WO2017216079A1 - Compact gas analysis device and method - Google Patents

Compact gas analysis device and method Download PDF

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Publication number
WO2017216079A1
WO2017216079A1 PCT/EP2017/064210 EP2017064210W WO2017216079A1 WO 2017216079 A1 WO2017216079 A1 WO 2017216079A1 EP 2017064210 W EP2017064210 W EP 2017064210W WO 2017216079 A1 WO2017216079 A1 WO 2017216079A1
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WO
WIPO (PCT)
Prior art keywords
gas
flow path
separators
analysis device
gsl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2017/064210
Other languages
English (en)
French (fr)
Inventor
Tamara Mathea Elisabeth NIJSEN
Johannes Weda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV filed Critical Koninklijke Philips NV
Priority to ES17729850T priority Critical patent/ES2970505T3/es
Priority to PL17729850.2T priority patent/PL3472610T3/pl
Priority to US16/310,469 priority patent/US11016066B2/en
Priority to CN201780037568.2A priority patent/CN109313173B/zh
Priority to EP17729850.2A priority patent/EP3472610B1/en
Priority to JP2018564249A priority patent/JP7197369B2/ja
Publication of WO2017216079A1 publication Critical patent/WO2017216079A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6034—Construction of the column joining multiple columns
    • G01N30/6039—Construction of the column joining multiple columns in series
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/465—Flow patterns using more than one column with serial coupling of separation columns with specially adapted interfaces between the columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
    • G01N33/0047—Organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G01N33/4975—Physical analysis of biological material of gaseous biological material, e.g. breath other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/0095—Separation specially adapted for use outside laboratory, e.g. field sampling, portable equipments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/025—Gas chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/628—Multiplexing, i.e. several columns sharing a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6034—Construction of the column joining multiple columns
    • G01N30/6043—Construction of the column joining multiple columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/78—Detectors specially adapted therefor using more than one detector

Definitions

  • the invention relates generally to analysis of gas. Specifically, the invention relates to a method and a device suited for medical analysis of gas, e.g. breath exhaled from a person or gas based on samples from skin, urine or feces.
  • Prior art methods typically include a separation and a detector step, if necessary with a pre-concentrator in order to increase the concentration.
  • high end GC-MS systems used for this purpose comprise a chromatographic column that separate the individual compounds of the matrix, and a mass spectrometry detector that can accurately detect each compound that is separated, giving the selectivity and specificity that is needed.
  • GC-MS systems are very expensive and bulky, and require highly skilled technicians to operate, as well as regular calibration and cleaning. Thus, such high-end equipment is not suited for use e.g. in a hospital close to the patients.
  • At least one detector comprising a sensor arranged to generate respective first and second responses to outputs from the first and second gas separators
  • a communication module arranged to generate output data in response to the first and second responses from the at least one detector.
  • the gas analysis device can be used to separate gaseous mixtures into multiple mixtures that can be further analysed. This can be used in a clinical setting, sampling breath samples directly from the side-stream of the tubing of a mechanical ventilator e.g. in intensive care units, or sampling from a bag containing a breath sample from patients that are able to breathe on their own. It can also be used in other applications where gases need to be analysed for the presence of specific components. It is to be understood that the device may be used as well to analyse VOCs in gases based on samples from skin, urine or feces. Further, the device may be used in general to analyse gas also for non-medical applications.
  • the flow path may comprise a plurality of parallel flow paths each comprising a serial flow path between a plurality of gas separators, and comprising one common detector arranged to generate a response to an output from each of the plurality of gas separators in said respective parallel flow paths separated over time.
  • each parallel flow path with a plurality of gas separators in serial configuration can be detected by one common detector, if detection is split into separate time slots.
  • a moisture removal filter may be included, e.g. if the gas analysis device is to be used for breath air directly from a person or animal.
  • FIG. 3 illustrates yet another embodiment with parallel branches of a plurality of gas separators with one common detector for all of the parallel branches
  • FIG. 2 illustrates in a schematic representation an embodiment with a flow path FP having parallel brachnes each having a plurality of gas separators GSl l to GS3_n conncected in a serial path.
  • a flow path FP having parallel brachnes each having a plurality of gas separators GSl l to GS3_n conncected in a serial path.
  • three parallel connections each with a serial connection of three gas separators are seen, however 'n' indicates that the gas analysis device may in general comprise more than three parallel branches, and each branch may comprise more than three gas separators in serial connection.
  • FIGs 1-3 embodiments of FIGs 1-3.
  • the invention provides A gas analysis device suited for e.g.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Combustion & Propulsion (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
PCT/EP2017/064210 2016-06-17 2017-06-12 Compact gas analysis device and method Ceased WO2017216079A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES17729850T ES2970505T3 (es) 2016-06-17 2017-06-12 Dispositivo compacto de análisis de gases y método
PL17729850.2T PL3472610T3 (pl) 2016-06-17 2017-06-12 Zwarte urządzenie do analizy gazu i sposób
US16/310,469 US11016066B2 (en) 2016-06-17 2017-06-12 Compact gas analysis device and method
CN201780037568.2A CN109313173B (zh) 2016-06-17 2017-06-12 紧凑型气体分析设备和方法
EP17729850.2A EP3472610B1 (en) 2016-06-17 2017-06-12 Compact gas analysis device and method
JP2018564249A JP7197369B2 (ja) 2016-06-17 2017-06-12 コンパクトなガス分析装置及び方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662351342P 2016-06-17 2016-06-17
US62/351,342 2016-06-17

Publications (1)

Publication Number Publication Date
WO2017216079A1 true WO2017216079A1 (en) 2017-12-21

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PCT/EP2017/064210 Ceased WO2017216079A1 (en) 2016-06-17 2017-06-12 Compact gas analysis device and method

Country Status (7)

Country Link
US (1) US11016066B2 (enExample)
EP (1) EP3472610B1 (enExample)
JP (1) JP7197369B2 (enExample)
CN (1) CN109313173B (enExample)
ES (1) ES2970505T3 (enExample)
PL (1) PL3472610T3 (enExample)
WO (1) WO2017216079A1 (enExample)

Cited By (2)

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WO2020109424A1 (en) * 2018-11-28 2020-06-04 Koninklijke Philips N.V. Gas analysis sampling with overload detection
JP2022534188A (ja) * 2019-05-15 2022-07-28 ノウ バイオロジカル、インコーポレイテッド 発作検知装置

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US12320787B2 (en) * 2020-06-22 2025-06-03 Waters Technologies Corporation Insulated serial column chromatography arrangements and systems
CN113504231B (zh) * 2021-02-10 2024-07-19 北京朗观视觉科技有限公司 一种手持式尾气检测装置
US12360101B2 (en) * 2021-10-01 2025-07-15 Nicholas Grant Electronic systems and methods for health analysis from breath

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US20050063865A1 (en) * 2002-09-27 2005-03-24 Ulrich Bonne Phased VII micro fluid analyzer having a modular structure
US20110005300A1 (en) * 2009-07-07 2011-01-13 Tricorntech Corporation CASCADED GAS CHROMATOGRAPHS (CGCs) WITH INDIVIDUAL TEMPERATURE CONTROL AND GAS ANALYSIS SYSTEMS USING SAME
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020109424A1 (en) * 2018-11-28 2020-06-04 Koninklijke Philips N.V. Gas analysis sampling with overload detection
CN113167769A (zh) * 2018-11-28 2021-07-23 皇家飞利浦有限公司 具有过载检测的气体分析采样
JP2022501616A (ja) * 2018-11-28 2022-01-06 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. 過装填検出によるガス分析サンプリング
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JP2022534188A (ja) * 2019-05-15 2022-07-28 ノウ バイオロジカル、インコーポレイテッド 発作検知装置

Also Published As

Publication number Publication date
US11016066B2 (en) 2021-05-25
EP3472610A1 (en) 2019-04-24
JP2019520567A (ja) 2019-07-18
ES2970505T3 (es) 2024-05-29
CN109313173A (zh) 2019-02-05
CN109313173B (zh) 2022-03-15
JP7197369B2 (ja) 2022-12-27
US20190331660A1 (en) 2019-10-31
EP3472610B1 (en) 2023-12-20
PL3472610T3 (pl) 2024-05-20

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