ES2828660T3 - Método y aparato para determinar recuentos de leucocitos - Google Patents

Método y aparato para determinar recuentos de leucocitos Download PDF

Info

Publication number
ES2828660T3
ES2828660T3 ES13742312T ES13742312T ES2828660T3 ES 2828660 T3 ES2828660 T3 ES 2828660T3 ES 13742312 T ES13742312 T ES 13742312T ES 13742312 T ES13742312 T ES 13742312T ES 2828660 T3 ES2828660 T3 ES 2828660T3
Authority
ES
Spain
Prior art keywords
light
concentration
leukocyte
biological sample
erythrocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13742312T
Other languages
English (en)
Spanish (es)
Inventor
Patricio Vidal
Christophe Godefroy
Phaisit Chewputtanagul
Jiuliu Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of ES2828660T3 publication Critical patent/ES2828660T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/1031Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06Quantitative determination
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59Transmissivity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012Red blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016White blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1006Investigating individual particles for cytology
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1019Associating Coulter-counter and optical flow cytometer [OFC]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1402Data analysis by thresholding or gating operations performed on the acquired signals or stored data
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1413Hydrodynamic focussing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486Counting the particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4915Blood using flow cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Primary Health Care (AREA)
  • Data Mining & Analysis (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES13742312T 2012-07-05 2013-07-03 Método y aparato para determinar recuentos de leucocitos Active ES2828660T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261668377P 2012-07-05 2012-07-05
PCT/US2013/049367 WO2014008424A1 (en) 2012-07-05 2013-07-03 Method and apparatus for determining white blood cell counts

Publications (1)

Publication Number Publication Date
ES2828660T3 true ES2828660T3 (es) 2021-05-27

Family

ID=49878794

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13742312T Active ES2828660T3 (es) 2012-07-05 2013-07-03 Método y aparato para determinar recuentos de leucocitos

Country Status (9)

Country Link
US (2) US9096885B2 (enExample)
EP (1) EP2870458B1 (enExample)
JP (1) JP6321637B2 (enExample)
KR (1) KR101963477B1 (enExample)
CN (1) CN104541149B (enExample)
BR (1) BR112015000018B1 (enExample)
ES (1) ES2828660T3 (enExample)
IN (1) IN2014DN10974A (enExample)
WO (1) WO2014008424A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5868982B2 (ja) 2010-09-16 2016-02-24 ザ ジェネラル ホスピタル コーポレイション 診断のための赤血球動力学
CN104541149B (zh) 2012-07-05 2017-03-01 贝克曼考尔特公司 用于确定白血细胞计数的方法和装置
CN105051521B (zh) 2013-03-15 2020-03-24 贝克曼考尔特公司 用于设计流式细胞术中的面板的系统和方法
DE102013216362A1 (de) * 2013-08-19 2015-02-19 Siemens Healthcare Diagnostics Products Gmbh Analyseverfahren zur Klassifikationsunterstützung
JP2018505392A (ja) * 2014-12-10 2018-02-22 ネオゲノミクス ラボラトリーズ, インコーポレイテッド 自動化されたフローサイトメトリ分析方法及びシステム
US10264515B2 (en) * 2014-12-22 2019-04-16 Qualcomm Incorporated Enhanced access network query protocol (ANQP) signaling to scale to support large numbers of service providers at an access point (AP)
CN106687810B (zh) * 2014-12-31 2019-10-22 深圳迈瑞生物医疗电子股份有限公司 一种非诊断目的的有核红细胞报警方法、装置及流式细胞分析仪
CN104732229B (zh) * 2015-03-16 2018-04-27 华南理工大学 一种用于宫颈涂片图像中重叠细胞的分割方法
US10955423B2 (en) 2015-12-15 2021-03-23 The General Hospital Corporation Methods of estimating blood glucose and related systems
KR102411950B1 (ko) * 2016-01-28 2022-06-22 베크만 컬터, 인코포레이티드 감염 검출 및 감별 시스템들 및 방법들
US10190961B2 (en) * 2016-03-18 2019-01-29 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Sample analyzer and sample analyzing method thereof
US11293852B2 (en) * 2016-04-07 2022-04-05 The General Hospital Corporation White blood cell population dynamics
CN109963936A (zh) * 2016-09-08 2019-07-02 雅培实验室 自动体液分析
EP3638987B1 (en) 2017-06-14 2025-01-01 Cytochip Inc. Devices and methods for cell analysis
WO2018232589A1 (zh) * 2017-06-20 2018-12-27 深圳迈瑞生物医疗电子股份有限公司 一种血小板聚集识别的方法、装置和细胞分析仪
WO2019055520A1 (en) 2017-09-13 2019-03-21 Graftworx, Inc. SYSTEMS AND METHODS FOR DETECTION OF PERIPROTETIC INFECTION
WO2019083844A1 (en) 2017-10-23 2019-05-02 Cytochip Inc. DEVICES AND METHOD FOR MEASURING TARGET ANALYTES AND PARTICLES
US11852640B2 (en) 2017-10-27 2023-12-26 Beckman Coulter, Inc. Hematology analyzers and methods of operation
WO2019118929A1 (en) * 2017-12-15 2019-06-20 Gastroklenz Inc. Sensor monitoring system for in-dwelling catheter based treatments
US11521706B2 (en) 2018-04-20 2022-12-06 Beckman Coulter, Inc. Testing and representing suspicion of sepsis
WO2019204804A1 (en) 2018-04-20 2019-10-24 Beckman Coulter, Inc. Sepsis infection determination systems and methods
CN111684263A (zh) 2018-04-28 2020-09-18 深圳迈瑞生物医疗电子股份有限公司 血液分析系统、血液分析仪、血液分析方法及存储介质
CN111801568B (zh) 2018-04-28 2024-05-24 深圳迈瑞生物医疗电子股份有限公司 测定血小板浓度的方法及系统
CN111656161B (zh) 2018-04-28 2024-02-20 深圳迈瑞生物医疗电子股份有限公司 样本分析仪异常的报警方法、系统及存储介质
EP3806712A1 (en) 2018-06-15 2021-04-21 Beckman Coulter, Inc. Method of determining sepsis in the presence of blast flagging
CN108663306B (zh) * 2018-07-27 2024-02-09 北京指真生物科技有限公司 一种流式细胞分析装置及补偿方法
EP3997713B1 (en) 2019-07-12 2025-06-11 Beckman Coulter, Inc. Method of detecting sepsis using vital signs, including systolic blood pressure, hematology parameters, and combinations thereof
WO2021011356A1 (en) 2019-07-12 2021-01-21 Beckman Coulter, Inc. Systems and methods for evaluating immune response to infection
US12019040B2 (en) 2019-09-30 2024-06-25 Cornell University System and devices for monitoring cell-containing materials and methods of their use
CN112986104B (zh) * 2019-12-17 2025-05-13 爱科来株式会社 测定装置和测定方法
EP3842782B1 (en) 2019-12-27 2024-06-26 Beckman Coulter, Inc. Sample preparation instrument
EP4365570A1 (en) * 2022-11-04 2024-05-08 Horiba, Ltd. Measurement method, measurement system, and test reagent kit

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58115346A (ja) * 1981-12-29 1983-07-09 Shimadzu Corp 血球種類識別装置
JPH0664053B2 (ja) * 1986-11-27 1994-08-22 東亜医用電子株式会社 フロ−サイトメトリ−による白血球の分類方法
KR970007077B1 (ko) * 1987-03-13 1997-05-02 코울터 일렉트로닉스 인커퍼레이티드 광산란 기술을 이용한 다중-부분식별 분석 방법
DE69434942T2 (de) * 1993-02-25 2007-11-29 Abbott Laboratories, Abbott Park Mehrzweckreagenzsystem zur schnellen lysierung von vollblutproben
DE69432410T2 (de) 1993-05-14 2004-03-04 Coulter International Corp., Miami Retikulozyt bestimmungsverfahren und geraet, das lichtstreuungstechniken verwendet
US5656499A (en) * 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
CA2235772C (en) * 1995-10-23 2002-12-31 Cytometrics, Inc. Method and apparatus for reflected imaging analysis
US5733784A (en) * 1995-11-20 1998-03-31 Abbott Laboratories Reagent system and method for the differentiation and identification of reticulocytes
EP1003847A4 (en) * 1997-09-04 2005-04-06 Science Res Lab Inc SEPARATION OF CELLS BY USE OF ELECTRIC FIELDS
US5874310A (en) * 1997-11-21 1999-02-23 Coulter International Corp. Method for differentiation of nucleated red blood cells
US6228652B1 (en) 1999-02-16 2001-05-08 Coulter International Corp. Method and apparatus for analyzing cells in a whole blood sample
US6524858B1 (en) * 1999-03-31 2003-02-25 Bayer Corporation Single channel, single dilution detection method for the identification and quantification of blood cells and platelets in a whole blood sample using an automated hematology analyzer
US6744245B2 (en) 2001-07-27 2004-06-01 Coulter International Corp. Particle count correction method and apparatus
US6916658B2 (en) * 2001-07-27 2005-07-12 Beckman Coulter, Inc. Method for measurement of immature granulocytes
CN1276252C (zh) * 2001-07-27 2006-09-20 贝克曼库尔特有限公司 有核红细胞的测量方法
EP1682865B1 (en) 2003-10-12 2018-08-15 Beckman Coulter, Inc. Method of using a reference control composition for measurement of nucleated red blood cells
US7198953B2 (en) * 2003-10-12 2007-04-03 Beckman Coulter, Inc. Method of using a reference control composition for measurement of nucleated red blood cells
EP1714146B1 (en) * 2004-02-10 2022-08-03 Beckman Coulter, Inc. Method of measurement of nucleated red blood cells
US7208319B2 (en) 2004-02-10 2007-04-24 Beckman Coulter, Inc. Method of measurement of nucleated red blood cells
US7390662B2 (en) 2005-11-09 2008-06-24 Beckman Coulter, Inc. Method and apparatus for performing platelet measurement
JP4982385B2 (ja) * 2005-02-01 2012-07-25 アムニス コーポレイション イメージングフローサイトメータを使用した血液及び細胞の分析
JP2009511001A (ja) 2005-09-15 2009-03-19 アルテミス ヘルス,インク. 細胞及びその他の粒子を磁気濃縮するためのデバイス並びに方法
US7796797B2 (en) 2005-09-28 2010-09-14 Sysmex Corporation Apparatus for obtaining an image of a blood cell and method for obtaining an image of a blood cell
JP4690163B2 (ja) * 2005-09-28 2011-06-01 シスメックス株式会社 血液撮像装置、血液撮像方法、処理装置、及び撮像本体装置
US7661326B2 (en) 2006-10-26 2010-02-16 Beckman Coulter, Inc. Apparatus for aspirating and dispensing liquids in an automated analyzer
US8094299B2 (en) 2008-07-24 2012-01-10 Beckman Coulter, Inc. Transducer module
US8512977B2 (en) 2008-09-19 2013-08-20 Beckman Coulter, Inc. Analyzing reticulocytes
US8603773B2 (en) 2008-09-19 2013-12-10 Beckman Coulter Method and system for analyzing a blood sample
US8417012B2 (en) 2008-11-04 2013-04-09 Beckman Coulter, Inc. Non-linear histogram segmentation for particle analysis
ES2796655T3 (es) 2008-11-14 2020-11-27 Beckman Coulter Inc Celdas de flujo óptico monolíticas y método de fabricación
US9464978B2 (en) 2009-03-04 2016-10-11 Beckman Coulter, Inc. Cross-instrument method and system for cell population discrimination
JP5871792B2 (ja) * 2009-04-27 2016-03-01 アボット・ラボラトリーズAbbott Laboratories 自動血液分析器において、レーザーからの前方散乱を用いることによる、赤血球細胞を白血球細胞から判別する方法
US8911669B2 (en) * 2009-08-24 2014-12-16 Abbott Laboratories Method for flagging a sample
CN104541149B (zh) 2012-07-05 2017-03-01 贝克曼考尔特公司 用于确定白血细胞计数的方法和装置

Also Published As

Publication number Publication date
US9588102B2 (en) 2017-03-07
KR20150036329A (ko) 2015-04-07
WO2014008424A1 (en) 2014-01-09
US20140011232A1 (en) 2014-01-09
KR101963477B1 (ko) 2019-03-28
US20150330963A1 (en) 2015-11-19
CN104541149B (zh) 2017-03-01
IN2014DN10974A (enExample) 2015-09-18
CN104541149A (zh) 2015-04-22
JP6321637B2 (ja) 2018-05-09
BR112015000018A2 (pt) 2017-06-27
EP2870458A1 (en) 2015-05-13
JP2015522165A (ja) 2015-08-03
BR112015000018B1 (pt) 2021-11-09
EP2870458B1 (en) 2020-09-09
US9096885B2 (en) 2015-08-04

Similar Documents

Publication Publication Date Title
ES2828660T3 (es) Método y aparato para determinar recuentos de leucocitos
US12437873B2 (en) Infection detection and differentiation systems and methods
US9939453B2 (en) Immature platelet enumeration systems and methods
ES2772453T3 (es) Sistemas y métodos para el recuento de plaquetas con ajuste de agregaciones