ES2854674T3 - Tratamiento de uniones estrechas con fugas o dañadas y mejora de la matriz extracelular - Google Patents

Tratamiento de uniones estrechas con fugas o dañadas y mejora de la matriz extracelular Download PDF

Info

Publication number
ES2854674T3
ES2854674T3 ES08732273T ES08732273T ES2854674T3 ES 2854674 T3 ES2854674 T3 ES 2854674T3 ES 08732273 T ES08732273 T ES 08732273T ES 08732273 T ES08732273 T ES 08732273T ES 2854674 T3 ES2854674 T3 ES 2854674T3
Authority
ES
Spain
Prior art keywords
self
xaa
formulation
xaaneu
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08732273T
Other languages
English (en)
Spanish (es)
Inventor
Rutledge Ellis-Behnke
Stephen Kelly
Terrence Norchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arch Biosurgery Inc
Original Assignee
Arch Biosurgery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arch Biosurgery Inc filed Critical Arch Biosurgery Inc
Application granted granted Critical
Publication of ES2854674T3 publication Critical patent/ES2854674T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
ES08732273T 2007-03-14 2008-03-14 Tratamiento de uniones estrechas con fugas o dañadas y mejora de la matriz extracelular Active ES2854674T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89487207P 2007-03-14 2007-03-14
PCT/US2008/057104 WO2008113030A2 (en) 2007-03-14 2008-03-14 Treatment of leaky or damaged tight junctions and enhancing extracellular matrix

Publications (1)

Publication Number Publication Date
ES2854674T3 true ES2854674T3 (es) 2021-09-22

Family

ID=39462068

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08732273T Active ES2854674T3 (es) 2007-03-14 2008-03-14 Tratamiento de uniones estrechas con fugas o dañadas y mejora de la matriz extracelular

Country Status (7)

Country Link
US (2) US9415084B2 (enExample)
EP (1) EP2146733B1 (enExample)
JP (4) JP2010521495A (enExample)
CA (1) CA2680824C (enExample)
DK (1) DK2146733T3 (enExample)
ES (1) ES2854674T3 (enExample)
WO (1) WO2008113030A2 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006241123B2 (en) 2005-04-25 2013-10-03 Massachusetts Institute Of Technology Compositions and methods for promoting hemostasis and other physiological activities
US9162005B2 (en) 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
US8143042B2 (en) 2006-01-12 2012-03-27 Massachusetts Institute Of Technology Biodegradable elastomers
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
EP2438962A3 (en) 2006-02-13 2012-07-18 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
CN101472620A (zh) * 2006-04-25 2009-07-01 麻省理工学院 用于影响污染物、机体流体或其它实体移动和/或影响其它生理状况的组合物和方法
WO2009033730A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratoires Ag Peptide gxgrgdspca as a therapeutic agent
WO2009043457A2 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
WO2009046843A1 (en) * 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag Therapeutic uses of peptides kvlpvpq and/or tdvngdgrhdl
RU2016102347A (ru) 2008-10-06 2018-11-20 3-Д Матрикс, Лтд. Агент для окклюзии тканей
US20110200560A1 (en) * 2009-05-26 2011-08-18 Massachusetts Institute Of Technology Non-ionic self-assembling peptides and uses thereof
US9084752B2 (en) * 2009-12-14 2015-07-21 The University Of Hong Kong Compositions and methods for controlling proliferation and differentiation of cells
US9439941B2 (en) 2009-12-14 2016-09-13 The University Of Hong Kong Nano cancer barrier device (NCBD) to immobilize and inhibit the division of metastic cancer stem cells
US20110143993A1 (en) * 2009-12-15 2011-06-16 The Brigham And Women's Hospital, Inc. Endothelial basement membrane targeting peptide ligands
JP5855651B2 (ja) * 2010-07-16 2016-02-09 マサチューセッツ インスティテュート オブ テクノロジー 改変を組み込んだ自己組織化ペプチドおよびその使用方法
US8741833B2 (en) * 2010-07-16 2014-06-03 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
JP5934710B2 (ja) * 2010-10-07 2016-06-15 マサチューセッツ インスティテュート オブ テクノロジー ローレンツ力直動型の無針式ジェット注射システムを用いた固形物および/または流体の供給
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
US8663932B2 (en) 2010-12-21 2014-03-04 Leidos, Inc. Methods and compositions for wound treatment
CN104902974B (zh) 2012-07-06 2017-07-28 三维矩阵有限公司 肽溶液的灌装加工法
IN2014KN02933A (enExample) 2012-07-19 2015-05-08 Alethia Biotherapeutics Inc
EP2698162A1 (en) 2012-08-15 2014-02-19 Credentis AG Method for producing a composition for treating a tooth lesion
US9241891B2 (en) * 2012-10-30 2016-01-26 The Procter & Gamble Company Personal care compositions comprising self-assembling peptides
KR102186698B1 (ko) * 2013-03-30 2020-12-07 가부시키가이샤 도우사 고가쿠 겐큐쇼 당쇄-폴리펩티드 복합체
DK3035974T3 (da) * 2013-08-22 2020-01-02 Arch Biosurgery Inc Implanterbare net til styring af bevægelsen af fluider
EP3049054B1 (en) 2013-09-25 2018-04-04 Credentis AG Dental care product for tooth whitening
EP2853256A1 (en) 2013-09-25 2015-04-01 Credentis AG Dental care product for tooth whitening
WO2015053338A1 (ja) * 2013-10-08 2015-04-16 学校法人東京理科大学 カチオン性ペプチドおよびそれを含む医薬組成物
RU2016139369A (ru) 2014-03-10 2018-04-10 3-Д Матрикс, Лтд. Композиции самоорганизующихся пептидов
EP3628337B1 (en) 2014-03-10 2025-05-28 3-D Matrix, Ltd. Sterilization and filtration of peptide compositions
US10245299B2 (en) 2014-03-10 2019-04-02 3-D Matrix, Ltd. Autoassembling peptides for the treatment of pulmonary bulla
WO2015145797A1 (ja) * 2014-03-28 2015-10-01 大塚化学株式会社 止血用医薬組成物
US11298397B2 (en) 2015-12-18 2022-04-12 3-D Matrix, Ltd. Hemostatic composition and hemostatic method using hemostatic composition
US10814038B2 (en) 2016-01-06 2020-10-27 3-D Matrix, Ltd. Combination compositions
EP3248590A1 (en) 2016-05-24 2017-11-29 Credentis AG Personal dental care product for caries treatment
EP3248591A1 (en) 2016-05-24 2017-11-29 Credentis AG Method and product for caries treatment
US20190060506A1 (en) * 2017-08-22 2019-02-28 The Board Of Trustees Of The Leland Stanford Junior University Elafin Incorporated Biomaterials for the Treatment of Chronic Tissue Ulcers
EP3723726A1 (en) 2017-12-15 2020-10-21 3-D Matrix, Ltd. Surfactant peptide nanostructures and uses in drug delivery
CN111867616A (zh) * 2018-01-11 2020-10-30 国立大学法人东京大学 Ntcp抑制剂
WO2019182905A1 (en) * 2018-03-23 2019-09-26 Arch Biosurgery, Inc. Sap and peptidomimetics for treatment of eye disease
CN112165952A (zh) 2018-03-23 2021-01-01 阿奇生物外科有限公司 用于减轻炎症症状的sap和拟肽组合物
CN113194976A (zh) * 2018-10-05 2021-07-30 学校法人久留米大学 用于肠道中的溃疡或瘘管的治疗或预防的医药组合物
AU2020292274B2 (en) 2019-06-13 2024-05-23 Hollister Incorporated Reusable urinary catheter products
EP3952929A1 (en) 2019-06-25 2022-02-16 Hollister Incorporated Reusable urinary catheter products
EP3831360A1 (en) 2019-12-04 2021-06-09 Credentis AG Personal dental care product for preventing demineralisation
CN111116717B (zh) * 2020-01-03 2021-10-29 中国科学院大学温州研究院(温州生物材料与工程研究所) 含有n-甲基-d-葡糖胺单元的糖肽水凝胶、制备方法及其应用
EP4090350A1 (en) 2020-01-13 2022-11-23 Arch Biosurgery, Inc. Self-assembling peptide gel formulation and methods of use
US11154470B1 (en) 2020-07-31 2021-10-26 vVardis AG Anti-inflammatory and senolytic dental care product with tooth whitening characteristics
WO2022173926A1 (en) * 2021-02-10 2022-08-18 3-D Matrix, Ltd. Pharmaceutical composition containing specific self-assembling peptide rada16 for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease
WO2024128081A1 (ja) * 2022-12-16 2024-06-20 東亞合成株式会社 合成ペプチド及び構築物
CN116789854B (zh) * 2023-06-08 2024-04-02 东北农业大学 兼具细菌捕获与抑菌功能的纳米抗菌肽及制备方法和应用
WO2025226888A1 (en) * 2024-04-26 2025-10-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ecm-derived injectable embolic for permanent treatment of cerebral aneurysms

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098728A (en) * 1976-01-02 1978-07-04 Solomon Rosenblatt Medical surgical sponge and method of making same
US4211227A (en) * 1978-07-03 1980-07-08 The Kendall Company Surgical sponge material
US4272398A (en) * 1978-08-17 1981-06-09 The United States Of America As Represented By The Secretary Of Agriculture Microencapsulation process
US4636208A (en) * 1984-10-05 1987-01-13 Ewald Rath Surgical sponge
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US5019646A (en) 1987-08-25 1991-05-28 Regents Of The University Of Minnesota Polypeptides with fibronectin activity
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
EP0609212A4 (en) * 1989-12-04 1995-04-19 Kensey Nash Corp PLUG DEVICE FOR SEALING OPENINGS AND METHOD FOR USE.
US5180375A (en) * 1991-05-02 1993-01-19 Feibus Miriam H Woven surgical drain and woven surgical sponge
US5222974A (en) * 1991-11-08 1993-06-29 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5670483A (en) * 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5645565A (en) * 1995-06-13 1997-07-08 Ethicon Endo-Surgery, Inc. Surgical plug
US6368877B1 (en) * 1997-06-25 2002-04-09 Massachusetts Institute Of Technology Self-assembling peptide surfaces for cell patterning and interactions
US6235340B1 (en) 1998-04-10 2001-05-22 Massachusetts Institute Of Technology Biopolymer-resistant coatings
WO2000041732A1 (en) * 1999-01-19 2000-07-20 The Children's Hospital Of Philadelphia Hydrogel compositions for controlled delivery of virus vectors and methods of use thereof
WO2000063079A1 (en) * 1999-04-15 2000-10-26 Ultracell Medical Technologies Of Connecticut, Inc. Method for producing surgical sponge device and product thereof
US6844324B1 (en) * 1999-11-12 2005-01-18 Massachusetts Institute Of Technology Modular peptide mediated intracellular delivery system and uses therefore
US6953659B2 (en) * 2000-07-14 2005-10-11 Massachusetts Institute Of Technology Direct, externally imposed control of nucleic acids
US6953656B2 (en) * 2000-07-14 2005-10-11 Massachusetts Institute Of Technology Direct, externally imposed control of polypeptides
US6846319B2 (en) * 2000-12-14 2005-01-25 Core Medical, Inc. Devices for sealing openings through tissue and apparatus and methods for delivering them
ATE419333T1 (de) 2001-02-06 2009-01-15 Massachusetts Inst Technology Peptidgerüstverkapselung von gewebszellen und verwendungen davon
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
WO2003006043A1 (en) 2001-07-10 2003-01-23 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
US20060199778A1 (en) * 2001-09-19 2006-09-07 Rutledge Ellis-Behnke Methods and products related to non-viral transfection
WO2003084980A2 (en) 2002-04-02 2003-10-16 Northwestern University Peptide amphiphile solutions and self assembled peptide nanofiber networks
US20040242469A1 (en) * 2002-05-13 2004-12-02 Lee Richard T. Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof
CA2387257C (en) * 2002-05-23 2009-07-28 Suncor Energy Inc. Static deaeration conditioner for processing of bitumen froth
GB0216286D0 (en) 2002-07-15 2002-08-21 Univ Leeds Network
EP1542709A2 (en) 2002-08-06 2005-06-22 EPIX Pharmaceuticals, Inc. Peptide aggregates
US7713923B2 (en) * 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
WO2005014615A2 (en) 2003-06-25 2005-02-17 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
US7846891B2 (en) * 2003-10-17 2010-12-07 Massachusetts Institute Of Technology Self-assembling peptides for regeneration and repair of neural tissue
GB0413346D0 (en) 2004-06-15 2004-07-21 Theryte Ltd Treating cancer
EP1843776A4 (en) * 2004-07-06 2011-05-11 3D Matrix Inc PURIFIED AMPHILIC PEPTIDE COMPOSITIONS AND ITS USE
US7884185B2 (en) * 2004-07-28 2011-02-08 University Of Delaware Hydrogels and uses thereof
US8039258B2 (en) 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
US7399831B2 (en) * 2004-10-25 2008-07-15 The Brigham And Women's Hospital, Inc. Targeted delivery of biological factors using self-assembling peptide nanofibers
EP1833504A4 (en) * 2005-01-04 2009-08-12 Brigham & Womens Hospital PERMANENT DELIVERY OF SELF-ARRANGING PEPTIDE NANOFIBER USING THE PDGF
US9162005B2 (en) * 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
AU2006241123B2 (en) * 2005-04-25 2013-10-03 Massachusetts Institute Of Technology Compositions and methods for promoting hemostasis and other physiological activities
CN101472620A (zh) * 2006-04-25 2009-07-01 麻省理工学院 用于影响污染物、机体流体或其它实体移动和/或影响其它生理状况的组合物和方法
US20070287741A1 (en) * 2006-06-13 2007-12-13 Uri Herzberg Compositions and methods for preventing or reducing postoperative ileus and gastric stasis in mammals
US20120085262A1 (en) 2010-08-26 2012-04-12 Freudenberg Forschungsdienste Kg Production of Highly Concentrated Solutions of Self-Assembling Proteins

Also Published As

Publication number Publication date
EP2146733A2 (en) 2010-01-27
JP2013177467A (ja) 2013-09-09
JP5860437B2 (ja) 2016-02-16
JP2017105833A (ja) 2017-06-15
US9415084B2 (en) 2016-08-16
EP2146733B1 (en) 2020-11-25
JP2010521495A (ja) 2010-06-24
DK2146733T3 (da) 2021-01-11
WO2008113030A3 (en) 2009-04-02
JP6112621B2 (ja) 2017-04-12
JP2015028086A (ja) 2015-02-12
US20160324918A1 (en) 2016-11-10
CA2680824A1 (en) 2008-09-18
WO2008113030A2 (en) 2008-09-18
CA2680824C (en) 2018-06-26
US20080274979A1 (en) 2008-11-06

Similar Documents

Publication Publication Date Title
ES2854674T3 (es) Tratamiento de uniones estrechas con fugas o dañadas y mejora de la matriz extracelular
ES2427565T3 (es) Péptidos autoensambladores para promover la hemostasia
US10682386B2 (en) Compositions for prevention of adhesions and other barrier applications
ES2673947T3 (es) Composiciones y métodos para afectar al movimiento de contaminantes, líquidos corporales u otras entidades y/o afectar a otras condiciones fisiológicas
KR20110083648A (ko) 조직 폐색제
HK1140431B (en) Treatment of leaky or damaged tight junctions and enhancing extracellular matrix
HK1140431A (en) Treatment of leaky or damaged tight junctions and enhancing extracellular matrix
HK1184397A (en) Compositions for prevention of adhesions and other barrier applications
HK1155356A (en) Compositions and methods for promoting hemostasis and other physiological activities
HK1132469A (en) Compositions and methods for affecting movement of contaminants, bodily fluids or other entities and/or affecting other physiological conditions
HK1112847B (en) Self-assembling peptides for promoting hemostasis