ES2972533T3 - Moduladores del receptor de NMDA a base de espirolactama, y sus usos - Google Patents
Moduladores del receptor de NMDA a base de espirolactama, y sus usos Download PDFInfo
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- ES2972533T3 ES2972533T3 ES17751911T ES17751911T ES2972533T3 ES 2972533 T3 ES2972533 T3 ES 2972533T3 ES 17751911 T ES17751911 T ES 17751911T ES 17751911 T ES17751911 T ES 17751911T ES 2972533 T3 ES2972533 T3 ES 2972533T3
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- alkyl
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- hydroxyl
- halogen
- compound
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- DAKXWFFETZRUSE-UHFFFAOYSA-N methyl 4-methyl-1-(phenylmethoxymethyl)cyclohexane-1-carboxylate Chemical compound C(C1=CC=CC=C1)OCC1(CCC(CC1)C)C(=O)OC DAKXWFFETZRUSE-UHFFFAOYSA-N 0.000 description 19
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662369465P | 2016-08-01 | 2016-08-01 | |
| US201762523413P | 2017-06-22 | 2017-06-22 | |
| PCT/US2017/044813 WO2018026763A1 (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam nmda receptor modulators and uses thereof |
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| Publication Number | Publication Date |
|---|---|
| ES2972533T3 true ES2972533T3 (es) | 2024-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17751911T Active ES2972533T3 (es) | 2016-08-01 | 2017-08-01 | Moduladores del receptor de NMDA a base de espirolactama, y sus usos |
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Families Citing this family (12)
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| WO2010033757A1 (en) | 2008-09-18 | 2010-03-25 | Naurex, Inc. | Nmda receptor modulators and uses thereof |
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| JP2019527235A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用 |
| KR102503590B1 (ko) | 2016-08-01 | 2023-02-24 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| SG11201900551WA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| CA3031563C (en) | 2016-08-01 | 2023-12-05 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
| EA201990424A1 (ru) | 2016-08-01 | 2019-08-30 | Аптиникс Инк. | Спиролактамовые модуляторы nmda-рецептора и их применение |
| SG11202007256PA (en) | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
| CN114685277A (zh) * | 2020-12-31 | 2022-07-01 | 苏州瑞博生物技术股份有限公司 | 化合物及羟基丙酸盐类化合物的纯化方法 |
| CN113956183B (zh) * | 2021-10-28 | 2023-06-20 | 成都市科隆化学品有限公司 | 一种Boc-Ser(Bzl)-OH及其制备方法 |
| WO2024054919A1 (en) * | 2022-09-08 | 2024-03-14 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda receptor modulators and uses thereof |
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- 2017-08-01 KR KR1020197005660A patent/KR102503590B1/ko active Active
- 2017-08-01 EP EP17751911.3A patent/EP3490974B1/en active Active
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| AU2017306136B2 (en) | 2021-10-21 |
| KR102503590B1 (ko) | 2023-02-24 |
| WO2018026763A1 (en) | 2018-02-08 |
| SG11201900558RA (en) | 2019-02-27 |
| CL2019000246A1 (es) | 2019-06-21 |
| KR20190033593A (ko) | 2019-03-29 |
| JP2019528259A (ja) | 2019-10-10 |
| US11512051B2 (en) | 2022-11-29 |
| EP3490974B1 (en) | 2023-12-06 |
| CN109906218A (zh) | 2019-06-18 |
| US20220002242A1 (en) | 2022-01-06 |
| CN109906218B (zh) | 2023-01-17 |
| CO2019000941A2 (es) | 2019-02-08 |
| CA3031534A1 (en) | 2018-02-08 |
| PH12019500207A1 (en) | 2019-06-17 |
| AU2017306136A1 (en) | 2019-01-31 |
| US20190161442A1 (en) | 2019-05-30 |
| IL264488A (en) | 2019-03-31 |
| EP3490974C0 (en) | 2023-12-06 |
| EP3490974A1 (en) | 2019-06-05 |
| MX2019001318A (es) | 2019-07-01 |
| PE20190500A1 (es) | 2019-04-10 |
| US10961189B2 (en) | 2021-03-30 |
| CA3031534C (en) | 2023-10-17 |
| JP7036792B2 (ja) | 2022-03-15 |
| MX385336B (es) | 2025-03-18 |
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