KINASE INHIBITOR AND ITS ACTIVE METABOLITES
KR20210057704A (ko) Epac 억제제로서의 티에노[2,3-b]피리딘 유도체 및 이들의 약학적 용도
CN118414152A (zh) 治疗神经系统和心血管病状的方法
RU2802968C1 (ru) Новые производные метилхиназолинона
WO2025101588A1 (en) Tetrahydroisoquinoline heterobifunctional bcl-xl degraders
WO2025101575A1 (en) Tetrahydroisoquinoline heterobifunctional bcl-x l degraders
ES2387359B1 (es) Inhibidores de GSK-3 útiles en enfermedades neurodegenerativas, inflamatorias, cáncer, diabetes y en procesos regenerativos