ES2880029T3 - Derivados de anfotericina B - Google Patents
Derivados de anfotericina B Download PDFInfo
- Publication number
- ES2880029T3 ES2880029T3 ES16780813T ES16780813T ES2880029T3 ES 2880029 T3 ES2880029 T3 ES 2880029T3 ES 16780813 T ES16780813 T ES 16780813T ES 16780813 T ES16780813 T ES 16780813T ES 2880029 T3 ES2880029 T3 ES 2880029T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- alkyl
- group
- substituted
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *N(*)C1OC1N(*)* Chemical compound *N(*)C1OC1N(*)* 0.000 description 18
- POOPWPIOIMBTOH-UHFFFAOYSA-O C(C1)C2OC1C[NH2+]C2 Chemical compound C(C1)C2OC1C[NH2+]C2 POOPWPIOIMBTOH-UHFFFAOYSA-O 0.000 description 1
- GWVMLCQWXVFZCN-UHFFFAOYSA-O C1[NH2+]Cc2c1cccc2 Chemical compound C1[NH2+]Cc2c1cccc2 GWVMLCQWXVFZCN-UHFFFAOYSA-O 0.000 description 1
- DYEYPHPPTYUUQQ-UHFFFAOYSA-N CC(C1C(C)CC=CC1)N Chemical compound CC(C1C(C)CC=CC1)N DYEYPHPPTYUUQQ-UHFFFAOYSA-N 0.000 description 1
- YUTLQJWEGKHPKK-UHFFFAOYSA-N CC(N1CC(CN)C1)=O Chemical compound CC(N1CC(CN)C1)=O YUTLQJWEGKHPKK-UHFFFAOYSA-N 0.000 description 1
- XTGCJRCYGWLUHJ-UHFFFAOYSA-N CN1CCOCCC1 Chemical compound CN1CCOCCC1 XTGCJRCYGWLUHJ-UHFFFAOYSA-N 0.000 description 1
- JMGQDYJFBQGUDC-ZBHICJROSA-N CN1[C@@H](C2)COC2C1 Chemical compound CN1[C@@H](C2)COC2C1 JMGQDYJFBQGUDC-ZBHICJROSA-N 0.000 description 1
- QWCGXANSAOXRFE-UHFFFAOYSA-N COCCOCCN Chemical compound COCCOCCN QWCGXANSAOXRFE-UHFFFAOYSA-N 0.000 description 1
- CDDGNGVFPQRJJM-UHFFFAOYSA-N FC1CNCC1 Chemical compound FC1CNCC1 CDDGNGVFPQRJJM-UHFFFAOYSA-N 0.000 description 1
- KTHZBRAXOLUNBN-UHFFFAOYSA-N NCC1COC1 Chemical compound NCC1COC1 KTHZBRAXOLUNBN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562147949P | 2015-04-15 | 2015-04-15 | |
| PCT/US2016/027703 WO2016168568A1 (en) | 2015-04-15 | 2016-04-15 | Derivatives of amphotericin b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2880029T3 true ES2880029T3 (es) | 2021-11-23 |
Family
ID=57126898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16780813T Active ES2880029T3 (es) | 2015-04-15 | 2016-04-15 | Derivados de anfotericina B |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9957290B2 (OSRAM) |
| EP (2) | EP3929203A1 (OSRAM) |
| JP (3) | JP7240811B2 (OSRAM) |
| CA (2) | CA3213127A1 (OSRAM) |
| ES (1) | ES2880029T3 (OSRAM) |
| PT (1) | PT3283171T (OSRAM) |
| WO (1) | WO2016168568A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105848721B (zh) | 2013-10-07 | 2019-08-23 | 伊利诺伊大学评议会 | 具有提高的治疗指数的两性霉素b衍生物 |
| MA39568A1 (fr) * | 2014-06-12 | 2017-09-29 | Shionogi & Co | Dérivé de macrolide de polyène |
| WO2016168568A1 (en) * | 2015-04-15 | 2016-10-20 | Revolution Medicines, Inc. | Derivatives of amphotericin b |
| WO2017100171A1 (en) * | 2015-12-08 | 2017-06-15 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| WO2018106571A1 (en) * | 2016-12-06 | 2018-06-14 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| JP7477177B2 (ja) * | 2018-09-07 | 2024-05-01 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ | 毒性が低減されたハイブリッドアムホテリシンｂ誘導体 |
| EP4009984A4 (en) * | 2019-08-08 | 2023-09-06 | The Board Of Trustees Of The University Of Illinois | HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY |
| AU2020325163A1 (en) * | 2019-08-08 | 2022-03-03 | The Board Of Trustees Of The University Of Illinois | Hybrid amide derivatives of amphotericin B |
| FR3112145A1 (fr) * | 2020-07-03 | 2022-01-07 | Nanotracks Diagnostics | Derives uree de macrolides polyeniques, composes chimiques particuliers susceptibles d’etre utilises pour obtenir ces derives uree, compositions les contenant et utilisations |
| WO2022003181A1 (fr) * | 2020-07-03 | 2022-01-06 | Nanotracks Diagnostics | Derivés urée de l'amphotéricine amb, compositions les contenant et leurs utilisations, dérivés isocyanate d'alkyle omega-aminés et leur utilisation pour obtenir lesdits dérivés urée |
| EP4192248B1 (en) * | 2020-08-10 | 2025-12-03 | The Board Of Trustees Of The University Of Illinois | Hybrid amide derivatives of amphotericin b |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8829592D0 (en) | 1988-12-19 | 1989-02-08 | Beecham Group Plc | Novel compounds |
| EP0350164A3 (en) * | 1988-06-13 | 1991-07-24 | Beecham Group Plc | Amphotericin derivatives |
| EP0431870A1 (en) * | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Amphotericin B derivatives |
| JP3507486B2 (ja) | 1991-03-15 | 2004-03-15 | アムジエン・インコーポレーテツド | 顆粒球コロニー刺激因子の肺内投与 |
| GB9203476D0 (en) | 1992-02-19 | 1992-04-08 | Smithkline Beecham Plc | Novel compounds |
| US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| US5606038A (en) | 1995-04-10 | 1997-02-25 | Competitive Technologies, Inc. | Amphiphilic polyene macrolide antibiotic compounds |
| PL180253B1 (pl) * | 1995-05-13 | 2001-01-31 | Politechnika Gdanska | Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL |
| US6664241B2 (en) | 2000-05-31 | 2003-12-16 | Micrologix Biotech Inc. | Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof |
| EP1987049A1 (en) * | 2006-02-23 | 2008-11-05 | ETH Zürich | Amphotericin derivatives |
| JP5240704B2 (ja) * | 2007-10-05 | 2013-07-17 | 国立大学法人群馬大学 | 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法 |
| WO2013186384A1 (en) | 2012-06-15 | 2013-12-19 | Blirt S.A. | N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application |
| WO2014165676A1 (en) | 2013-04-03 | 2014-10-09 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| CN105848721B (zh) * | 2013-10-07 | 2019-08-23 | 伊利诺伊大学评议会 | 具有提高的治疗指数的两性霉素b衍生物 |
| WO2015164289A1 (en) * | 2014-04-21 | 2015-10-29 | Cidara Therapeutics, Inc. | Compositions and methods for the treatment of fungal infections |
| JP6543272B2 (ja) | 2014-05-16 | 2019-07-10 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ | 低減された毒性を有するアンホテリシンｂ誘導体 |
| MA39568A1 (fr) | 2014-06-12 | 2017-09-29 | Shionogi & Co | Dérivé de macrolide de polyène |
| WO2016014779A1 (en) | 2014-07-23 | 2016-01-28 | The Board Of Trustees Of The University Of Illinois | Antifungal polyene macrolide derivatives with reduced mammalian toxicity |
| WO2016040779A1 (en) | 2014-09-12 | 2016-03-17 | The Board Of Trustees Of The University Of Illinois | Urea derivatives of polyene macrolide antibiotics |
| US10087206B2 (en) | 2014-10-17 | 2018-10-02 | The Board Of Trustees Of The University Of Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin B |
| WO2016112243A1 (en) | 2015-01-08 | 2016-07-14 | The Board Of Trustees Of The University Of Illinois | Urea derivatives of amphotericin b derived from secondary amines |
| US20180273571A1 (en) | 2015-01-08 | 2018-09-27 | The Board Of Trustees Of The University Of Illinois | Concise synthesis of urea derivatives of amphotericin b |
| WO2016168568A1 (en) * | 2015-04-15 | 2016-10-20 | Revolution Medicines, Inc. | Derivatives of amphotericin b |
-
2016
- 2016-04-15 WO PCT/US2016/027703 patent/WO2016168568A1/en not_active Ceased
- 2016-04-15 CA CA3213127A patent/CA3213127A1/en active Pending
- 2016-04-15 CA CA3021061A patent/CA3021061C/en active Active
- 2016-04-15 US US15/099,837 patent/US9957290B2/en active Active
- 2016-04-15 EP EP21175661.4A patent/EP3929203A1/en active Pending
- 2016-04-15 PT PT167808138T patent/PT3283171T/pt unknown
- 2016-04-15 ES ES16780813T patent/ES2880029T3/es active Active
- 2016-04-15 EP EP16780813.8A patent/EP3283171B1/en active Active
- 2016-04-15 JP JP2017553875A patent/JP7240811B2/ja active Active
-
2018
- 2018-04-09 US US15/948,122 patent/US10597420B2/en active Active
-
2020
- 2020-02-25 US US16/800,694 patent/US10882883B2/en active Active
-
2021
- 2021-02-16 JP JP2021022476A patent/JP2021075570A/ja not_active Abandoned
-
2022
- 2022-12-22 JP JP2022205228A patent/JP2023030103A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018514522A (ja) | 2018-06-07 |
| US10882883B2 (en) | 2021-01-05 |
| EP3283171B1 (en) | 2021-05-26 |
| WO2016168568A1 (en) | 2016-10-20 |
| US9957290B2 (en) | 2018-05-01 |
| CA3021061C (en) | 2023-10-24 |
| JP7240811B2 (ja) | 2023-03-16 |
| CA3213127A1 (en) | 2016-10-20 |
| US20160304548A1 (en) | 2016-10-20 |
| US20200262858A1 (en) | 2020-08-20 |
| JP2021075570A (ja) | 2021-05-20 |
| HK1244248A1 (zh) | 2018-08-03 |
| CA3021061A1 (en) | 2016-10-20 |
| US10597420B2 (en) | 2020-03-24 |
| PT3283171T (pt) | 2021-07-14 |
| EP3283171A4 (en) | 2019-03-13 |
| JP2023030103A (ja) | 2023-03-07 |
| EP3929203A1 (en) | 2021-12-29 |
| US20180273572A1 (en) | 2018-09-27 |
| EP3283171A1 (en) | 2018-02-21 |
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