DK3558314T3 - Rho kinase inhibitor BA-1049 (R) og aktive metabolitter deraf - Google Patents
Rho kinase inhibitor BA-1049 (R) og aktive metabolitter deraf Download PDFInfo
- Publication number
- DK3558314T3 DK3558314T3 DK17882341.5T DK17882341T DK3558314T3 DK 3558314 T3 DK3558314 T3 DK 3558314T3 DK 17882341 T DK17882341 T DK 17882341T DK 3558314 T3 DK3558314 T3 DK 3558314T3
- Authority
- DK
- Denmark
- Prior art keywords
- kinase inhibitor
- active metabolites
- rho kinase
- rho
- metabolites
- Prior art date
Links
- 239000002207 metabolite Substances 0.000 title 1
- 239000003590 rho kinase inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437181P | 2016-12-21 | 2016-12-21 | |
| PCT/US2017/031836 WO2018118109A1 (en) | 2016-12-21 | 2017-05-09 | Rho kinase inhibitor ba-1049 (r) and active metabolites thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3558314T3 true DK3558314T3 (da) | 2024-11-04 |
Family
ID=62627011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17882341.5T DK3558314T3 (da) | 2016-12-21 | 2017-05-09 | Rho kinase inhibitor BA-1049 (R) og aktive metabolitter deraf |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP3558314B1 (enExample) |
| JP (2) | JP7117306B2 (enExample) |
| DK (1) | DK3558314T3 (enExample) |
| ES (1) | ES3002432T3 (enExample) |
| FI (1) | FI3558314T3 (enExample) |
| PL (1) | PL3558314T3 (enExample) |
| PT (1) | PT3558314T (enExample) |
| WO (1) | WO2018118109A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10857157B2 (en) | 2015-01-26 | 2020-12-08 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
| US10106525B2 (en) | 2015-01-26 | 2018-10-23 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
| US11198680B2 (en) | 2016-12-21 | 2021-12-14 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
| WO2018118109A1 (en) * | 2016-12-21 | 2018-06-28 | BioAxone BioSciences, Inc. | Rho kinase inhibitor ba-1049 (r) and active metabolites thereof |
| WO2019014322A1 (en) | 2017-07-11 | 2019-01-17 | BioAxone BioSciences, Inc. | KINASE INHIBITORS FOR THE TREATMENT OF DISEASES |
| DK3877364T3 (da) * | 2018-11-06 | 2024-09-23 | Cervello Therapeutics LLC | Rock-kinasehæmmere |
| US12253482B2 (en) | 2019-11-01 | 2025-03-18 | Kirin Holdings Kabushiki Kaisha | Method for determining structure of substance in multicomponent sample |
| WO2021100852A1 (ja) * | 2019-11-21 | 2021-05-27 | キリンホールディングス株式会社 | 結晶スポンジ法による構造解析のための結晶構造解析用試料の調製方法 |
| JP7213839B2 (ja) * | 2019-11-21 | 2023-01-27 | キリンホールディングス株式会社 | 結晶スポンジ法による構造解析のための結晶構造解析用試料の調製方法 |
| WO2023060820A1 (zh) * | 2021-10-15 | 2023-04-20 | 合肥中科普瑞昇生物医药科技有限公司 | 胃癌原代细胞的培养基和培养方法 |
| CA3238227A1 (en) | 2021-11-11 | 2023-05-19 | The Doshisha | Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040266755A1 (en) * | 2003-05-29 | 2004-12-30 | Schering Aktiengesellschaft | Prodrugs of 1-(1-hydroxy-5-isoquinolinesulfonyl) homopiperazine |
| EP1720874A4 (en) * | 2004-02-24 | 2010-03-03 | Bioaxone Therapeutique Inc | 4-SUBSTITUTED PIPERIDINE DERIVATIVES |
| JP4652112B2 (ja) | 2005-04-26 | 2011-03-16 | 富士フイルム株式会社 | 投射型表示装置 |
| CN101622243B (zh) | 2007-02-28 | 2013-12-04 | 旭化成制药株式会社 | 磺酰胺衍生物 |
| EP2323659A4 (en) | 2008-08-05 | 2012-03-14 | Abbott Lab | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES |
| US8957093B2 (en) | 2011-06-06 | 2015-02-17 | The Scripps Research Institute | N-biphenylmethylindole modulators of PPARG |
| BR112015021458B1 (pt) * | 2013-03-06 | 2022-06-07 | Incyte Holdings Corporation | "processos e intermediários para preparar {1-{1-[3-flúor2-(trifluormetil)isonicotinoil] piperidin-4-il}-3-[4-(7hpirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrila, útil no tratamento de doenças relacionadas com a atividade de janus quinases |
| WO2015165341A1 (zh) * | 2014-04-28 | 2015-11-05 | 南京明德新药研发股份有限公司 | 作为rho激酶抑制剂的异喹啉磺酰衍生物 |
| US9902702B2 (en) * | 2014-07-15 | 2018-02-27 | Bristol-Myers Squibb Company | Spirocycloheptanes as inhibitors of rock |
| US9687483B2 (en) * | 2015-01-26 | 2017-06-27 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors |
| WO2018118109A1 (en) | 2016-12-21 | 2018-06-28 | BioAxone BioSciences, Inc. | Rho kinase inhibitor ba-1049 (r) and active metabolites thereof |
-
2017
- 2017-05-09 WO PCT/US2017/031836 patent/WO2018118109A1/en not_active Ceased
- 2017-05-09 ES ES17882341T patent/ES3002432T3/es active Active
- 2017-05-09 DK DK17882341.5T patent/DK3558314T3/da active
- 2017-05-09 FI FIEP17882341.5T patent/FI3558314T3/fi active
- 2017-05-09 PL PL17882341.5T patent/PL3558314T3/pl unknown
- 2017-05-09 EP EP17882341.5A patent/EP3558314B1/en active Active
- 2017-05-09 PT PT178823415T patent/PT3558314T/pt unknown
- 2017-05-09 JP JP2019534685A patent/JP7117306B2/ja active Active
- 2017-05-09 EP EP24208222.0A patent/EP4509138A3/en active Pending
-
2022
- 2022-06-30 JP JP2022105969A patent/JP7461414B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018118109A1 (en) | 2018-06-28 |
| PL3558314T3 (pl) | 2025-02-24 |
| ES3002432T3 (en) | 2025-03-06 |
| JP2022141695A (ja) | 2022-09-29 |
| EP3558314A4 (en) | 2020-08-26 |
| JP2020502248A (ja) | 2020-01-23 |
| JP7461414B2 (ja) | 2024-04-03 |
| EP4509138A3 (en) | 2025-04-23 |
| EP4509138A2 (en) | 2025-02-19 |
| JP7117306B2 (ja) | 2022-08-12 |
| FI3558314T3 (fi) | 2024-11-29 |
| EP3558314A1 (en) | 2019-10-30 |
| PT3558314T (pt) | 2024-12-19 |
| EP3558314B1 (en) | 2024-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY2024020I1 (el) | Αναστολεις kras g12c | |
| DK3558314T3 (da) | Rho kinase inhibitor BA-1049 (R) og aktive metabolitter deraf | |
| IL283639A (en) | Kif18a inhibitors | |
| DK3870579T3 (da) | Tyk2-inhibitorer og anvendelser deraf | |
| DK3658557T3 (da) | Tyk2-inhibitorer og anvendelser deraf | |
| IL280593A (en) | Pyrrolopyrimidine itk inhibitors | |
| DK3458802T3 (da) | Magasin og kassette | |
| IL285461A (en) | Processes and compounds | |
| HUE057801T2 (hu) | Aminotriazolopiridinek mint kináz inhibitorok | |
| DK3389658T3 (da) | Glycosidasehæmmere og anvendelser deraf | |
| DK3606519T3 (da) | ASK1-inhibitorforbindelser og anvendelser deraf | |
| DK3571192T3 (da) | Jak1-selektive inhibitorer | |
| DK4043466T3 (da) | PRC2-inhibitorer | |
| EP3804707A4 (en) | KINASE INHIBITOR | |
| DK3621694T5 (da) | Lrrc33-inhibitorer og anvendelse heraf | |
| HUE058292T2 (hu) | Aminoimidazopiridazinok mint kináz inhibitorok | |
| DK3783000T3 (da) | Makrocyklisk kinasehæmmer | |
| DK3474883T3 (da) | Komplementinhibitorer og anvendelser deraf | |
| DK3630744T3 (da) | Pyrazol-magl-inhibitorer | |
| DK3532459T3 (da) | Lsd1-hæmmere og medicinske anvendelser deraf | |
| DK3595665T3 (da) | Dobbelthæmmere af magl og faah | |
| DK3956322T3 (da) | Jak1-selektiv kinaseinhibitor | |
| IL281514A (en) | O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors | |
| DK3533281T3 (da) | Fremgangsmåder og indretninger til random access | |
| DK3280405T3 (da) | Inhibitorer og anvendelser deraf |