ES2956732T3 - Métodos de detección de ácidos nucleicos diana en una muestra - Google Patents
Métodos de detección de ácidos nucleicos diana en una muestra Download PDFInfo
- Publication number
- ES2956732T3 ES2956732T3 ES17726083T ES17726083T ES2956732T3 ES 2956732 T3 ES2956732 T3 ES 2956732T3 ES 17726083 T ES17726083 T ES 17726083T ES 17726083 T ES17726083 T ES 17726083T ES 2956732 T3 ES2956732 T3 ES 2956732T3
- Authority
- ES
- Spain
- Prior art keywords
- nucleic acid
- binding
- molecule
- region
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/30—Characterised by physical treatment
- C12Q2523/319—Photocleavage, photolysis, photoactivation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/113—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being electroactive, e.g. redox labels
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662337074P | 2016-05-16 | 2016-05-16 | |
| US201762492889P | 2017-05-01 | 2017-05-01 | |
| PCT/US2017/032947 WO2017201073A1 (en) | 2016-05-16 | 2017-05-16 | Methods for detecting target nucleic acids in a sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2956732T3 true ES2956732T3 (es) | 2023-12-27 |
Family
ID=58772988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17726083T Active ES2956732T3 (es) | 2016-05-16 | 2017-05-16 | Métodos de detección de ácidos nucleicos diana en una muestra |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20170327876A1 (enExample) |
| EP (2) | EP4324929B1 (enExample) |
| JP (3) | JP7457457B2 (enExample) |
| KR (1) | KR102490693B1 (enExample) |
| CN (2) | CN109715825B (enExample) |
| AU (2) | AU2017268257B2 (enExample) |
| ES (1) | ES2956732T3 (enExample) |
| SG (1) | SG11201809913PA (enExample) |
| WO (1) | WO2017201073A1 (enExample) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2766498B1 (en) | 2011-10-14 | 2019-06-19 | President and Fellows of Harvard College | Sequencing by structure assembly |
| ES2991004T3 (es) | 2011-12-22 | 2024-12-02 | Harvard College | Métodos para la detección de analitos |
| EP3578666A1 (en) | 2013-03-12 | 2019-12-11 | President and Fellows of Harvard College | Method of generating a three-dimensional nucleic acid containing matrix |
| WO2016007839A1 (en) | 2014-07-11 | 2016-01-14 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
| ES2968004T3 (es) | 2014-07-30 | 2024-05-06 | Harvard College | Construcción de bibliotecas de sondas |
| DK3901281T4 (da) | 2015-04-10 | 2025-10-20 | Illumina Inc | Rumligt adskilt, multipleks nukleinsyreanalyse af biologiske prøver |
| CA3022290A1 (en) | 2016-04-25 | 2017-11-02 | President And Fellows Of Harvard College | Hybridization chain reaction methods for in situ molecular detection |
| EP4050112A1 (en) | 2016-06-21 | 2022-08-31 | 10X Genomics, Inc. | Nucleic acid sequencing |
| US10415080B2 (en) * | 2016-11-21 | 2019-09-17 | Nanostring Technologies, Inc. | Chemical compositions and methods of using same |
| KR102145417B1 (ko) * | 2017-05-24 | 2020-08-19 | 지니너스 주식회사 | 무세포 핵산으로부터 수득된 서열 분석 데이터에 대한 배경 대립인자의 빈도 분포를 생성하는 방법 및 이를 이용하여 무세포 핵산으로부터 변이를 검출하는 방법 |
| US11788123B2 (en) | 2017-05-26 | 2023-10-17 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| ES3029737T3 (en) | 2017-10-06 | 2025-06-25 | 10X Genomics Inc | Rna templated ligation |
| WO2019200326A1 (en) | 2018-04-13 | 2019-10-17 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
| KR102893736B1 (ko) * | 2018-05-14 | 2025-11-28 | 브루커 스페이셜 바이올로지, 인크. | 화학 조성물 및 이의 사용 방법 |
| WO2019241250A1 (en) * | 2018-06-11 | 2019-12-19 | Foundation Medicine, Inc. | Compositions and methods for evaluating genomic alterations |
| WO2020014036A1 (en) * | 2018-07-09 | 2020-01-16 | Ultivue, Inc. | Methods for multicolor multiplex imaging |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
| CN117778535A (zh) * | 2018-10-25 | 2024-03-29 | Illumina公司 | 使用索引和条形码识别阵列上的配体的方法和组合物 |
| WO2020123320A2 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Imaging system hardware |
| US12460250B2 (en) | 2018-12-13 | 2025-11-04 | President And Fellows Of Harvard College | Amplification methods and systems for MERFISH and other applications |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| WO2020240025A1 (en) | 2019-05-31 | 2020-12-03 | Cartana Ab | Method of detecting target nucleic acid molecules |
| KR102336454B1 (ko) * | 2019-06-17 | 2021-12-08 | 강릉원주대학교산학협력단 | 핵산 검출 방법 |
| WO2020254672A1 (en) | 2019-06-19 | 2020-12-24 | Therycell Gmbh | Spatial characterisation of target structures in a sample |
| CN114041044A (zh) * | 2019-07-01 | 2022-02-11 | 达芬奇生物有限公司 | 高容量分子检测 |
| KR102375106B1 (ko) * | 2019-10-04 | 2022-03-17 | 프로지니어 주식회사 | 핵산 검출 시스템 |
| WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| US20230029257A1 (en) * | 2019-12-12 | 2023-01-26 | President And Fellows Of Harvard College | Compositions and methods for light-directed biomolecular barcoding |
| GB201919032D0 (en) | 2019-12-20 | 2020-02-05 | Cartana Ab | Method of detecting an analyte |
| CN115038794A (zh) | 2019-12-23 | 2022-09-09 | 10X基因组学有限公司 | 在基于分区的测定中使用固定生物样品的组合物和方法 |
| EP4667585A2 (en) | 2019-12-23 | 2025-12-24 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US12110548B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Bi-directional in situ analysis |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| WO2021158925A1 (en) | 2020-02-07 | 2021-08-12 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| EP4107284A1 (en) | 2020-02-17 | 2022-12-28 | 10X Genomics, Inc. | In situ analysis of chromatin interaction |
| WO2021168287A1 (en) | 2020-02-21 | 2021-08-26 | 10X Genomics, Inc. | Methods and compositions for integrated in situ spatial assay |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| US12188085B2 (en) | 2020-03-05 | 2025-01-07 | 10X Genomics, Inc. | Three-dimensional spatial transcriptomics with sequencing readout |
| EP4139485B1 (en) | 2020-04-22 | 2023-09-06 | 10X Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
| WO2021237087A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| US12209273B2 (en) | 2020-06-12 | 2025-01-28 | 10X Genomics, Inc. | Nucleic acid assays using click chemistry bioconjugation |
| AU2021294274A1 (en) | 2020-06-18 | 2022-12-08 | Resolve Biosciences Gmbh | Multiplex method for detecting different analytes and different subgroups/variations of an analyte in a sample |
| AU2021294334A1 (en) | 2020-06-25 | 2023-02-02 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US20220049303A1 (en) | 2020-08-17 | 2022-02-17 | Readcoor, Llc | Methods and systems for spatial mapping of genetic variants |
| US12297499B2 (en) | 2020-08-17 | 2025-05-13 | 10X Genomics, Inc. | Multicomponent nucleic acid probes for sample analysis |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US12071667B2 (en) | 2020-11-04 | 2024-08-27 | 10X Genomics, Inc. | Sequence analysis using meta-stable nucleic acid molecules |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| AU2021409136A1 (en) | 2020-12-21 | 2023-06-29 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| US12060603B2 (en) | 2021-01-19 | 2024-08-13 | 10X Genomics, Inc. | Methods for internally controlled in situ assays using padlock probes |
| US12275984B2 (en) | 2021-03-02 | 2025-04-15 | 10X Genomics, Inc. | Sequential hybridization and quenching |
| WO2022216824A1 (en) * | 2021-04-06 | 2022-10-13 | Akoya Biosciences, Inc. | Detection of labeled analytes in biological samples |
| EP4305196B1 (en) | 2021-04-14 | 2025-04-02 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
| WO2022236054A1 (en) | 2021-05-06 | 2022-11-10 | 10X Genomics, Inc. | Methods for increasing resolution of spatial analysis |
| EP4341847A1 (en) * | 2021-05-19 | 2024-03-27 | Leica Microsystems CMS GmbH | Marker, method and device for analyzing a biological sample |
| CA3213718A1 (en) * | 2021-05-24 | 2022-12-01 | Long Cai | Linked amplification tethered with exponential radiance |
| WO2022256503A1 (en) | 2021-06-03 | 2022-12-08 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| US12139751B2 (en) | 2021-07-30 | 2024-11-12 | 10X Genomics, Inc. | Circularizable probes for in situ analysis |
| EP4326900B1 (en) | 2021-07-30 | 2024-09-04 | 10X Genomics, Inc. | Methods and compositions for synchronizing reactions in situ |
| US12391984B2 (en) | 2021-08-03 | 2025-08-19 | 10X Genomics, Inc. | Compositions and methods for rolling circle amplification |
| WO2023014825A1 (en) * | 2021-08-03 | 2023-02-09 | Akoya Biosciences, Inc. | Rna detection by selective labeling and amplification |
| US12460251B2 (en) | 2021-08-03 | 2025-11-04 | 10X Genomics, Inc. | Stabilization and/or compaction of nucleic acid molecules |
| US12435364B2 (en) | 2021-08-16 | 2025-10-07 | 10X Genomics, Inc. | Probes comprising a split barcode region and methods of use |
| EP4196605B1 (en) | 2021-09-01 | 2024-12-04 | 10X Genomics, Inc. | Methods for blocking a capture probe on a spatial array |
| WO2023086880A1 (en) | 2021-11-10 | 2023-05-19 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| WO2023102118A2 (en) | 2021-12-01 | 2023-06-08 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| EP4490737A1 (en) | 2022-03-08 | 2025-01-15 | 10X Genomics, Inc. | In situ code design methods for minimizing optical crowding |
| EP4499867A2 (en) | 2022-03-24 | 2025-02-05 | Digital Biology Inc. | Tissue spatial omics |
| AU2023243205A1 (en) | 2022-04-01 | 2024-09-19 | 10X Genomics, Inc. | Compositions and methods for targeted masking of autofluorescence |
| WO2023220300A1 (en) | 2022-05-11 | 2023-11-16 | 10X Genomics, Inc. | Compositions and methods for in situ sequencing |
| WO2023245190A1 (en) | 2022-06-17 | 2023-12-21 | 10X Genomics, Inc. | Catalytic de-crosslinking of samples for in situ analysis |
| US12116626B2 (en) | 2022-08-16 | 2024-10-15 | 10X Genomics, Inc. | AP50 polymerases and uses thereof |
| EP4662234A2 (en) * | 2023-02-08 | 2025-12-17 | Toreador Therapeutics, Inc. | Super-resolution microscopy (srm) multiplexing with cleavable moieties |
| WO2024196728A2 (en) | 2023-03-17 | 2024-09-26 | Nanostring Technologies, Inc. | Nucleic acid probes for combined sequencing and spatial analysis |
| WO2024196764A2 (en) | 2023-03-17 | 2024-09-26 | Nanostring Technologies, Inc. | Assay for recombinase accessible chromatin and related compositions and methods |
| US12319956B2 (en) | 2023-07-31 | 2025-06-03 | 10X Genomics, Inc. | Methods and systems for targeted RNA cleavage and target RNA-primed rolling circle amplification |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230558A (en) | 1978-10-02 | 1980-10-28 | Coulter Electronics, Inc. | Single drop separator |
| US4318846A (en) | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| US4757141A (en) | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
| US5091519A (en) | 1986-05-01 | 1992-02-25 | Amoco Corporation | Nucleotide compositions with linking groups |
| US4811218A (en) | 1986-06-02 | 1989-03-07 | Applied Biosystems, Inc. | Real time scanning electrophoresis apparatus for DNA sequencing |
| US5151507A (en) | 1986-07-02 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| US5066580A (en) | 1988-08-31 | 1991-11-19 | Becton Dickinson And Company | Xanthene dyes that emit to the red of fluorescein |
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
| US5847162A (en) | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
| US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US5853993A (en) * | 1996-10-21 | 1998-12-29 | Hewlett-Packard Company | Signal enhancement method and kit |
| US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
| US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US6426513B1 (en) | 1998-09-18 | 2002-07-30 | Massachusetts Institute Of Technology | Water-soluble thiol-capped nanocrystals |
| US6251303B1 (en) | 1998-09-18 | 2001-06-26 | Massachusetts Institute Of Technology | Water-soluble fluorescent nanocrystals |
| AU3174600A (en) * | 1999-03-10 | 2000-09-28 | Asm Scientific, Inc. | A method for direct nucleic acid sequencing |
| US6649138B2 (en) | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
| US6576291B2 (en) | 2000-12-08 | 2003-06-10 | Massachusetts Institute Of Technology | Preparation of nanocrystallites |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| JP4567436B2 (ja) | 2001-07-20 | 2010-10-20 | ライフ テクノロジーズ コーポレーション | 発光ナノ粒子およびそれらの調製方法 |
| US7057026B2 (en) * | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| WO2004067742A1 (ja) * | 2003-01-31 | 2004-08-12 | Keio University | 切断可能な対応付け分子およびそれを用いるスクリーニング方法 |
| WO2004094666A1 (en) * | 2003-04-24 | 2004-11-04 | Dzieglewska, Hanna | Allele-specific mutation detection assay |
| CN101189345A (zh) * | 2005-02-01 | 2008-05-28 | Ab先进基因分析公司 | 珠基测序的试剂、方法和文库 |
| EP1954708A4 (en) | 2005-11-23 | 2009-05-13 | Univ Utah Res Found | Methods and compositions involving intrinsic genes |
| JP2009519717A (ja) * | 2005-12-16 | 2009-05-21 | アプレラ コーポレイション | 位相を固定した配列決定のための方法およびシステム |
| EP1963500B1 (en) | 2005-12-23 | 2013-02-13 | Nanostring Technologies, Inc. | Compositions comprising oriented, immobilized macromolecules and methods for their preparation |
| WO2007076129A2 (en) | 2005-12-23 | 2007-07-05 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| AU2007268027B2 (en) | 2006-05-22 | 2012-08-09 | Bruker Spatial Biology, Inc. | Systems and methods for analyzing nanoreporters |
| US7745129B1 (en) * | 2006-07-12 | 2010-06-29 | Kenneth David Schatz | Methods for sequencing of a necleic acid |
| EP2099928B1 (en) * | 2006-12-01 | 2016-01-27 | Affymetrix, Inc. | Two-stage nucleic acid amplification using an amplification oligomer |
| EP2155899A2 (en) | 2007-04-10 | 2010-02-24 | Nanostring Technologies, Inc. | Methods and computer systems for identifying target-specific sequences for use in nanoreporters |
| WO2009046149A1 (en) * | 2007-10-01 | 2009-04-09 | Applied Biosystems Inc. | Chase ligation sequencing |
| AU2008335362B2 (en) * | 2007-12-05 | 2013-07-25 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
| US20090298709A1 (en) * | 2008-05-28 | 2009-12-03 | Affymetrix, Inc. | Assays for determining telomere length and repeated sequence copy number |
| PT2297359E (pt) | 2008-05-30 | 2014-03-19 | Univ North Carolina | Perfis de expressão de genes para prognosticar resultados relativos ao cancro da mama |
| GB2461026B (en) * | 2008-06-16 | 2011-03-09 | Plc Diagnostics Inc | System and method for nucleic acids sequencing by phased synthesis |
| EP2331704B1 (en) | 2008-08-14 | 2016-11-30 | Nanostring Technologies, Inc | Stable nanoreporters |
| US10072287B2 (en) * | 2009-09-10 | 2018-09-11 | Centrillion Technology Holdings Corporation | Methods of targeted sequencing |
| EP3236264A3 (en) | 2009-10-13 | 2017-11-08 | Nanostring Technologies, Inc | Protein detection via nanoreporters |
| CA2785529C (en) | 2010-02-11 | 2019-01-08 | Nanostring Technologies, Inc. | Compositions and methods for the detection of small rnas |
| WO2011106583A1 (en) * | 2010-02-26 | 2011-09-01 | Ventana Medical Systems, Inc. | Polytag probes |
| EP2547795B1 (en) | 2010-03-16 | 2015-01-14 | Nanostring Technologies, Inc | Compositions and methods for the detection of genomic features |
| US20120003648A1 (en) * | 2010-07-01 | 2012-01-05 | Affymetrix, Inc. | Signal Multiplexing and Signal Amplification |
| US9066963B2 (en) | 2011-03-15 | 2015-06-30 | The University Of North Carolina At Chapel Hill | Methods of treating breast cancer with anthracycline therapy |
| US9758834B2 (en) | 2011-03-28 | 2017-09-12 | Nanostring Technologies, Inc. | Compositions and methods for diagnosing cancer |
| JP6100685B2 (ja) * | 2011-05-16 | 2017-03-22 | 地方独立行政法人 大阪府立病院機構 | 血中dnaの定量的検出による悪性新生物の病勢の進行を評価する方法 |
| US20140248611A1 (en) * | 2011-06-16 | 2014-09-04 | Nippon Steel & Sumikin Eco-Tech Corporation | Nucleic acid probe for assaying nucleic acids |
| CA2839705A1 (en) | 2011-06-24 | 2012-12-27 | Nanostring Technologies, Inc. | Multivariate diagnostic assays and methods for using same |
| EP2766498B1 (en) * | 2011-10-14 | 2019-06-19 | President and Fellows of Harvard College | Sequencing by structure assembly |
| AU2012345789B2 (en) | 2011-11-30 | 2018-02-15 | British Columbia Cancer Agency Branch | Methods of treating breast cancer with taxane therapy |
| AU2013266419B2 (en) | 2012-05-22 | 2018-09-27 | British Columbia Cancer Agency Branch | NANO46 genes and methods to predict breast cancer outcome |
| CA2877378A1 (en) | 2012-06-29 | 2014-01-03 | Nanostring Technologies, Inc. | Methods of treating breast cancer with gemcitabine therapy |
| WO2014075067A1 (en) | 2012-11-12 | 2014-05-15 | Nanostring Technologies, Inc. | Methods to predict breast cancer outcome |
| WO2014182598A1 (en) * | 2013-05-06 | 2014-11-13 | Physicians Choice Laboratory Services, Llc | Diagnostic assay combining cellular and cell free nucleic acid |
| EP3008209A2 (en) * | 2013-06-14 | 2016-04-20 | Nanostring Technologies, Inc | Multiplexable tag-based reporter system |
| US20160194701A1 (en) * | 2014-11-21 | 2016-07-07 | Nanostring Technologies, Inc. | Enzyme- and amplification-free sequencing |
-
2017
- 2017-05-16 WO PCT/US2017/032947 patent/WO2017201073A1/en not_active Ceased
- 2017-05-16 KR KR1020187036460A patent/KR102490693B1/ko active Active
- 2017-05-16 EP EP23183318.7A patent/EP4324929B1/en active Active
- 2017-05-16 CN CN201780043954.2A patent/CN109715825B/zh active Active
- 2017-05-16 EP EP17726083.3A patent/EP3458601B1/en active Active
- 2017-05-16 JP JP2018560101A patent/JP7457457B2/ja active Active
- 2017-05-16 SG SG11201809913PA patent/SG11201809913PA/en unknown
- 2017-05-16 AU AU2017268257A patent/AU2017268257B2/en active Active
- 2017-05-16 US US15/597,055 patent/US20170327876A1/en not_active Abandoned
- 2017-05-16 ES ES17726083T patent/ES2956732T3/es active Active
- 2017-05-16 CN CN202211727492.5A patent/CN116200462B/zh active Active
-
2019
- 2019-05-20 US US16/417,109 patent/US20190271028A1/en not_active Abandoned
-
2022
- 2022-03-07 US US17/688,174 patent/US20220282313A1/en not_active Abandoned
- 2022-06-01 JP JP2022089840A patent/JP2022122964A/ja active Pending
-
2023
- 2023-12-06 AU AU2023278046A patent/AU2023278046A1/en active Pending
-
2024
- 2024-05-20 US US18/668,982 patent/US20240309432A1/en active Pending
- 2024-08-23 JP JP2024143175A patent/JP2024161084A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN116200462A (zh) | 2023-06-02 |
| EP3458601A1 (en) | 2019-03-27 |
| US20170327876A1 (en) | 2017-11-16 |
| KR20190012184A (ko) | 2019-02-08 |
| SG11201809913PA (en) | 2018-12-28 |
| US20190271028A1 (en) | 2019-09-05 |
| AU2017268257A1 (en) | 2018-11-29 |
| US20240309432A1 (en) | 2024-09-19 |
| AU2023278046A1 (en) | 2024-01-04 |
| JP2022122964A (ja) | 2022-08-23 |
| JP2024161084A (ja) | 2024-11-15 |
| CN109715825A (zh) | 2019-05-03 |
| CN109715825B (zh) | 2023-01-06 |
| US20220282313A1 (en) | 2022-09-08 |
| CA3023566A1 (en) | 2017-11-23 |
| EP3458601B1 (en) | 2023-07-05 |
| AU2017268257B2 (en) | 2023-09-07 |
| JP7457457B2 (ja) | 2024-03-28 |
| JP2019522463A (ja) | 2019-08-15 |
| CN116200462B (zh) | 2025-10-03 |
| EP4324929A1 (en) | 2024-02-21 |
| KR102490693B1 (ko) | 2023-01-19 |
| EP4324929B1 (en) | 2025-09-17 |
| WO2017201073A1 (en) | 2017-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2956732T3 (es) | Métodos de detección de ácidos nucleicos diana en una muestra | |
| JP7532458B2 (ja) | 化学組成物とそれを利用する方法 | |
| ES2910099T3 (es) | Secuenciación sin enzimas y sin amplificación | |
| CN118265800A (zh) | 用于多路fish的比率计量符号与顺序编码 | |
| CA3023566C (en) | Methods for detecting target nucleic acids in a sample |