ES2828660T3 - Método y aparato para determinar recuentos de leucocitos - Google Patents

Método y aparato para determinar recuentos de leucocitos Download PDF

Info

Publication number
ES2828660T3
ES2828660T3 ES13742312T ES13742312T ES2828660T3 ES 2828660 T3 ES2828660 T3 ES 2828660T3 ES 13742312 T ES13742312 T ES 13742312T ES 13742312 T ES13742312 T ES 13742312T ES 2828660 T3 ES2828660 T3 ES 2828660T3
Authority
ES
Spain
Prior art keywords
light
concentration
leukocyte
biological sample
erythrocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13742312T
Other languages
English (en)
Spanish (es)
Inventor
Patricio Vidal
Christophe Godefroy
Phaisit Chewputtanagul
Jiuliu Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of ES2828660T3 publication Critical patent/ES2828660T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/1031Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06Quantitative determination
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59Transmissivity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012Red blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016White blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1006Investigating individual particles for cytology
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1019Associating Coulter-counter and optical flow cytometer [OFC]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1402Data analysis by thresholding or gating operations performed on the acquired signals or stored data
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1413Hydrodynamic focussing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486Counting the particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4915Blood using flow cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Primary Health Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Electrochemistry (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES13742312T 2012-07-05 2013-07-03 Método y aparato para determinar recuentos de leucocitos Active ES2828660T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261668377P 2012-07-05 2012-07-05
PCT/US2013/049367 WO2014008424A1 (en) 2012-07-05 2013-07-03 Method and apparatus for determining white blood cell counts

Publications (1)

Publication Number Publication Date
ES2828660T3 true ES2828660T3 (es) 2021-05-27

Family

ID=49878794

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13742312T Active ES2828660T3 (es) 2012-07-05 2013-07-03 Método y aparato para determinar recuentos de leucocitos

Country Status (9)

Country Link
US (2) US9096885B2 (en:Method)
EP (1) EP2870458B1 (en:Method)
JP (1) JP6321637B2 (en:Method)
KR (1) KR101963477B1 (en:Method)
CN (1) CN104541149B (en:Method)
BR (1) BR112015000018B1 (en:Method)
ES (1) ES2828660T3 (en:Method)
IN (1) IN2014DN10974A (en:Method)
WO (1) WO2014008424A1 (en:Method)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3246709A3 (en) 2010-09-16 2018-02-14 The General Hospital Corporation Red blood cell dynamics for diagnosis
ES2828660T3 (es) 2012-07-05 2021-05-27 Beckman Coulter Inc Método y aparato para determinar recuentos de leucocitos
ES3038281T3 (en) 2013-03-15 2025-10-10 Beckman Coulter Inc Systems and methods for panel design in flow cytometry
DE102013216362A1 (de) * 2013-08-19 2015-02-19 Siemens Healthcare Diagnostics Products Gmbh Analyseverfahren zur Klassifikationsunterstützung
CA2969912A1 (en) * 2014-12-10 2016-06-16 Neogenomics Laboratories, Inc. Automated flow cytometry analysis method and system
US10264515B2 (en) * 2014-12-22 2019-04-16 Qualcomm Incorporated Enhanced access network query protocol (ANQP) signaling to scale to support large numbers of service providers at an access point (AP)
WO2016106688A1 (zh) * 2014-12-31 2016-07-07 深圳迈瑞生物医疗电子股份有限公司 一种有核红细胞报警方法、装置及流式细胞分析仪
CN104732229B (zh) * 2015-03-16 2018-04-27 华南理工大学 一种用于宫颈涂片图像中重叠细胞的分割方法
US10955423B2 (en) 2015-12-15 2021-03-23 The General Hospital Corporation Methods of estimating blood glucose and related systems
US11114205B2 (en) * 2016-01-28 2021-09-07 Beckman Coulter, Inc. Infection detection and differentiation systems and methods
US10190961B2 (en) * 2016-03-18 2019-01-29 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Sample analyzer and sample analyzing method thereof
WO2017177192A1 (en) * 2016-04-07 2017-10-12 The General Hospital Corporation White blood cell population dynamics
US11193927B2 (en) * 2016-09-08 2021-12-07 Abbott Laboratories Automated body fluid analysis
CN113049476B (zh) * 2017-06-14 2024-05-24 芯易诊有限公司 用于分析样品中的颗粒和/或细胞的装置和方法
CN110383037B (zh) * 2017-06-20 2022-07-01 深圳迈瑞生物医疗电子股份有限公司 一种血小板聚集识别的方法、装置和细胞分析仪
EP3682239B1 (en) * 2017-09-13 2023-03-22 Alio, Inc. Systems and methods for detecting a periprosthetic infection
WO2019083844A1 (en) 2017-10-23 2019-05-02 Cytochip Inc. DEVICES AND METHOD FOR MEASURING TARGET ANALYTES AND PARTICLES
US11852640B2 (en) 2017-10-27 2023-12-26 Beckman Coulter, Inc. Hematology analyzers and methods of operation
MX2020006123A (es) * 2017-12-15 2020-09-21 Gastroklenz Inc Sistema de monitoreo de sensor para tratamientos basados en cateter permanente.
CN112041938A (zh) 2018-04-20 2020-12-04 拜克门寇尔特公司 败血症感染确定系统和方法
US11521706B2 (en) 2018-04-20 2022-12-06 Beckman Coulter, Inc. Testing and representing suspicion of sepsis
WO2019206312A1 (zh) * 2018-04-28 2019-10-31 深圳迈瑞生物医疗电子股份有限公司 样本分析仪异常的报警方法、系统及存储介质
EP3789751B1 (en) 2018-04-28 2024-06-26 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Method and system for determining platelet concentration
WO2019206311A1 (zh) * 2018-04-28 2019-10-31 深圳迈瑞生物医疗电子股份有限公司 血液分析系统、血液分析仪、血液分析方法及存储介质
CN111989032B (zh) 2018-06-15 2024-07-19 拜克门寇尔特公司 存在母细胞标志时确定败血症的方法
CN108663306B (zh) * 2018-07-27 2024-02-09 北京指真生物科技有限公司 一种流式细胞分析装置及补偿方法
EP3997461A1 (en) 2019-07-12 2022-05-18 Beckman Coulter, Inc. Systems and methods for evaluating immune response to infection
JP7657195B2 (ja) 2019-07-12 2025-04-04 ベックマン コールター, インコーポレイテッド 収縮期血圧、血液パラメーター、およびこれらの組み合わせを含むバイタルサインを使用して敗血症を検出する方法
US12019040B2 (en) 2019-09-30 2024-06-25 Cornell University System and devices for monitoring cell-containing materials and methods of their use
US11959908B2 (en) * 2019-12-17 2024-04-16 Arkray, Inc. Measurement device and measurement method
US12332265B2 (en) 2019-12-27 2025-06-17 Beckman Coulter, Inc. Sample preparation instrument
EP4365570A1 (en) * 2022-11-04 2024-05-08 Horiba, Ltd. Measurement method, measurement system, and test reagent kit

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58115346A (ja) * 1981-12-29 1983-07-09 Shimadzu Corp 血球種類識別装置
JPH0664053B2 (ja) * 1986-11-27 1994-08-22 東亜医用電子株式会社 フロ−サイトメトリ−による白血球の分類方法
KR970007077B1 (ko) 1987-03-13 1997-05-02 코울터 일렉트로닉스 인커퍼레이티드 광산란 기술을 이용한 다중-부분식별 분석 방법
WO1994018828A1 (en) * 1993-02-25 1994-09-01 Abbott Laboratories Multipurpose reagent system for rapid lysis of whole blood samples
EP0698211B1 (en) 1993-05-14 2003-04-02 Coulter International Corporation Reticulocyte analyzing method and apparatus utilizing light scatter techniques
US5656499A (en) * 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
JP3267625B2 (ja) 1995-10-23 2002-03-18 サイトメトリクス インコーポレイテッド 反射画像分析の方法および装置
US5733784A (en) * 1995-11-20 1998-03-31 Abbott Laboratories Reagent system and method for the differentiation and identification of reticulocytes
WO1999011771A1 (en) * 1997-09-04 1999-03-11 Science Research Laboratory, Inc. Cell separation using electric fields
US5874310A (en) * 1997-11-21 1999-02-23 Coulter International Corp. Method for differentiation of nucleated red blood cells
US6228652B1 (en) 1999-02-16 2001-05-08 Coulter International Corp. Method and apparatus for analyzing cells in a whole blood sample
US6524858B1 (en) * 1999-03-31 2003-02-25 Bayer Corporation Single channel, single dilution detection method for the identification and quantification of blood cells and platelets in a whole blood sample using an automated hematology analyzer
JP2005506525A (ja) * 2001-07-27 2005-03-03 ベックマン コールター,インコーポレーテッド 有核赤血球の計測法の方法
US6744245B2 (en) 2001-07-27 2004-06-01 Coulter International Corp. Particle count correction method and apparatus
US6916658B2 (en) * 2001-07-27 2005-07-12 Beckman Coulter, Inc. Method for measurement of immature granulocytes
US7198953B2 (en) * 2003-10-12 2007-04-03 Beckman Coulter, Inc. Method of using a reference control composition for measurement of nucleated red blood cells
JP4873712B2 (ja) 2003-10-12 2012-02-08 ベックマン コールター, インコーポレイテッド 有核赤血球の測定のためのリファレンスコントロールの使用方法
WO2005076995A2 (en) * 2004-02-10 2005-08-25 Beckman Coulter, Inc. Method of measurement of nucleated red blood cells
US7208319B2 (en) 2004-02-10 2007-04-24 Beckman Coulter, Inc. Method of measurement of nucleated red blood cells
US7390662B2 (en) 2005-11-09 2008-06-24 Beckman Coulter, Inc. Method and apparatus for performing platelet measurement
WO2006083969A2 (en) * 2005-02-01 2006-08-10 Amnis Corporation Blood analysis using a flow imaging cytometer
CN101305087A (zh) * 2005-09-15 2008-11-12 阿尔特弥斯康复公司 用于磁富集细胞和其他颗粒的装置和方法
US7796797B2 (en) * 2005-09-28 2010-09-14 Sysmex Corporation Apparatus for obtaining an image of a blood cell and method for obtaining an image of a blood cell
JP4690163B2 (ja) * 2005-09-28 2011-06-01 シスメックス株式会社 血液撮像装置、血液撮像方法、処理装置、及び撮像本体装置
US7661326B2 (en) 2006-10-26 2010-02-16 Beckman Coulter, Inc. Apparatus for aspirating and dispensing liquids in an automated analyzer
US8094299B2 (en) 2008-07-24 2012-01-10 Beckman Coulter, Inc. Transducer module
US8512977B2 (en) 2008-09-19 2013-08-20 Beckman Coulter, Inc. Analyzing reticulocytes
US8603773B2 (en) 2008-09-19 2013-12-10 Beckman Coulter Method and system for analyzing a blood sample
US8417012B2 (en) 2008-11-04 2013-04-09 Beckman Coulter, Inc. Non-linear histogram segmentation for particle analysis
CN102282453B (zh) 2008-11-14 2013-08-14 贝克曼考尔特公司 整体式光学流动室和制造方法
US9464978B2 (en) 2009-03-04 2016-10-11 Beckman Coulter, Inc. Cross-instrument method and system for cell population discrimination
JP5871792B2 (ja) * 2009-04-27 2016-03-01 アボット・ラボラトリーズAbbott Laboratories 自動血液分析器において、レーザーからの前方散乱を用いることによる、赤血球細胞を白血球細胞から判別する方法
US8911669B2 (en) * 2009-08-24 2014-12-16 Abbott Laboratories Method for flagging a sample
ES2828660T3 (es) 2012-07-05 2021-05-27 Beckman Coulter Inc Método y aparato para determinar recuentos de leucocitos

Also Published As

Publication number Publication date
US20150330963A1 (en) 2015-11-19
JP2015522165A (ja) 2015-08-03
EP2870458A1 (en) 2015-05-13
WO2014008424A1 (en) 2014-01-09
CN104541149B (zh) 2017-03-01
US9588102B2 (en) 2017-03-07
KR20150036329A (ko) 2015-04-07
KR101963477B1 (ko) 2019-03-28
BR112015000018A2 (pt) 2017-06-27
US9096885B2 (en) 2015-08-04
CN104541149A (zh) 2015-04-22
JP6321637B2 (ja) 2018-05-09
IN2014DN10974A (en:Method) 2015-09-18
BR112015000018B1 (pt) 2021-11-09
US20140011232A1 (en) 2014-01-09
EP2870458B1 (en) 2020-09-09

Similar Documents

Publication Publication Date Title
ES2828660T3 (es) Método y aparato para determinar recuentos de leucocitos
US12437873B2 (en) Infection detection and differentiation systems and methods
US9939453B2 (en) Immature platelet enumeration systems and methods
ES2772453T3 (es) Sistemas y métodos para el recuento de plaquetas con ajuste de agregaciones