ES2774488T3 - Ratones modificados genéticamente que expresan moléculas quiméricas del complejo de histocompatibilidad mayor (MHC) de clase II - Google Patents
Ratones modificados genéticamente que expresan moléculas quiméricas del complejo de histocompatibilidad mayor (MHC) de clase II Download PDFInfo
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- ES2774488T3 ES2774488T3 ES17171524T ES17171524T ES2774488T3 ES 2774488 T3 ES2774488 T3 ES 2774488T3 ES 17171524 T ES17171524 T ES 17171524T ES 17171524 T ES17171524 T ES 17171524T ES 2774488 T3 ES2774488 T3 ES 2774488T3
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| RS55949B1 (sr) | 2011-10-28 | 2017-09-29 | Regeneron Pharmaeuticals Inc | Humanizovani il-6 i il-6 receptor |
| SMT202200205T1 (it) | 2011-10-28 | 2022-07-21 | Regeneron Pharma | Topi geneticamente modificati che esprimono molecole chimeriche del complesso maggiore di istocompatibilità (mhc) ii |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| CA2900832A1 (en) | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| WO2014130667A1 (en) * | 2013-02-22 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
| CA2903025C (en) * | 2013-03-11 | 2025-10-07 | Regeneron Pharmaceuticals, Inc. | TRANSGENIC MICE EXPRESSING CHIMERIC MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS II MOLECULES |
| LT3175706T (lt) | 2013-09-23 | 2019-02-25 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, išskyrus žmogų, turintys humanizuotą signalą reguliuojančio baltymo geną |
| RU2674910C2 (ru) * | 2013-10-15 | 2018-12-13 | Регенерон Фармасьютикалс, Инк. | Животные с гуманизированным геном il-15 |
| WO2015077071A1 (en) | 2013-11-19 | 2015-05-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| KR102439412B1 (ko) | 2014-04-08 | 2022-09-02 | 리제너론 파아마슈티컬스, 인크. | 인간화된 Fc-감마 수용체를 갖는 비-인간 동물 |
| NO2785538T3 (OSRAM) | 2014-05-07 | 2018-08-04 | ||
| RS60097B1 (sr) | 2014-06-19 | 2020-05-29 | Regeneron Pharma | Ne-humane životinje koje imaju humanizovani gen za programiranu ćelijsku smrt 1 |
| RU2017113134A (ru) | 2014-09-19 | 2018-10-19 | Регенерон Фармасьютикалз, Инк. | Химерные антигенные рецепторы |
| CA2967823A1 (en) | 2014-11-24 | 2016-06-02 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing humanized cd3 complex |
| SMT201900178T1 (it) | 2014-12-05 | 2019-05-10 | Regeneron Pharma | Animali diversi dall’uomo aventi un gruppo umanizzato del gene 47 di differenziazione |
| IL282649B (en) | 2014-12-09 | 2022-07-01 | Regeneron Pharma | Non-human animals with a humanized gene for differentiation cluster 274 |
| RS64540B1 (sr) | 2015-04-06 | 2023-09-29 | Regeneron Pharma | Imunski odgovori posredovani humanizovanim t ćelijama kod ne-humanih životinja |
| PL3376857T3 (pl) | 2015-11-20 | 2021-09-13 | Regeneron Pharmaceuticals, Inc. | Zwierzęta inne niż człowiek posiadające humanizowany gen aktywacji limfocytów 3 |
| CN108779159B (zh) * | 2016-02-04 | 2022-12-30 | 瑞泽恩制药公司 | 具有经改造的angptl8基因的非人动物 |
| EP3422845B1 (en) | 2016-02-29 | 2021-06-02 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| PT3462853T (pt) | 2016-06-03 | 2023-04-21 | Regeneron Pharma | Animais não humanos que expressam desoxinucleotidiltransferase terminal exógena |
| CN116064611A (zh) | 2017-11-30 | 2023-05-05 | 瑞泽恩制药公司 | 包含人源化trkb基因座的非人动物 |
| LT3772927T (lt) | 2018-03-24 | 2025-02-10 | Regeneron Pharmaceuticals, Inc. | Genetiškai modifikuotos pelės arba žiurkės, skirtos gaminti terapinius antikūnus prieš peptidų- mhc kompleksus, jų gamybos būdai ir panaudojimas |
| CN116420679B (zh) | 2018-03-26 | 2025-10-03 | 瑞泽恩制药公司 | 用于测试治疗剂的人源化啮齿动物 |
| WO2020018511A1 (en) | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of ditra disease and uses thereof |
| CN114585744A (zh) * | 2019-10-22 | 2022-06-03 | 纽约市哥伦比亚大学理事会 | 转基因猪、其制造方法和用途以及制造人免疫系统小鼠的方法 |
| KR20220110233A (ko) | 2019-12-02 | 2022-08-05 | 리제너론 파마슈티칼스 인코포레이티드 | 펩티드-mhc ii 단백질 작제물 및 그의 용도 |
| JP2024512702A (ja) | 2021-03-31 | 2024-03-19 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｔｃｒβレパートリーの改善された多様性を伴うヒト化細胞免疫系の構成要素を含む、遺伝的に改変されたマウス |
| CA3258639A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules to modulate T lymphocyte activity, and their uses |
| EP4536836A1 (en) | 2022-06-07 | 2025-04-16 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
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