ES2970505T3 - Dispositivo compacto de análisis de gases y método - Google Patents
Dispositivo compacto de análisis de gases y método Download PDFInfo
- Publication number
- ES2970505T3 ES2970505T3 ES17729850T ES17729850T ES2970505T3 ES 2970505 T3 ES2970505 T3 ES 2970505T3 ES 17729850 T ES17729850 T ES 17729850T ES 17729850 T ES17729850 T ES 17729850T ES 2970505 T3 ES2970505 T3 ES 2970505T3
- Authority
- ES
- Spain
- Prior art keywords
- gas
- separators
- flow path
- response
- analysis device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000004868 gas analysis Methods 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims description 22
- 230000004044 response Effects 0.000 claims abstract description 30
- 238000004458 analytical method Methods 0.000 claims abstract description 17
- 238000004891 communication Methods 0.000 claims abstract description 8
- 238000004817 gas chromatography Methods 0.000 claims abstract description 6
- 239000007789 gas Substances 0.000 claims description 83
- 239000000126 substance Substances 0.000 claims description 4
- 201000010099 disease Diseases 0.000 abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 13
- 239000000090 biomarker Substances 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 9
- 239000012855 volatile organic compound Substances 0.000 description 9
- 210000002700 urine Anatomy 0.000 description 6
- 238000000576 coating method Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 210000003608 fece Anatomy 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 206010051606 Necrotising colitis Diseases 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 208000004995 necrotizing enterocolitis Diseases 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 239000003039 volatile agent Substances 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
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- 238000001819 mass spectrum Methods 0.000 description 1
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- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 244000052769 pathogen Species 0.000 description 1
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- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6034—Construction of the column joining multiple columns
- G01N30/6039—Construction of the column joining multiple columns in series
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/465—Flow patterns using more than one column with serial coupling of separation columns with specially adapted interfaces between the columns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/466—Flow patterns using more than one column with separation columns in parallel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/468—Flow patterns using more than one column involving switching between different column configurations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/0047—Organic compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
- G01N33/4975—Physical analysis of biological material of gaseous biological material, e.g. breath other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N2030/0095—Separation specially adapted for use outside laboratory, e.g. field sampling, portable equipments
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/025—Gas chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N2030/628—Multiplexing, i.e. several columns sharing a single detector
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6034—Construction of the column joining multiple columns
- G01N30/6043—Construction of the column joining multiple columns in parallel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/78—Detectors specially adapted therefor using more than one detector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Combustion & Propulsion (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662351342P | 2016-06-17 | 2016-06-17 | |
| PCT/EP2017/064210 WO2017216079A1 (en) | 2016-06-17 | 2017-06-12 | Compact gas analysis device and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2970505T3 true ES2970505T3 (es) | 2024-05-29 |
Family
ID=59055206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17729850T Active ES2970505T3 (es) | 2016-06-17 | 2017-06-12 | Dispositivo compacto de análisis de gases y método |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11016066B2 (enExample) |
| EP (1) | EP3472610B1 (enExample) |
| JP (1) | JP7197369B2 (enExample) |
| CN (1) | CN109313173B (enExample) |
| ES (1) | ES2970505T3 (enExample) |
| PL (1) | PL3472610T3 (enExample) |
| WO (1) | WO2017216079A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113167769B (zh) * | 2018-11-28 | 2024-01-30 | 皇家飞利浦有限公司 | 具有过载检测的气体分析采样 |
| US11020042B2 (en) * | 2019-05-15 | 2021-06-01 | Know Biological, Inc. | Seizure detection device |
| TWI772776B (zh) * | 2020-04-09 | 2022-08-01 | 美商艾諾斯股份有限公司 | 肺炎偵測裝置 |
| US12320787B2 (en) * | 2020-06-22 | 2025-06-03 | Waters Technologies Corporation | Insulated serial column chromatography arrangements and systems |
| CN113504231B (zh) * | 2021-02-10 | 2024-07-19 | 北京朗观视觉科技有限公司 | 一种手持式尾气检测装置 |
| US12360101B2 (en) * | 2021-10-01 | 2025-07-15 | Nicholas Grant | Electronic systems and methods for health analysis from breath |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0658919A (ja) * | 1992-06-12 | 1994-03-04 | Hideo Ueda | 呼気分析方法及び装置 |
| RU2054669C1 (ru) | 1992-08-05 | 1996-02-20 | Фирма "Геба" | Хроматограф |
| US6497138B1 (en) * | 2000-10-18 | 2002-12-24 | Agilent Technologies, Inc., | Multilayered gas chromatograph |
| US6632268B2 (en) * | 2001-02-08 | 2003-10-14 | Oakland University | Method and apparatus for comprehensive two-dimensional gas chromatography |
| FR2825649B1 (fr) * | 2001-06-08 | 2003-10-17 | Francois Paul Geli | Support pour analyse comparatives d'echantillons sur micro-colonnes de fractionnement avec gradients de longueur, phases stationnaires alternees, et elutions digitalisees |
| US6852933B2 (en) | 2001-06-13 | 2005-02-08 | Fred Messerle | Mobile scale assembly |
| US20050063865A1 (en) | 2002-09-27 | 2005-03-24 | Ulrich Bonne | Phased VII micro fluid analyzer having a modular structure |
| JP2005221341A (ja) * | 2004-02-04 | 2005-08-18 | Horiba Ltd | 揮発性有機化合物測定装置 |
| US20060178592A1 (en) | 2005-02-07 | 2006-08-10 | Aperson Biosystems Corp. | System and method for controlling the flow of exhaled breath during analysis |
| JP5157281B2 (ja) * | 2007-06-26 | 2013-03-06 | 株式会社島津製作所 | マルチディメンジョナルガスクロマトグラフ装置 |
| JP5002365B2 (ja) * | 2007-08-06 | 2012-08-15 | 株式会社日立製作所 | 質量分析装置及び質量分析方法 |
| KR100983827B1 (ko) | 2007-08-20 | 2010-09-27 | 동양물산기업 주식회사 | 구강 및 날숨 가스 성분 분석 장치 및 이에 적합한 방법 |
| US8087283B2 (en) | 2008-06-17 | 2012-01-03 | Tricorntech Corporation | Handheld gas analysis systems for point-of-care medical applications |
| JP5251727B2 (ja) * | 2009-05-22 | 2013-07-31 | 株式会社島津製作所 | マルチディメンジョナルガスクロマトグラフ装置 |
| US8999245B2 (en) * | 2009-07-07 | 2015-04-07 | Tricorn Tech Corporation | Cascaded gas chromatographs (CGCs) with individual temperature control and gas analysis systems using same |
| US8707760B2 (en) | 2009-07-31 | 2014-04-29 | Tricorntech Corporation | Gas collection and analysis system with front-end and back-end pre-concentrators and moisture removal |
| GB0920315D0 (en) | 2009-11-20 | 2010-01-06 | Univ Bristol | A diagnostic apparatus |
| JP2011112603A (ja) * | 2009-11-30 | 2011-06-09 | Shimadzu Corp | マルチディメンジョナルガスクロマトグラフ装置 |
| JP5522669B2 (ja) | 2010-02-05 | 2014-06-18 | シャープ株式会社 | アセトン分析装置 |
| US8978444B2 (en) * | 2010-04-23 | 2015-03-17 | Tricorn Tech Corporation | Gas analyte spectrum sharpening and separation with multi-dimensional micro-GC for gas chromatography analysis |
| CN104939831B (zh) * | 2010-09-09 | 2018-11-09 | 森撒部伊斯公司 | 从受试者的呼出气中收集样本的系统和方法及其用途 |
| AU2013205139B2 (en) * | 2011-09-25 | 2016-03-17 | Labrador Diagnostics Llc | Systems and methods for multi-analysis |
| WO2013070954A1 (en) * | 2011-11-09 | 2013-05-16 | The Regents Of The University Of Michigan | Devices and methods for adaptive micro-gas chromatography |
| CA2897533A1 (en) * | 2013-01-08 | 2014-07-17 | Capnia, Inc. | Breath selection for analysis |
| JP2014153075A (ja) * | 2013-02-05 | 2014-08-25 | Shimadzu Corp | ガス流路切替装置、ガス流路切替方法及びガス流路切替プログラム |
| CA2900626A1 (en) * | 2013-02-12 | 2014-08-21 | Capnia, Inc. | Sampling and storage registry device for breath gas analysis |
| CN203241391U (zh) * | 2013-05-09 | 2013-10-16 | 四川大学 | 呼出气在线富集气相色谱快速检测装置 |
| WO2015124468A1 (en) | 2014-02-19 | 2015-08-27 | Koninklijke Philips N.V. | Method of detecting ards and systems for detecting ards |
-
2017
- 2017-06-12 JP JP2018564249A patent/JP7197369B2/ja active Active
- 2017-06-12 WO PCT/EP2017/064210 patent/WO2017216079A1/en not_active Ceased
- 2017-06-12 CN CN201780037568.2A patent/CN109313173B/zh active Active
- 2017-06-12 ES ES17729850T patent/ES2970505T3/es active Active
- 2017-06-12 EP EP17729850.2A patent/EP3472610B1/en active Active
- 2017-06-12 PL PL17729850.2T patent/PL3472610T3/pl unknown
- 2017-06-12 US US16/310,469 patent/US11016066B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11016066B2 (en) | 2021-05-25 |
| EP3472610A1 (en) | 2019-04-24 |
| JP2019520567A (ja) | 2019-07-18 |
| CN109313173A (zh) | 2019-02-05 |
| CN109313173B (zh) | 2022-03-15 |
| JP7197369B2 (ja) | 2022-12-27 |
| US20190331660A1 (en) | 2019-10-31 |
| EP3472610B1 (en) | 2023-12-20 |
| WO2017216079A1 (en) | 2017-12-21 |
| PL3472610T3 (pl) | 2024-05-20 |
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