ES2821969T3 - Derivados de 8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano - Google Patents
Derivados de 8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano Download PDFInfo
- Publication number
- ES2821969T3 ES2821969T3 ES17700390T ES17700390T ES2821969T3 ES 2821969 T3 ES2821969 T3 ES 2821969T3 ES 17700390 T ES17700390 T ES 17700390T ES 17700390 T ES17700390 T ES 17700390T ES 2821969 T3 ES2821969 T3 ES 2821969T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- unsubstituted
- phenyl
- saturated
- diazaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CN(C)[C@](*)(CC1)CC[C@@]1(CN1*)N(CC2(*)*CC2)C1=* Chemical compound CN(C)[C@](*)(CC1)CC[C@@]1(CN1*)N(CC2(*)*CC2)C1=* 0.000 description 5
- JNVNMRNNXAYZDI-WKILWMFISA-N CN(C)[C@](CC1)(CC[C@]1(CN1)NC1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@]1(CN1)NC1=O)c1ccccc1 JNVNMRNNXAYZDI-WKILWMFISA-N 0.000 description 2
- GEQNGODHNOPBMI-UHFFFAOYSA-N C=CC1(COC1)OCc1ccccc1 Chemical compound C=CC1(COC1)OCc1ccccc1 GEQNGODHNOPBMI-UHFFFAOYSA-N 0.000 description 1
- URIALMKIAROEIX-PSWAGMNNSA-N CC(C)(CN(C[C@](CC1)(CC[C@]1(c1ccccc1)N(C)C)N1CC2CC2)C1=O)O Chemical compound CC(C)(CN(C[C@](CC1)(CC[C@]1(c1ccccc1)N(C)C)N1CC2CC2)C1=O)O URIALMKIAROEIX-PSWAGMNNSA-N 0.000 description 1
- KIOYDBLXEFETPO-UHFFFAOYSA-N CC(CN(CC(CCC=O)CCSO)C(NCC1(CCC1)O)=O)(CC1)CCC1(c1ccccc1)N(C)C Chemical compound CC(CN(CC(CCC=O)CCSO)C(NCC1(CCC1)O)=O)(CC1)CCC1(c1ccccc1)N(C)C KIOYDBLXEFETPO-UHFFFAOYSA-N 0.000 description 1
- JSYCTCQNKHEOCN-UHFFFAOYSA-N CC1C=CC=CC1C(CC1)(CCC1(CN1CC(OC(C)(C)C)=O)N(CC2CC2)C1=O)N(C)C Chemical compound CC1C=CC=CC1C(CC1)(CCC1(CN1CC(OC(C)(C)C)=O)N(CC2CC2)C1=O)N(C)C JSYCTCQNKHEOCN-UHFFFAOYSA-N 0.000 description 1
- FPFPSEBIOFRNAQ-UHFFFAOYSA-N CN(C)C(CC1)(CCC1(C#N)N)c1ccccc1 Chemical compound CN(C)C(CC1)(CCC1(C#N)N)c1ccccc1 FPFPSEBIOFRNAQ-UHFFFAOYSA-N 0.000 description 1
- OBLFDAAENCOHLA-UHFFFAOYSA-N CN(C)C(CC1)(CCC1(CN)NCC(F)(F)F)c1ccccc1 Chemical compound CN(C)C(CC1)(CCC1(CN)NCC(F)(F)F)c1ccccc1 OBLFDAAENCOHLA-UHFFFAOYSA-N 0.000 description 1
- XRFKVYZQKLANJF-UHFFFAOYSA-N CN(C)C(CC1)(CCC1(CN1)N(CC2(CCC2)O)C1=O)c1ccccc1 Chemical compound CN(C)C(CC1)(CCC1(CN1)N(CC2(CCC2)O)C1=O)c1ccccc1 XRFKVYZQKLANJF-UHFFFAOYSA-N 0.000 description 1
- QGFDSGLEDXSQON-UHFFFAOYSA-N CN(C)C(CC1)(CCC1(CN1CC2CCSCC2)N(CC2(CCC2)O)C1=O)c1ccccc1 Chemical compound CN(C)C(CC1)(CCC1(CN1CC2CCSCC2)N(CC2(CCC2)O)C1=O)c1ccccc1 QGFDSGLEDXSQON-UHFFFAOYSA-N 0.000 description 1
- XHZRFKHUXXJATF-UHFFFAOYSA-N CN(C)C(CC1)(CCC1(CN1CCC2(COC2)O)N(CC2CCC2)C1=O)c1ccccc1 Chemical compound CN(C)C(CC1)(CCC1(CN1CCC2(COC2)O)N(CC2CCC2)C1=O)c1ccccc1 XHZRFKHUXXJATF-UHFFFAOYSA-N 0.000 description 1
- MEVKXTNGTLJYCF-UHFFFAOYSA-N CN(C)C(CC1)(CCC1(CN1CCC2(COC2)OCc2ccccc2)N(CC2CCC2)C1=O)c1ccccc1 Chemical compound CN(C)C(CC1)(CCC1(CN1CCC2(COC2)OCc2ccccc2)N(CC2CCC2)C1=O)c1ccccc1 MEVKXTNGTLJYCF-UHFFFAOYSA-N 0.000 description 1
- RIOIFODCEWMZAU-UHFFFAOYSA-N CN(C)CC(CC1)(CCC1C(CN1C(CC2)CCN2c2cncnc2)N(CC2CC2)C1=O)c1ccccc1 Chemical compound CN(C)CC(CC1)(CCC1C(CN1C(CC2)CCN2c2cncnc2)N(CC2CC2)C1=O)c1ccccc1 RIOIFODCEWMZAU-UHFFFAOYSA-N 0.000 description 1
- JIQFSTPXEPFMBY-CALCHBBNSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC(F)(F)F)C1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC(F)(F)F)C1=O)c1ccccc1 JIQFSTPXEPFMBY-CALCHBBNSA-N 0.000 description 1
- ITFUXLDQVXVYOI-HDICACEKSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC(O)=O)C1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC(O)=O)C1=O)c1ccccc1 ITFUXLDQVXVYOI-HDICACEKSA-N 0.000 description 1
- JFISOFKMMIWMSB-ZRZAMGCNSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1CC(OC)=O)N(CC2CC2)C1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1CC(OC)=O)N(CC2CC2)C1=O)c1ccccc1 JFISOFKMMIWMSB-ZRZAMGCNSA-N 0.000 description 1
- JHDGANSNLOBQLY-UHFFFAOYSA-N O=CCC1(COC1)OCc1ccccc1 Chemical compound O=CCC1(COC1)OCc1ccccc1 JHDGANSNLOBQLY-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N OC(C(F)(F)F)=O Chemical compound OC(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- DNDYXRLLHQICBB-UHFFFAOYSA-N OCCC1(COC1)OCc1ccccc1 Chemical compound OCCC1(COC1)OCc1ccccc1 DNDYXRLLHQICBB-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151015 | 2016-01-13 | ||
| PCT/EP2017/025008 WO2017121650A1 (en) | 2016-01-13 | 2017-01-13 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2821969T3 true ES2821969T3 (es) | 2021-04-28 |
Family
ID=55129636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17700390T Active ES2821969T3 (es) | 2016-01-13 | 2017-01-13 | Derivados de 8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US20170197949A1 (https=) |
| EP (1) | EP3402782B1 (https=) |
| JP (1) | JP6917379B2 (https=) |
| KR (1) | KR20180097734A (https=) |
| CN (1) | CN108602778B (https=) |
| AR (1) | AR107359A1 (https=) |
| AU (1) | AU2017206911B2 (https=) |
| BR (1) | BR112018014301B1 (https=) |
| CA (1) | CA3011182A1 (https=) |
| CL (1) | CL2018001909A1 (https=) |
| CO (1) | CO2018008450A2 (https=) |
| CY (1) | CY1123366T1 (https=) |
| DK (1) | DK3402782T3 (https=) |
| EA (1) | EA034898B1 (https=) |
| EC (1) | ECSP18060875A (https=) |
| ES (1) | ES2821969T3 (https=) |
| HR (1) | HRP20201660T1 (https=) |
| HU (1) | HUE051642T2 (https=) |
| IL (1) | IL260488B (https=) |
| LT (1) | LT3402782T (https=) |
| MX (1) | MX379359B (https=) |
| PT (1) | PT3402782T (https=) |
| RS (1) | RS60855B1 (https=) |
| SI (1) | SI3402782T1 (https=) |
| TW (1) | TWI654181B (https=) |
| WO (1) | WO2017121650A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3402782T1 (sl) | 2016-01-13 | 2020-11-30 | Grunenthal Gmbh | 8-amino-2-okso-1,3-diaza-spiro-(4,5)-dekanski derivati |
| JP6854823B2 (ja) | 2016-01-13 | 2021-04-07 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ３−（カルボキシメチル）−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 |
| EP3722284B1 (en) | 2016-01-13 | 2025-01-22 | Grünenthal GmbH | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| PL3402783T3 (pl) | 2016-01-13 | 2020-08-24 | Grünenthal GmbH | Pochodne 3-(karboksyetylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu |
| US20170197947A1 (en) | 2016-01-13 | 2017-07-13 | Gruenenthal Gmbh | 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| WO2019039852A1 (ko) | 2017-08-22 | 2019-02-28 | 주식회사 엘지화학 | 방열 소재 디스펜싱 장치의 결정방법 |
| JP7446316B2 (ja) | 2019-01-11 | 2024-03-08 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換ピロリジンアミドｉｉｉ |
| CN110092790B (zh) * | 2019-06-11 | 2020-07-24 | 东北农业大学 | 一种生物碱类化合物及其制备方法和应用 |
| US20240400537A1 (en) | 2023-04-25 | 2024-12-05 | Gruenenthal Gmbh | Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| KR100855204B1 (ko) | 2001-04-18 | 2008-09-01 | 유로-셀티크 소시에떼 아노뉨 | 노시셉틴 유사체 |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| DE10135636A1 (de) * | 2001-07-17 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 4-Aminocyclohexanole |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| WO2004005293A2 (en) | 2002-07-05 | 2004-01-15 | Targacept, Inc. | N-aryl diazaspiracyclic compounds and methods of preparation and use thereof |
| DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| US20080287478A1 (en) | 2003-05-23 | 2008-11-20 | Lars Bo Laurenborg Hansen | Nociceptin Analogues and Uses Thereof |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| DE102005023784A1 (de) | 2005-05-19 | 2006-11-30 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| JP5079011B2 (ja) | 2006-10-19 | 2012-11-21 | エフ．ホフマン−ラ ロシュ アーゲー | 糖尿病のための１１β−ＨＳＤ１阻害剤としてのイミダゾロン及びイミダゾリジノン誘導体 |
| JP5490677B2 (ja) | 2007-04-09 | 2014-05-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体 |
| ES2464102T3 (es) * | 2008-03-27 | 2014-05-30 | Grünenthal GmbH | Derivados de 4-aminociclohexano sustituidos |
| TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
| WO2010151815A2 (en) | 2009-06-25 | 2010-12-29 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
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| SI3402782T1 (sl) | 2016-01-13 | 2020-11-30 | Grunenthal Gmbh | 8-amino-2-okso-1,3-diaza-spiro-(4,5)-dekanski derivati |
| TWI730032B (zh) | 2016-01-13 | 2021-06-11 | 美商必治妥美雅史谷比公司 | 作為ｒｏｃｋ抑制劑之螺庚烷水楊酸醯胺及相關化合物 |
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| US20170197947A1 (en) | 2016-01-13 | 2017-07-13 | Gruenenthal Gmbh | 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
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2017
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- 2017-01-13 US US15/405,627 patent/US20170197949A1/en not_active Abandoned
- 2017-01-13 WO PCT/EP2017/025008 patent/WO2017121650A1/en not_active Ceased
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2018
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2021
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