ES2983707T3 - Agente para el crecimiento del cabello - Google Patents
Agente para el crecimiento del cabello Download PDFInfo
- Publication number
- ES2983707T3 ES2983707T3 ES17789674T ES17789674T ES2983707T3 ES 2983707 T3 ES2983707 T3 ES 2983707T3 ES 17789674 T ES17789674 T ES 17789674T ES 17789674 T ES17789674 T ES 17789674T ES 2983707 T3 ES2983707 T3 ES 2983707T3
- Authority
- ES
- Spain
- Prior art keywords
- hair
- agent
- inositol
- growth
- chiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003779 hair growth Effects 0.000 title claims abstract description 74
- CDAISMWEOUEBRE-UHFFFAOYSA-N inositol Chemical compound OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims abstract description 100
- 210000004209 hair Anatomy 0.000 claims description 98
- 210000004919 hair shaft Anatomy 0.000 claims description 87
- 239000003795 chemical substances by application Substances 0.000 claims description 69
- CDAISMWEOUEBRE-LKPKBOIGSA-N 1D-chiro-inositol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-LKPKBOIGSA-N 0.000 claims description 49
- 230000031774 hair cycle Effects 0.000 claims description 41
- 230000012010 growth Effects 0.000 claims description 22
- 239000002537 cosmetic Substances 0.000 claims description 17
- 230000003797 telogen phase Effects 0.000 claims description 13
- 239000011148 porous material Substances 0.000 claims description 12
- 230000001737 promoting effect Effects 0.000 claims description 12
- 201000004384 Alopecia Diseases 0.000 claims description 9
- 208000024963 hair loss Diseases 0.000 claims description 9
- 230000003676 hair loss Effects 0.000 claims description 8
- 206010022489 Insulin Resistance Diseases 0.000 claims description 7
- 230000003247 decreasing effect Effects 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 210000004761 scalp Anatomy 0.000 claims description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 88
- 239000012085 test solution Substances 0.000 description 33
- 239000000243 solution Substances 0.000 description 31
- 230000000694 effects Effects 0.000 description 26
- 239000013642 negative control Substances 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 21
- 241000699670 Mus sp. Species 0.000 description 19
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 19
- 229960000367 inositol Drugs 0.000 description 19
- 241000699666 Mus <mouse, genus> Species 0.000 description 16
- 239000000126 substance Substances 0.000 description 14
- 239000006143 cell culture medium Substances 0.000 description 13
- 101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 description 9
- 239000007864 aqueous solution Substances 0.000 description 9
- 241000282693 Cercopithecidae Species 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 230000003698 anagen phase Effects 0.000 description 7
- 230000004663 cell proliferation Effects 0.000 description 7
- 230000035755 proliferation Effects 0.000 description 6
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 5
- 230000003778 catagen phase Effects 0.000 description 5
- 210000003780 hair follicle Anatomy 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 238000011814 C57BL/6N mouse Methods 0.000 description 4
- 241000282567 Macaca fascicularis Species 0.000 description 4
- CDAISMWEOUEBRE-NIPYSYMMSA-N epi-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](O)[C@H]1O CDAISMWEOUEBRE-NIPYSYMMSA-N 0.000 description 4
- 230000003659 hair regrowth Effects 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 229920001342 Bakelite® Polymers 0.000 description 3
- 230000032823 cell division Effects 0.000 description 3
- 238000012136 culture method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- CDAISMWEOUEBRE-GNIYUCBRSA-N muco-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H]1O CDAISMWEOUEBRE-GNIYUCBRSA-N 0.000 description 3
- 230000003658 preventing hair loss Effects 0.000 description 3
- CDAISMWEOUEBRE-CDRYSYESSA-N scyllo-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-CDRYSYESSA-N 0.000 description 3
- 238000004904 shortening Methods 0.000 description 3
- 208000002271 trichotillomania Diseases 0.000 description 3
- DSCFFEYYQKSRSV-UHFFFAOYSA-N 1L-O1-methyl-muco-inositol Natural products COC1C(O)C(O)C(O)C(O)C1O DSCFFEYYQKSRSV-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 241000282553 Macaca Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000030695 Sparse hair Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 238000001516 cell proliferation assay Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000035617 depilation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 230000003662 hair growth rate Effects 0.000 description 2
- 239000003676 hair preparation Substances 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 235000021374 legumes Nutrition 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 description 2
- -1 poultice Substances 0.000 description 2
- 230000003813 thin hair Effects 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000019300 CLIPPERS Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000219051 Fagopyrum Species 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- DSCFFEYYQKSRSV-MBXCVVGISA-N L-Quebrachitol Chemical compound COC1[C@H](O)[C@@H](O)C(O)[C@H](O)[C@H]1O DSCFFEYYQKSRSV-MBXCVVGISA-N 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000002386 air freshener Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 230000007698 birth defect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011262 co‐therapy Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- DUSHUSLJJMDGTE-ZJPMUUANSA-N cyproterone Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DUSHUSLJJMDGTE-ZJPMUUANSA-N 0.000 description 1
- 229960003843 cyproterone Drugs 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000008266 hair spray Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000002267 hypothalamic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
- 229960003105 metformin Drugs 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 238000013116 obese mouse model Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 210000001738 temporomandibular joint Anatomy 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 229940035722 triiodothyronine Drugs 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016100903 | 2016-04-27 | ||
| JP2016091063 | 2016-04-28 | ||
| PCT/JP2017/016783 WO2017188393A1 (ja) | 2016-04-27 | 2017-04-27 | 育毛剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2983707T3 true ES2983707T3 (es) | 2024-10-24 |
Family
ID=60160827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17789674T Active ES2983707T3 (es) | 2016-04-27 | 2017-04-27 | Agente para el crecimiento del cabello |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10933001B2 (https=) |
| EP (2) | EP3449897B1 (https=) |
| JP (2) | JP6244065B1 (https=) |
| CN (2) | CN114668679B (https=) |
| ES (1) | ES2983707T3 (https=) |
| MY (1) | MY186907A (https=) |
| SG (2) | SG11201809434YA (https=) |
| WO (1) | WO2017188393A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7580183B2 (ja) * | 2018-06-29 | 2024-11-11 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7519753B2 (ja) * | 2018-06-29 | 2024-07-22 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7203521B2 (ja) * | 2018-06-29 | 2023-01-13 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7203522B2 (ja) * | 2018-06-29 | 2023-01-13 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7425536B2 (ja) * | 2018-12-28 | 2024-01-31 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む外用組成物 |
| JP7350498B2 (ja) * | 2019-03-14 | 2023-09-26 | 小林製薬株式会社 | 外用組成物 |
| CN117695372A (zh) | 2019-10-18 | 2024-03-15 | 安佳榜控股股份公司 | 头皮保养剂 |
| US11491103B1 (en) * | 2020-07-02 | 2022-11-08 | Mahisha Jones | Hair growth formula |
| JP2024006574A (ja) * | 2022-07-04 | 2024-01-17 | 小林製薬株式会社 | 毛髪ボリュームアップ外用組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0245407A (ja) | 1988-08-05 | 1990-02-15 | Yokohama Rubber Co Ltd:The | Ｌ−クエブラキトール化粧料 |
| EP0465508B1 (en) | 1989-03-08 | 2000-05-31 | The University Of Virginia Patent Foundation | Pharmaceutical composition for insulin-resistant diabetics |
| US5428066A (en) * | 1989-03-08 | 1995-06-27 | Larner; Joseph | Method of reducing elevated blood sugar in humans |
| US5043162A (en) * | 1990-09-05 | 1991-08-27 | Trager Seymour F | Hair growth promoter |
| US5091596A (en) * | 1990-12-20 | 1992-02-25 | Univ. Of Va. Alumni Patents Foundation | Method for producing chiro-inositol |
| US5906979A (en) * | 1998-01-27 | 1999-05-25 | Insmed Pharmaceuticals, Inc. | Compositions and methods for treating metabolic diseases characterized by hyperandrogenism and/or anovulation and/or infertility |
| US6342645B2 (en) * | 1999-12-30 | 2002-01-29 | Insmed Pharmaceuticals, Inc. | Methods for the production and isolation of D-chiro-inositol from kasugamycin and the use of D-chiro-inositol obtained therefrom |
| CA2406871A1 (en) * | 2000-02-23 | 2001-08-30 | Orentreich Foundation For The Advancement Of Science, Inc. | Methods and compositions for the treatment of alopecia and other disorders of the pilosebaceous apparatus |
| US20020032177A1 (en) * | 2000-04-28 | 2002-03-14 | Insmed Pharmaceuticals, Inc. | Use of D-chiro-inositol in the treatment of conditions associated with hypothalamic gene expression |
| US6660891B2 (en) * | 2000-05-15 | 2003-12-09 | Insmed Incorporated | Methods for the production of D-chiro-inositol and the use of D-chiro inositol obtained therefrom |
| JP2006028026A (ja) * | 2004-07-12 | 2006-02-02 | Doctor Program Kk | 育毛剤 |
| US20080103116A1 (en) * | 2006-11-01 | 2008-05-01 | Jennings-Spring Barbara L | Method of treatment and compositions of D-chiro inositol and phosphates thereof |
| US20100055060A1 (en) | 2006-11-27 | 2010-03-04 | Naoyuki Yoshida | Cosmetic composition |
-
2017
- 2017-04-27 US US16/096,210 patent/US10933001B2/en active Active
- 2017-04-27 MY MYPI2018703963A patent/MY186907A/en unknown
- 2017-04-27 EP EP17789674.3A patent/EP3449897B1/en active Active
- 2017-04-27 WO PCT/JP2017/016783 patent/WO2017188393A1/ja not_active Ceased
- 2017-04-27 SG SG11201809434YA patent/SG11201809434YA/en unknown
- 2017-04-27 JP JP2017529108A patent/JP6244065B1/ja active Active
- 2017-04-27 SG SG10202107298RA patent/SG10202107298RA/en unknown
- 2017-04-27 CN CN202210386649.6A patent/CN114668679B/zh active Active
- 2017-04-27 EP EP24186161.6A patent/EP4417264A3/en active Pending
- 2017-04-27 CN CN201780035127.9A patent/CN109310598B/zh active Active
- 2017-04-27 ES ES17789674T patent/ES2983707T3/es active Active
- 2017-09-19 JP JP2017179099A patent/JP7005244B2/ja active Active
-
2021
- 2021-01-26 US US17/158,838 patent/US11534377B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3449897A4 (en) | 2020-01-15 |
| EP4417264A3 (en) | 2024-11-20 |
| US11534377B2 (en) | 2022-12-27 |
| US10933001B2 (en) | 2021-03-02 |
| CN109310598A (zh) | 2019-02-05 |
| CN114668679B (zh) | 2024-06-25 |
| JP6244065B1 (ja) | 2017-12-06 |
| SG11201809434YA (en) | 2018-11-29 |
| CN114668679A (zh) | 2022-06-28 |
| SG10202107298RA (en) | 2021-08-30 |
| US20210145713A1 (en) | 2021-05-20 |
| CN109310598B (zh) | 2022-04-19 |
| JP2018024692A (ja) | 2018-02-15 |
| JP7005244B2 (ja) | 2022-02-10 |
| EP3449897A1 (en) | 2019-03-06 |
| EP3449897B1 (en) | 2024-07-17 |
| US20190133904A1 (en) | 2019-05-09 |
| EP4417264A2 (en) | 2024-08-21 |
| EP3449897C0 (en) | 2024-07-17 |
| JPWO2017188393A1 (ja) | 2018-05-10 |
| WO2017188393A1 (ja) | 2017-11-02 |
| MY186907A (en) | 2021-08-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2983707T3 (es) | Agente para el crecimiento del cabello | |
| BRPI0905408A2 (pt) | uso cosmético de pelo menos um monossacarìdeo, composição, e, dispositivo | |
| CA2770683A1 (en) | Vitamin d3 and analogs thereof for treating alopecia | |
| CN104352418A (zh) | 一种抗衰老精华液 | |
| CN104352385A (zh) | 抗衰老精华液 | |
| JP2017528505A (ja) | 発毛増進、皮膚再生促進及び創傷治癒のための組成物及び方法 | |
| TW202128208A (zh) | 育毛劑 | |
| CN104352382A (zh) | 精华液 | |
| ES2874152T3 (es) | Composición cosmética para promover el crecimiento del cabello | |
| CN104352384A (zh) | 具有抗衰老功效的精华液 | |
| ES2773742T3 (es) | Combinación de carotenoide, fitoestrógeno y vitamina C para hidratar la piel | |
| KR101355477B1 (ko) | 알파 하이드록시산을 유효성분으로 포함하는 모발성장 촉진용 조성물 | |
| FR3071742A1 (fr) | Procede d'utilisation d'un inhibiteur de let-7b en cosmetique et/ou en nutraceutique | |
| HK40110863A (en) | Hair-growth agent | |
| HK40071981A (zh) | 育毛剂 | |
| HK40001177B (en) | Hair-growth agent | |
| HK40001177A (en) | Hair-growth agent | |
| HK40071981B (zh) | 育毛剂 | |
| JP2021155406A (ja) | 育毛促進用組成物 | |
| TW202042829A (zh) | 銀杏癒傷組織的萃取物用於提升Ｔｇｍ１基因、ＫＲＴ基因、ＡＱＰ３基因、ＦＬＧ－Ｆ基因、ＧＢＡ基因、ＨＡＳ基因、ＣＣＴ基因、Ｐｉｎｋ１基因、Ａｔｇ基因、ＳＩＲＴ１基因、ＮＡＤＳＹＮ基因、ＭＲＰＳ５基因或Ｕｂｌ－５基因的表現量、提升皮膚的保濕能力及抗老化之用途、用於誘導及增殖銀杏癒傷組織的方法、及用於培養銀杏癒傷組織的培養基 | |
| CN106236639B (zh) | 一种化妆用组合物 | |
| KR101511447B1 (ko) | 데커신을 유효성분으로 포함하는 체모성장 저해용 조성물 | |
| ES2354103B1 (es) | Composición capilar activadora de las sirtuinas y utilización de la misma. | |
| JP2018199656A (ja) | 育毛用組成物 | |
| KR101984276B1 (ko) | 베르베린 하이드로클로라이드를 유효성분으로 포함하는 체모성장 저해용 조성물 |