ES2973040T3 - Plataforma de estructura de núcleo/cáscara para inmunoterapia - Google Patents

Plataforma de estructura de núcleo/cáscara para inmunoterapia Download PDF

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Publication number
ES2973040T3
ES2973040T3 ES21210308T ES21210308T ES2973040T3 ES 2973040 T3 ES2973040 T3 ES 2973040T3 ES 21210308 T ES21210308 T ES 21210308T ES 21210308 T ES21210308 T ES 21210308T ES 2973040 T3 ES2973040 T3 ES 2973040T3
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mrna
cells
vaccine
cancer
antigen
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Spanish (es)
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Haifa Shen
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The Methodist Hospital
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The Methodist Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4204—Epidermal growth factor receptors [EGFR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/13—B-cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
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    • A61K2039/55511—Organic adjuvants
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    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES21210308T 2017-01-27 2018-01-26 Plataforma de estructura de núcleo/cáscara para inmunoterapia Active ES2973040T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762451575P 2017-01-27 2017-01-27

Publications (1)

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ES2973040T3 true ES2973040T3 (es) 2024-06-18

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ES21210308T Active ES2973040T3 (es) 2017-01-27 2018-01-26 Plataforma de estructura de núcleo/cáscara para inmunoterapia
ES18715827T Active ES2905591T3 (es) 2017-01-27 2018-01-26 Plataforma de estructura de núcleo/cáscara para inmunoterapia

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ES18715827T Active ES2905591T3 (es) 2017-01-27 2018-01-26 Plataforma de estructura de núcleo/cáscara para inmunoterapia

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Country Link
US (2) US11382964B2 (cg-RX-API-DMAC10.html)
EP (3) EP3573656B1 (cg-RX-API-DMAC10.html)
JP (2) JP7181880B2 (cg-RX-API-DMAC10.html)
KR (2) KR102627347B1 (cg-RX-API-DMAC10.html)
CN (2) CN109152830B (cg-RX-API-DMAC10.html)
AU (1) AU2018212887B2 (cg-RX-API-DMAC10.html)
CA (1) CA3051136A1 (cg-RX-API-DMAC10.html)
DK (2) DK4008344T5 (cg-RX-API-DMAC10.html)
ES (2) ES2973040T3 (cg-RX-API-DMAC10.html)
SG (1) SG11201906744VA (cg-RX-API-DMAC10.html)
WO (1) WO2018140826A1 (cg-RX-API-DMAC10.html)

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EP3364949A4 (en) 2015-10-22 2019-07-31 ModernaTX, Inc. CANCER VACCINES
KR102627347B1 (ko) 2017-01-27 2024-01-22 더 메서디스트 하스피틀 면역 요법을 위한 코어/쉘 구조 플랫폼
US11433143B2 (en) 2017-05-18 2022-09-06 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
CA3063932A1 (en) * 2017-05-18 2018-11-12 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
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MA54192A (fr) * 2018-11-07 2021-09-15 Modernatx Inc Vaccins à arn contre le cancer
CN109260157A (zh) * 2018-11-19 2019-01-25 上海交通大学 一种正电荷多肽脂质体纳米制剂及其制备方法与应用
AU2020207087A1 (en) * 2019-01-12 2021-08-12 The Methodist Hospital Self-assembled peptide nanoparticle and use thereof
CA3133177A1 (en) * 2019-03-14 2020-09-17 Engene, Inc. Chitosan polyplex-based localized expression of il-12 alone or in combination with type-i ifn inducers for treatment of mucosal cancers
WO2020210805A1 (en) 2019-04-11 2020-10-15 The Johns Hopkins University Nanoparticles for drug delivery to brain
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WO2021028439A1 (en) * 2019-08-14 2021-02-18 Curevac Ag Rna combinations and compositions with decreased immunostimulatory properties
DE102019122014A1 (de) * 2019-08-15 2021-02-18 Technische Universität Darmstadt Reduktion der Knochenresorption, insbesondere bei chronischen Gelenkerkrankungen
CN114728154A (zh) * 2019-10-09 2022-07-08 瓦克塞斯技术公司 基于丝素蛋白的微针及其用途
WO2021081043A1 (en) * 2019-10-22 2021-04-29 The Johns Hopkins University Mucus penetrating particle compositions and methods of use thereof enhancing immune response
KR102579284B1 (ko) * 2020-09-22 2023-09-18 비피진 주식회사 신규의 cd47 바인더와 폴리뉴클레오티드를 포함하는 암 치료를 위한 리포좀 복합체
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CN114699420A (zh) * 2022-03-08 2022-07-05 南方科技大学 一种用于治疗前列腺癌组合物及其制备方法与应用
CN114699538A (zh) * 2022-04-02 2022-07-05 中国药科大学 一种核-壳式高效基因药物递送系统及其制备方法
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CN117045809B (zh) * 2023-09-27 2025-08-29 国家纳米科学中心 异种哺乳动物细胞来源的囊泡在制备疫苗载体中的应用
KR20250063352A (ko) * 2023-11-01 2025-05-08 가톨릭대학교 산학협력단 mRNA가 봉입된 이중 나노입자, 이의 제조방법 및 이의 약학적 용도
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