ES2923298T3 - Moduladores de STING a base de ciclopentano (estimulador de los genes del interferón) - Google Patents

Moduladores de STING a base de ciclopentano (estimulador de los genes del interferón) Download PDF

Info

Publication number
ES2923298T3
ES2923298T3 ES19717149T ES19717149T ES2923298T3 ES 2923298 T3 ES2923298 T3 ES 2923298T3 ES 19717149 T ES19717149 T ES 19717149T ES 19717149 T ES19717149 T ES 19717149T ES 2923298 T3 ES2923298 T3 ES 2923298T3
Authority
ES
Spain
Prior art keywords
pharmaceutically acceptable
compound
acceptable salt
cancer
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES19717149T
Other languages
English (en)
Spanish (es)
Inventor
Martin James Wythes
Indrawan James Mcalpine
Ryan Patman
Eugene Yuanjin Rui
Andrew Fensome
Andreas Maderna
Mehran Jalaie
Ketan S Gajiwala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2923298T3 publication Critical patent/ES2923298T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES19717149T 2018-03-15 2019-03-12 Moduladores de STING a base de ciclopentano (estimulador de los genes del interferón) Active ES2923298T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862643467P 2018-03-15 2018-03-15
US201862666204P 2018-05-03 2018-05-03
US201862742532P 2018-10-08 2018-10-08
US201962809990P 2019-02-25 2019-02-25
PCT/IB2019/052009 WO2019175776A1 (fr) 2018-03-15 2019-03-12 Modulateurs de sting (stimulateur des gènes de l'interféron) à base de cyclopentane

Publications (1)

Publication Number Publication Date
ES2923298T3 true ES2923298T3 (es) 2022-09-26

Family

ID=66103038

Family Applications (1)

Application Number Title Priority Date Filing Date
ES19717149T Active ES2923298T3 (es) 2018-03-15 2019-03-12 Moduladores de STING a base de ciclopentano (estimulador de los genes del interferón)

Country Status (24)

Country Link
US (4) US10538542B2 (fr)
EP (1) EP3765474B1 (fr)
JP (1) JP7266942B2 (fr)
KR (1) KR20200131878A (fr)
CN (1) CN111918871A (fr)
AU (1) AU2019234043A1 (fr)
BR (1) BR112020018593A2 (fr)
CA (1) CA3093631C (fr)
CL (1) CL2020002352A1 (fr)
CR (1) CR20200382A (fr)
DO (1) DOP2020000160A (fr)
EC (1) ECSP20057847A (fr)
ES (1) ES2923298T3 (fr)
IL (1) IL277278A (fr)
MA (1) MA52012A (fr)
MX (1) MX2020009587A (fr)
NI (1) NI202000058A (fr)
PE (1) PE20210412A1 (fr)
PH (1) PH12020551486A1 (fr)
RU (1) RU2020130048A (fr)
SG (1) SG11202008102VA (fr)
TW (1) TWI741268B (fr)
UY (1) UY38145A (fr)
WO (1) WO2019175776A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11203610B2 (en) 2017-12-20 2021-12-21 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
JP7037667B2 (ja) 2017-12-20 2022-03-16 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する３’３’環状ジヌクレオチド
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TW202028179A (zh) 2018-10-08 2020-08-01 美商普萊恩醫療公司 胺基酸化合物及使用方法
CA3155569A1 (fr) * 2019-09-25 2021-04-01 Pfizer Inc. Modulateurs polyheterocycliques de sting (stimulateur des genes de l'interferon)
TW202200136A (zh) 2020-04-10 2022-01-01 日商小野藥品工業股份有限公司 癌治療方法
US11964978B2 (en) * 2021-03-18 2024-04-23 Pfizer Inc. Modulators of STING (stimulator of interferon genes)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
PE20170198A1 (es) 2014-06-04 2017-04-08 Glaxosmithkline Ip Dev Ltd Dinucleotidos ciclicos como moduladores de sting
GB201501462D0 (en) 2015-01-29 2015-03-18 Glaxosmithkline Ip Dev Ltd Novel compounds

Also Published As

Publication number Publication date
PE20210412A1 (es) 2021-03-04
SG11202008102VA (en) 2020-09-29
BR112020018593A2 (pt) 2020-12-29
EP3765474B1 (fr) 2022-06-15
ECSP20057847A (es) 2021-04-29
RU2020130048A3 (fr) 2022-04-15
WO2019175776A1 (fr) 2019-09-19
EP3765474A1 (fr) 2021-01-20
IL277278A (en) 2020-10-29
US10538542B2 (en) 2020-01-21
UY38145A (es) 2019-10-31
JP2021518335A (ja) 2021-08-02
US10968242B2 (en) 2021-04-06
CN111918871A (zh) 2020-11-10
MA52012A (fr) 2021-01-20
CA3093631A1 (fr) 2019-09-19
CR20200382A (es) 2020-12-10
US20190284216A1 (en) 2019-09-19
CL2020002352A1 (es) 2020-12-18
MX2020009587A (es) 2020-10-05
CA3093631C (fr) 2023-01-24
US20200102334A1 (en) 2020-04-02
AU2019234043A1 (en) 2020-09-17
DOP2020000160A (es) 2020-09-30
TW201945036A (zh) 2019-12-01
JP7266942B2 (ja) 2023-05-01
US20230382932A1 (en) 2023-11-30
PH12020551486A1 (en) 2021-08-23
NI202000058A (es) 2021-01-08
KR20200131878A (ko) 2020-11-24
TWI741268B (zh) 2021-10-01
US20210230196A1 (en) 2021-07-29
RU2020130048A (ru) 2022-04-15

Similar Documents

Publication Publication Date Title
ES2923298T3 (es) Moduladores de STING a base de ciclopentano (estimulador de los genes del interferón)
ES2848724T3 (es) Compuestos dinucleotídicos cíclicos
AU2018229498B2 (en) Heterocyclic amides useful as protein modulators
EP3728282B1 (fr) Dinucléotides 2'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting
EP3728283B1 (fr) Dinucléotides 3'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting
ES2623794T3 (es) Intermedios para la preparación de moduladores de receptores tipo toll
AU2018212788A1 (en) Cyclic dinucleotides as STING agonists
ES2909616T3 (es) Dinucleótidos cíclicos como agentes anticáncer
JP6831324B2 (ja) 特定のタンパク質キナーゼ阻害剤
EP3762397A1 (fr) Dinucléotides cycliques en tant qu'agents anticancéreux
WO2019052359A1 (fr) Effet antitumoral et utilisation d'analogue de ribavirine dihétérocyclique
OA19842A (en) Cyclopentane-based modulators of sting (stimulator of interferon genes).
KR20230107586A (ko) 다기능성 사이클릭 디뉴클레오티드 및 이의 용도
EA046381B1 (ru) Ингибиторы эктонуклеотидазы и способы их применения
BR102017021041A2 (pt) Compostos de dinucleotídeo cíclico