ES2774436T3 - Utilización de derivados de pirazolopirimidinas en el tratamiento de trastornos vinculados a PI3K - Google Patents
Utilización de derivados de pirazolopirimidinas en el tratamiento de trastornos vinculados a PI3K Download PDFInfo
- Publication number
- ES2774436T3 ES2774436T3 ES14710739T ES14710739T ES2774436T3 ES 2774436 T3 ES2774436 T3 ES 2774436T3 ES 14710739 T ES14710739 T ES 14710739T ES 14710739 T ES14710739 T ES 14710739T ES 2774436 T3 ES2774436 T3 ES 2774436T3
- Authority
- ES
- Spain
- Prior art keywords
- mmol
- methyl
- chloro
- compound
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C[C@@](c1cc(*)c(*)c(*)c1*)Nc1c(C(C)=[N+])c(*)ncn1 Chemical compound C[C@@](c1cc(*)c(*)c(*)c1*)Nc1c(C(C)=[N+])c(*)ncn1 0.000 description 3
- DTQVDTLACAAQTR-UHFFFAOYSA-N OC(C(F)(F)F)=O Chemical compound OC(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 3
- MRVLFHBXSHLHOL-UHFFFAOYSA-N CC(c1cc(Cl)c(C)c(-c(cc2)cnc2C(N(C)C)=O)c1OC)[n]1nc(C)c2c(N)nccc12 Chemical compound CC(c1cc(Cl)c(C)c(-c(cc2)cnc2C(N(C)C)=O)c1OC)[n]1nc(C)c2c(N)nccc12 MRVLFHBXSHLHOL-UHFFFAOYSA-N 0.000 description 1
- ONBDXQSSHKXZSF-UHFFFAOYSA-N CC(c1cc(Cl)c(C)c(-c2ccc(C(N(C)CCO)=O)nc2)c1OC)[n]1nc(C)c2c1ncnc2N Chemical compound CC(c1cc(Cl)c(C)c(-c2ccc(C(N(C)CCO)=O)nc2)c1OC)[n]1nc(C)c2c1ncnc2N ONBDXQSSHKXZSF-UHFFFAOYSA-N 0.000 description 1
- KATAAFRJKJMWFE-UHFFFAOYSA-N CC(c1cc(Cl)c(C)c(-c2cncc(C(N(C)C)=O)c2)c1OC)[n]1nc(C)c2c(N)ncnc12 Chemical compound CC(c1cc(Cl)c(C)c(-c2cncc(C(N(C)C)=O)c2)c1OC)[n]1nc(C)c2c(N)ncnc12 KATAAFRJKJMWFE-UHFFFAOYSA-N 0.000 description 1
- CLAWHHQEEYBJHW-UHFFFAOYSA-N CCOc(c(C(C)=O)c1)c(C(CO2)NC2=O)c(F)c1Cl Chemical compound CCOc(c(C(C)=O)c1)c(C(CO2)NC2=O)c(F)c1Cl CLAWHHQEEYBJHW-UHFFFAOYSA-N 0.000 description 1
- IMLHIRHIJBANDD-UHFFFAOYSA-N CCOc(c(C(C)=O)c1)c(C=C)c(F)c1Cl Chemical compound CCOc(c(C(C)=O)c1)c(C=C)c(F)c1Cl IMLHIRHIJBANDD-UHFFFAOYSA-N 0.000 description 1
- ODLPGTJSNVNPJT-UHFFFAOYSA-N CCOc(c(C(C)O)c1)c(C(C2)CNC2=O)c(C#N)c1Cl Chemical compound CCOc(c(C(C)O)c1)c(C(C2)CNC2=O)c(C#N)c1Cl ODLPGTJSNVNPJT-UHFFFAOYSA-N 0.000 description 1
- FBRKRAOGHVCFCB-SFVWDYPZSA-N CCOc(c(C(C)[n]1nc(C)c2c(N)ncnc12)c1)c(C2CN(C[C@H](C)O)C2)c(C)c1Cl Chemical compound CCOc(c(C(C)[n]1nc(C)c2c(N)ncnc12)c1)c(C2CN(C[C@H](C)O)C2)c(C)c1Cl FBRKRAOGHVCFCB-SFVWDYPZSA-N 0.000 description 1
- QNVANHSLAQSVON-UHFFFAOYSA-N CCOc(c(C(CO1)NC1=O)c1F)c(C(C)Cl)cc1Cl Chemical compound CCOc(c(C(CO1)NC1=O)c1F)c(C(C)Cl)cc1Cl QNVANHSLAQSVON-UHFFFAOYSA-N 0.000 description 1
- AWHBRNHVGRVECL-UHFFFAOYSA-N CCOc(c(C(CO1)NC1=O)c1F)c(C(C)O)cc1Cl Chemical compound CCOc(c(C(CO1)NC1=O)c1F)c(C(C)O)cc1Cl AWHBRNHVGRVECL-UHFFFAOYSA-N 0.000 description 1
- UKFAGMZZZSPUFZ-UHFFFAOYSA-N CCOc(c(C1(C)OCCO1)c1)c(C(C2)CNC2=O)c(F)c1Cl Chemical compound CCOc(c(C1(C)OCCO1)c1)c(C(C2)CNC2=O)c(F)c1Cl UKFAGMZZZSPUFZ-UHFFFAOYSA-N 0.000 description 1
- ODJLISKSECPGOQ-UHFFFAOYSA-N CC[O](C)c(c(C(C1)CN1C(C(C)(C)O)=O)c1C#N)c(C(C)[n]2nc(C)c3c2ncnc3N)cc1Cl Chemical compound CC[O](C)c(c(C(C1)CN1C(C(C)(C)O)=O)c1C#N)c(C(C)[n]2nc(C)c3c2ncnc3N)cc1Cl ODJLISKSECPGOQ-UHFFFAOYSA-N 0.000 description 1
- CJNJLCYTPKHVSM-YNODCEANSA-N C[C@H](CN(C1)CC1c(c(C)c(cc1C(C)[n]2nc(C)c3c(N)ncnc23)Cl)c1OC)O Chemical compound C[C@H](CN(C1)CC1c(c(C)c(cc1C(C)[n]2nc(C)c3c(N)ncnc23)Cl)c1OC)O CJNJLCYTPKHVSM-YNODCEANSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361771480P | 2013-03-01 | 2013-03-01 | |
| PCT/US2014/019372 WO2014134426A1 (en) | 2013-03-01 | 2014-02-28 | USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3Kδ RELATED DISORDERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2774436T3 true ES2774436T3 (es) | 2020-07-21 |
Family
ID=50288319
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14710739T Active ES2774436T3 (es) | 2013-03-01 | 2014-02-28 | Utilización de derivados de pirazolopirimidinas en el tratamiento de trastornos vinculados a PI3K |
| ES19208523T Active ES2945212T3 (es) | 2013-03-01 | 2014-02-28 | Utilización de derivados de pirazolopirimidinas para el tratamiento de trastornos relacionados con PI3K |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19208523T Active ES2945212T3 (es) | 2013-03-01 | 2014-02-28 | Utilización de derivados de pirazolopirimidinas para el tratamiento de trastornos relacionados con PI3K |
Country Status (32)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2845856A1 (en) | 2009-06-29 | 2015-03-11 | Incyte Corporation | Pyrimidinones as PI3K inhibitors |
| UA121539C2 (uk) | 2011-09-02 | 2020-06-25 | Інсайт Холдинґс Корпорейшн | Гетероцикліламіни як інгібітори рі3к |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| EP2943485B1 (en) | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| ME03780B (me) | 2013-01-15 | 2021-04-20 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
| TWI841376B (zh) | 2013-03-01 | 2024-05-01 | 美商英塞特控股公司 | 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途 |
| TW201605866A (zh) | 2013-08-23 | 2016-02-16 | 英塞特公司 | 可用作ｐｉｍ激酶抑制劑之呋喃并－及噻吩并－吡啶甲醯胺化合物 |
| CN106413716B (zh) | 2014-04-08 | 2020-03-27 | 因赛特公司 | 通过jak和pi3k抑制剂组合治疗b细胞恶性肿瘤 |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016010897A1 (en) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
| WO2016130501A1 (en) | 2015-02-09 | 2016-08-18 | Incyte Corporation | Aza-heteroaryl compounds as pi3k-gamma inhibitors |
| UA122332C2 (uk) | 2015-02-27 | 2020-10-26 | Інсайт Корпорейшн | Солі інгібітора pi3k і способи їх отримання |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| TWI744256B (zh) | 2015-11-06 | 2021-11-01 | 美商英塞特公司 | 作為ＰＩ３Ｋ-γ抑制劑之雜環化合物 |
| TW201734003A (zh) | 2016-01-05 | 2017-10-01 | 英塞特公司 | 作為ＰＩ３Ｋ-γ抑制劑之吡啶及嘧啶化合物 |
| KR102375929B1 (ko) | 2016-03-31 | 2022-03-16 | 온크터널 테라퓨틱스, 인코포레이티드. | 인돌린 유사체 및 이의 용도 |
| AR108875A1 (es) | 2016-06-24 | 2018-10-03 | Incyte Corp | COMPUESTOS HETEROCÍCLICOS COMO INHIBIDORES DE PI3K-g |
| IL272988B (en) * | 2017-09-08 | 2022-08-01 | Beigene Ltd | Imidazo-[1,5-a]pyrazine derivatives as pi3k-delta inhibitors |
| AU2018350980C1 (en) | 2017-10-18 | 2024-12-12 | Incyte Corporation | Condensed imidazole derivatives substituted by tertiary hydroxy groups as pi3k-y gamma inhibitors |
| US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| PH12020500583B1 (en) | 2018-01-10 | 2024-02-21 | Idorsia Pharmaceuticals Ltd | 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as c5a receptor modulators for treating vasculitis and inflammatory diseases |
| MD3762368T2 (ro) | 2018-03-08 | 2022-07-31 | Incyte Corp | Compuși diol aminopirazină ca inhibitori ai PI3K-Y |
| MX2020012826A (es) * | 2018-06-01 | 2021-03-09 | Incyte Corp | Regimen de dosificacion para el tratamiento de trastornos relacionados con fosfatidilinositol 3-cinasas (pi3k). |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| TWI727392B (zh) * | 2018-08-13 | 2021-05-11 | 美商基利科學股份有限公司 | 噻二唑irak4抑制劑 |
| CN110833552A (zh) * | 2018-08-15 | 2020-02-25 | 广西梧州制药（集团）股份有限公司 | 吡唑并嘧啶衍生物在治疗狼疮肾炎的用途 |
| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165) |
| CA3203587A1 (en) | 2020-11-30 | 2022-06-02 | Incyte Corporation | Combination therapy with an anti-cd19 antibody and parsaclisib |
| WO2022115120A1 (en) | 2020-11-30 | 2022-06-02 | Incyte Corporation | Combination therapy with an anti-cd19 antibody and parsaclisib |
| CN112808550B (zh) * | 2020-12-28 | 2021-10-01 | 青岛理工大学 | 用于海洋工程的劣化免疫仿生防护界面及制备方法 |
| TW202329976A (zh) | 2021-12-16 | 2023-08-01 | 美商英塞特公司 | Ｐ１３Ｋ—δ抑制劑之局部調配物 |
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| UA121539C2 (uk) * | 2011-09-02 | 2020-06-25 | Інсайт Холдинґс Корпорейшн | Гетероцикліламіни як інгібітори рі3к |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| TWI841376B (zh) | 2013-03-01 | 2024-05-01 | 美商英塞特控股公司 | 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途 |
| US10077277B2 (en) * | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| UA122332C2 (uk) * | 2015-02-27 | 2020-10-26 | Інсайт Корпорейшн | Солі інгібітора pi3k і способи їх отримання |
| MX2020012826A (es) * | 2018-06-01 | 2021-03-09 | Incyte Corp | Regimen de dosificacion para el tratamiento de trastornos relacionados con fosfatidilinositol 3-cinasas (pi3k). |
| US11161838B2 (en) * | 2018-11-13 | 2021-11-02 | Incyte Corporation | Heterocyclic derivatives as PI3K inhibitors |
-
2014
- 2014-02-27 TW TW112117019A patent/TWI841376B/zh active
- 2014-02-27 TW TW108100664A patent/TWI687220B/zh active
- 2014-02-27 TW TW103106906A patent/TWI657090B/zh active
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