DK4008344T5 - Kerne/skal struktur platform til immunterapi - Google Patents

Kerne/skal struktur platform til immunterapi Download PDF

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Publication number
DK4008344T5
DK4008344T5 DK21210308.9T DK21210308T DK4008344T5 DK 4008344 T5 DK4008344 T5 DK 4008344T5 DK 21210308 T DK21210308 T DK 21210308T DK 4008344 T5 DK4008344 T5 DK 4008344T5
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Prior art keywords
core
shell structure
immune therapy
structure platform
platform
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DK21210308.9T
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Danish (da)
English (en)
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DK4008344T3 (da
Inventor
Haifa Shen
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Methodist Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4204—Epidermal growth factor receptors [EGFR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/13—B-cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
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    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK21210308.9T 2017-01-27 2018-01-26 Kerne/skal struktur platform til immunterapi DK4008344T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762451575P 2017-01-27 2017-01-27
EP18715827.4A EP3573656B1 (en) 2017-01-27 2018-01-26 Core/shell structure platform for immunotherapy

Publications (2)

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DK4008344T3 DK4008344T3 (da) 2024-01-29
DK4008344T5 true DK4008344T5 (da) 2024-08-05

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DK21210308.9T DK4008344T5 (da) 2017-01-27 2018-01-26 Kerne/skal struktur platform til immunterapi
DK18715827.4T DK3573656T3 (da) 2017-01-27 2018-01-26 Kerne/skal-struktur-platform til immunterapi

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US (2) US11382964B2 (cg-RX-API-DMAC10.html)
EP (3) EP3573656B1 (cg-RX-API-DMAC10.html)
JP (2) JP7181880B2 (cg-RX-API-DMAC10.html)
KR (2) KR102627347B1 (cg-RX-API-DMAC10.html)
CN (2) CN109152830B (cg-RX-API-DMAC10.html)
AU (1) AU2018212887B2 (cg-RX-API-DMAC10.html)
CA (1) CA3051136A1 (cg-RX-API-DMAC10.html)
DK (2) DK4008344T5 (cg-RX-API-DMAC10.html)
ES (2) ES2973040T3 (cg-RX-API-DMAC10.html)
SG (1) SG11201906744VA (cg-RX-API-DMAC10.html)
WO (1) WO2018140826A1 (cg-RX-API-DMAC10.html)

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US11433143B2 (en) 2017-05-18 2022-09-06 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
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MA54192A (fr) * 2018-11-07 2021-09-15 Modernatx Inc Vaccins à arn contre le cancer
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CN112245575B (zh) * 2020-10-26 2024-07-26 上海杏禾医疗科技有限公司 含支化聚合物和mRNA的核壳结构的抗肿瘤疫苗及其用途
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CN114699538A (zh) * 2022-04-02 2022-07-05 中国药科大学 一种核-壳式高效基因药物递送系统及其制备方法
BE1031669B1 (fr) * 2023-06-02 2025-01-14 Inhatarget Therapeutics Composition pharmaceutique pour inhalation
BE1031668B1 (fr) * 2023-06-02 2025-01-16 Inhatarget Therapeutics Composition pharmaceutique pour inhalation
CN117045809B (zh) * 2023-09-27 2025-08-29 国家纳米科学中心 异种哺乳动物细胞来源的囊泡在制备疫苗载体中的应用
KR20250063352A (ko) * 2023-11-01 2025-05-08 가톨릭대학교 산학협력단 mRNA가 봉입된 이중 나노입자, 이의 제조방법 및 이의 약학적 용도
CN117442552B (zh) * 2023-11-20 2024-03-26 山东大学 一种淋巴结内t细胞区靶向纳米粒及其水凝胶
CN117883410A (zh) * 2024-01-22 2024-04-16 华中科技大学同济医学院附属协和医院 包封有mRNA及Acod1基因si-RNA的脂质体纳米颗粒及其应用
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