ES2884674T3 - Tratamiento del cáncer con el profármaco activado por hipoxia TH-302 en combinación con docetaxel o pemetrexed - Google Patents
Tratamiento del cáncer con el profármaco activado por hipoxia TH-302 en combinación con docetaxel o pemetrexed Download PDFInfo
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- ES2884674T3 ES2884674T3 ES09822657T ES09822657T ES2884674T3 ES 2884674 T3 ES2884674 T3 ES 2884674T3 ES 09822657 T ES09822657 T ES 09822657T ES 09822657 T ES09822657 T ES 09822657T ES 2884674 T3 ES2884674 T3 ES 2884674T3
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10725308P | 2008-10-21 | 2008-10-21 | |
| US11836808P | 2008-11-26 | 2008-11-26 | |
| US15070009P | 2009-02-06 | 2009-02-06 | |
| US15116309P | 2009-02-09 | 2009-02-09 | |
| US24417209P | 2009-09-21 | 2009-09-21 | |
| PCT/US2009/061541 WO2010048330A1 (en) | 2008-10-21 | 2009-10-21 | Treatment of cancer using hypoxia activated prodrugs |
Publications (1)
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| ES2884674T3 true ES2884674T3 (es) | 2021-12-10 |
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| WO (1) | WO2010048330A1 (enExample) |
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| WO2013096684A1 (en) * | 2011-12-22 | 2013-06-27 | Threshold Pharmaceuticals, Inc. | Hypoxia activated prodrugs and mtor inhibitors for treating cancer |
| EP2793882A4 (en) | 2011-12-22 | 2015-04-29 | Threshold Pharmaceuticals Inc | ADMINISTRATION OF HYPOXIA-ACTIVATED PRODRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER |
| ES2909741T3 (es) * | 2012-02-21 | 2022-05-10 | Immunogenesis Inc | Tratamiento del cáncer |
| JP2014001204A (ja) * | 2012-05-23 | 2014-01-09 | Kumamoto Univ | 腫瘍細胞選択的抗がん剤 |
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| EP2983591A4 (en) * | 2013-04-10 | 2016-12-28 | Threshold Pharmaceuticals Inc | PREDICTIVE AND RESPONSE BIOMARKERS FOR TH-302 CANCER THERAPY |
| US20160158253A1 (en) | 2013-07-26 | 2016-06-09 | Threshold Pharmaceuticals, Inc. | Treatment of pancreatic cancer with a combination of a hypoxia-activated prodrug and a taxane |
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| CN104628772A (zh) * | 2013-11-07 | 2015-05-20 | 四川恒康发展有限责任公司 | 一种抗肿瘤前药及其激活剂、组合物和应用 |
| KR102359214B1 (ko) | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
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| MY192888A (en) | 2015-03-10 | 2022-09-14 | Ascentawits Pharmaceuticals Ltd | Dna alkylating agents |
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| JP2019094284A (ja) * | 2017-11-21 | 2019-06-20 | 日本化薬株式会社 | ペメトレキセドを含有する注射用溶液製剤 |
| CN109999183B (zh) * | 2019-04-15 | 2021-03-09 | 中国科学技术大学 | 一种含有乏氧激活前药的纳米簇化酶及其制备方法和应用 |
| JP7762796B2 (ja) | 2021-08-27 | 2025-10-30 | アセンタウィッツ ファーマシューティカルズ リミテッド | Ｐａｒｐ阻害剤に耐性のある患者のｔｈ－３０２による治療 |
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| WO2023198188A1 (zh) | 2022-04-15 | 2023-10-19 | 深圳艾欣达伟医药科技有限公司 | 使用th-302单药或联用parp抑制剂治疗癌症的方法 |
| WO2023226959A1 (zh) | 2022-05-23 | 2023-11-30 | 深圳艾欣达伟医药科技有限公司 | 烷化剂前药与细胞周期抑制剂联用治疗癌症的方法 |
| EP4591866A1 (en) | 2022-09-22 | 2025-07-30 | Ascentawits Pharmaceuticals, Ltd. | Use of hypoxia-activated compound in preparation of medicament for treating cancer patient |
| TW202434258A (zh) * | 2023-02-27 | 2024-09-01 | 大陸商深圳艾欣達偉醫藥科技有限公司 | 溶液、凍乾製劑、凍乾製劑單位包裝、注射液及注射液配製方法 |
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| ES2884044T3 (es) | 2006-12-26 | 2021-12-10 | Immunogenesis Inc | Profármaco alquilante de fosforamidato para el tratamiento del cáncer |
| WO2008151253A1 (en) | 2007-06-04 | 2008-12-11 | Threshold Pharmaceuticals, Inc. | Hypoxia activated prodrugs of antineoplastic agents |
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| WO2009033165A1 (en) | 2007-09-06 | 2009-03-12 | Threshold Pharmaceuticals, Inc. | Hypoxia activated prodrugs of bis-alkylating agents |
-
2009
- 2009-10-21 US US13/125,303 patent/US8946275B2/en active Active
- 2009-10-21 JP JP2011533309A patent/JP5765634B2/ja active Active
- 2009-10-21 ES ES09822657T patent/ES2884674T3/es active Active
- 2009-10-21 EP EP09822657.4A patent/EP2350664B1/en active Active
- 2009-10-21 WO PCT/US2009/061541 patent/WO2010048330A1/en not_active Ceased
-
2014
- 2014-12-17 US US14/574,082 patent/US20150258125A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5765634B2 (ja) | 2015-08-19 |
| EP2350664A1 (en) | 2011-08-03 |
| EP2350664A4 (en) | 2014-04-30 |
| EP2350664B1 (en) | 2021-05-19 |
| US20150258125A1 (en) | 2015-09-17 |
| WO2010048330A1 (en) | 2010-04-29 |
| US20130202716A1 (en) | 2013-08-08 |
| JP2012506448A (ja) | 2012-03-15 |
| US8946275B2 (en) | 2015-02-03 |
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