ES2782380T5 - Método de especificación y cultivo de linaje del músculo esquelético escalable - Google Patents

Método de especificación y cultivo de linaje del músculo esquelético escalable Download PDF

Info

Publication number
ES2782380T5
ES2782380T5 ES14858383T ES14858383T ES2782380T5 ES 2782380 T5 ES2782380 T5 ES 2782380T5 ES 14858383 T ES14858383 T ES 14858383T ES 14858383 T ES14858383 T ES 14858383T ES 2782380 T5 ES2782380 T5 ES 2782380T5
Authority
ES
Spain
Prior art keywords
cell line
myogenic
self
differentiation
culture medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14858383T
Other languages
English (en)
Spanish (es)
Other versions
ES2782380T3 (es
Inventor
Nicholas Genovese
R Roberts
Bhanu Telugu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Upside Foods Inc
University of Missouri Columbia
University of Missouri St Louis
Original Assignee
Upside Foods Inc
University of Missouri Columbia
University of Missouri St Louis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53005145&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2782380(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upside Foods Inc, University of Missouri Columbia, University of Missouri St Louis filed Critical Upside Foods Inc
Publication of ES2782380T3 publication Critical patent/ES2782380T3/es
Application granted granted Critical
Publication of ES2782380T5 publication Critical patent/ES2782380T5/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L13/00Meat products; Meat meal; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/39Steroid hormones
    • C12N2501/392Sexual steroids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • C12N2501/415Wnt; Frizzeled
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60Transcription factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60Transcription factors
    • C12N2501/602Sox-2
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60Transcription factors
    • C12N2501/603Oct-3/4
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60Transcription factors
    • C12N2501/604Klf-4
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70Enzymes
    • C12N2501/72Transferases [EC 2.]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70Enzymes
    • C12N2501/72Transferases [EC 2.]
    • C12N2501/727Kinases (EC 2.7.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999Small molecules not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fodder In General (AREA)
ES14858383T 2013-10-30 2014-10-30 Método de especificación y cultivo de linaje del músculo esquelético escalable Active ES2782380T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361962068P 2013-10-30 2013-10-30
PCT/US2014/063250 WO2015066377A1 (en) 2013-10-30 2014-10-30 Method for scalable skeletal muscle lineage specification and cultivation

Publications (2)

Publication Number Publication Date
ES2782380T3 ES2782380T3 (es) 2020-09-14
ES2782380T5 true ES2782380T5 (es) 2023-05-08

Family

ID=53005145

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14858383T Active ES2782380T5 (es) 2013-10-30 2014-10-30 Método de especificación y cultivo de linaje del músculo esquelético escalable

Country Status (10)

Country Link
US (3) US20160251625A1 (enExample)
EP (1) EP3071040B2 (enExample)
JP (2) JP6728049B2 (enExample)
CN (2) CN111154726A (enExample)
AU (2) AU2014342180B2 (enExample)
BR (1) BR112016009803B1 (enExample)
CA (1) CA2928726A1 (enExample)
ES (1) ES2782380T5 (enExample)
IL (2) IL296889A (enExample)
WO (1) WO2015066377A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016009803B1 (pt) 2013-10-30 2022-02-08 The Curators Of The University Of Missouri Método para especificação e cultivo de linhagem muscular esquelética escalonável
US11318167B2 (en) 2015-12-11 2022-05-03 The Johns Hopkins University Isolation of fusion-competent myoblasts and therapeutic applications thereof related to muscular dystrophy
CA3011484A1 (en) * 2016-01-14 2017-07-20 Memphis Meats, Inc. Methods for extending the replicative capacity of somatic cells during an ex vivo cultivation process
CN109714962A (zh) 2016-07-11 2019-05-03 耶路撒冷希伯来大学的益生研究开发有限公司 用于在体外培养细胞的系统和方法
ES2985769T3 (es) 2017-05-06 2024-11-07 Upside Foods Inc Composiciones y métodos para aumentar la densidad de cultivo de una biomasa celular dentro de una infraestructura de cultivo
US20200140821A1 (en) * 2017-06-07 2020-05-07 Wild Type, Inc. Ex vivo meat production
WO2019014652A1 (en) 2017-07-13 2019-01-17 Memphis Meats, Inc. COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CELL CULTURES USED IN FOOD PRODUCTION
BR112020000952A2 (pt) 2017-07-15 2020-07-14 Aleph Farms composições de carne cultivada
GB2573327B (en) * 2018-05-03 2021-05-12 Mosa Meat Bv Apparatus and process for production of tissue from cells
US12478571B2 (en) 2018-12-17 2025-11-25 Pontis Biologics, Inc. Enzyme based compositions and methods for removing dental calculi
EP3969571A4 (en) 2019-05-14 2023-05-24 Aleph Farms Ltd. AGGREGATES OF PLURIPOTENT CELLS AND THEIR USE
CA3200542A1 (en) 2019-05-28 2020-12-03 Upside Foods, Inc. Apparatuses and methods for preparing a comestible meat product
IL292318B2 (en) 2019-11-20 2023-04-01 Upside Foods Inc Devices and methods for preparing a meat product
CN115443330A (zh) * 2019-12-02 2022-12-06 奥方特蛋白质科技有限公司 使用体外细胞培养生产肉类的方法
US20210235733A1 (en) 2020-02-04 2021-08-05 Memphis Meats, Inc. Characteristics of meat products
WO2021248141A1 (en) 2020-06-05 2021-12-09 Upside Foods, Inc. Nutrient media for the production of slaughter-free meat
GB202008821D0 (en) * 2020-06-10 2020-07-22 Highersteaks Ltd Systems and methods for cell conversion
US12252681B2 (en) 2020-08-18 2025-03-18 Upside Foods, Inc. Systems, devices, and methods for sterilizing bioreactors and culture media
US20220195368A1 (en) * 2020-12-21 2022-06-23 Upside Foods, Inc. Fluid conduit with radial expansion of fluid flow
US11912967B2 (en) 2020-12-22 2024-02-27 Upside Foods, Inc. Systems and methods for cultivating tissue on porous substrates
WO2022156939A1 (en) * 2021-01-22 2022-07-28 HigherSteaks Limited Products for cell conversion
EP4304383A4 (en) 2021-03-10 2025-02-26 Terasaki Institute For Biomedical Innovation GROWTH FACTORS FOR LABORATORY-GROWN MEAT AND OTHER APPLICATIONS
AU2022254053A1 (en) 2021-04-07 2023-10-12 Upside Foods, Inc. Generation of cell-based products for consumption that comprise proteins derived from exotic, endangered, and extinct species
CN117795058A (zh) 2021-04-28 2024-03-29 阿普赛德食品公司 生产用于人类消费的基于细胞的产品
BR112023022889A2 (pt) 2021-05-06 2024-01-23 Yeda Res & Dev Método para induzir fibras musculares hipertróficas para produção de carne industrial
JP2024520498A (ja) * 2021-05-28 2024-05-24 エービーエス グローバル インコーポレイテッド 家畜におけるインビトロ育種システム及び方法
JP2024523133A (ja) 2021-06-11 2024-06-28 アップサイド フーズ, インコーポレイテッド 乾燥細胞粉末を含む細胞ベースの肉製品、及びそのような製品の製造方法
CA3221762A1 (en) 2021-06-16 2022-12-22 Upside Foods, Inc. Plant fat-based scaffolds for the growth of cell-based meats and methods of making such products
EP4367219A1 (en) 2021-07-09 2024-05-15 Suprême Foodstuffs comprising cells differentiated from engineered oligopotent stem cells
CA3231125A1 (en) 2021-10-19 2023-04-27 Joshua MARCH Plant base/animal cell hybrid meat substitute
IL313347A (en) * 2021-12-23 2024-08-01 Upside Foods Inc Myogenic tissue augmentation: late transition myogenicity
EP4292440A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Suspension based chicken product formulation
EP4293109A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Non-skeletal muscle-derived cells as a source of suspension capable myogenic cells for cultured foods
US11981884B2 (en) 2022-10-17 2024-05-14 Upside Foods, Inc. Pipe-based bioreactors for producing comestible meat products and methods of using the same
WO2025011578A1 (zh) * 2023-07-10 2025-01-16 中国农业大学 一种猪多能干细胞的肌源性分化方法及其用于细胞培养肉制备
EP4497814A1 (de) 2023-07-28 2025-01-29 Green Elephant Biotech GmbH Vorrichtung zur vermehrung von differenzierten und undifferenzierten zellen und verwendung der vorrichtung für die herstellung von kultivierten lebensmitteln
WO2025049891A1 (en) 2023-09-01 2025-03-06 Upside Foods, Inc. Transposon system and methods of using the same
US20250120418A1 (en) * 2023-10-12 2025-04-17 Btl Healthcare Technologies A.S. Pet food, methods and devices for producing pet food
WO2025141211A1 (en) * 2023-12-29 2025-07-03 Meatable B.V. Cells for forward programming

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510254A (en) 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
AU642184B2 (en) * 1989-12-21 1993-10-14 University Of Georgia Research Foundation, Inc., The Bovine myogenic factor gene
US5298422A (en) * 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
WO1999031222A1 (en) 1997-12-18 1999-06-24 Willem Frederik Van Eelen Industrial scale production of meat from in vitro cell cultures
WO1999043786A2 (en) 1998-02-27 1999-09-02 Purdue Research Foundation Submucosa gel compositions
US6537782B1 (en) 1998-06-01 2003-03-25 Chugai Seiyaku Kabushiki Kaisha Media for culturing animal cells and process for producing protein by using the same
US6835390B1 (en) 2000-11-17 2004-12-28 Jon Vein Method for producing tissue engineered meat for consumption
EP1639097B1 (en) * 2003-06-25 2013-08-07 Ottawa Health Research Institute Methods and compositions for modulating stem cell growth and differentiation
DE102004017484B4 (de) 2004-04-08 2006-07-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung einer biologischen Materialzusammensetzung tierischen Ursprungs
US20060121006A1 (en) 2004-09-10 2006-06-08 Chancellor Michael B Production of nutritional and therapeutic products from cultured animal cells
WO2006041429A2 (en) 2004-09-17 2006-04-20 Jon Vein Tissue engineered meat for consumption and a method for producing tissue engineered meat for consumption
JP2009514824A (ja) * 2005-11-02 2009-04-09 ネステク ソシエテ アノニム 雄の哺乳動物における体脂肪の蓄積を低減するためのイソフラボン組成物及びその使用方法
KR20080108487A (ko) * 2006-02-28 2008-12-15 트르스티스 오브 보스톤 유니버시티 대사 조절인자 및 그의 용도
DE102007029699B4 (de) 2007-06-27 2010-12-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Isolierte proliferierende Zellen mit Stammzelleigenschaften aus adultem Gewebe von wechselwarmen Wirbeltieren, stabile Zellkulturen davon und Verfahren zu deren Herstellung
CN101624570B (zh) 2008-07-07 2011-04-13 刘志军 中药培养养殖肉灵芝方法及养殖肉灵芝保健品的制备方法
WO2010068897A2 (en) 2008-12-12 2010-06-17 Kedar Challakere Stem cell enhanced protein products and uses thereof
US20110091604A1 (en) 2009-10-21 2011-04-21 Seth Adrian Miller Synthetic meat
WO2012034101A2 (en) 2010-09-09 2012-03-15 The Regents Of The University Of California Expandable cell source of neuronal stem cell populations and methods for obtaining and using them
BR112013031770A2 (pt) * 2011-06-10 2016-12-06 Univ Georgia população de células-tronco aviárias de pluripotência induzida, ave quimérica, método de reprogamação de uma célula embrionária aviária ou célula somática adulta, método de manipulação genética de espécies aviárias, método de instilar a resistência à doença em uma célula-tronco aviária pluripotente induzida, método de instilar a resistência à doença em uma população de célula-tronco aviária pluripotente, método para produzir um gameta de ave quimérica, método de produção de material imunogênico para uma vacina e vacina
US8900572B2 (en) * 2011-06-14 2014-12-02 UNIVERSITé LAVAL Myogenic differentiation of stem cells and uses thereof
US8883503B2 (en) 2011-06-23 2014-11-11 Indian Institute Of Technology Kanpur Hydrogel scaffolds for tissue engineering
US10039306B2 (en) 2012-03-16 2018-08-07 Impossible Foods Inc. Methods and compositions for consumables
BR112014000614A2 (pt) 2011-07-12 2017-07-11 Maraxi Inc métodos e composições para consumíveis
PL2736357T3 (pl) 2011-07-26 2019-02-28 The Curators Of The University Of Missouri Poddawane inżynierii jadalne mięso
CA2792081C (en) * 2011-10-11 2020-10-27 Bond University Ltd Layered compositions comprising 3d nanofibre webbing for tissue repair
JP6083877B2 (ja) * 2011-11-18 2017-02-22 国立大学法人京都大学 多能性幹細胞から骨格筋細胞への分化誘導方法
US9737875B2 (en) 2012-03-16 2017-08-22 Impossible Foods Inc. Affinity reagents for protein purification
CN104603293A (zh) 2012-03-28 2015-05-06 现代牧场有限公司 工程的皮革和其制造方法
RU2672489C2 (ru) 2013-01-11 2018-11-15 Импоссибл Фудз Инк. Немолочный аналог сыра, содержащий коацерват
EP2959005B1 (en) 2013-02-22 2021-10-06 The Board of Trustees of the Leland Stanford Junior University Medical use relating to telomere extension
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
BR112016009803B1 (pt) 2013-10-30 2022-02-08 The Curators Of The University Of Missouri Método para especificação e cultivo de linhagem muscular esquelética escalonável
US9526267B2 (en) 2014-04-17 2016-12-27 Savage River, Inc. Nutrient-dense meat structured protein products
US20150296834A1 (en) 2014-04-17 2015-10-22 Savage River, Inc. dba Beyond Meat, Inc. Plant based meat structured protein products
WO2017019125A1 (en) 2015-07-24 2017-02-02 Synthetic Genomics, Inc. A protein rich food ingredient from biomass and methods of production
CA3011484A1 (en) 2016-01-14 2017-07-20 Memphis Meats, Inc. Methods for extending the replicative capacity of somatic cells during an ex vivo cultivation process
ES2985769T3 (es) 2017-05-06 2024-11-07 Upside Foods Inc Composiciones y métodos para aumentar la densidad de cultivo de una biomasa celular dentro de una infraestructura de cultivo
WO2019014652A1 (en) 2017-07-13 2019-01-17 Memphis Meats, Inc. COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CELL CULTURES USED IN FOOD PRODUCTION

Also Published As

Publication number Publication date
JP6728049B2 (ja) 2020-07-22
EP3071040B1 (en) 2020-01-01
ES2782380T3 (es) 2020-09-14
BR112016009803B1 (pt) 2022-02-08
CN111154726A (zh) 2020-05-15
EP3071040B2 (en) 2022-12-28
CA2928726A1 (en) 2015-05-07
AU2019202244A1 (en) 2019-04-18
IL245292A0 (en) 2016-06-30
AU2019202244B2 (en) 2021-09-23
IL245292B (en) 2022-10-01
US20160251625A1 (en) 2016-09-01
IL245292B2 (en) 2023-02-01
AU2014342180A1 (en) 2016-05-19
US20210171912A1 (en) 2021-06-10
CN105899079A (zh) 2016-08-24
EP3071040A1 (en) 2016-09-28
BR112016009803A2 (pt) 2017-12-05
IL296889A (en) 2022-12-01
EP3071040A4 (en) 2017-06-21
US10920196B2 (en) 2021-02-16
JP2020089381A (ja) 2020-06-11
WO2015066377A1 (en) 2015-05-07
AU2014342180B2 (en) 2019-01-03
US20160227830A1 (en) 2016-08-11
BR112016009803A8 (pt) 2018-01-30
JP2016535601A (ja) 2016-11-17

Similar Documents

Publication Publication Date Title
ES2782380T5 (es) Método de especificación y cultivo de linaje del músculo esquelético escalable
JP6131433B2 (ja) 細胞rna発現のための方法
ES2589122T3 (es) Estimulación de la ruta de la Wnt en la reprogramación de células somáticas
ES2695550T3 (es) Método para rejuvenecer células
US20110014164A1 (en) Efficient induction of pluripotent stem cells using small molecule compounds
Mo et al. Generation and characterization of bat-induced pluripotent stem cells
Yakhkeshi et al. In vitro improvement of quail primordial germ cell expansion through activation of TGF‐beta signaling pathway
CN105764334B (zh) 加强肿瘤生长的方法
EP2734617B1 (en) Use of cellular extracts for obtaining pluripotent stem cells
US20210395692A1 (en) Method For Reducing Differentiation Resistance Of Pluripotent Stem Cells
Lluis et al. Resetting epigenetic signatures to induce somatic cell reprogramming
HK1229164B (en) Method for scalable skeletal muscle lineage specification and cultivation
HK1229164A1 (en) Method for scalable skeletal muscle lineage specification and cultivation
Siddall et al. Myc-what we have learned from flies
Gu et al. Hyperthermia suppresses the biological characteristics and migration of chicken primordial germ cells
Almeida An investigation of cell cycle regulation during in vitro models of diapause
EP2646557B1 (en) Method for cellular rna expression
Rambow Investigation of the tumorigenicity of GoST cells derived from miPS cells
FATHIMA ISOLATION AND CHARACTERIZATION OF MYOSATELLITE CELLS FROM CLARIAS MAGUR (HAMILTON, 1822)
Francis Induced Pluripotent Stem Cells as an Alternative to Embryonic Stem Cells for the Treatment of Type 1 Diabetes