ES2884674T3 - Tratamiento del cáncer con el profármaco activado por hipoxia TH-302 en combinación con docetaxel o pemetrexed - Google Patents
Tratamiento del cáncer con el profármaco activado por hipoxia TH-302 en combinación con docetaxel o pemetrexed Download PDFInfo
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- ES2884674T3 ES2884674T3 ES09822657T ES09822657T ES2884674T3 ES 2884674 T3 ES2884674 T3 ES 2884674T3 ES 09822657 T ES09822657 T ES 09822657T ES 09822657 T ES09822657 T ES 09822657T ES 2884674 T3 ES2884674 T3 ES 2884674T3
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10725308P | 2008-10-21 | 2008-10-21 | |
| US11836808P | 2008-11-26 | 2008-11-26 | |
| US15070009P | 2009-02-06 | 2009-02-06 | |
| US15116309P | 2009-02-09 | 2009-02-09 | |
| US24417209P | 2009-09-21 | 2009-09-21 | |
| PCT/US2009/061541 WO2010048330A1 (en) | 2008-10-21 | 2009-10-21 | Treatment of cancer using hypoxia activated prodrugs |
Publications (1)
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| ES2884674T3 true ES2884674T3 (es) | 2021-12-10 |
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| JP2015500884A (ja) * | 2011-12-22 | 2015-01-08 | スレッショルド ファーマシューティカルズ，インコーポレイテッド | 癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤 |
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| WO2016011195A1 (en) * | 2014-07-17 | 2016-01-21 | Threshold Pharmaceuticals, Inc. | Th-302 solid forms and methods related thereto |
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| JP2019094284A (ja) * | 2017-11-21 | 2019-06-20 | 日本化薬株式会社 | ペメトレキセドを含有する注射用溶液製剤 |
| CN109999183B (zh) * | 2019-04-15 | 2021-03-09 | 中国科学技术大学 | 一种含有乏氧激活前药的纳米簇化酶及其制备方法和应用 |
| WO2023025291A1 (zh) * | 2021-08-27 | 2023-03-02 | 深圳艾欣达伟医药科技有限公司 | 冻干制剂溶液及冻干制剂、方法和用途 |
| US20250387419A1 (en) | 2021-08-27 | 2025-12-25 | Ascentawits Pharmaceuticals, Ltd. | Parp inhibitor-resistant patient treated with th-302 |
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| CN119233822A (zh) | 2022-05-23 | 2024-12-31 | 深圳艾欣达伟医药科技有限公司 | 烷化剂前药与细胞周期抑制剂联用治疗癌症的方法 |
| CN119894521A (zh) | 2022-09-22 | 2025-04-25 | 深圳艾欣达伟医药科技有限公司 | 乏氧激活的化合物在制备治疗癌症患者的药物中的用途 |
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| BRPI0612845A8 (pt) * | 2005-06-29 | 2018-01-23 | Threshold Pharmaceuticals Inc | composto, formulação farmacêutica, métodos para tratar câncer e para sintetizar um composto de fórmula alq-dispasador |
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| WO2009033165A1 (en) | 2007-09-06 | 2009-03-12 | Threshold Pharmaceuticals, Inc. | Hypoxia activated prodrugs of bis-alkylating agents |
-
2009
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- 2009-10-21 ES ES09822657T patent/ES2884674T3/es active Active
- 2009-10-21 JP JP2011533309A patent/JP5765634B2/ja active Active
- 2009-10-21 EP EP09822657.4A patent/EP2350664B1/en active Active
- 2009-10-21 WO PCT/US2009/061541 patent/WO2010048330A1/en not_active Ceased
-
2014
- 2014-12-17 US US14/574,082 patent/US20150258125A1/en not_active Abandoned
Also Published As
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| US20130202716A1 (en) | 2013-08-08 |
| EP2350664B1 (en) | 2021-05-19 |
| EP2350664A1 (en) | 2011-08-03 |
| JP2012506448A (ja) | 2012-03-15 |
| EP2350664A4 (en) | 2014-04-30 |
| US8946275B2 (en) | 2015-02-03 |
| US20150258125A1 (en) | 2015-09-17 |
| WO2010048330A1 (en) | 2010-04-29 |
| JP5765634B2 (ja) | 2015-08-19 |
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