EP1844426A4 - Blood analysis using a flow imaging cytometer - Google Patents

Blood analysis using a flow imaging cytometer

Info

Publication number
EP1844426A4
EP1844426A4 EP06720094.9A EP06720094A EP1844426A4 EP 1844426 A4 EP1844426 A4 EP 1844426A4 EP 06720094 A EP06720094 A EP 06720094A EP 1844426 A4 EP1844426 A4 EP 1844426A4
Authority
EP
European Patent Office
Prior art keywords
blood analysis
flow imaging
imaging cytometer
cytometer
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06720094.9A
Other languages
German (de)
French (fr)
Other versions
EP1844426A2 (en
Inventor
William Ortyn
David Basiji
Thaddeous George
Philip Morrissey
Brian Hall
David Perry
Cathleen Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amnis LLC
Original Assignee
Amnis LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amnis LLC filed Critical Amnis LLC
Publication of EP1844426A2 publication Critical patent/EP1844426A2/en
Publication of EP1844426A4 publication Critical patent/EP1844426A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Multimedia (AREA)
  • Biomedical Technology (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP06720094.9A 2005-02-01 2006-02-01 Blood analysis using a flow imaging cytometer Withdrawn EP1844426A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64937305P 2005-02-01 2005-02-01
PCT/US2006/003573 WO2006083969A2 (en) 2005-02-01 2006-02-01 Blood analysis using a flow imaging cytometer

Publications (2)

Publication Number Publication Date
EP1844426A2 EP1844426A2 (en) 2007-10-17
EP1844426A4 true EP1844426A4 (en) 2016-09-07

Family

ID=36777881

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06720094.9A Withdrawn EP1844426A4 (en) 2005-02-01 2006-02-01 Blood analysis using a flow imaging cytometer

Country Status (3)

Country Link
EP (1) EP1844426A4 (en)
JP (1) JP4982385B2 (en)
WO (1) WO2006083969A2 (en)

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US9164037B2 (en) 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
JP5013410B2 (en) * 2007-03-14 2012-08-29 独立行政法人産業技術総合研究所 Fine particle measuring method and apparatus
WO2008143849A2 (en) * 2007-05-14 2008-11-27 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
WO2008156669A1 (en) 2007-06-15 2008-12-24 Historx, Inc. Method and system for standardizing microscope instruments
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
WO2009029810A1 (en) 2007-08-31 2009-03-05 Historx, Inc. Automatic exposure time selection for imaging tissue
US7782452B2 (en) * 2007-08-31 2010-08-24 Kla-Tencor Technologies Corp. Systems and method for simultaneously inspecting a specimen with two distinct channels
US7817254B2 (en) * 2008-01-30 2010-10-19 Palo Alto Research Center Incorporated Obtaining information from time variation of sensing results
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
FR2935802B1 (en) * 2008-09-05 2012-12-28 Horiba Abx Sas METHOD AND DEVICE FOR CLASSIFYING, VISUALIZING AND EXPLORING BIOLOGICAL DATA
EP2335221B8 (en) 2008-09-16 2016-05-25 Novartis AG Reproducible quantification of biomarker expression
JP5438962B2 (en) * 2008-12-25 2014-03-12 シスメックス株式会社 Cell image display device
US9025850B2 (en) 2010-06-25 2015-05-05 Cireca Theranostics, Llc Method for analyzing biological specimens by spectral imaging
US9129371B2 (en) 2010-06-25 2015-09-08 Cireca Theranostics, Llc Method for analyzing biological specimens by spectral imaging
JP6019017B2 (en) * 2010-06-25 2016-11-02 シレカ セラノスティクス エルエルシーＣｉｒｅｃａ Ｔｈｅｒａｎｏｓｔｉｃｓ，Ｌｌｃ Method for analyzing biological specimens with spectral images
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US9228898B2 (en) * 2011-03-31 2016-01-05 Gnubio, Inc. Scalable spectroscopic detection and measurement
JP6014590B2 (en) * 2011-06-27 2016-10-25 シスメックス株式会社 Cell analysis apparatus and cell analysis method
WO2013033271A2 (en) * 2011-08-29 2013-03-07 Derren Barken Method to augment immune system in response to disease or injury
BR112015000018B1 (en) * 2012-07-05 2021-11-09 Beckman Coulter, Inc AUTOMATED SYSTEM AND METHOD TO DETERMINE A BLOOD WHITE CELLS CONDITION IN A BIOLOGICAL SAMPLE
WO2014164757A1 (en) * 2013-03-11 2014-10-09 Roche Diagnostics Hematology, Inc. Imaging blood cells
CA2907504C (en) * 2013-03-27 2023-01-17 Theranos, Inc. Methods, devices, and systems for sample analysis
CA2913667A1 (en) * 2013-05-28 2014-12-04 Chemometec A/S Image forming cytometer
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
KR20170039250A (en) 2014-08-28 2017-04-10 시스멕스 가부시키가이샤 Particle image-capturing device and particle image-capturing method
EP4137798A1 (en) 2015-02-19 2023-02-22 1087 Systems, Inc. Scanning infrared measurement system
US10460439B1 (en) 2015-08-12 2019-10-29 Cireca Theranostics, Llc Methods and systems for identifying cellular subtypes in an image of a biological specimen
JP6654271B2 (en) 2016-06-10 2020-02-26 ルミネックス コーポレーション Method of integrating bright field and fluorescence channels for cell image segmentation and morphological analysis using images acquired from an imaging flow cytometer (IFC)
CN107356515B (en) * 2017-07-20 2020-04-03 上海睿钰生物科技有限公司 Method and system for determining fluorescence intensity of fluorescence image
WO2019151307A1 (en) 2018-01-30 2019-08-08 国立研究開発法人理化学研究所 Mask structure optimization device, mask structure optimization method, and program
FR3078777B1 (en) * 2018-03-07 2020-11-13 Alain Rousseau METHOD OF ANALYSIS OF A BIOLOGICAL SAMPLE CONTAINING BIOLOGICAL CELLS, AND ANALYSIS APPARATUS FOR IMPLEMENTING THE PROCESS OF ANALYSIS
JP7109229B2 (en) * 2018-03-30 2022-07-29 シスメックス株式会社 Flow cytometer and particle detection method
JP2019195304A (en) 2018-05-10 2019-11-14 学校法人順天堂 Image analysis method, device, computer program, and generation method of deep learning algorithm
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
EP4245140A3 (en) 2019-04-18 2024-01-17 ABS Global, Inc. System and process for continuous addition of cryoprotectant
JP7381003B2 (en) * 2019-04-26 2023-11-15 学校法人順天堂 METHODS, APPARATUS AND COMPUTER PROGRAMS TO ASSIST DISEASE ANALYSIS AND METHODS, APPARATUS AND PROGRAMS FOR TRAINING COMPUTER ALGORITHM
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US20230245478A1 (en) * 2020-07-30 2023-08-03 Hamamatsu Photonics K.K. Assessment device, assessment method, assessment program, and recording medium

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US6259807B1 (en) * 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US20040021868A1 (en) * 1999-01-25 2004-02-05 Ortyn William E. Imaging and analyzing parameters of small moving objects such as cells
WO2004088574A1 (en) * 2003-04-02 2004-10-14 Amersham Biosciences Uk Limited Method of, and computer software for, classification of cells into subpopulations
US20040229210A1 (en) * 1999-05-14 2004-11-18 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics

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JPS62134559A (en) * 1985-12-07 1987-06-17 Japan Spectroscopic Co Method and apparatus for automatic analysis of blood cell
JP4018063B2 (en) * 2000-10-12 2007-12-05 アムニス コーポレイション Imaging system and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6259807B1 (en) * 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US20040021868A1 (en) * 1999-01-25 2004-02-05 Ortyn William E. Imaging and analyzing parameters of small moving objects such as cells
US20040229210A1 (en) * 1999-05-14 2004-11-18 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
WO2004088574A1 (en) * 2003-04-02 2004-10-14 Amersham Biosciences Uk Limited Method of, and computer software for, classification of cells into subpopulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KORST ET AL: "Nucleated red blood cells: An update on the marker for fetal asphyxia", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 175, no. 4, 1 October 1996 (1996-10-01), pages 843 - 846, XP005453639, ISSN: 0002-9378, DOI: 10.1016/S0002-9378(96)80010-X *

Also Published As

Publication number Publication date
JP2008533440A (en) 2008-08-21
WO2006083969A3 (en) 2008-06-26
WO2006083969A2 (en) 2006-08-10
EP1844426A2 (en) 2007-10-17
JP4982385B2 (en) 2012-07-25

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