JP7240811B2 - アムホテリシンｂの誘導体 - Google Patents

アムホテリシンｂの誘導体 Download PDF

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Publication number
JP7240811B2
JP7240811B2 JP2017553875A JP2017553875A JP7240811B2 JP 7240811 B2 JP7240811 B2 JP 7240811B2 JP 2017553875 A JP2017553875 A JP 2017553875A JP 2017553875 A JP2017553875 A JP 2017553875A JP 7240811 B2 JP7240811 B2 JP 7240811B2
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JP
Japan
Prior art keywords
alkyl
compound
group
cycloalkyl
heterocyclyl
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JP2017553875A
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English (en)
Japanese (ja)
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JP2018514522A (ja
JP2018514522A5 (OSRAM
Inventor
ディー バーク，マーティン
ピー トットゥムカラ，アルン
ティー メレム，ケヴィン
ケイ スウィーニー，ザッカリー
エス コルタン，エレナ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elion Therapeutics Inc
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Sfunga Therapeutics Inc
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Application filed by Sfunga Therapeutics Inc filed Critical Sfunga Therapeutics Inc
Publication of JP2018514522A publication Critical patent/JP2018514522A/ja
Publication of JP2018514522A5 publication Critical patent/JP2018514522A5/ja
Priority to JP2022205228A priority Critical patent/JP2023030103A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2017553875A 2015-04-15 2016-04-15 アムホテリシンｂの誘導体 Active JP7240811B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022205228A JP2023030103A (ja) 2015-04-15 2022-12-22 アムホテリシンｂの誘導体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562147949P 2015-04-15 2015-04-15
US62/147,949 2015-04-15
PCT/US2016/027703 WO2016168568A1 (en) 2015-04-15 2016-04-15 Derivatives of amphotericin b

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2021022476A Division JP2021075570A (ja) 2015-04-15 2021-02-16 アムホテリシンｂの誘導体
JP2022205228A Division JP2023030103A (ja) 2015-04-15 2022-12-22 アムホテリシンｂの誘導体

Publications (3)

Publication Number Publication Date
JP2018514522A JP2018514522A (ja) 2018-06-07
JP2018514522A5 JP2018514522A5 (OSRAM) 2021-04-08
JP7240811B2 true JP7240811B2 (ja) 2023-03-16

Family

ID=57126898

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017553875A Active JP7240811B2 (ja) 2015-04-15 2016-04-15 アムホテリシンｂの誘導体
JP2021022476A Abandoned JP2021075570A (ja) 2015-04-15 2021-02-16 アムホテリシンｂの誘導体
JP2022205228A Pending JP2023030103A (ja) 2015-04-15 2022-12-22 アムホテリシンｂの誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021022476A Abandoned JP2021075570A (ja) 2015-04-15 2021-02-16 アムホテリシンｂの誘導体
JP2022205228A Pending JP2023030103A (ja) 2015-04-15 2022-12-22 アムホテリシンｂの誘導体

Country Status (7)

Country Link
US (3) US9957290B2 (OSRAM)
EP (2) EP3929203A1 (OSRAM)
JP (3) JP7240811B2 (OSRAM)
CA (2) CA3213127A1 (OSRAM)
ES (1) ES2880029T3 (OSRAM)
PT (1) PT3283171T (OSRAM)
WO (1) WO2016168568A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105848721B (zh) 2013-10-07 2019-08-23 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
MA39568A1 (fr) * 2014-06-12 2017-09-29 Shionogi & Co Dérivé de macrolide de polyène
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
JP7477177B2 (ja) * 2018-09-07 2024-05-01 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
EP4009984A4 (en) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY
AU2020325163A1 (en) * 2019-08-08 2022-03-03 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin B
FR3112145A1 (fr) * 2020-07-03 2022-01-07 Nanotracks Diagnostics Derives uree de macrolides polyeniques, composes chimiques particuliers susceptibles d’etre utilises pour obtenir ces derives uree, compositions les contenant et utilisations
WO2022003181A1 (fr) * 2020-07-03 2022-01-06 Nanotracks Diagnostics Derivés urée de l'amphotéricine amb, compositions les contenant et leurs utilisations, dérivés isocyanate d'alkyle omega-aminés et leur utilisation pour obtenir lesdits dérivés urée
EP4192248B1 (en) * 2020-08-10 2025-12-03 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin b

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017034A1 (en) 1992-02-19 1993-09-02 Smithkline Beecham Plc Amphotericin b derivatives
WO1996032404A1 (en) 1995-04-10 1996-10-17 Competitive Technologies Of Pa, Inc. Amphiphilic polyene macrolide antibiotic compounds
JP2003534382A (ja) 2000-05-31 2003-11-18 マイクロロジックス バイオテック，インコーポレイテッド ポリエンマクロライドの水溶性アミド誘導体ならびにそれらの調製および使用
WO2013186384A1 (en) 2012-06-15 2013-12-19 Blirt S.A. N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application
JP2018502851A (ja) 2015-01-08 2018-02-01 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ アムホテリシンｂの尿素誘導体の簡便な合成法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8829592D0 (en) 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
EP0350164A3 (en) * 1988-06-13 1991-07-24 Beecham Group Plc Amphotericin derivatives
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
JP3507486B2 (ja) 1991-03-15 2004-03-15 アムジエン・インコーポレーテツド 顆粒球コロニー刺激因子の肺内投与
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
PL180253B1 (pl) * 1995-05-13 2001-01-31 Politechnika Gdanska Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL
EP1987049A1 (en) * 2006-02-23 2008-11-05 ETH Zürich Amphotericin derivatives
JP5240704B2 (ja) * 2007-10-05 2013-07-17 国立大学法人群馬大学 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法
WO2014165676A1 (en) 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
CN105848721B (zh) * 2013-10-07 2019-08-23 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
WO2015164289A1 (en) * 2014-04-21 2015-10-29 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
JP6543272B2 (ja) 2014-05-16 2019-07-10 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 低減された毒性を有するアンホテリシンｂ誘導体
MA39568A1 (fr) 2014-06-12 2017-09-29 Shionogi & Co Dérivé de macrolide de polyène
WO2016014779A1 (en) 2014-07-23 2016-01-28 The Board Of Trustees Of The University Of Illinois Antifungal polyene macrolide derivatives with reduced mammalian toxicity
WO2016040779A1 (en) 2014-09-12 2016-03-17 The Board Of Trustees Of The University Of Illinois Urea derivatives of polyene macrolide antibiotics
US10087206B2 (en) 2014-10-17 2018-10-02 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B
WO2016112243A1 (en) 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Urea derivatives of amphotericin b derived from secondary amines
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017034A1 (en) 1992-02-19 1993-09-02 Smithkline Beecham Plc Amphotericin b derivatives
WO1996032404A1 (en) 1995-04-10 1996-10-17 Competitive Technologies Of Pa, Inc. Amphiphilic polyene macrolide antibiotic compounds
JP2003534382A (ja) 2000-05-31 2003-11-18 マイクロロジックス バイオテック，インコーポレイテッド ポリエンマクロライドの水溶性アミド誘導体ならびにそれらの調製および使用
WO2013186384A1 (en) 2012-06-15 2013-12-19 Blirt S.A. N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application
JP2018502851A (ja) 2015-01-08 2018-02-01 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ アムホテリシンｂの尿素誘導体の簡便な合成法

Also Published As

Publication number Publication date
JP2018514522A (ja) 2018-06-07
US10882883B2 (en) 2021-01-05
EP3283171B1 (en) 2021-05-26
WO2016168568A1 (en) 2016-10-20
US9957290B2 (en) 2018-05-01
CA3021061C (en) 2023-10-24
CA3213127A1 (en) 2016-10-20
US20160304548A1 (en) 2016-10-20
US20200262858A1 (en) 2020-08-20
JP2021075570A (ja) 2021-05-20
HK1244248A1 (zh) 2018-08-03
CA3021061A1 (en) 2016-10-20
ES2880029T3 (es) 2021-11-23
US10597420B2 (en) 2020-03-24
PT3283171T (pt) 2021-07-14
EP3283171A4 (en) 2019-03-13
JP2023030103A (ja) 2023-03-07
EP3929203A1 (en) 2021-12-29
US20180273572A1 (en) 2018-09-27
EP3283171A1 (en) 2018-02-21

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