JP2018514522A5 - - Google Patents
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- Publication number
- JP2018514522A5 JP2018514522A5 JP2017553875A JP2017553875A JP2018514522A5 JP 2018514522 A5 JP2018514522 A5 JP 2018514522A5 JP 2017553875 A JP2017553875 A JP 2017553875A JP 2017553875 A JP2017553875 A JP 2017553875A JP 2018514522 A5 JP2018514522 A5 JP 2018514522A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- heterocyclyl
- cycloalkyl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- -1 haloalkyl compound Chemical class 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 0 CNc1c[n](*)nc1 Chemical compound CNc1c[n](*)nc1 0.000 description 4
- WHZFORZLQNBCRK-UHFFFAOYSA-N CC(C)(CNC)C(O)=O Chemical compound CC(C)(CNC)C(O)=O WHZFORZLQNBCRK-UHFFFAOYSA-N 0.000 description 1
- PUCIFWNOVLZUQE-UHFFFAOYSA-N CNC(C1)CC1C(O)=O Chemical compound CNC(C1)CC1C(O)=O PUCIFWNOVLZUQE-UHFFFAOYSA-N 0.000 description 1
- GUBJAZXBGXPDQU-UHFFFAOYSA-N CNCC(NS(C1CC1)(=O)=O)=O Chemical compound CNCC(NS(C1CC1)(=O)=O)=O GUBJAZXBGXPDQU-UHFFFAOYSA-N 0.000 description 1
- INHXDXHRLDILRK-UHFFFAOYSA-N CNCCc1nnn[nH]1 Chemical compound CNCCc1nnn[nH]1 INHXDXHRLDILRK-UHFFFAOYSA-N 0.000 description 1
- LQICKCWPFRQEFI-UHFFFAOYSA-N CNc1nnn[nH]1 Chemical compound CNc1nnn[nH]1 LQICKCWPFRQEFI-UHFFFAOYSA-N 0.000 description 1
- YKAVYNOVGOFMCC-UHFFFAOYSA-N C[Cs](C)Nc1ncn[nH]1 Chemical compound C[Cs](C)Nc1ncn[nH]1 YKAVYNOVGOFMCC-UHFFFAOYSA-N 0.000 description 1
- ZHCLIFKUVIFYBY-UHFFFAOYSA-N NCc1nnn[nH]1 Chemical compound NCc1nnn[nH]1 ZHCLIFKUVIFYBY-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022205228A JP2023030103A (ja) | 2015-04-15 | 2022-12-22 | アムホテリシンｂの誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562147949P | 2015-04-15 | 2015-04-15 | |
| US62/147,949 | 2015-04-15 | ||
| PCT/US2016/027703 WO2016168568A1 (en) | 2015-04-15 | 2016-04-15 | Derivatives of amphotericin b |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021022476A Division JP2021075570A (ja) | 2015-04-15 | 2021-02-16 | アムホテリシンｂの誘導体 |
| JP2022205228A Division JP2023030103A (ja) | 2015-04-15 | 2022-12-22 | アムホテリシンｂの誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514522A JP2018514522A (ja) | 2018-06-07 |
| JP2018514522A5 true JP2018514522A5 (OSRAM) | 2021-04-08 |
| JP7240811B2 JP7240811B2 (ja) | 2023-03-16 |
Family
ID=57126898
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553875A Active JP7240811B2 (ja) | 2015-04-15 | 2016-04-15 | アムホテリシンｂの誘導体 |
| JP2021022476A Abandoned JP2021075570A (ja) | 2015-04-15 | 2021-02-16 | アムホテリシンｂの誘導体 |
| JP2022205228A Pending JP2023030103A (ja) | 2015-04-15 | 2022-12-22 | アムホテリシンｂの誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021022476A Abandoned JP2021075570A (ja) | 2015-04-15 | 2021-02-16 | アムホテリシンｂの誘導体 |
| JP2022205228A Pending JP2023030103A (ja) | 2015-04-15 | 2022-12-22 | アムホテリシンｂの誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9957290B2 (OSRAM) |
| EP (2) | EP3929203A1 (OSRAM) |
| JP (3) | JP7240811B2 (OSRAM) |
| CA (2) | CA3213127A1 (OSRAM) |
| ES (1) | ES2880029T3 (OSRAM) |
| PT (1) | PT3283171T (OSRAM) |
| WO (1) | WO2016168568A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105848721B (zh) | 2013-10-07 | 2019-08-23 | 伊利诺伊大学评议会 | 具有提高的治疗指数的两性霉素b衍生物 |
| MA39568A1 (fr) * | 2014-06-12 | 2017-09-29 | Shionogi & Co | Dérivé de macrolide de polyène |
| WO2016168568A1 (en) * | 2015-04-15 | 2016-10-20 | Revolution Medicines, Inc. | Derivatives of amphotericin b |
| WO2017100171A1 (en) * | 2015-12-08 | 2017-06-15 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| WO2018106571A1 (en) * | 2016-12-06 | 2018-06-14 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| JP7477177B2 (ja) * | 2018-09-07 | 2024-05-01 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ | 毒性が低減されたハイブリッドアムホテリシンｂ誘導体 |
| EP4009984A4 (en) * | 2019-08-08 | 2023-09-06 | The Board Of Trustees Of The University Of Illinois | HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY |
| AU2020325163A1 (en) * | 2019-08-08 | 2022-03-03 | The Board Of Trustees Of The University Of Illinois | Hybrid amide derivatives of amphotericin B |
| FR3112145A1 (fr) * | 2020-07-03 | 2022-01-07 | Nanotracks Diagnostics | Derives uree de macrolides polyeniques, composes chimiques particuliers susceptibles d’etre utilises pour obtenir ces derives uree, compositions les contenant et utilisations |
| WO2022003181A1 (fr) * | 2020-07-03 | 2022-01-06 | Nanotracks Diagnostics | Derivés urée de l'amphotéricine amb, compositions les contenant et leurs utilisations, dérivés isocyanate d'alkyle omega-aminés et leur utilisation pour obtenir lesdits dérivés urée |
| EP4192248B1 (en) * | 2020-08-10 | 2025-12-03 | The Board Of Trustees Of The University Of Illinois | Hybrid amide derivatives of amphotericin b |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8829592D0 (en) | 1988-12-19 | 1989-02-08 | Beecham Group Plc | Novel compounds |
| EP0350164A3 (en) * | 1988-06-13 | 1991-07-24 | Beecham Group Plc | Amphotericin derivatives |
| EP0431870A1 (en) * | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Amphotericin B derivatives |
| JP3507486B2 (ja) | 1991-03-15 | 2004-03-15 | アムジエン・インコーポレーテツド | 顆粒球コロニー刺激因子の肺内投与 |
| GB9203476D0 (en) | 1992-02-19 | 1992-04-08 | Smithkline Beecham Plc | Novel compounds |
| US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| US5606038A (en) | 1995-04-10 | 1997-02-25 | Competitive Technologies, Inc. | Amphiphilic polyene macrolide antibiotic compounds |
| PL180253B1 (pl) * | 1995-05-13 | 2001-01-31 | Politechnika Gdanska | Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL |
| US6664241B2 (en) | 2000-05-31 | 2003-12-16 | Micrologix Biotech Inc. | Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof |
| EP1987049A1 (en) * | 2006-02-23 | 2008-11-05 | ETH Zürich | Amphotericin derivatives |
| JP5240704B2 (ja) * | 2007-10-05 | 2013-07-17 | 国立大学法人群馬大学 | 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法 |
| WO2013186384A1 (en) | 2012-06-15 | 2013-12-19 | Blirt S.A. | N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application |
| WO2014165676A1 (en) | 2013-04-03 | 2014-10-09 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| CN105848721B (zh) * | 2013-10-07 | 2019-08-23 | 伊利诺伊大学评议会 | 具有提高的治疗指数的两性霉素b衍生物 |
| WO2015164289A1 (en) * | 2014-04-21 | 2015-10-29 | Cidara Therapeutics, Inc. | Compositions and methods for the treatment of fungal infections |
| JP6543272B2 (ja) | 2014-05-16 | 2019-07-10 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ | 低減された毒性を有するアンホテリシンｂ誘導体 |
| MA39568A1 (fr) | 2014-06-12 | 2017-09-29 | Shionogi & Co | Dérivé de macrolide de polyène |
| WO2016014779A1 (en) | 2014-07-23 | 2016-01-28 | The Board Of Trustees Of The University Of Illinois | Antifungal polyene macrolide derivatives with reduced mammalian toxicity |
| WO2016040779A1 (en) | 2014-09-12 | 2016-03-17 | The Board Of Trustees Of The University Of Illinois | Urea derivatives of polyene macrolide antibiotics |
| US10087206B2 (en) | 2014-10-17 | 2018-10-02 | The Board Of Trustees Of The University Of Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin B |
| WO2016112243A1 (en) | 2015-01-08 | 2016-07-14 | The Board Of Trustees Of The University Of Illinois | Urea derivatives of amphotericin b derived from secondary amines |
| US20180273571A1 (en) | 2015-01-08 | 2018-09-27 | The Board Of Trustees Of The University Of Illinois | Concise synthesis of urea derivatives of amphotericin b |
| WO2016168568A1 (en) * | 2015-04-15 | 2016-10-20 | Revolution Medicines, Inc. | Derivatives of amphotericin b |
-
2016
- 2016-04-15 WO PCT/US2016/027703 patent/WO2016168568A1/en not_active Ceased
- 2016-04-15 CA CA3213127A patent/CA3213127A1/en active Pending
- 2016-04-15 CA CA3021061A patent/CA3021061C/en active Active
- 2016-04-15 US US15/099,837 patent/US9957290B2/en active Active
- 2016-04-15 EP EP21175661.4A patent/EP3929203A1/en active Pending
- 2016-04-15 PT PT167808138T patent/PT3283171T/pt unknown
- 2016-04-15 ES ES16780813T patent/ES2880029T3/es active Active
- 2016-04-15 EP EP16780813.8A patent/EP3283171B1/en active Active
- 2016-04-15 JP JP2017553875A patent/JP7240811B2/ja active Active
-
2018
- 2018-04-09 US US15/948,122 patent/US10597420B2/en active Active
-
2020
- 2020-02-25 US US16/800,694 patent/US10882883B2/en active Active
-
2021
- 2021-02-16 JP JP2021022476A patent/JP2021075570A/ja not_active Abandoned
-
2022
- 2022-12-22 JP JP2022205228A patent/JP2023030103A/ja active Pending
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