CN111154726A - 可扩展性骨骼肌谱系特化和培育的方法 - Google Patents

可扩展性骨骼肌谱系特化和培育的方法 Download PDF

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CN111154726A
CN111154726A CN202010084479.7A CN202010084479A CN111154726A CN 111154726 A CN111154726 A CN 111154726A CN 202010084479 A CN202010084479 A CN 202010084479A CN 111154726 A CN111154726 A CN 111154726A
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cell line
cell
self
species
differentiation
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Chinese (zh)
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N·J·吉诺维斯
R·M·罗伯茨
B·P·V·L·泰卢固
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Upside Foods Inc
University of Missouri St Louis
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Memphis Meats Inc
University of Missouri St Louis
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Application filed by Memphis Meats Inc, University of Missouri St Louis filed Critical Memphis Meats Inc
Publication of CN111154726A publication Critical patent/CN111154726A/zh
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    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
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CN202010084479.7A 2013-10-30 2014-10-30 可扩展性骨骼肌谱系特化和培育的方法 Pending CN111154726A (zh)

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US201361962068P 2013-10-30 2013-10-30
US61/962068 2013-10-30
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AU (2) AU2014342180B2 (enExample)
BR (1) BR112016009803B1 (enExample)
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ES (1) ES2782380T5 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025011578A1 (zh) * 2023-07-10 2025-01-16 中国农业大学 一种猪多能干细胞的肌源性分化方法及其用于细胞培养肉制备

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2928726A1 (en) 2013-10-30 2015-05-07 The Curators Of The University Of Missouri Method for scalable skeletal muscle lineage specification and cultivation
WO2017100498A1 (en) 2015-12-11 2017-06-15 The Johns Hopkins University Isolation of fusion-competent myoblasts and therapeutic applications thereof related to muscular dystrophy
MX2018008733A (es) * 2016-01-14 2019-01-28 Memphis Meats Inc Metodos para extender la capacidad replicativa de las celulas somaticas durante un proceso de cultivo ex vivo.
US12325866B2 (en) 2016-07-11 2025-06-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Systems and methods for growing cells in vitro
US11976302B2 (en) 2017-05-06 2024-05-07 Upside Foods, Inc. Compositions and methods for increasing the culture density of a cellular biomass within a cultivation infrastructure
CA3066060A1 (en) * 2017-06-07 2018-12-13 Wild Type, Inc. Ex vivo meat production
WO2019014652A1 (en) 2017-07-13 2019-01-17 Memphis Meats, Inc. COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CELL CULTURES USED IN FOOD PRODUCTION
SG11201914083TA (en) 2017-07-15 2020-01-30 Technion Res & Dev Foundation Cultured meat compositions
GB2573327B (en) * 2018-05-03 2021-05-12 Mosa Meat Bv Apparatus and process for production of tissue from cells
US12478571B2 (en) 2018-12-17 2025-11-25 Pontis Biologics, Inc. Enzyme based compositions and methods for removing dental calculi
JP2022535192A (ja) 2019-05-14 2022-08-05 アレフ ファームス リミテッド 多能性細胞凝集体およびそれらの使用
CN117802035A (zh) 2019-05-28 2024-04-02 阿普赛德食品公司 用于生长可食用肉制品的基材
MX2022006095A (es) 2019-11-20 2022-08-16 Upside Foods Inc Aparatos y sistemas para preparar un producto carnico.
EP4069824A1 (en) * 2019-12-02 2022-10-12 Avant Meats Company Limited Methods of meat production by in vitro cell cultivation
US20210235733A1 (en) 2020-02-04 2021-08-05 Memphis Meats, Inc. Characteristics of meat products
IL298798A (en) 2020-06-05 2023-02-01 Upside Foods Inc Nutrient media for the production of slaughter-free meat
GB202008821D0 (en) * 2020-06-10 2020-07-22 Highersteaks Ltd Systems and methods for cell conversion
US12252681B2 (en) 2020-08-18 2025-03-18 Upside Foods, Inc. Systems, devices, and methods for sterilizing bioreactors and culture media
US20220195368A1 (en) * 2020-12-21 2022-06-23 Upside Foods, Inc. Fluid conduit with radial expansion of fluid flow
US11912967B2 (en) * 2020-12-22 2024-02-27 Upside Foods, Inc. Systems and methods for cultivating tissue on porous substrates
US20250283044A1 (en) * 2021-01-22 2025-09-11 HigherSteaks Limited Products for cell conversion
US20240150724A1 (en) 2021-03-10 2024-05-09 Terasaki Institute For Biomedical Innovation Production of heme for cell-based meat products
WO2022216742A1 (en) 2021-04-07 2022-10-13 Upside Foods, Inc. Generation of cell-based products for consumption that comprise proteins derived from exotic, endangered, and extinct species
US20220369665A1 (en) 2021-04-28 2022-11-24 Upside Foods, Inc. Generation of Cell-Based Products for Human Consumption
WO2022234586A1 (en) 2021-05-06 2022-11-10 Yeda Research And Development Co. Ltd. Method for inducing hypertrophic muscle fibers for industrial meat production
MX2023014087A (es) * 2021-05-28 2023-12-06 Abs Global Inc Sistemas y metodos de cria in vitro de ganado.
WO2022261647A1 (en) 2021-06-11 2022-12-15 Upside Foods, Inc. Comestible cell-based meat products comprising dry cell powder and methods of making such products
AU2021450828B2 (en) 2021-06-16 2024-09-19 Upside Foods, Inc. Plant fat-based scaffolds for the growth of cell-based meats and methods of making such products
EP4367219A1 (en) 2021-07-09 2024-05-15 Suprême Foodstuffs comprising cells differentiated from engineered oligopotent stem cells
CA3231125A1 (en) 2021-10-19 2023-04-27 Joshua MARCH Plant base/animal cell hybrid meat substitute
CN118541474A (zh) * 2021-12-23 2024-08-23 阿普赛德食品股份有限公司 放大肌原性组织：晚期传代肌原性
EP4292440A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Suspension based chicken product formulation
EP4293109A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Non-skeletal muscle-derived cells as a source of suspension capable myogenic cells for cultured foods
US11981884B2 (en) 2022-10-17 2024-05-14 Upside Foods, Inc. Pipe-based bioreactors for producing comestible meat products and methods of using the same
EP4497814A1 (de) 2023-07-28 2025-01-29 Green Elephant Biotech GmbH Vorrichtung zur vermehrung von differenzierten und undifferenzierten zellen und verwendung der vorrichtung für die herstellung von kultivierten lebensmitteln
WO2025049891A1 (en) 2023-09-01 2025-03-06 Upside Foods, Inc. Transposon system and methods of using the same
US20250120418A1 (en) * 2023-10-12 2025-04-17 Btl Healthcare Technologies A.S. Pet food, methods and devices for producing pet food
WO2025141211A1 (en) * 2023-12-29 2025-07-03 Meatable B.V. Cells for forward programming

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101291596A (zh) * 2005-11-02 2008-10-22 雀巢技术公司 减少雄性哺乳动物体脂肪积累的异黄酮组合物，以及其使用方法
WO2013073246A1 (en) * 2011-11-18 2013-05-23 Kyoto University Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510254A (en) 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
IE904639A1 (en) * 1989-12-21 1991-07-17 Univ Georgia Bovine myogenic factor gene
US5298422A (en) * 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
WO1999031222A1 (en) 1997-12-18 1999-06-24 Willem Frederik Van Eelen Industrial scale production of meat from in vitro cell cultures
US6264992B1 (en) 1998-02-27 2001-07-24 Purdue Research Foundation Submucosa as a growth substrate for cells
US6537782B1 (en) 1998-06-01 2003-03-25 Chugai Seiyaku Kabushiki Kaisha Media for culturing animal cells and process for producing protein by using the same
US6835390B1 (en) 2000-11-17 2004-12-28 Jon Vein Method for producing tissue engineered meat for consumption
AU2004249812B8 (en) * 2003-06-25 2011-09-15 Ottawa Hospital Research Institute Methods and compositions for modulating stem cell growth and differentiation
DE102004017484B4 (de) 2004-04-08 2006-07-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung einer biologischen Materialzusammensetzung tierischen Ursprungs
US20060121006A1 (en) 2004-09-10 2006-06-08 Chancellor Michael B Production of nutritional and therapeutic products from cultured animal cells
CA2580433A1 (en) 2004-09-17 2006-04-20 Jon Vein Tissue engineered meat for consumption and a method for producing tissue engineered meat for consumption
EP1996215A2 (en) * 2006-02-28 2008-12-03 Trustees Of Boston University Metabolic regulators and uses thereof
DE102007029699B4 (de) 2007-06-27 2010-12-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Isolierte proliferierende Zellen mit Stammzelleigenschaften aus adultem Gewebe von wechselwarmen Wirbeltieren, stabile Zellkulturen davon und Verfahren zu deren Herstellung
CN101624570B (zh) 2008-07-07 2011-04-13 刘志军 中药培养养殖肉灵芝方法及养殖肉灵芝保健品的制备方法
US20110301249A1 (en) 2008-12-12 2011-12-08 Kedar Challakere Stem cell enhanced protein products and uses therof
US20110091604A1 (en) 2009-10-21 2011-04-21 Seth Adrian Miller Synthetic meat
WO2012034101A2 (en) 2010-09-09 2012-03-15 The Regents Of The University Of California Expandable cell source of neuronal stem cell populations and methods for obtaining and using them
BR112013031770A2 (pt) * 2011-06-10 2016-12-06 Univ Georgia população de células-tronco aviárias de pluripotência induzida, ave quimérica, método de reprogamação de uma célula embrionária aviária ou célula somática adulta, método de manipulação genética de espécies aviárias, método de instilar a resistência à doença em uma célula-tronco aviária pluripotente induzida, método de instilar a resistência à doença em uma população de célula-tronco aviária pluripotente, método para produzir um gameta de ave quimérica, método de produção de material imunogênico para uma vacina e vacina
US8900572B2 (en) * 2011-06-14 2014-12-02 UNIVERSITé LAVAL Myogenic differentiation of stem cells and uses thereof
WO2012176023A1 (en) 2011-06-23 2012-12-27 Indian Institute Of Technology Kanpur Hydrogel scaffolds for tissue engineering
CA2841473C (en) 2011-07-12 2020-08-11 Maraxi, Inc. Methods and compositions for consumables
US10039306B2 (en) 2012-03-16 2018-08-07 Impossible Foods Inc. Methods and compositions for consumables
EP2736357B9 (en) 2011-07-26 2019-01-09 The Curators Of The University Of Missouri Engineered comestible meat
CA2792081C (en) * 2011-10-11 2020-10-27 Bond University Ltd Layered compositions comprising 3d nanofibre webbing for tissue repair
EP2825694A4 (en) 2012-03-16 2016-04-20 Impossible Foods Inc AFFINITY REAGENTS FOR PROTEIN CLEANING
CN104603293A (zh) 2012-03-28 2015-05-06 现代牧场有限公司 工程的皮革和其制造方法
CN114847358A (zh) 2013-01-11 2022-08-05 非凡食品有限公司 包含凝聚物的非乳制干酪仿品
PT2959005T (pt) 2013-02-22 2021-12-30 Univ Leland Stanford Junior Utilização médica relacionada com extensão de telómero
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
CA2928726A1 (en) 2013-10-30 2015-05-07 The Curators Of The University Of Missouri Method for scalable skeletal muscle lineage specification and cultivation
US9526267B2 (en) 2014-04-17 2016-12-27 Savage River, Inc. Nutrient-dense meat structured protein products
US20150296834A1 (en) 2014-04-17 2015-10-22 Savage River, Inc. dba Beyond Meat, Inc. Plant based meat structured protein products
CA2992860A1 (en) 2015-07-24 2017-02-02 Synthetic Genomics, Inc. A protein rich food ingredient from biomass and methods of production
MX2018008733A (es) 2016-01-14 2019-01-28 Memphis Meats Inc Metodos para extender la capacidad replicativa de las celulas somaticas durante un proceso de cultivo ex vivo.
US11976302B2 (en) 2017-05-06 2024-05-07 Upside Foods, Inc. Compositions and methods for increasing the culture density of a cellular biomass within a cultivation infrastructure
WO2019014652A1 (en) 2017-07-13 2019-01-17 Memphis Meats, Inc. COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CELL CULTURES USED IN FOOD PRODUCTION

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101291596A (zh) * 2005-11-02 2008-10-22 雀巢技术公司 减少雄性哺乳动物体脂肪积累的异黄酮组合物，以及其使用方法
WO2013073246A1 (en) * 2011-11-18 2013-05-23 Kyoto University Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HOLLENBERG S M.: "Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination" *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025011578A1 (zh) * 2023-07-10 2025-01-16 中国农业大学 一种猪多能干细胞的肌源性分化方法及其用于细胞培养肉制备

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